Click here to switch to the map view.

The map label for this gene is dhaT [H]

Identifier: 28379474

GI number: 28379474

Start: 2712741

End: 2713913

Strand: Direct

Name: dhaT [H]

Synonym: lp_3051

Alternate gene names: 28379474

Gene position: 2712741-2713913 (Clockwise)

Preceding gene: 28379473

Following gene: 28379495

Centisome position: 82.0

GC content: 48.85

Gene sequence:

>1173_bases
ATGACTGAACGTAATTTTGATTTCTTAATGCCTAGCGTTAACTTTTTCGGTCCTGGTGTCATTAGTAAAATCGGCGAGCG
TGCCAAAACTCTTGGTATGCACAAGCCAGTCATCGTCACCGACAAATTTCTTGAAAGTCTGCCAGACGGCGCCGTTGCTC
AGGTGCGGCGGTCACTGGATGCTGCCGGGATTGACTACGTAATTTATAATCAAGTTGAGCCCAACCCTAAAATTCATAAC
ATTCAAGCTGTTAAAGCCTTATATCAAGCCAATCAAGCGGACTCCCTGATTACTATTGGCGGTGGTTCTGCCCACGATAC
CGGAAAAGGTGCCGGCATCATCATGACTAACGGCGACGATATCACTAAGTTAGCGGGGATCGAAACACTCAAGAATGCCC
TACCACCACTGATTGCGGTCAACACTACCGCTGGGACTGGTTCTGAATTGACCCGTCACTGTGTCATTACGAATGAAGAA
ACGCATTATAAGTTCGTCGTTGCTTCATGGCGTAACATGCCACTCGTGTCCTTTAACGATCCCACTCTCATGCTAGATGT
TCCTAAGGGACTCACGGCCGCAACTGGCATGGATGCTTTTGTCCAGGCTATCGAACCCTTTGTTTCTGTCGATCACAATC
CGATTACCGATTCACAGTGCATCCAGGCCATCAAATTAATCGAAACATCATTACGCGAAGCCGTCGCCAATGGGCATAAC
CTAGAAGCCCGGACACACATGGTCGAAGCTGAAATGTTAGCCGGCATGGCCTTTAACAACGCCAATCTAGGTTACGTGCA
CGCCATGGCCCACCAGCTCGGCGGCCAATATGACGCACCCCACGGTGTCTGCTGCGCGCTGCTCTTACCCTACGTTGAAG
AATATAATCTAATCGCGTGCCCCGAACGTTTCGCCGAGCTCGCCAAAATTATGGGCGAAAACACTGATGGCTTATCGACT
CGTGATGCTGCCGAATTAGCTATCAAAGCGATGAAACAACTCAGCGAAGACGTTGGCATTCCGCATTCCATCAAGGAAAT
TGGCGCCAAGATCGAGGACTTCGAACACATGGCGACTAATGCGCTTAAAGACGGTAACGCCTTCTCTAACCCACGCAAAG
GTACTAAAGAAGACATCATCAAGATTTTCCAAGCCGCATATGATGCCAAGTAA

Upstream 100 bases:

>100_bases
TAATTAGCCAAAAAGTATTGCAAATTGTAATTATTACGACTATAATTTGATTCGTAAATTAGTAATGATAGCGATTACAA
TATAAAAAGAGGTTATTAAT

Downstream 100 bases:

>100_bases
TCCCCCATTCAAAGTTAACTAAATCATTCACAGCAAATAATCGGTTCAAGAATTCATAGTAAATTCTTGAACCGATTATT
TGATTGGGACCTCTCTACAA

Product: 1,3-propanediol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTERNFDFLMPSVNFFGPGVISKIGERAKTLGMHKPVIVTDKFLESLPDGAVAQVRRSLDAAGIDYVIYNQVEPNPKIHN
IQAVKALYQANQADSLITIGGGSAHDTGKGAGIIMTNGDDITKLAGIETLKNALPPLIAVNTTAGTGSELTRHCVITNEE
THYKFVVASWRNMPLVSFNDPTLMLDVPKGLTAATGMDAFVQAIEPFVSVDHNPITDSQCIQAIKLIETSLREAVANGHN
LEARTHMVEAEMLAGMAFNNANLGYVHAMAHQLGGQYDAPHGVCCALLLPYVEEYNLIACPERFAELAKIMGENTDGLST
RDAAELAIKAMKQLSEDVGIPHSIKEIGAKIEDFEHMATNALKDGNAFSNPRKGTKEDIIKIFQAAYDAK

Sequences:

>Translated_390_residues
MTERNFDFLMPSVNFFGPGVISKIGERAKTLGMHKPVIVTDKFLESLPDGAVAQVRRSLDAAGIDYVIYNQVEPNPKIHN
IQAVKALYQANQADSLITIGGGSAHDTGKGAGIIMTNGDDITKLAGIETLKNALPPLIAVNTTAGTGSELTRHCVITNEE
THYKFVVASWRNMPLVSFNDPTLMLDVPKGLTAATGMDAFVQAIEPFVSVDHNPITDSQCIQAIKLIETSLREAVANGHN
LEARTHMVEAEMLAGMAFNNANLGYVHAMAHQLGGQYDAPHGVCCALLLPYVEEYNLIACPERFAELAKIMGENTDGLST
RDAAELAIKAMKQLSEDVGIPHSIKEIGAKIEDFEHMATNALKDGNAFSNPRKGTKEDIIKIFQAAYDAK
>Mature_389_residues
TERNFDFLMPSVNFFGPGVISKIGERAKTLGMHKPVIVTDKFLESLPDGAVAQVRRSLDAAGIDYVIYNQVEPNPKIHNI
QAVKALYQANQADSLITIGGGSAHDTGKGAGIIMTNGDDITKLAGIETLKNALPPLIAVNTTAGTGSELTRHCVITNEET
HYKFVVASWRNMPLVSFNDPTLMLDVPKGLTAATGMDAFVQAIEPFVSVDHNPITDSQCIQAIKLIETSLREAVANGHNL
EARTHMVEAEMLAGMAFNNANLGYVHAMAHQLGGQYDAPHGVCCALLLPYVEEYNLIACPERFAELAKIMGENTDGLSTR
DAAELAIKAMKQLSEDVGIPHSIKEIGAKIEDFEHMATNALKDGNAFSNPRKGTKEDIIKIFQAAYDAK

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=422, Percent_Identity=27.0142180094787, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI48994951, Length=379, Percent_Identity=44.3271767810026, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=39.4666666666667, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI87082107, Length=385, Percent_Identity=37.6623376623377, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI1787493, Length=409, Percent_Identity=30.8068459657702, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789386, Length=353, Percent_Identity=23.5127478753541, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537053, Length=412, Percent_Identity=25.9708737864078, Blast_Score=140, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6321181, Length=384, Percent_Identity=41.6666666666667, Blast_Score=301, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24657991, Length=412, Percent_Identity=28.3980582524272, Blast_Score=148, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 42160; Mature: 42028

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERNFDFLMPSVNFFGPGVISKIGERAKTLGMHKPVIVTDKFLESLPDGAVAQVRRSLD
CCCCCCHHCCCCCHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCHHHHHHHHHHH
AAGIDYVIYNQVEPNPKIHNIQAVKALYQANQADSLITIGGGSAHDTGKGAGIIMTNGDD
HCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEECCCC
ITKLAGIETLKNALPPLIAVNTTAGTGSELTRHCVITNEETHYKFVVASWRNMPLVSFND
HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHEEEEEECCCCCEEEEEEECCCCCEEEECC
PTLMLDVPKGLTAATGMDAFVQAIEPFVSVDHNPITDSQCIQAIKLIETSLREAVANGHN
CEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LEARTHMVEAEMLAGMAFNNANLGYVHAMAHQLGGQYDAPHGVCCALLLPYVEEYNLIAC
CHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEC
PERFAELAKIMGENTDGLSTRDAAELAIKAMKQLSEDVGIPHSIKEIGAKIEDFEHMATN
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHH
ALKDGNAFSNPRKGTKEDIIKIFQAAYDAK
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TERNFDFLMPSVNFFGPGVISKIGERAKTLGMHKPVIVTDKFLESLPDGAVAQVRRSLD
CCCCCHHCCCCCHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCHHHHHHHHHHH
AAGIDYVIYNQVEPNPKIHNIQAVKALYQANQADSLITIGGGSAHDTGKGAGIIMTNGDD
HCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEECCCC
ITKLAGIETLKNALPPLIAVNTTAGTGSELTRHCVITNEETHYKFVVASWRNMPLVSFND
HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHEEEEEECCCCCEEEEEEECCCCCEEEECC
PTLMLDVPKGLTAATGMDAFVQAIEPFVSVDHNPITDSQCIQAIKLIETSLREAVANGHN
CEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LEARTHMVEAEMLAGMAFNNANLGYVHAMAHQLGGQYDAPHGVCCALLLPYVEEYNLIAC
CHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEC
PERFAELAKIMGENTDGLSTRDAAELAIKAMKQLSEDVGIPHSIKEIGAKIEDFEHMATN
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHH
ALKDGNAFSNPRKGTKEDIIKIFQAAYDAK
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]