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The map label for this gene is glmS

Identifier: 28572321

GI number: 28572321

Start: 184178

End: 186028

Strand: Direct

Name: glmS

Synonym: TW158

Alternate gene names: 28572321

Gene position: 184178-186028 (Clockwise)

Preceding gene: 28572320

Following gene: 28572323

Centisome position: 19.89

GC content: 46.57

Gene sequence:

>1851_bases
ATGTGTGGGATCATTGGTTATTCTGGCCCGCGCCCTGCGGCAGAGGTTCTGTTAAAAGGCTTAGAGCGCCTTGAATACAG
GGGCTACGATTCTGCAGGTATCGCGGTTGTAACAGATAAAGCTTATATTGAGAGCGTAAAGAAATCCGGAAAGCTTAATG
TCCTAAAAACATGCCTTGAAAGGCGCACAACACCCATTGTTGGGTCTACAGGAATTGGCCATACGCGATGGGCAACCCAC
GGCGAACCCAGTGATAGAAATGCGCATCCACATATGGATACAGAACAGAGCTTAGCAATAGTTCACAACGGGATCATAGA
AAACAGCGATGTTTTAAAAAGGGAACTACTTGCGTCGGGAAAAAGCTTCACAAGTGAAACAGACACAGAGGTCGTTGCGC
ATTTACTGTCTGACGCTTTTAAGAAAACACAAGATCTGGTTCAAGCATTTGTAGAAGTTACGCAGCGACTCGAAGGTGCG
TTTGCAGTTGTTGCAATTCACAAAGATCAGCCGAATACCATTGTTGCTGCCAAAAATAATTCACCGCTGCTATTAGGATT
TGGTCAGGGTGAGAATTTCCTGGCCAGTGATATTGCTGCATTTGCAGAATATACACAGCGTGTGGCAAATATTGATCAAG
AGCGAATAGTCGCTCTATCAGGTGATTCTGTTTACATAACTGATTTTGCTGGGCACCCTGTCGATTATGAAGTACATACC
GTAAGCTGGCATCCGGCATCTGTTGATAGTTCCGGCTGGTCATCTTTTATGCTTAAAGAGATCTTTGAAGAACCACAAGC
TGTTGAGAATACCCTGAAAGGGCGCACGGAGGATGGCACAGTCATCCTGCCAGAATGTGATCACATCCGGGATGACCTGC
TTGCAATAGATAGGGTAGTGCTTGTGGGCTGCGGAACGGCCGCCTACGCGGCAATGACTGCTAGTTACTCTATCGAAGCC
TGGGCAGGTTTACCAGTGTCTGTTGAGTTAAGCCACGAATTTAGATACCGCGAACCGGTTCTTAATTCAAAAACTTTAGC
TGTATTTATAAGTCAGTCCGGGGAAACCATGGACAGCCTGATGGCCGTTCGGTATGCGCGGCAGGCTGGGGTCAAAACCA
TTTCTGTTTGTAATGTAATGGACAGTTCTATTCCAAAAGAAAGTCATGCTGTGATATATACCAAAGCCGGCCCCGAAGTA
GCTGTTGCGAGTACAAAGTCTTTTGTCTGTCAAATTGTTGTTTTGTACTTGTTGGCACTATACCTTGGACAGTTGCGTGG
CTTTCGGTCGATTTTTCCAAGACAGAAAGCGGTTTGCGAGTTAAATCGCTTGCCGGTAAAACTGAAACAGGTTCTGGAGA
TTTATGAAAGTGTTCGTCAGCTTGCGCATTGGATGAGCGATTCTCGCTCAATTCTGTTTTTAGGTCGACATGCAGGCTAT
CCGATTGCACTAGAAGCAGCACTGAAGCTAAAAGAGCTCGCGTATATACATGCTGAGGGATTTGCTGCCGGTGAGCTGAA
ACACGGCCCGATTGCCTTGATTGAGCCGGGACAGCCAGTTTTTGTAATAGTTCCATCACCGGTTGGTTCGCCAATTTTGC
ACGCGAAGGTTATTTCGAATATTCGAGAAATAAAATCCCGTGGTGCTAGGATCATTGCTATTGCCGCAGAGGGCGACTCG
GCTGTTTTACCACACGCTGATAGCGTTTTGAGGATACCGCTTACGCGTTACAGTTTTGAGCCACTTTTATCTATAGTACC
CCTGCAGATCTTTGCCCTTGAGCTAGCCGCTGATAAGGGGTTTGATGTCGATCGCCCCAGAAATCTGGCCAAAAGCGTTA
CAGTTGAGTGA

Upstream 100 bases:

>100_bases
TCCGGAAATTCGTCTATTTTTGGTTATGTGTGAAGCTCTGTTCGCTTACAATAAAGAAATTACAAAAATCTGAACAACCA
AGATGATACACTGAAGTTCC

Downstream 100 bases:

>100_bases
ACCTTGCCCCTATTCGAGAAATAAAATCCCCATCATTGCTATTGCTGCAGAGGGCGACTCGGCTGTTTTACCACGCGCTG
ATAGCCTTATCCCCTGATGT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MCGIIGYSGPRPAAEVLLKGLERLEYRGYDSAGIAVVTDKAYIESVKKSGKLNVLKTCLERRTTPIVGSTGIGHTRWATH
GEPSDRNAHPHMDTEQSLAIVHNGIIENSDVLKRELLASGKSFTSETDTEVVAHLLSDAFKKTQDLVQAFVEVTQRLEGA
FAVVAIHKDQPNTIVAAKNNSPLLLGFGQGENFLASDIAAFAEYTQRVANIDQERIVALSGDSVYITDFAGHPVDYEVHT
VSWHPASVDSSGWSSFMLKEIFEEPQAVENTLKGRTEDGTVILPECDHIRDDLLAIDRVVLVGCGTAAYAAMTASYSIEA
WAGLPVSVELSHEFRYREPVLNSKTLAVFISQSGETMDSLMAVRYARQAGVKTISVCNVMDSSIPKESHAVIYTKAGPEV
AVASTKSFVCQIVVLYLLALYLGQLRGFRSIFPRQKAVCELNRLPVKLKQVLEIYESVRQLAHWMSDSRSILFLGRHAGY
PIALEAALKLKELAYIHAEGFAAGELKHGPIALIEPGQPVFVIVPSPVGSPILHAKVISNIREIKSRGARIIAIAAEGDS
AVLPHADSVLRIPLTRYSFEPLLSIVPLQIFALELAADKGFDVDRPRNLAKSVTVE

Sequences:

>Translated_616_residues
MCGIIGYSGPRPAAEVLLKGLERLEYRGYDSAGIAVVTDKAYIESVKKSGKLNVLKTCLERRTTPIVGSTGIGHTRWATH
GEPSDRNAHPHMDTEQSLAIVHNGIIENSDVLKRELLASGKSFTSETDTEVVAHLLSDAFKKTQDLVQAFVEVTQRLEGA
FAVVAIHKDQPNTIVAAKNNSPLLLGFGQGENFLASDIAAFAEYTQRVANIDQERIVALSGDSVYITDFAGHPVDYEVHT
VSWHPASVDSSGWSSFMLKEIFEEPQAVENTLKGRTEDGTVILPECDHIRDDLLAIDRVVLVGCGTAAYAAMTASYSIEA
WAGLPVSVELSHEFRYREPVLNSKTLAVFISQSGETMDSLMAVRYARQAGVKTISVCNVMDSSIPKESHAVIYTKAGPEV
AVASTKSFVCQIVVLYLLALYLGQLRGFRSIFPRQKAVCELNRLPVKLKQVLEIYESVRQLAHWMSDSRSILFLGRHAGY
PIALEAALKLKELAYIHAEGFAAGELKHGPIALIEPGQPVFVIVPSPVGSPILHAKVISNIREIKSRGARIIAIAAEGDS
AVLPHADSVLRIPLTRYSFEPLLSIVPLQIFALELAADKGFDVDRPRNLAKSVTVE
>Mature_616_residues
MCGIIGYSGPRPAAEVLLKGLERLEYRGYDSAGIAVVTDKAYIESVKKSGKLNVLKTCLERRTTPIVGSTGIGHTRWATH
GEPSDRNAHPHMDTEQSLAIVHNGIIENSDVLKRELLASGKSFTSETDTEVVAHLLSDAFKKTQDLVQAFVEVTQRLEGA
FAVVAIHKDQPNTIVAAKNNSPLLLGFGQGENFLASDIAAFAEYTQRVANIDQERIVALSGDSVYITDFAGHPVDYEVHT
VSWHPASVDSSGWSSFMLKEIFEEPQAVENTLKGRTEDGTVILPECDHIRDDLLAIDRVVLVGCGTAAYAAMTASYSIEA
WAGLPVSVELSHEFRYREPVLNSKTLAVFISQSGETMDSLMAVRYARQAGVKTISVCNVMDSSIPKESHAVIYTKAGPEV
AVASTKSFVCQIVVLYLLALYLGQLRGFRSIFPRQKAVCELNRLPVKLKQVLEIYESVRQLAHWMSDSRSILFLGRHAGY
PIALEAALKLKELAYIHAEGFAAGELKHGPIALIEPGQPVFVIVPSPVGSPILHAKVISNIREIKSRGARIIAIAAEGDS
AVLPHADSVLRIPLTRYSFEPLLSIVPLQIFALELAADKGFDVDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=688, Percent_Identity=35.7558139534884, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=35.1744186046512, Blast_Score=378, Evalue=1e-104,
Organism=Homo sapiens, GI29570798, Length=199, Percent_Identity=27.6381909547739, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1790167, Length=618, Percent_Identity=42.2330097087379, Blast_Score=480, Evalue=1e-136,
Organism=Escherichia coli, GI1788651, Length=175, Percent_Identity=29.7142857142857, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082251, Length=321, Percent_Identity=23.0529595015576, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532899, Length=722, Percent_Identity=33.3795013850416, Blast_Score=347, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17539970, Length=435, Percent_Identity=36.551724137931, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=36.0919540229885, Blast_Score=265, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6322745, Length=436, Percent_Identity=33.7155963302752, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6323731, Length=433, Percent_Identity=27.7136258660508, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=34.9514563106796, Blast_Score=113, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6323958, Length=212, Percent_Identity=27.8301886792453, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357745, Length=692, Percent_Identity=35.8381502890173, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI28573187, Length=263, Percent_Identity=26.615969581749, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24659598, Length=185, Percent_Identity=29.1891891891892, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24659604, Length=179, Percent_Identity=29.608938547486, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_TROW8 (Q83IA1)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789101.1
- ProteinModelPortal:   Q83IA1
- SMR:   Q83IA1
- STRING:   Q83IA1
- GeneID:   1064453
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW158
- eggNOG:   COG0449
- HOGENOM:   HBG645312
- OMA:   ALVDDSM
- PhylomeDB:   Q83IA1
- ProtClustDB:   PRK00331
- BioCyc:   TWHI218496:TW0146-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67173; Mature: 67173

