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The map label for this gene is ygcA [C]

Identifier: 28379606

GI number: 28379606

Start: 2874457

End: 2875902

Strand: Direct

Name: ygcA [C]

Synonym: lp_3226

Alternate gene names: 28379606

Gene position: 2874457-2875902 (Clockwise)

Preceding gene: 28379598

Following gene: 28379607

Centisome position: 86.89

GC content: 48.48

Gene sequence:

>1446_bases
ATGCCACAATCTAATCATTATTCGCACCAATCCCGATCGCACAATGATCGGCGCCGACAACAGCCGGATGAAAAAGTGCA
AGCGACCGTTAACATCGGCCAGCGTTTTCCACTGACCATTCGGCGTTTAGGCATTAACGGTGAAGGTATTGGCTATTACA
AACACGTCATCACCTTCGTCAAGGGCGCCCTTCCTGAAGAAGTCGTTGTTGCTGAAGTAACCGCCGTGCACCCACGTTAC
CTAGAAGCTAAGATTCGTAGTATTCGCAAGCCTAGTCCTGACCGGGTCGATCCCCGCGATGCCTATGCGGGCGAAGTCGG
TGGTTTTGAATTAGAACACCTCGACTACCCGGCCCAATTAGCCTTTAAGCAAGATTTAATTCGTCAAGCACTCGAAAAAT
ACCGCCCAGCTGGTTATCGACACTATGATGTTCGGCCCACCATTGGGATGACTAATCCTTATGAATACCGCAACAAAGCC
CAATTTCAAGTTCGTTTAATTGATGGGCACGTCGCTGCTGGCTTATATAAAGAAAATAGTCATGACCTAGTCGACTTACC
GACCTGTTCGGTGCAAATGCCGGCGACAATGACAGTCATGCGTCAAGTCGTGGCTTGGCTGGAGGAACTCCAAGTACCGA
TTTACGATGAAGAACATAATTCTGGCATCGTCAAGACAATCGTTGTGCGTGAAGCGGCCGCCACTGGTGAAATTCAGCTG
GTCTTCATCACAAATACACCCAAGTTACCGAAAAAGCATCAATTATTGATGAAAATCGCTGAAAAACTGCCAATGGTCGT
GTCGGTCATGCAAAATATCAATGCTGGTAAAACTTCATTGATCTGGGGTGACCAAACAACATTACTGGCCGGCAAACCAA
CTATTACGGAGGAGCTAGACGGCCTAGTCTTCGATTTATCTGCTCGGGCCTTCTTCCAATTGAACCCGCAGCAAACCAAG
AAACTCTATCGCTTAGCACGCGAAGCTTTGAACTTAGCGCCTAACGAGACGTTGGTCGACGCTTATTCGGGTGTCGGAAC
GATTGGTTTATCACTAGCCGACGTGGCTAAGGAAGTTCGGGGAATGGATACCATTCCAGCAGCCGTTGCAGATGCCAATG
CCAACGCCCAACGCAATCAAATCACTAATGCTCATTATGAAGTTGGTGAGGCGGAAGTCTTGTTACCGCAATGGTTAGCG
AGCGGTTTTGCGCCCGATGCAATGGTCGTTGATCCACCCCGTACTGGTTTAGATAACGTCTTAATTGATGCCATCTTGCA
AAGCGCACCGGAAAAACTCGTCTACATTTCATGCAACCCATCGACGCTTGCTCAGGATTTACAAGCACTTACCCGCGGAT
ATCAAGTCGACTATATTCAATCGATCGACATGTTCCCACAAACAGCTCGTTGCGAAGCCGTCGTCCGCTTCACGAAGCGT
CATTAA

Upstream 100 bases:

>100_bases
GGCGACTTTCAAACAATCCTCCTCAGTTATCCTGTGTCTTTCCACATGCTATAATGGAGGTTAACACAGTTCACAGAAAA
ACGAGGTCAAAATCAAACTT

Downstream 100 bases:

>100_bases
TTTGCCACTCACTGCCAATCATATGAGGGGGAATCATCATGGCAGCTACTGATAGTCAAATTGCATTAACGATGACCTTT
ACGTTACGGCCACCATTCAA

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MPQSNHYSHQSRSHNDRRRQQPDEKVQATVNIGQRFPLTIRRLGINGEGIGYYKHVITFVKGALPEEVVVAEVTAVHPRY
LEAKIRSIRKPSPDRVDPRDAYAGEVGGFELEHLDYPAQLAFKQDLIRQALEKYRPAGYRHYDVRPTIGMTNPYEYRNKA
QFQVRLIDGHVAAGLYKENSHDLVDLPTCSVQMPATMTVMRQVVAWLEELQVPIYDEEHNSGIVKTIVVREAAATGEIQL
VFITNTPKLPKKHQLLMKIAEKLPMVVSVMQNINAGKTSLIWGDQTTLLAGKPTITEELDGLVFDLSARAFFQLNPQQTK
KLYRLAREALNLAPNETLVDAYSGVGTIGLSLADVAKEVRGMDTIPAAVADANANAQRNQITNAHYEVGEAEVLLPQWLA
SGFAPDAMVVDPPRTGLDNVLIDAILQSAPEKLVYISCNPSTLAQDLQALTRGYQVDYIQSIDMFPQTARCEAVVRFTKR
H

Sequences:

>Translated_481_residues
MPQSNHYSHQSRSHNDRRRQQPDEKVQATVNIGQRFPLTIRRLGINGEGIGYYKHVITFVKGALPEEVVVAEVTAVHPRY
LEAKIRSIRKPSPDRVDPRDAYAGEVGGFELEHLDYPAQLAFKQDLIRQALEKYRPAGYRHYDVRPTIGMTNPYEYRNKA
QFQVRLIDGHVAAGLYKENSHDLVDLPTCSVQMPATMTVMRQVVAWLEELQVPIYDEEHNSGIVKTIVVREAAATGEIQL
VFITNTPKLPKKHQLLMKIAEKLPMVVSVMQNINAGKTSLIWGDQTTLLAGKPTITEELDGLVFDLSARAFFQLNPQQTK
KLYRLAREALNLAPNETLVDAYSGVGTIGLSLADVAKEVRGMDTIPAAVADANANAQRNQITNAHYEVGEAEVLLPQWLA
SGFAPDAMVVDPPRTGLDNVLIDAILQSAPEKLVYISCNPSTLAQDLQALTRGYQVDYIQSIDMFPQTARCEAVVRFTKR
H
>Mature_480_residues
PQSNHYSHQSRSHNDRRRQQPDEKVQATVNIGQRFPLTIRRLGINGEGIGYYKHVITFVKGALPEEVVVAEVTAVHPRYL
EAKIRSIRKPSPDRVDPRDAYAGEVGGFELEHLDYPAQLAFKQDLIRQALEKYRPAGYRHYDVRPTIGMTNPYEYRNKAQ
FQVRLIDGHVAAGLYKENSHDLVDLPTCSVQMPATMTVMRQVVAWLEELQVPIYDEEHNSGIVKTIVVREAAATGEIQLV
FITNTPKLPKKHQLLMKIAEKLPMVVSVMQNINAGKTSLIWGDQTTLLAGKPTITEELDGLVFDLSARAFFQLNPQQTKK
LYRLAREALNLAPNETLVDAYSGVGTIGLSLADVAKEVRGMDTIPAAVADANANAQRNQITNAHYEVGEAEVLLPQWLAS
GFAPDAMVVDPPRTGLDNVLIDAILQSAPEKLVYISCNPSTLAQDLQALTRGYQVDYIQSIDMFPQTARCEAVVRFTKRH

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=373, Percent_Identity=30.0268096514745, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI51173878, Length=373, Percent_Identity=30.0268096514745, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI269784678, Length=209, Percent_Identity=35.4066985645933, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI269784680, Length=209, Percent_Identity=35.4066985645933, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI269784676, Length=209, Percent_Identity=35.4066985645933, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI20149688, Length=209, Percent_Identity=35.4066985645933, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1789148, Length=456, Percent_Identity=26.7543859649123, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787083, Length=328, Percent_Identity=25.3048780487805, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790403, Length=155, Percent_Identity=29.6774193548387, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666579, Length=422, Percent_Identity=27.9620853080569, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y3226_LACPL (Q88SY9)

