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The map label for this gene is cadA [H]

Identifier: 28379680

GI number: 28379680

Start: 2960524

End: 2962368

Strand: Direct

Name: cadA [H]

Synonym: lp_3327

Alternate gene names: 28379680

Gene position: 2960524-2962368 (Clockwise)

Preceding gene: 28379677

Following gene: 28379682

Centisome position: 89.49

GC content: 49.7

Gene sequence:

>1845_bases
ATGCGGCACTACTATAAATTAATTTTAACGGTCAGCGTCGGTATCATTGCGGTTATTTTACAGTTTGGTTTGCACTACCA
ATTGGCAGCACAAATCATCATTACATTAATGGGGTCACTTATGGCCTTATCAATGTTAGTTGAGATGATCAAAACCTTAC
GTTCAGGTAAGTACGGGGTTGATTTATTAGCAATTACGGCGATTGTGGCAACACTAGCTGTCGGCGAATATTGGGCTAGC
CTTGTCGTTCTAATTATGCTCACTGGGGGTGACTCGTTAGAAGATTATGCGGCCAAACGAGCGAATACCGAATTGAAAGC
CTTGCTCGATAATTCACCACGTATTGCCCACCGCTCAGTCGCCGGCCAATTAACAGATATTGCCGTTGAAGATGTCCAAA
TTGGTGATCAGCTAGTCGTCAAACCTGGTGAGCTAGTTCCAGTAGACGGTCACCTTATTCAAGGAACGGCACTCTTTGAT
GAATCTTCATTGACGGGTGAATCTAAGCCAGTCGACAAGCACGTTGGCGATGACATTATGTCTGGTGCGGTCAACGGCGA
TAGTGCTGTTACAATGGTTGTTGATAAATTAGCCATTGATAGTCAATACCAACAGTTAGTCAAATTGGTTAAAGAATCCG
AATCACGACCAGCCAAATTCGTACGGCTGGCCGATCGCTATGCAGTCCCATTCACCTTGGTAGCATACGTCATTGCCGGA
GTAGCTTGGGCATTCAGCGGTGATCCCCACCGATTTGCAGAAGTCCTCGTAGTGGCTTCACCTTGCCCGCTGATTCTCGC
CGCACCCGTTGCACTCGTCTCAGGGATGAGCCGAACTAGTCGGAACGGAATCGTGGTCAAGACTGGGGACATGTTGGAGA
AGTTATCTACGGCTAAGTCCGCCGCGTTTGATAAGACGGGGACCATTACCAGTGGTCAATTAACAGTCAACCAAATTGTT
CCTCAGCCTGGTTTTACTGCCGAACAAATCTTGCACCTCGCAGCGAGCGCTGAACAAAACTCAAGTCATATCCTGGCCCG
CTCACTCGTCAAGTATGCGAGTGCCACTAGCCTCAGCCCGGCAACACAATTAGCAGAAGTAACGGGTAATGGGGTCACGG
CAACGATTGAGCAGCAACAGGTCAAAGTGGGCAAACTTAAATTCGTCGCACCGACTACAACCGCCAAGCCACTTGCTACC
ACTGCTATCTACGTCGGCATTGATGACCAGTACGCGGGTTACATCACGTTTATCGACAATGTCCGCCCCGAAGCAGCCGC
CACGCTTCAAGCACTCCACGCTGAGGGCGTTCAAAACGTCATGATGCTTACTGGTGACCAACAGGCAATTGCTGATCATA
TTGCCGCCGATGTCGGTATCGATACCGTTGCTGCCGACCTCCTACCCGCAGATAAAATTGCCCACTTAAAGGCTGTACCA
GCGGGCGAACGCCCCGTTATCATGGTTGGCGATGGTGTTAACGACGCGCCTTCCCTGGCTGTTGCTGACGTCGGCATCGC
CATGGGCGCCCATGGCTCAACTGCTGCTAGTGAATCGGCCGACGTCGTCATCTTAAAAGACGATCTTAGTCGCGTGGTCA
CGGCGGTGCGCATTGCTAAAGATACCATGCAAGTGGCTAAACAAGCCGTTTGGATTGGGATTGCTATCTGTACGATCTTG
ATGTTGATTGCCAGCACTGGTATCATTCCGGCACTCTTTGGCGCTATGCTTCAAGAAGTTGTTGATACGGTCTCAATTCT
TTGGGCGCTACGTGCATTACGGGATCGGCCACAATCATCAGTCTCATCAACAACCACAACTCCCATAACAAAGGATGTGA
GCTAA

Upstream 100 bases:

>100_bases
TTTTAGTTTAGAATCATTCTTATCTGTTTCAATTAAACCGATTTCATGTTATTCTTGTAACAAGTAAAAAAACGTTATCA
TCTAAAAGGAGGGGAACTGC

Downstream 100 bases:

>100_bases
CCATGCCAGAATGGCTCTTACGATGGGCACAATCGGCACTGACTTTTGTCGTTGTTTTAACGTTCGTTTCAGTCGTTTTA
CTCAACGTACCACTAAAAGA

Product: cadmium-/zinc-/cobalt-transporting ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MRHYYKLILTVSVGIIAVILQFGLHYQLAAQIIITLMGSLMALSMLVEMIKTLRSGKYGVDLLAITAIVATLAVGEYWAS
LVVLIMLTGGDSLEDYAAKRANTELKALLDNSPRIAHRSVAGQLTDIAVEDVQIGDQLVVKPGELVPVDGHLIQGTALFD
ESSLTGESKPVDKHVGDDIMSGAVNGDSAVTMVVDKLAIDSQYQQLVKLVKESESRPAKFVRLADRYAVPFTLVAYVIAG
VAWAFSGDPHRFAEVLVVASPCPLILAAPVALVSGMSRTSRNGIVVKTGDMLEKLSTAKSAAFDKTGTITSGQLTVNQIV
PQPGFTAEQILHLAASAEQNSSHILARSLVKYASATSLSPATQLAEVTGNGVTATIEQQQVKVGKLKFVAPTTTAKPLAT
TAIYVGIDDQYAGYITFIDNVRPEAAATLQALHAEGVQNVMMLTGDQQAIADHIAADVGIDTVAADLLPADKIAHLKAVP
AGERPVIMVGDGVNDAPSLAVADVGIAMGAHGSTAASESADVVILKDDLSRVVTAVRIAKDTMQVAKQAVWIGIAICTIL
MLIASTGIIPALFGAMLQEVVDTVSILWALRALRDRPQSSVSSTTTTPITKDVS

Sequences:

>Translated_614_residues
MRHYYKLILTVSVGIIAVILQFGLHYQLAAQIIITLMGSLMALSMLVEMIKTLRSGKYGVDLLAITAIVATLAVGEYWAS
LVVLIMLTGGDSLEDYAAKRANTELKALLDNSPRIAHRSVAGQLTDIAVEDVQIGDQLVVKPGELVPVDGHLIQGTALFD
ESSLTGESKPVDKHVGDDIMSGAVNGDSAVTMVVDKLAIDSQYQQLVKLVKESESRPAKFVRLADRYAVPFTLVAYVIAG
VAWAFSGDPHRFAEVLVVASPCPLILAAPVALVSGMSRTSRNGIVVKTGDMLEKLSTAKSAAFDKTGTITSGQLTVNQIV
PQPGFTAEQILHLAASAEQNSSHILARSLVKYASATSLSPATQLAEVTGNGVTATIEQQQVKVGKLKFVAPTTTAKPLAT
TAIYVGIDDQYAGYITFIDNVRPEAAATLQALHAEGVQNVMMLTGDQQAIADHIAADVGIDTVAADLLPADKIAHLKAVP
AGERPVIMVGDGVNDAPSLAVADVGIAMGAHGSTAASESADVVILKDDLSRVVTAVRIAKDTMQVAKQAVWIGIAICTIL
MLIASTGIIPALFGAMLQEVVDTVSILWALRALRDRPQSSVSSTTTTPITKDVS
>Mature_614_residues
MRHYYKLILTVSVGIIAVILQFGLHYQLAAQIIITLMGSLMALSMLVEMIKTLRSGKYGVDLLAITAIVATLAVGEYWAS
LVVLIMLTGGDSLEDYAAKRANTELKALLDNSPRIAHRSVAGQLTDIAVEDVQIGDQLVVKPGELVPVDGHLIQGTALFD
ESSLTGESKPVDKHVGDDIMSGAVNGDSAVTMVVDKLAIDSQYQQLVKLVKESESRPAKFVRLADRYAVPFTLVAYVIAG
VAWAFSGDPHRFAEVLVVASPCPLILAAPVALVSGMSRTSRNGIVVKTGDMLEKLSTAKSAAFDKTGTITSGQLTVNQIV
PQPGFTAEQILHLAASAEQNSSHILARSLVKYASATSLSPATQLAEVTGNGVTATIEQQQVKVGKLKFVAPTTTAKPLAT
TAIYVGIDDQYAGYITFIDNVRPEAAATLQALHAEGVQNVMMLTGDQQAIADHIAADVGIDTVAADLLPADKIAHLKAVP
AGERPVIMVGDGVNDAPSLAVADVGIAMGAHGSTAASESADVVILKDDLSRVVTAVRIAKDTMQVAKQAVWIGIAICTIL
MLIASTGIIPALFGAMLQEVVDTVSILWALRALRDRPQSSVSSTTTTPITKDVS