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 611-611

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGYSGPRPAAEVLLKGLERLEYRGYDSAGIAVVTDKAYIESVKKSGKLNVLKTCLE
CCEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCHHHHHHHHH
RRTTPIVGSTGIGHTRWATHGEPSDRNAHPHMDTEQSLAIVHNGIIENSDVLKRELLASG
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCC
KSFTSETDTEVVAHLLSDAFKKTQDLVQAFVEVTQRLEGAFAVVAIHKDQPNTIVAAKNN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCC
SPLLLGFGQGENFLASDIAAFAEYTQRVANIDQERIVALSGDSVYITDFAGHPVDYEVHT
CCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHEEEEECCEEEEEECCCCCCCEEEEE
VSWHPASVDSSGWSSFMLKEIFEEPQAVENTLKGRTEDGTVILPECDHIRDDLLAIDRVV
EEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHH
LVGCGTAAYAAMTASYSIEAWAGLPVSVELSHEFRYREPVLNSKTLAVFISQSGETMDSL
EEECCHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHH
MAVRYARQAGVKTISVCNVMDSSIPKESHAVIYTKAGPEVAVASTKSFVCQIVVLYLLAL
HHHHHHHHCCCCEEEHHHHHHHCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHHH
YLGQLRGFRSIFPRQKAVCELNRLPVKLKQVLEIYESVRQLAHWMSDSRSILFLGRHAGY
HHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
PIALEAALKLKELAYIHAEGFAAGELKHGPIALIEPGQPVFVIVPSPVGSPILHAKVISN
CEEHHHHHHHHHHHEEEECCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHH
IREIKSRGARIIAIAAEGDSAVLPHADSVLRIPLTRYSFEPLLSIVPLQIFALELAADKG
HHHHHHCCCEEEEEEECCCCEECCCCCCEEEEEHHHCCHHHHHHHHHHHHHHEEHHCCCC
FDVDRPRNLAKSVTVE
CCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIIGYSGPRPAAEVLLKGLERLEYRGYDSAGIAVVTDKAYIESVKKSGKLNVLKTCLE
CCEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCHHHHHHHHH
RRTTPIVGSTGIGHTRWATHGEPSDRNAHPHMDTEQSLAIVHNGIIENSDVLKRELLASG
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCC
KSFTSETDTEVVAHLLSDAFKKTQDLVQAFVEVTQRLEGAFAVVAIHKDQPNTIVAAKNN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCC
SPLLLGFGQGENFLASDIAAFAEYTQRVANIDQERIVALSGDSVYITDFAGHPVDYEVHT
CCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHEEEEECCEEEEEECCCCCCCEEEEE
VSWHPASVDSSGWSSFMLKEIFEEPQAVENTLKGRTEDGTVILPECDHIRDDLLAIDRVV
EEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHH
LVGCGTAAYAAMTASYSIEAWAGLPVSVELSHEFRYREPVLNSKTLAVFISQSGETMDSL
EEECCHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHH
MAVRYARQAGVKTISVCNVMDSSIPKESHAVIYTKAGPEVAVASTKSFVCQIVVLYLLAL
HHHHHHHHCCCCEEEHHHHHHHCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHHH
YLGQLRGFRSIFPRQKAVCELNRLPVKLKQVLEIYESVRQLAHWMSDSRSILFLGRHAGY
HHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
PIALEAALKLKELAYIHAEGFAAGELKHGPIALIEPGQPVFVIVPSPVGSPILHAKVISN
CEEHHHHHHHHHHHEEEECCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHH
IREIKSRGARIIAIAAEGDSAVLPHADSVLRIPLTRYSFEPLLSIVPLQIFALELAADKG
HHHHHHCCCEEEEEEECCCCEECCCCCCEEEEEHHHCCHHHHHHHHHHHHHHEEHHCCCC
FDVDRPRNLAKSVTVE
CCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174