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The map label for this gene is typA [H]

Identifier: 28572329

GI number: 28572329

Start: 205328

End: 207172

Strand: Direct

Name: typA [H]

Synonym: TW166

Alternate gene names: 28572329

Gene position: 205328-207172 (Clockwise)

Preceding gene: 28572328

Following gene: 28572330

Centisome position: 22.18

GC content: 47.32

Gene sequence:

>1845_bases
GTGATAACCAAGGATATAAGAAATATTGCTGTTGTAGCACATGTAGACCACGGCAAGACAACCCTGATTAGCGCGATGCT
TCAACAGACGAGCGATTCAACCACTGCAGAAGATAGGGTTCTTGACTCGCATGAGCTCGAGCGTGAAAAGGGAATCACGA
TTCTCGCAAAGAATACCGCAGTTACCTACAAGTCATCCGGAAGATCTGTGACACTAAATATAGTCGACACACCCGGGCAT
GCGGATTTCGGTGGAGAGGTCGAACGGGGAATGTCTATGGTCGATGGTGTTGTTGTACTGGTTGATGCAAGCGAAGGCCC
ACTTCCACAAACCCGCTTTGTTCTGAAAAAGGCATTACTCAAAAAGCTTCCGATTGTTCTTGCGGTTAATAAAACAGATA
GAAGTGATGCTCGTATAGATGATGTTGTTTCTGAATTTCAGGACTTATTAATATCCCTGGCAGAAGAGATAAACGATCCG
GCCATATACAGTATCCTTGATGTCCCGATTGTATATGTTTCTGGCAGGGCAGGCCGGGCGAGCATAAATAAGCCAGATAA
TGGACAATTGCCAGATAGAAATAATCTCGATGACCTATTTGAAAAAATAATAAGTTATATCCCGGCACCGGAATATGATA
AAAGCGCCCCACTCCAAGCACATGTTGCCAATATCGATGCCTCAGCGTTCTTGGGTCGCCTTGCTCTTACAAGAATTTAT
AACGGCAGCATATCAAAGGGACAGACAGTTTGCTGGGTAAATACCTCATCTAAACAGCGGGTGAATGTCAGGGTAACTGA
GCTGCTCAAGACAGTTGCTTTGGATCGCGTGCCCGTCCCTTCAGTCTCTGCTGGTGATATAGTCGCCATTGCTGGCATAC
CGGATGTAATGATAGGTGACTCCATATGCGACCCTGATGATGTCAGACCCCTGCCCGGTATATCCATTGATGAGCCGGCA
ATTTCGGTTGTTATCGGTGTCAACACATCTCCTTTGGCAGGGGGTGTCCCGGGCCATAAGCTCACGGCAACGCAAATAAA
AGAGCGACTTGACAGAGAGACAATTGGCAATGTTTCTATACGGGTCATTCCAACCCGGGGAACCGATGCCTGGGAAGTGC
AGGGTAGAGGAGAGCTGGCCCTTGCAGTTCTTATCGAGCAAATGCGAAGAGAAGGGTTTGAGCTAACCGTTGGAAAGCCC
AGCGCCGTAACACGTATTGTAGATGGTAGTCTCCATGAACCATATGAACTATTGACCGTAAACCTCATGGACGAGTATTT
TGGTTCAGTGACAAAATTACTTGCCGAACGGAAGTGCAGGGTGGAGAGCGTTATATCCAATGCCGGGTGGACAAATGCTG
ATTTTGTTGTCCCTTCAAGGGGGTTAATTGGATTTCGTACTGAGTTTTTGACAATTACTCGCGGCACTGGGACTGCAAAT
GCGATTTTTCATTCCTATGCTCCGTGGTCCGGTCAGATTAACCAGCGAGCACAAGGATCAGCCGTAGCCGATAGGGCAGG
GCATGTGACATCTTATGCAATCCTTGGGCTTCAGGAGAGGGTCTTGTTTTTTGTATCCCCATCCGAGCGGGTTTATGAAG
GTATGGTTGTCGGCAGAAACTCTCGTCCCGGCGACCTAAATGTTAATGTTACAAAAGGAAAAAAACTTACTAATACCCGC
TCTTCCACGGCTGAGGAGCTGGAGAAAATAGTCCCCGCCAGACATTTGTCACTTGAAGAATGTCTTGAGTTCGCGGGACC
GGATGAGTGTGTTGAGGTAACACCAGAGGCTATTAGGATTCGTAAGATTGAACTCAGTCAATCGGTTCGCAGTAAGCAAA
GGTGA