Specific function: Couples the hydrolysis of ATP with the transport of zinc into the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=287, Percent_Identity=33.1010452961672, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI55743071, Length=513, Percent_Identity=27.6803118908382, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI55743073, Length=488, Percent_Identity=26.2295081967213, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI48762687, Length=261, Percent_Identity=25.6704980842912, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI48762685, Length=234, Percent_Identity=28.6324786324786, Blast_Score=67, Evalue=7e-11,
Organism=Homo sapiens, GI118498343, Length=232, Percent_Identity=28.448275862069, Blast_Score=67, Evalue=7e-11,
Organism=Homo sapiens, GI48762689, Length=261, Percent_Identity=25.6704980842912, Blast_Score=67, Evalue=7e-11,
Organism=Homo sapiens, GI48762691, Length=261, Percent_Identity=25.6704980842912, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1789879, Length=602, Percent_Identity=31.7275747508306, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1786691, Length=526, Percent_Identity=32.8897338403042, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1786914, Length=459, Percent_Identity=26.797385620915, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI2367363, Length=186, Percent_Identity=30.1075268817204, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17556548, Length=647, Percent_Identity=29.3663060278207, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6320475, Length=542, Percent_Identity=27.1217712177122, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6319772, Length=585, Percent_Identity=24.957264957265, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321430, Length=542, Percent_Identity=23.4317343173432, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325221, Length=536, Percent_Identity=22.2014925373134, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320245, Length=174, Percent_Identity=31.6091954022989, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320243, Length=174, Percent_Identity=31.6091954022989, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320244, Length=174, Percent_Identity=31.6091954022989, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321271, Length=208, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221329854, Length=303, Percent_Identity=30.6930693069307, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24668704, Length=157, Percent_Identity=33.1210191082803, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281366617, Length=157, Percent_Identity=33.1210191082803, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161085803, Length=157, Percent_Identity=31.2101910828025, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668708, Length=157, Percent_Identity=33.1210191082803, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668696, Length=157, Percent_Identity=31.2101910828025, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 64614; Mature: 64614

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHYYKLILTVSVGIIAVILQFGLHYQLAAQIIITLMGSLMALSMLVEMIKTLRSGKYGV
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DLLAITAIVATLAVGEYWASLVVLIMLTGGDSLEDYAAKRANTELKALLDNSPRIAHRSV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCCHHHHHH
AGQLTDIAVEDVQIGDQLVVKPGELVPVDGHLIQGTALFDESSLTGESKPVDKHVGDDIM
HHHHHHHHHHHHCCCCEEEECCCCEEECCCEEEECEEEECCCCCCCCCCCCHHHCCHHHH
SGAVNGDSAVTMVVDKLAIDSQYQQLVKLVKESESRPAKFVRLADRYAVPFTLVAYVIAG
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHH
VAWAFSGDPHRFAEVLVVASPCPLILAAPVALVSGMSRTSRNGIVVKTGDMLEKLSTAKS
HHHHCCCCHHHHHHEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHH
AAFDKTGTITSGQLTVNQIVPQPGFTAEQILHLAASAEQNSSHILARSLVKYASATSLSP
HCCCCCCCEECCCEEEEHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCH
ATQLAEVTGNGVTATIEQQQVKVGKLKFVAPTTTAKPLATTAIYVGIDDQYAGYITFIDN
HHHHHHHCCCCEEEEEEHHHHEECCEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEECC
VRPEAAATLQALHAEGVQNVMMLTGDQQAIADHIAADVGIDTVAADLLPADKIAHLKAVP
CCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHCCCC
AGERPVIMVGDGVNDAPSLAVADVGIAMGAHGSTAASESADVVILKDDLSRVVTAVRIAK
CCCCCEEEECCCCCCCCCEEHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
DTMQVAKQAVWIGIAICTILMLIASTGIIPALFGAMLQEVVDTVSILWALRALRDRPQSS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VSSTTTTPITKDVS
CCCCCCCCCCCCCC
>Mature Secondary Structure
MRHYYKLILTVSVGIIAVILQFGLHYQLAAQIIITLMGSLMALSMLVEMIKTLRSGKYGV
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DLLAITAIVATLAVGEYWASLVVLIMLTGGDSLEDYAAKRANTELKALLDNSPRIAHRSV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCCHHHHHH
AGQLTDIAVEDVQIGDQLVVKPGELVPVDGHLIQGTALFDESSLTGESKPVDKHVGDDIM
HHHHHHHHHHHHCCCCEEEECCCCEEECCCEEEECEEEECCCCCCCCCCCCHHHCCHHHH
SGAVNGDSAVTMVVDKLAIDSQYQQLVKLVKESESRPAKFVRLADRYAVPFTLVAYVIAG
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHH
VAWAFSGDPHRFAEVLVVASPCPLILAAPVALVSGMSRTSRNGIVVKTGDMLEKLSTAKS
HHHHCCCCHHHHHHEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHH
AAFDKTGTITSGQLTVNQIVPQPGFTAEQILHLAASAEQNSSHILARSLVKYASATSLSP
HCCCCCCCEECCCEEEEHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCH
ATQLAEVTGNGVTATIEQQQVKVGKLKFVAPTTTAKPLATTAIYVGIDDQYAGYITFIDN
HHHHHHHCCCCEEEEEEHHHHEECCEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEECC
VRPEAAATLQALHAEGVQNVMMLTGDQQAIADHIAADVGIDTVAADLLPADKIAHLKAVP
CCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHCCCC
AGERPVIMVGDGVNDAPSLAVADVGIAMGAHGSTAASESADVVILKDDLSRVVTAVRIAK
CCCCCEEEECCCCCCCCCEEHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
DTMQVAKQAVWIGIAICTILMLIASTGIIPALFGAMLQEVVDTVSILWALRALRDRPQSS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VSSTTTTPITKDVS
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]