Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 28572459

GI number: 28572459

Start: 340094

End: 341434

Strand: Direct

Name: ffh [H]

Synonym: TW303

Alternate gene names: 28572459

Gene position: 340094-341434 (Clockwise)

Preceding gene: 28572455

Following gene: 28572460

Centisome position: 36.73

GC content: 47.87

Gene sequence:

>1341_bases
GTGTTTGAGACCGTTTCTGGCCGTTTTTTGAATGCGCTTTCTACGCTCCGCGGTAGGGGGAGTCTGGTCAAACGAGATAT
TGATGTTGTTCTCAGTGAGGTTTATAAAACTCTTCTTGACTCAGATGTGTCATTTGAAATTGCACAGGCCTTTGTGCATA
GGGTGCGTGGCAGGTCGATGTCACAGGAGTCTCTGCGTGCAATCAATCCGCACAAACGTGTCACCCAGATTGTTTGGGAG
GAGCTTGTAGACCTTTTAGGTCACCAGAAGACTGCCCTAAAATTCTCCCGCACATTCCCTACCATTATCATGCTGGTTGG
CCTTCAGGGCTCTGGCAAAACCTCTTTTGCCGGAAAGCTAGCTAAATGGCTTATGGAGCGTGGGCATACGGCTGCGCTTG
GTGCATGCGACCTGCAAAGGCCGGCAGCTGCCAGTCAACTTCAGGCAGTTGCAGAGCAGGCCGGTGCCAGCGTACTAATA
CCCAAGTCAGGTAATGTCCTAGACGCTGTAAAAACTGTCGTCAAGACCGCACGAGAAAAACAATTCAGTGTTTTGATTAT
TGACACTGCCGGCCGCATGAATGCCGATTCGGACATGATGGACCAACTGAGCGAAATTGACAGGCTTGCAAAGCCACATC
AGACTTTGCTGGTTGTTGATTCTGCAACAGGCCAGGAGGCTTTAAATATTACCCGTGTTTTCTGCCAGCACCTCAGTGTA
ACGGGGGTTGTTATGTCAAAGCTTGATAGCGACGTAAAAGCGGGTGCAGCTCTATCGGTTTCATCACTTAGGCCGATTAT
TTTTTCCTGCATTGGTGAAGGGGTTGATGATCTTGAACAGTTTAATCCTGACAGTGTAGCGCGTCGCATGCTCGGCATGC
AGGGCCCCCTTGAGGAGCTCGACGATGTTCTGAGGCTTTCTGACAAAACCCCAGACTCACATTCGCCCATTACCCTAGAG
GATTTTTTGGACTCTATACAAAAGATAAAAAATATGAGACACAAGCTTTTGGCTTTCTTCCCCAACTCAGGCGATCTTGA
AAGCATGCTAGATAGCAGTGAAACTATTCGTATGCAGGCAATTGTGAGGTCTATGACTCCGCAAGAAAGGGCACAGCCGC
GTATGCTCAACGCGTCCCGTAGATTGAGAATTGCCACAGGGTCTGGAACAACAGTCAATGATATAAATCGGCTTATTCAA
AAATTTGAGCATGTATTGAAGGTTTTAAGTTCCGGCAATAGCATGAAACACATGACATTCATGAATGGCCGTTTTCCATC
ATTTGGCATGCGGCGCAATAACAGCAAAACTGCGAAGTCAAAACGGAGAAAGCATCGCTAG

Upstream 100 bases:

>100_bases
GGGTAAATTCGAGTGCACCCCGTTGGGATACGTCCGCTCTGTTCTGACTGTCTAAGTCAGGATTTCGCTTAAAACCGGAC
TAATCGGGTTAAAATTGAGT

Downstream 100 bases:

>100_bases
TACTGGTTTTCAGTAAATAGTTTTCACTGTTTAAAAACCCATCAAAGCACCCAACGCCCTGCACCAAACTGTACGGTATT
ACTGCGGTATACAACACCGC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFETVSGRFLNALSTLRGRGSLVKRDIDVVLSEVYKTLLDSDVSFEIAQAFVHRVRGRSMSQESLRAINPHKRVTQIVWE
ELVDLLGHQKTALKFSRTFPTIIMLVGLQGSGKTSFAGKLAKWLMERGHTAALGACDLQRPAAASQLQAVAEQAGASVLI
PKSGNVLDAVKTVVKTAREKQFSVLIIDTAGRMNADSDMMDQLSEIDRLAKPHQTLLVVDSATGQEALNITRVFCQHLSV
TGVVMSKLDSDVKAGAALSVSSLRPIIFSCIGEGVDDLEQFNPDSVARRMLGMQGPLEELDDVLRLSDKTPDSHSPITLE
DFLDSIQKIKNMRHKLLAFFPNSGDLESMLDSSETIRMQAIVRSMTPQERAQPRMLNASRRLRIATGSGTTVNDINRLIQ
KFEHVLKVLSSGNSMKHMTFMNGRFPSFGMRRNNSKTAKSKRRKHR

Sequences:

>Translated_446_residues
MFETVSGRFLNALSTLRGRGSLVKRDIDVVLSEVYKTLLDSDVSFEIAQAFVHRVRGRSMSQESLRAINPHKRVTQIVWE
ELVDLLGHQKTALKFSRTFPTIIMLVGLQGSGKTSFAGKLAKWLMERGHTAALGACDLQRPAAASQLQAVAEQAGASVLI
PKSGNVLDAVKTVVKTAREKQFSVLIIDTAGRMNADSDMMDQLSEIDRLAKPHQTLLVVDSATGQEALNITRVFCQHLSV
TGVVMSKLDSDVKAGAALSVSSLRPIIFSCIGEGVDDLEQFNPDSVARRMLGMQGPLEELDDVLRLSDKTPDSHSPITLE
DFLDSIQKIKNMRHKLLAFFPNSGDLESMLDSSETIRMQAIVRSMTPQERAQPRMLNASRRLRIATGSGTTVNDINRLIQ
KFEHVLKVLSSGNSMKHMTFMNGRFPSFGMRRNNSKTAKSKRRKHR
>Mature_446_residues
MFETVSGRFLNALSTLRGRGSLVKRDIDVVLSEVYKTLLDSDVSFEIAQAFVHRVRGRSMSQESLRAINPHKRVTQIVWE
ELVDLLGHQKTALKFSRTFPTIIMLVGLQGSGKTSFAGKLAKWLMERGHTAALGACDLQRPAAASQLQAVAEQAGASVLI
PKSGNVLDAVKTVVKTAREKQFSVLIIDTAGRMNADSDMMDQLSEIDRLAKPHQTLLVVDSATGQEALNITRVFCQHLSV
TGVVMSKLDSDVKAGAALSVSSLRPIIFSCIGEGVDDLEQFNPDSVARRMLGMQGPLEELDDVLRLSDKTPDSHSPITLE
DFLDSIQKIKNMRHKLLAFFPNSGDLESMLDSSETIRMQAIVRSMTPQERAQPRMLNASRRLRIATGSGTTVNDINRLIQ
KFEHVLKVLSSGNSMKHMTFMNGRFPSFGMRRNNSKTAKSKRRKHR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=460, Percent_Identity=26.7391304347826, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI226371618, Length=406, Percent_Identity=27.5862068965517, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI23308697, Length=333, Percent_Identity=25.8258258258258, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI295424842, Length=333, Percent_Identity=25.8258258258258, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI89061728, Length=140, Percent_Identity=30.7142857142857, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788963, Length=421, Percent_Identity=35.3919239904988, Blast_Score=271, Evalue=4e-74,
Organism=Escherichia coli, GI1789874, Length=214, Percent_Identity=32.2429906542056, Blast_Score=118, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17539958, Length=439, Percent_Identity=26.4236902050114, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI193206261, Length=318, Percent_Identity=27.3584905660377, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=405, Percent_Identity=28.8888888888889, Blast_Score=153, Evalue=6e-38,
Organism=Drosophila melanogaster, GI17647949, Length=460, Percent_Identity=25, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24641198, Length=320, Percent_Identity=25.625, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49373; Mature: 49373

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFETVSGRFLNALSTLRGRGSLVKRDIDVVLSEVYKTLLDSDVSFEIAQAFVHRVRGRSM
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
SQESLRAINPHKRVTQIVWEELVDLLGHQKTALKFSRTFPTIIMLVGLQGSGKTSFAGKL
CHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCCCHHHHHH
AKWLMERGHTAALGACDLQRPAAASQLQAVAEQAGASVLIPKSGNVLDAVKTVVKTAREK
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHC
QFSVLIIDTAGRMNADSDMMDQLSEIDRLAKPHQTLLVVDSATGQEALNITRVFCQHLSV
CEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
TGVVMSKLDSDVKAGAALSVSSLRPIIFSCIGEGVDDLEQFNPDSVARRMLGMQGPLEEL
HHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCCCHHHH
DDVLRLSDKTPDSHSPITLEDFLDSIQKIKNMRHKLLAFFPNSGDLESMLDSSETIRMQA
HHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHCCHHHHHHHH
IVRSMTPQERAQPRMLNASRRLRIATGSGTTVNDINRLIQKFEHVLKVLSSGNSMKHMTF
HHHHCCCHHHCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
MNGRFPSFGMRRNNSKTAKSKRRKHR
ECCCCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MFETVSGRFLNALSTLRGRGSLVKRDIDVVLSEVYKTLLDSDVSFEIAQAFVHRVRGRSM
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
SQESLRAINPHKRVTQIVWEELVDLLGHQKTALKFSRTFPTIIMLVGLQGSGKTSFAGKL
CHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCCCHHHHHH
AKWLMERGHTAALGACDLQRPAAASQLQAVAEQAGASVLIPKSGNVLDAVKTVVKTAREK
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHC
QFSVLIIDTAGRMNADSDMMDQLSEIDRLAKPHQTLLVVDSATGQEALNITRVFCQHLSV
CEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
TGVVMSKLDSDVKAGAALSVSSLRPIIFSCIGEGVDDLEQFNPDSVARRMLGMQGPLEEL
HHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCCCHHHH
DDVLRLSDKTPDSHSPITLEDFLDSIQKIKNMRHKLLAFFPNSGDLESMLDSSETIRMQA
HHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHCCHHHHHHHH
IVRSMTPQERAQPRMLNASRRLRIATGSGTTVNDINRLIQKFEHVLKVLSSGNSMKHMTF
HHHHCCCHHHCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
MNGRFPSFGMRRNNSKTAKSKRRKHR
ECCCCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]