Upstream 100 bases:

>100_bases
ACAACTGTTAGTGCTGTATATATACTGAACAAGCTATTACTGTGTTATTTAACTGTGTTACCAGTTATTTAACTGTGTTA
CTTATAAGGAAAACATATCT

Downstream 100 bases:

>100_bases
CCGCATCTTTGCTAATATTAGCTTCAACACTGTTCCGTACCCTGCTATCCGTATTGTATACTCAGTCAGCCACACTATAT
ACTCATACGCTAATCCAAGC

Product: transcription factor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MITKDIRNIAVVAHVDHGKTTLISAMLQQTSDSTTAEDRVLDSHELEREKGITILAKNTAVTYKSSGRSVTLNIVDTPGH
ADFGGEVERGMSMVDGVVVLVDASEGPLPQTRFVLKKALLKKLPIVLAVNKTDRSDARIDDVVSEFQDLLISLAEEINDP
AIYSILDVPIVYVSGRAGRASINKPDNGQLPDRNNLDDLFEKIISYIPAPEYDKSAPLQAHVANIDASAFLGRLALTRIY
NGSISKGQTVCWVNTSSKQRVNVRVTELLKTVALDRVPVPSVSAGDIVAIAGIPDVMIGDSICDPDDVRPLPGISIDEPA
ISVVIGVNTSPLAGGVPGHKLTATQIKERLDRETIGNVSIRVIPTRGTDAWEVQGRGELALAVLIEQMRREGFELTVGKP
SAVTRIVDGSLHEPYELLTVNLMDEYFGSVTKLLAERKCRVESVISNAGWTNADFVVPSRGLIGFRTEFLTITRGTGTAN
AIFHSYAPWSGQINQRAQGSAVADRAGHVTSYAILGLQERVLFFVSPSERVYEGMVVGRNSRPGDLNVNVTKGKKLTNTR
SSTAEELEKIVPARHLSLEECLEFAGPDECVEVTPEAIRIRKIELSQSVRSKQR

Sequences:

>Translated_614_residues
MITKDIRNIAVVAHVDHGKTTLISAMLQQTSDSTTAEDRVLDSHELEREKGITILAKNTAVTYKSSGRSVTLNIVDTPGH
ADFGGEVERGMSMVDGVVVLVDASEGPLPQTRFVLKKALLKKLPIVLAVNKTDRSDARIDDVVSEFQDLLISLAEEINDP
AIYSILDVPIVYVSGRAGRASINKPDNGQLPDRNNLDDLFEKIISYIPAPEYDKSAPLQAHVANIDASAFLGRLALTRIY
NGSISKGQTVCWVNTSSKQRVNVRVTELLKTVALDRVPVPSVSAGDIVAIAGIPDVMIGDSICDPDDVRPLPGISIDEPA
ISVVIGVNTSPLAGGVPGHKLTATQIKERLDRETIGNVSIRVIPTRGTDAWEVQGRGELALAVLIEQMRREGFELTVGKP
SAVTRIVDGSLHEPYELLTVNLMDEYFGSVTKLLAERKCRVESVISNAGWTNADFVVPSRGLIGFRTEFLTITRGTGTAN
AIFHSYAPWSGQINQRAQGSAVADRAGHVTSYAILGLQERVLFFVSPSERVYEGMVVGRNSRPGDLNVNVTKGKKLTNTR
SSTAEELEKIVPARHLSLEECLEFAGPDECVEVTPEAIRIRKIELSQSVRSKQR
>Mature_614_residues
MITKDIRNIAVVAHVDHGKTTLISAMLQQTSDSTTAEDRVLDSHELEREKGITILAKNTAVTYKSSGRSVTLNIVDTPGH
ADFGGEVERGMSMVDGVVVLVDASEGPLPQTRFVLKKALLKKLPIVLAVNKTDRSDARIDDVVSEFQDLLISLAEEINDP
AIYSILDVPIVYVSGRAGRASINKPDNGQLPDRNNLDDLFEKIISYIPAPEYDKSAPLQAHVANIDASAFLGRLALTRIY
NGSISKGQTVCWVNTSSKQRVNVRVTELLKTVALDRVPVPSVSAGDIVAIAGIPDVMIGDSICDPDDVRPLPGISIDEPA
ISVVIGVNTSPLAGGVPGHKLTATQIKERLDRETIGNVSIRVIPTRGTDAWEVQGRGELALAVLIEQMRREGFELTVGKP
SAVTRIVDGSLHEPYELLTVNLMDEYFGSVTKLLAERKCRVESVISNAGWTNADFVVPSRGLIGFRTEFLTITRGTGTAN
AIFHSYAPWSGQINQRAQGSAVADRAGHVTSYAILGLQERVLFFVSPSERVYEGMVVGRNSRPGDLNVNVTKGKKLTNTR
SSTAEELEKIVPARHLSLEECLEFAGPDECVEVTPEAIRIRKIELSQSVRSKQR

