Click here to switch to the map view.

The map label for this gene is flp [H]

Identifier: 28379769

GI number: 28379769

Start: 3052232

End: 3052897

Strand: Direct

Name: flp [H]

Synonym: lp_3444

Alternate gene names: 28379769

Gene position: 3052232-3052897 (Clockwise)

Preceding gene: 28379766

Following gene: 28379770

Centisome position: 92.26

GC content: 46.4

Gene sequence:

>666_bases
ATGGCAGAACATGAATGTGTGCAGTTAGTCCCAATTTTTAGCGAACTCGGTAGTGAACAATTAGACACTATCGAATCGAT
CGTTCGTCACCACCACTATCCAGCCGGCAGCACTTTATTTGGTGCTGACGATCCACTGGATTCACTGATGATTGTTGCCA
ATGGGCAGGTTAAAGTCTATCAGCTAGCTGCCAATGGTCGCGAGCAGTTACTATACCTATTACAAACTGGTGATATCGAT
GGCGAAGCTGCCTTATTTGAAAATCAACGGCGAACCTCATTCGGTGAAGCCTTAGTACCGACGGATGTTTGCAGTATTCG
CCGTTCAGACTTTCAAGACTTGATGCAAAAATATCCCAGTATCAGCATCAACGTCTTAAACGTCTTTGGCAAACGTCTCA
GTCAACTGGAACGTCAAACAACCAGCACGGCCACTGAATCCGTCGAAGCCCGTTTAGCGAACTATATCACTGAAACAGCG
GCAGCGCTCAAAACCGACACGTTTAAACTACCATTAAAGAAAAAAGACCTGGCGACGTTCCTCGGCACCACCCCTGAAAG
CATCAGCCGTAAGCTCGCCTTATTCGAGCGTCAAGGCCTAATTACGCAAAAGCCTGGCAAGGTCATCGAAATTAACGATG
CCGACCAGCTATTATTAACTGAATAA

Upstream 100 bases:

>100_bases
AATATAGTTATTAAAACAGTAGGAAATTTAAAACGTCAAACCCTATCTACCAAGCAAAATCTGTTATAGTTAGGGTGAAT
TTATTCAGGAGGTGGGCCTT

Downstream 100 bases:

>100_bases
TGACTACTAATTAAATTATCCCTTCCCCCGGATGACTAGCGAAATCACTGTTAGTCATCCGGGGGCTTTTACGTCAACCA
TCACGCTGCCTCATAAGGTG

Product: transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MAEHECVQLVPIFSELGSEQLDTIESIVRHHHYPAGSTLFGADDPLDSLMIVANGQVKVYQLAANGREQLLYLLQTGDID
GEAALFENQRRTSFGEALVPTDVCSIRRSDFQDLMQKYPSISINVLNVFGKRLSQLERQTTSTATESVEARLANYITETA
AALKTDTFKLPLKKKDLATFLGTTPESISRKLALFERQGLITQKPGKVIEINDADQLLLTE

Sequences:

>Translated_221_residues
MAEHECVQLVPIFSELGSEQLDTIESIVRHHHYPAGSTLFGADDPLDSLMIVANGQVKVYQLAANGREQLLYLLQTGDID
GEAALFENQRRTSFGEALVPTDVCSIRRSDFQDLMQKYPSISINVLNVFGKRLSQLERQTTSTATESVEARLANYITETA
AALKTDTFKLPLKKKDLATFLGTTPESISRKLALFERQGLITQKPGKVIEINDADQLLLTE
>Mature_220_residues
AEHECVQLVPIFSELGSEQLDTIESIVRHHHYPAGSTLFGADDPLDSLMIVANGQVKVYQLAANGREQLLYLLQTGDIDG
EAALFENQRRTSFGEALVPTDVCSIRRSDFQDLMQKYPSISINVLNVFGKRLSQLERQTTSTATESVEARLANYITETAA
ALKTDTFKLPLKKKDLATFLGTTPESISRKLALFERQGLITQKPGKVIEINDADQLLLTE

Specific function: Global Transcription Factor That Controls The Expression Of Over 100 Target Genes In Response To Anoxia. It Facilitates The Adaptation To Anaerobic Growth Conditions By Regulating The Expression Of Gene Products That Are Involved In Anaerobic Energy Metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=208, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789756, Length=205, Percent_Identity=28.2926829268293, Blast_Score=77, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 24528; Mature: 24397

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEHECVQLVPIFSELGSEQLDTIESIVRHHHYPAGSTLFGADDPLDSLMIVANGQVKVY
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEEEEECCCEEEE
QLAANGREQLLYLLQTGDIDGEAALFENQRRTSFGEALVPTDVCSIRRSDFQDLMQKYPS
EECCCCHHHEEEEEECCCCCCCHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ISINVLNVFGKRLSQLERQTTSTATESVEARLANYITETAAALKTDTFKLPLKKKDLATF
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHH
LGTTPESISRKLALFERQGLITQKPGKVIEINDADQLLLTE
HCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEECC
>Mature Secondary Structure 
AEHECVQLVPIFSELGSEQLDTIESIVRHHHYPAGSTLFGADDPLDSLMIVANGQVKVY
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEEEEECCCEEEE
QLAANGREQLLYLLQTGDIDGEAALFENQRRTSFGEALVPTDVCSIRRSDFQDLMQKYPS
EECCCCHHHEEEEEECCCCCCCHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ISINVLNVFGKRLSQLERQTTSTATESVEARLANYITETAAALKTDTFKLPLKKKDLATF
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHH
LGTTPESISRKLALFERQGLITQKPGKVIEINDADQLLLTE
HCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113923; 8441692 [H]