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The map label for this gene is gyrA1 [H]

Identifier: 28572181

GI number: 28572181

Start: 6438

End: 8897

Strand: Direct

Name: gyrA1 [H]

Synonym: TW006

Alternate gene names: 28572181

Gene position: 6438-8897 (Clockwise)

Preceding gene: 28572180

Following gene: 28572182

Centisome position: 0.7

GC content: 49.27

Gene sequence:

>2460_bases
TTGTCTGAGCAAAATATTAACCAAGTAGATCTTCGCGAGGAGATGCAGCGGTCGTATCTCGACTACGCCATGAGCGTTAT
AATCGGTCGTGCCTTACCCGACGTCCGGGATGGTCTTAAGCCCGTACATCGCAGGGTTTTGTACGCGATGTACAAAGGGG
GTTATAGACCAGAAAAGGCTTTTTCAAAATGTGCCAGGGTTGTCGGCGATGTTATGGGTCAATTTCATCCTCATGGGGAT
GCGGCAATTTATGACGCACTTGTCCGTCTTGTGCAGCCGTGGGCCATGCGCTATCCGCTTGCGCAGGGCCAGGGGAACTT
TGGCTCTCCGGGCAATGATGGCGCTGCCGCCCCTCGTTACACAGAAACGAAAATGGCCACACTCGCGATTGAGATGGTCA
GGGATATTGATGAGGATACTGTTGATTTTTCCCCAAATTATGATGGCGAAAGCGTTGAACCCACAGTTATGCCGTGCCGC
TTTCCCAATCTTTTGGTTAATGGCTCAGTCGGTATTGCGGTTGGTATGGCAACCAATATCCCGCCGCATAACCTTGCCGA
GGTGTCGGCCGGTGCTCTGTGGTGCCTCGAAAATCCGGATGCAACAGATGAGGAGTTGACAGAAGCTCTTCTGGAAAGAA
TAAAAGGTCCCGATTTTCCCACCGGTGCTACGGTGTTGGACACCGGAGGCATAAAAGACGCCTATCTCACGGGCCGCGGC
AGCGTGGTTATGCGAGGCGTTGTTGATATTGAAGAAATAGACGGAAGGACCTGCCTTGTTGTGCGCGAACTTCCTTATCA
AGTCAATCCGGATAATTTGGCTTTAAAGATAGCCTCTCTCGTTAAGGAAAATAAACTTTCGGGAATTGCTGATATTCGGG
ATGAAACAAGCGGTAGAACCGGCCAGCGGTTGATAATCGTCCTCAAGCGAGATGCTGTCGCTCGGGTGGTTCTGAATAGC
CTATACAAACATACACAGCTTCAAGAGAACTTTGGGGTCAATATGCTTGCGATTGTTGACGGGGCACCCAGAACCCTTTC
CCTCTGTTCGTTCATTCGTTTATGGGTTGAACACCAAATAGAAGTCATCGTCCGGCGCACTACCTTCAGGCTTGCCAGGG
CCGAGCAGCGCGCGCATATTCTCAGGGCCTATCTAAGGGCTCTGGACCAGATCGACGAGGTTATACAGCTCATTCGATCT
TCTAAGAGCGCCGAGGAGGCTCAGTCTAACCTTATGGCGCTCCTGAAAATAGACGAAACACAGGCTCGTGCAATCCTTGA
TCTTCAGTTGCGGCGCCTTGCCGCCCTCGAGCGACAAAGGATTATCTCTGAGGCAAGAGAAATAGAAGAGCTAATATCCA
GCTTCAGGAAGATTCTTTCTGACAAGACCGCCCAGTGCCAGGTTATTGCAGAAGAATTGAGGGAAATAGGTCAAAAACAC
TCAGACGCACGACGCACAGAAATAATTCGGGGGTTTGATGGGTCGGTGTCTATTGAAGACCTGATTCCGGTGGAACCTGT
AGTTGTTGTTATGACCCGCTGTGGTTATATAAAACGAACACGTATTGATCAGTATAGGTCTCAACATAGGGGTGGTCGCG
GCGTAAAAGGCGCCCAAGTTAAGGCTGATGATGTCGTGCTGCAGTTTATCTCTACAACAACACACAACTGGCTCATGTTT
TTTACCAATACAGGGAGGGTTTATCGCGCAAAAGCCTATGAAGTCCCGGAGGCAAGCAGGGAGGCTCGTGGTCAGCATGT
TGCAAATCTTCTTCCGCTAAAACCGAATGAGGCGGTGACCAGGATTTTATCTGTCTCTAATTTTGATAGCGAGGATACAA
GCCTTGTTTTGGCCACTAAAGATGGATATGTGAAAAAAACAACCCTTAAAGAGTACGATACATCGCTTAGCACTGGTGTT
ATAGCAATAAAGCTTCGGCCCGGAGATAAGCTTGTATCTGCAGTGCTTGCAAGAAGTGATCAGGACATCATACTGGTTAC
AAAAAATGCCAGATCGCTCAGGTTTAAATCCGGTACATTGCGCCCCTTATCTAGGGGATCATACGGCGTAAAGGGTATAT
CTCTTCGCGAAAACGATCTCCTTCTTTCAGCTGAGCTGATTCTTTCGGACGACAGCTATATATTTGTTGTCAGCGAGAGG
GGTTATGCAAAGCGCTCTAGGGTTGGTGATTACAAACTTCAGGCCCGGGGCGGGATTGGCGTACGGGTTGCAAACATAAC
CGAGCAAAAGGGCGTACTTGCTGACATGCTCGTTGTCAATGACGATGATGAGGTTCTTGTAATTCTTGCAAGCGGTAAGG
TTATTCGCTCATCTGTTGCCGAGGTCTCCCCAACTCTTCGATATACTACCGGGGTCGTTTTTGTCCGCATGTCTGACGGG
GATAAAATTCTGGCCATGACGATAGCAGAGAAATGCGATGACCTGGAAGGGCAGGGGTGA