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=403, Percent_Identity=28.0397022332506, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI94966754, Length=159, Percent_Identity=37.7358490566038, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI4503483, Length=146, Percent_Identity=34.2465753424658, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI18390331, Length=190, Percent_Identity=33.1578947368421, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=36.0294117647059, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=36.0294117647059, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI310132016, Length=113, Percent_Identity=38.0530973451327, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI310110807, Length=113, Percent_Identity=38.0530973451327, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI310123363, Length=113, Percent_Identity=38.0530973451327, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI25306287, Length=335, Percent_Identity=26.2686567164179, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI25306283, Length=150, Percent_Identity=36.6666666666667, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI19923640, Length=150, Percent_Identity=36.6666666666667, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI34147630, Length=313, Percent_Identity=26.1980830670927, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI94966752, Length=156, Percent_Identity=29.4871794871795, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI223555963, Length=335, Percent_Identity=25.3731343283582, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI5729864, Length=335, Percent_Identity=25.3731343283582, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI48994988, Length=617, Percent_Identity=44.0842787682334, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1788922, Length=515, Percent_Identity=26.4077669902913, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1789738, Length=495, Percent_Identity=25.4545454545455, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790835, Length=379, Percent_Identity=23.2189973614776, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789737, Length=274, Percent_Identity=27.7372262773723, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790412, Length=274, Percent_Identity=27.7372262773723, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17557151, Length=397, Percent_Identity=25.6926952141058, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17552882, Length=187, Percent_Identity=32.0855614973262, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17556745, Length=150, Percent_Identity=37.3333333333333, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17506493, Length=184, Percent_Identity=30.4347826086957, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71988811, Length=161, Percent_Identity=32.9192546583851, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71988819, Length=161, Percent_Identity=32.9192546583851, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17533571, Length=140, Percent_Identity=36.4285714285714, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17556456, Length=174, Percent_Identity=32.183908045977, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323320, Length=522, Percent_Identity=26.6283524904215, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324707, Length=148, Percent_Identity=37.8378378378378, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320593, Length=148, Percent_Identity=37.8378378378378, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323098, Length=216, Percent_Identity=33.7962962962963, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324761, Length=256, Percent_Identity=29.296875, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322359, Length=151, Percent_Identity=35.0993377483444, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=38.7323943661972, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78706572, Length=530, Percent_Identity=24.7169811320755, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=41.044776119403, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281363316, Length=343, Percent_Identity=27.1137026239067, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17864358, Length=343, Percent_Identity=27.1137026239067, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574573, Length=194, Percent_Identity=31.9587628865979, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24585711, Length=176, Percent_Identity=29.5454545454545, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24585713, Length=176, Percent_Identity=29.5454545454545, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24585709, Length=176, Percent_Identity=29.5454545454545, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24582462, Length=239, Percent_Identity=30.1255230125523, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19921738, Length=291, Percent_Identity=26.4604810996564, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221458488, Length=150, Percent_Identity=42, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28572034, Length=167, Percent_Identity=31.1377245508982, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66695; Mature: 66695