Other databases:

- EMBL:   AL935261
- RefSeq:   NP_786498.1
- ProteinModelPortal:   Q88SY9
- SMR:   Q88SY9
- GeneID:   1061842
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_3226
- NMPDR:   fig|220668.1.peg.2632
- HOGENOM:   HBG690163
- OMA:   QPQHAAI
- ProtClustDB:   CLSK581965
- BioCyc:   LPLA220668:LP_3226-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 53728; Mature: 53597

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 438-438 BINDING 313-313 BINDING 342-342 BINDING 363-363 BINDING 411-411

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQSNHYSHQSRSHNDRRRQQPDEKVQATVNIGQRFPLTIRRLGINGEGIGYYKHVITFV
CCCCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHH
KGALPEEVVVAEVTAVHPRYLEAKIRSIRKPSPDRVDPRDAYAGEVGGFELEHLDYPAQL
HCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCEEEECCCCCHHH
AFKQDLIRQALEKYRPAGYRHYDVRPTIGMTNPYEYRNKAQFQVRLIDGHVAAGLYKENS
HHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHCCCCEEEEEEECCEEEECEEECCC
HDLVDLPTCSVQMPATMTVMRQVVAWLEELQVPIYDEEHNSGIVKTIVVREAAATGEIQL
CCEEECCCCCEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHCCCCCEEE
VFITNTPKLPKKHQLLMKIAEKLPMVVSVMQNINAGKTSLIWGDQTTLLAGKPTITEELD
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCHHHHHC
GLVFDLSARAFFQLNPQQTKKLYRLAREALNLAPNETLVDAYSGVGTIGLSLADVAKEVR
CEEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHC
GMDTIPAAVADANANAQRNQITNAHYEVGEAEVLLPQWLASGFAPDAMVVDPPRTGLDNV
CCCCCCHHHHCCCCCCHHHHCCCCHHCCCCHHEEHHHHHHCCCCCCCEEECCCCCCHHHH
LIDAILQSAPEKLVYISCNPSTLAQDLQALTRGYQVDYIQSIDMFPQTARCEAVVRFTKR
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCEEHHHHHHCCCCHHHHHHHHHHHCC
H
C
>Mature Secondary Structure 
PQSNHYSHQSRSHNDRRRQQPDEKVQATVNIGQRFPLTIRRLGINGEGIGYYKHVITFV
CCCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHH
KGALPEEVVVAEVTAVHPRYLEAKIRSIRKPSPDRVDPRDAYAGEVGGFELEHLDYPAQL
HCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCEEEECCCCCHHH
AFKQDLIRQALEKYRPAGYRHYDVRPTIGMTNPYEYRNKAQFQVRLIDGHVAAGLYKENS
HHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHCCCCEEEEEEECCEEEECEEECCC
HDLVDLPTCSVQMPATMTVMRQVVAWLEELQVPIYDEEHNSGIVKTIVVREAAATGEIQL
CCEEECCCCCEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHCCCCCEEE
VFITNTPKLPKKHQLLMKIAEKLPMVVSVMQNINAGKTSLIWGDQTTLLAGKPTITEELD
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCHHHHHC
GLVFDLSARAFFQLNPQQTKKLYRLAREALNLAPNETLVDAYSGVGTIGLSLADVAKEVR
CEEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHC
GMDTIPAAVADANANAQRNQITNAHYEVGEAEVLLPQWLASGFAPDAMVVDPPRTGLDNV
CCCCCCHHHHCCCCCCHHHHCCCCHHCCCCHHEEHHHHHHCCCCCCCEEECCCCCCHHHH
LIDAILQSAPEKLVYISCNPSTLAQDLQALTRGYQVDYIQSIDMFPQTARCEAVVRFTKR
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCEEHHHHHHCCCCHHHHHHHHHHHCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566