Upstream 100 bases:

>100_bases
TGATGAGATTTTTTCTGTGCTTATGGGGGAGGATGTCGACTCTCGTCGTAAGTTCATCCAGCACAACGCCAGAGATGTTC
GCTTTTTGGATATATAGATA

Downstream 100 bases:

>100_bases
ATACAAAGCTTGTAAAAAGCTCCTCCTCACAGGCGGTTCTCCGCCTTGGGTCGATTAACGTTGTCTCCGCAGCCAGGACT
GCCTTTGTGTTCTCGCTTGC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MSEQNINQVDLREEMQRSYLDYAMSVIIGRALPDVRDGLKPVHRRVLYAMYKGGYRPEKAFSKCARVVGDVMGQFHPHGD
AAIYDALVRLVQPWAMRYPLAQGQGNFGSPGNDGAAAPRYTETKMATLAIEMVRDIDEDTVDFSPNYDGESVEPTVMPCR
FPNLLVNGSVGIAVGMATNIPPHNLAEVSAGALWCLENPDATDEELTEALLERIKGPDFPTGATVLDTGGIKDAYLTGRG
SVVMRGVVDIEEIDGRTCLVVRELPYQVNPDNLALKIASLVKENKLSGIADIRDETSGRTGQRLIIVLKRDAVARVVLNS
LYKHTQLQENFGVNMLAIVDGAPRTLSLCSFIRLWVEHQIEVIVRRTTFRLARAEQRAHILRAYLRALDQIDEVIQLIRS
SKSAEEAQSNLMALLKIDETQARAILDLQLRRLAALERQRIISEAREIEELISSFRKILSDKTAQCQVIAEELREIGQKH
SDARRTEIIRGFDGSVSIEDLIPVEPVVVVMTRCGYIKRTRIDQYRSQHRGGRGVKGAQVKADDVVLQFISTTTHNWLMF
FTNTGRVYRAKAYEVPEASREARGQHVANLLPLKPNEAVTRILSVSNFDSEDTSLVLATKDGYVKKTTLKEYDTSLSTGV
IAIKLRPGDKLVSAVLARSDQDIILVTKNARSLRFKSGTLRPLSRGSYGVKGISLRENDLLLSAELILSDDSYIFVVSER
GYAKRSRVGDYKLQARGGIGVRVANITEQKGVLADMLVVNDDDEVLVILASGKVIRSSVAEVSPTLRYTTGVVFVRMSDG
DKILAMTIAEKCDDLEGQG

Sequences:

>Translated_819_residues
MSEQNINQVDLREEMQRSYLDYAMSVIIGRALPDVRDGLKPVHRRVLYAMYKGGYRPEKAFSKCARVVGDVMGQFHPHGD
AAIYDALVRLVQPWAMRYPLAQGQGNFGSPGNDGAAAPRYTETKMATLAIEMVRDIDEDTVDFSPNYDGESVEPTVMPCR
FPNLLVNGSVGIAVGMATNIPPHNLAEVSAGALWCLENPDATDEELTEALLERIKGPDFPTGATVLDTGGIKDAYLTGRG
SVVMRGVVDIEEIDGRTCLVVRELPYQVNPDNLALKIASLVKENKLSGIADIRDETSGRTGQRLIIVLKRDAVARVVLNS
LYKHTQLQENFGVNMLAIVDGAPRTLSLCSFIRLWVEHQIEVIVRRTTFRLARAEQRAHILRAYLRALDQIDEVIQLIRS
SKSAEEAQSNLMALLKIDETQARAILDLQLRRLAALERQRIISEAREIEELISSFRKILSDKTAQCQVIAEELREIGQKH
SDARRTEIIRGFDGSVSIEDLIPVEPVVVVMTRCGYIKRTRIDQYRSQHRGGRGVKGAQVKADDVVLQFISTTTHNWLMF
FTNTGRVYRAKAYEVPEASREARGQHVANLLPLKPNEAVTRILSVSNFDSEDTSLVLATKDGYVKKTTLKEYDTSLSTGV
IAIKLRPGDKLVSAVLARSDQDIILVTKNARSLRFKSGTLRPLSRGSYGVKGISLRENDLLLSAELILSDDSYIFVVSER
GYAKRSRVGDYKLQARGGIGVRVANITEQKGVLADMLVVNDDDEVLVILASGKVIRSSVAEVSPTLRYTTGVVFVRMSDG
DKILAMTIAEKCDDLEGQG
>Mature_818_residues
SEQNINQVDLREEMQRSYLDYAMSVIIGRALPDVRDGLKPVHRRVLYAMYKGGYRPEKAFSKCARVVGDVMGQFHPHGDA
AIYDALVRLVQPWAMRYPLAQGQGNFGSPGNDGAAAPRYTETKMATLAIEMVRDIDEDTVDFSPNYDGESVEPTVMPCRF
PNLLVNGSVGIAVGMATNIPPHNLAEVSAGALWCLENPDATDEELTEALLERIKGPDFPTGATVLDTGGIKDAYLTGRGS
VVMRGVVDIEEIDGRTCLVVRELPYQVNPDNLALKIASLVKENKLSGIADIRDETSGRTGQRLIIVLKRDAVARVVLNSL
YKHTQLQENFGVNMLAIVDGAPRTLSLCSFIRLWVEHQIEVIVRRTTFRLARAEQRAHILRAYLRALDQIDEVIQLIRSS
KSAEEAQSNLMALLKIDETQARAILDLQLRRLAALERQRIISEAREIEELISSFRKILSDKTAQCQVIAEELREIGQKHS
DARRTEIIRGFDGSVSIEDLIPVEPVVVVMTRCGYIKRTRIDQYRSQHRGGRGVKGAQVKADDVVLQFISTTTHNWLMFF
TNTGRVYRAKAYEVPEASREARGQHVANLLPLKPNEAVTRILSVSNFDSEDTSLVLATKDGYVKKTTLKEYDTSLSTGVI
AIKLRPGDKLVSAVLARSDQDIILVTKNARSLRFKSGTLRPLSRGSYGVKGISLRENDLLLSAELILSDDSYIFVVSERG
YAKRSRVGDYKLQARGGIGVRVANITEQKGVLADMLVVNDDDEVLVILASGKVIRSSVAEVSPTLRYTTGVVFVRMSDGD
KILAMTIAEKCDDLEGQG

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=317, Percent_Identity=26.1829652996845, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI19913406, Length=165, Percent_Identity=32.1212121212121, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1788562, Length=849, Percent_Identity=42.6383981154299, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=682, Percent_Identity=35.1906158357771, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI212645845, Length=182, Percent_Identity=28.021978021978, Blast_Score=70, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17535065, Length=165, Percent_Identity=30.3030303030303, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=163, Percent_Identity=31.2883435582822, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136538, Length=166, Percent_Identity=33.7349397590361, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 90744; Mature: 90613

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQNINQVDLREEMQRSYLDYAMSVIIGRALPDVRDGLKPVHRRVLYAMYKGGYRPEKA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
FSKCARVVGDVMGQFHPHGDAAIYDALVRLVQPWAMRYPLAQGQGNFGSPGNDGAAAPRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
TETKMATLAIEMVRDIDEDTVDFSPNYDGESVEPTVMPCRFPNLLVNGSVGIAVGMATNI
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCCEEECCCCEEEEEEECCC
PPHNLAEVSAGALWCLENPDATDEELTEALLERIKGPDFPTGATVLDTGGIKDAYLTGRG
CCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCC
SVVMRGVVDIEEIDGRTCLVVRELPYQVNPDNLALKIASLVKENKLSGIADIRDETSGRT
CEEEEECEEHHHCCCCEEEEEEECCCEECCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCC
GQRLIIVLKRDAVARVVLNSLYKHTQLQENFGVNMLAIVDGAPRTLSLCSFIRLWVEHQI
CCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
EVIVRRTTFRLARAEQRAHILRAYLRALDQIDEVIQLIRSSKSAEEAQSNLMALLKIDET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEEEEEEECCH
QARAILDLQLRRLAALERQRIISEAREIEELISSFRKILSDKTAQCQVIAEELREIGQKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
SDARRTEIIRGFDGSVSIEDLIPVEPVVVVMTRCGYIKRTRIDQYRSQHRGGRGVKGAQV
CHHHHHHHHHCCCCCEEHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCEE
KADDVVLQFISTTTHNWLMFFTNTGRVYRAKAYEVPEASREARGQHVANLLPLKPNEAVT
CHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCHHHHHCHHHHHHCCCCCCCHHHH
RILSVSNFDSEDTSLVLATKDGYVKKTTLKEYDTSLSTGVIAIKLRPGDKLVSAVLARSD
HHHHHCCCCCCCCEEEEEECCCCEEECHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCC
QDIILVTKNARSLRFKSGTLRPLSRGSYGVKGISLRENDLLLSAELILSDDSYIFVVSER
CCEEEEECCCCEEEECCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEECCCCEEEEECCC
GYAKRSRVGDYKLQARGGIGVRVANITEQKGVLADMLVVNDDDEVLVILASGKVIRSSVA
CCHHHCCCCCEEEEECCCCEEEEECCCHHCCCEEEEEEECCCCCEEEEEECCHHHHHHHH
EVSPTLRYTTGVVFVRMSDGDKILAMTIAEKCDDLEGQG
HCCCCEEEEEEEEEEEECCCCEEEEEEHHHHHCCCCCCC
>Mature Secondary Structure 
SEQNINQVDLREEMQRSYLDYAMSVIIGRALPDVRDGLKPVHRRVLYAMYKGGYRPEKA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
FSKCARVVGDVMGQFHPHGDAAIYDALVRLVQPWAMRYPLAQGQGNFGSPGNDGAAAPRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
TETKMATLAIEMVRDIDEDTVDFSPNYDGESVEPTVMPCRFPNLLVNGSVGIAVGMATNI
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCCEEECCCCEEEEEEECCC
PPHNLAEVSAGALWCLENPDATDEELTEALLERIKGPDFPTGATVLDTGGIKDAYLTGRG
CCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCC
SVVMRGVVDIEEIDGRTCLVVRELPYQVNPDNLALKIASLVKENKLSGIADIRDETSGRT
CEEEEECEEHHHCCCCEEEEEEECCCEECCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCC
GQRLIIVLKRDAVARVVLNSLYKHTQLQENFGVNMLAIVDGAPRTLSLCSFIRLWVEHQI
CCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
EVIVRRTTFRLARAEQRAHILRAYLRALDQIDEVIQLIRSSKSAEEAQSNLMALLKIDET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEEEEEEECCH
QARAILDLQLRRLAALERQRIISEAREIEELISSFRKILSDKTAQCQVIAEELREIGQKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
SDARRTEIIRGFDGSVSIEDLIPVEPVVVVMTRCGYIKRTRIDQYRSQHRGGRGVKGAQV
CHHHHHHHHHCCCCCEEHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCEE
KADDVVLQFISTTTHNWLMFFTNTGRVYRAKAYEVPEASREARGQHVANLLPLKPNEAVT
CHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCHHHHHCHHHHHHCCCCCCCHHHH
RILSVSNFDSEDTSLVLATKDGYVKKTTLKEYDTSLSTGVIAIKLRPGDKLVSAVLARSD
HHHHHCCCCCCCCEEEEEECCCCEEECHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCC
QDIILVTKNARSLRFKSGTLRPLSRGSYGVKGISLRENDLLLSAELILSDDSYIFVVSER
CCEEEEECCCCEEEECCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEECCCCEEEEECCC
GYAKRSRVGDYKLQARGGIGVRVANITEQKGVLADMLVVNDDDEVLVILASGKVIRSSVA
CCHHHCCCCCEEEEECCCCEEEEECCCHHCCCEEEEEEECCCCCEEEEEECCHHHHHHHH
EVSPTLRYTTGVVFVRMSDGDKILAMTIAEKCDDLEGQG
HCCCCEEEEEEEEEEEECCCCEEEEEEHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7828880; 12000953 [H]