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITKDIRNIAVVAHVDHGKTTLISAMLQQTSDSTTAEDRVLDSHELEREKGITILAKNTA
CCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHCCCEEEEECEE
VTYKSSGRSVTLNIVDTPGHADFGGEVERGMSMVDGVVVLVDASEGPLPQTRFVLKKALL
EEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
KKLPIVLAVNKTDRSDARIDDVVSEFQDLLISLAEEINDPAIYSILDVPIVYVSGRAGRA
HHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEECCCCCC
SINKPDNGQLPDRNNLDDLFEKIISYIPAPEYDKSAPLQAHVANIDASAFLGRLALTRIY
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
NGSISKGQTVCWVNTSSKQRVNVRVTELLKTVALDRVPVPSVSAGDIVAIAGIPDVMIGD
CCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHCCC
SICDPDDVRPLPGISIDEPAISVVIGVNTSPLAGGVPGHKLTATQIKERLDRETIGNVSI
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEHHHHHHHHCHHHCCCEEE
RVIPTRGTDAWEVQGRGELALAVLIEQMRREGFELTVGKPSAVTRIVDGSLHEPYELLTV
EEEECCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCCCCHHHEEE
NLMDEYFGSVTKLLAERKCRVESVISNAGWTNADFVVPSRGLIGFRTEFLTITRGTGTAN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEEEEEECCCCCHH
AIFHSYAPWSGQINQRAQGSAVADRAGHVTSYAILGLQERVLFFVSPSERVYEGMVVGRN
HHEECCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHEECEEEEEEECCCHHHHCCEEEECC
SRPGDLNVNVTKGKKLTNTRSSTAEELEKIVPARHLSLEECLEFAGPDECVEVTPEAIRI
CCCCCEEEEEECCCEECCCCCHHHHHHHHHCCHHCCCHHHHHHHCCCCHHHHCCCCCEEE
RKIELSQSVRSKQR
EEEHHHHHHHHCCC
>Mature Secondary Structure
MITKDIRNIAVVAHVDHGKTTLISAMLQQTSDSTTAEDRVLDSHELEREKGITILAKNTA
CCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHCCCEEEEECEE
VTYKSSGRSVTLNIVDTPGHADFGGEVERGMSMVDGVVVLVDASEGPLPQTRFVLKKALL
EEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
KKLPIVLAVNKTDRSDARIDDVVSEFQDLLISLAEEINDPAIYSILDVPIVYVSGRAGRA
HHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEECCCCCC
SINKPDNGQLPDRNNLDDLFEKIISYIPAPEYDKSAPLQAHVANIDASAFLGRLALTRIY
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
NGSISKGQTVCWVNTSSKQRVNVRVTELLKTVALDRVPVPSVSAGDIVAIAGIPDVMIGD
CCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHCCC
SICDPDDVRPLPGISIDEPAISVVIGVNTSPLAGGVPGHKLTATQIKERLDRETIGNVSI
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEHHHHHHHHCHHHCCCEEE
RVIPTRGTDAWEVQGRGELALAVLIEQMRREGFELTVGKPSAVTRIVDGSLHEPYELLTV
EEEECCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCCCCHHHEEE
NLMDEYFGSVTKLLAERKCRVESVISNAGWTNADFVVPSRGLIGFRTEFLTITRGTGTAN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEEEEEECCCCCHH
AIFHSYAPWSGQINQRAQGSAVADRAGHVTSYAILGLQERVLFFVSPSERVYEGMVVGRN
HHEECCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHEECEEEEEEECCCHHHHCCEEEECC
SRPGDLNVNVTKGKKLTNTRSSTAEELEKIVPARHLSLEECLEFAGPDECVEVTPEAIRI
CCCCCEEEEEECCCEECCCCCHHHHHHHHHCCHHCCCHHHHHHHCCCCHHHHCCCCCEEE
RKIELSQSVRSKQR
EEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]