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The map label for this gene is echA12 [H]

Identifier: 284159414

GI number: 284159414

Start: 404958

End: 405707

Strand: Direct

Name: echA12 [H]

Synonym: BTH_I0363

Alternate gene names: 284159414

Gene position: 404958-405707 (Clockwise)

Preceding gene: 83720212

Following gene: 83721197

Centisome position: 10.63

GC content: 70.67

Gene sequence:

>750_bases
ATGAGCGGCGAAGGCGCGAACCGCAGCGGCCTCGCGGTCGCGAGCGAGGCGATGCATCGCGAGCTCGCCGACATCTGGCG
CGACGTCGACCGCGATCCCGACGCGCGCGTCGCGGTGATCCGCGGCGAAGGCAAGGGCTTCTCGGCGGGCGGCGATCTCG
CGCTCGTCGAGCGCATGGCCGACGATCACGCGGTGCGCGAGCGCGTCTGGCGCGAGGCGCGCGATCTCGTCTACAACGTG
ATCAATTGCAGCAAGCCGATCGTATCGGCGATGCACGGGCCCGCCGTCGGCGCGGGGCTCGTCGCGGGGCTGCTCGCCGA
CGTGTCGATCGCCGCGAAGAGCGCGCGGATCATCGACGGCCACACGCGTCTCGGCGTCGCCGCGGGCGATCACGCGGCGA
TCGTCTGGCCGCTGCTTTGCGGGATGGCGAAGGCGAAATACCACTTGCTCCTCTGCGAGCCCGTGAGCGGCGAAGAAGCC
GAGCGCATCGGGCTCGTGTCGCTCGCGGCCGACGATCACGATCTGCTGCCGAAGGCGTACGAAATCGCCGAGCGCCTCGC
GCAAGGCTCGGCAAGCGCGATCCGCTGGACCAAGTACGCGCTCAACAACTGGCTGCGGCTCGCGGGGCCGACGTTCGACG
CGTCGCTCGCGCTCGAATTCATGGGATTTTCCGGGCCGGACGTGCGCGAGGGAATTCGCTCGCTGCGCGAGCGCCGCGCG
CCGGACTTCACGGGCGACGCGCCGTCGTGA

Upstream 100 bases:

>100_bases
CCACTTCGAAGGAAGGTCCAGCATGACCGATCTCGCTCTCTATGCCGGCTATGAAGCACTGCGCATCCTGCGCCGGCCGC
ACGGCATCGTCGAAATCGTG

Downstream 100 bases:

>100_bases
GCGCCGCGCGCGCTATGATCGATCATGGACGCCGCCGCCGTGCGGCGTTTTCCCGCGACCCGCTTCACTCGCTTCGAAGG
ACTCGACGATGACCGACACC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSGEGANRSGLAVASEAMHRELADIWRDVDRDPDARVAVIRGEGKGFSAGGDLALVERMADDHAVRERVWREARDLVYNV
INCSKPIVSAMHGPAVGAGLVAGLLADVSIAAKSARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYHLLLCEPVSGEEA
ERIGLVSLAADDHDLLPKAYEIAERLAQGSASAIRWTKYALNNWLRLAGPTFDASLALEFMGFSGPDVREGIRSLRERRA
PDFTGDAPS

Sequences:

>Translated_249_residues
MSGEGANRSGLAVASEAMHRELADIWRDVDRDPDARVAVIRGEGKGFSAGGDLALVERMADDHAVRERVWREARDLVYNV
INCSKPIVSAMHGPAVGAGLVAGLLADVSIAAKSARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYHLLLCEPVSGEEA
ERIGLVSLAADDHDLLPKAYEIAERLAQGSASAIRWTKYALNNWLRLAGPTFDASLALEFMGFSGPDVREGIRSLRERRA
PDFTGDAPS
>Mature_248_residues
SGEGANRSGLAVASEAMHRELADIWRDVDRDPDARVAVIRGEGKGFSAGGDLALVERMADDHAVRERVWREARDLVYNVI
NCSKPIVSAMHGPAVGAGLVAGLLADVSIAAKSARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYHLLLCEPVSGEEAE
RIGLVSLAADDHDLLPKAYEIAERLAQGSASAIRWTKYALNNWLRLAGPTFDASLALEFMGFSGPDVREGIRSLRERRAP
DFTGDAPS

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=226, Percent_Identity=22.1238938053097, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787660, Length=239, Percent_Identity=30.9623430962343, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787659, Length=238, Percent_Identity=29.4117647058824, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788597, Length=236, Percent_Identity=26.6949152542373, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI221142681, Length=175, Percent_Identity=27.4285714285714, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17534483, Length=194, Percent_Identity=31.4432989690722, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=243, Percent_Identity=26.3374485596708, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=184, Percent_Identity=28.2608695652174, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=232, Percent_Identity=25, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17536985, Length=201, Percent_Identity=27.8606965174129, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24654903, Length=149, Percent_Identity=28.1879194630872, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24653139, Length=241, Percent_Identity=25.7261410788382, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI20129971, Length=240, Percent_Identity=24.1666666666667, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24653477, Length=240, Percent_Identity=24.1666666666667, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19920382, Length=207, Percent_Identity=28.5024154589372, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 26632; Mature: 26500

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGEGANRSGLAVASEAMHRELADIWRDVDRDPDARVAVIRGEGKGFSAGGDLALVERMA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHH
DDHAVRERVWREARDLVYNVINCSKPIVSAMHGPAVGAGLVAGLLADVSIAAKSARIIDG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECC
HTRLGVAAGDHAAIVWPLLCGMAKAKYHLLLCEPVSGEEAERIGLVSLAADDHDLLPKAY
CCEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHEEEEEEECCCHHHCHHHH
EIAERLAQGSASAIRWTKYALNNWLRLAGPTFDASLALEFMGFSGPDVREGIRSLRERRA
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCC
PDFTGDAPS
CCCCCCCCC
>Mature Secondary Structure 
SGEGANRSGLAVASEAMHRELADIWRDVDRDPDARVAVIRGEGKGFSAGGDLALVERMA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHH
DDHAVRERVWREARDLVYNVINCSKPIVSAMHGPAVGAGLVAGLLADVSIAAKSARIIDG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECC
HTRLGVAAGDHAAIVWPLLCGMAKAKYHLLLCEPVSGEEAERIGLVSLAADDHDLLPKAY
CCEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHEEEEEEECCCHHHCHHHH
EIAERLAQGSASAIRWTKYALNNWLRLAGPTFDASLALEFMGFSGPDVREGIRSLRERRA
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCC
PDFTGDAPS
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]