Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 28572446

GI number: 28572446

Start: 329121

End: 329531

Strand: Direct

Name: ndk [H]

Synonym: TW290

Alternate gene names: 28572446

Gene position: 329121-329531 (Clockwise)

Preceding gene: 28572445

Following gene: 28572447

Centisome position: 35.54

GC content: 48.66

Gene sequence:

>411_bases
TTGGAGCAGACACTCGTGATTATCAAGCCAGATGGGATTCGGCGTGGTTTGATCGGACAGGTATTGTCTCGCATTGAAGC
AAAAGGCTATCAAATAGTCGATATCCGCATGCTAGTTCCAGACAGACAGTCAGTTGAAGAGCATTACTTGGAACACCGGG
ATCGACATTTTTATCTTCCGCTCGTAGATTTCATGACCTCTGGGCCTATTGTTCTGGTTAGGGCAGAGGGTCATGGGGTT
GTAGATGCCCTTCGCACTCTCGTTGGCGTGTCAGACCCGACTTTAGCCTTGCCGGGCACAATTAGGGGCGATTTCGGGCG
CAACTGGGGTCTTGATGTTATACAGAATATAGTCCATGCCTCTGACTCGGTCAAGTCTGCTAAGCGTGAATTGGATATTT
GGTTTCCATAA

Upstream 100 bases:

>100_bases
TCTGCGAGGCACCATAACGGGCATATGAGGCAATAGGATTTGGATTAGACTGTGCTAGTCGGTAAATACTGTGCTAGTCG
GTAAATAAGGGGGAATTATT

Downstream 100 bases:

>100_bases
GGTTTTGCTTTGAATATTTCCTATTGCGTCAATCCCTTGGTCCTAATACCGTACCTTTAAAAATAACCTGTAACGGGAGT
GTTATTTACCGGTAAACTTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MEQTLVIIKPDGIRRGLIGQVLSRIEAKGYQIVDIRMLVPDRQSVEEHYLEHRDRHFYLPLVDFMTSGPIVLVRAEGHGV
VDALRTLVGVSDPTLALPGTIRGDFGRNWGLDVIQNIVHASDSVKSAKRELDIWFP

Sequences:

>Translated_136_residues
MEQTLVIIKPDGIRRGLIGQVLSRIEAKGYQIVDIRMLVPDRQSVEEHYLEHRDRHFYLPLVDFMTSGPIVLVRAEGHGV
VDALRTLVGVSDPTLALPGTIRGDFGRNWGLDVIQNIVHASDSVKSAKRELDIWFP
>Mature_136_residues
MEQTLVIIKPDGIRRGLIGQVLSRIEAKGYQIVDIRMLVPDRQSVEEHYLEHRDRHFYLPLVDFMTSGPIVLVRAEGHGV
VDALRTLVGVSDPTLALPGTIRGDFGRNWGLDVIQNIVHASDSVKSAKRELDIWFP

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI66392227, Length=135, Percent_Identity=42.962962962963, Blast_Score=128, Evalue=1e-30,
Organism=Homo sapiens, GI66392205, Length=135, Percent_Identity=42.962962962963, Blast_Score=128, Evalue=1e-30,
Organism=Homo sapiens, GI4505409, Length=135, Percent_Identity=42.962962962963, Blast_Score=128, Evalue=1e-30,
Organism=Homo sapiens, GI66392192, Length=135, Percent_Identity=42.962962962963, Blast_Score=128, Evalue=1e-30,
Organism=Homo sapiens, GI66392203, Length=135, Percent_Identity=42.962962962963, Blast_Score=128, Evalue=1e-30,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=42.2222222222222, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=42.2222222222222, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI37693993, Length=134, Percent_Identity=43.2835820895522, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI4826862, Length=134, Percent_Identity=44.0298507462687, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI37574614, Length=138, Percent_Identity=30.4347826086957, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI7019465, Length=138, Percent_Identity=30.4347826086957, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI5031951, Length=140, Percent_Identity=37.1428571428571, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788866, Length=135, Percent_Identity=40, Blast_Score=107, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17506807, Length=134, Percent_Identity=40.2985074626866, Blast_Score=121, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=134, Percent_Identity=47.0149253731343, Blast_Score=137, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45549037, Length=134, Percent_Identity=41.044776119403, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18860097, Length=139, Percent_Identity=30.9352517985612, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15309; Mature: 15309

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTLVIIKPDGIRRGLIGQVLSRIEAKGYQIVDIRMLVPDRQSVEEHYLEHRDRHFYLP
CCCCEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHHHCCCEEEEH
LVDFMTSGPIVLVRAEGHGVVDALRTLVGVSDPTLALPGTIRGDFGRNWGLDVIQNIVHA
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHC
SDSVKSAKRELDIWFP
CHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEQTLVIIKPDGIRRGLIGQVLSRIEAKGYQIVDIRMLVPDRQSVEEHYLEHRDRHFYLP
CCCCEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHHHCCCEEEEH
LVDFMTSGPIVLVRAEGHGVVDALRTLVGVSDPTLALPGTIRGDFGRNWGLDVIQNIVHA
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHC
SDSVKSAKRELDIWFP
CHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA