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The map label for this gene is pbuG [H]

Identifier: 28379207

GI number: 28379207

Start: 2412321

End: 2413628

Strand: Direct

Name: pbuG [H]

Synonym: lp_2712

Alternate gene names: 28379207

Gene position: 2412321-2413628 (Clockwise)

Preceding gene: 28379206

Following gene: 28379209

Centisome position: 72.92

GC content: 47.94

Gene sequence:

>1308_bases
ATTATTCTAGAACAATTATTTCATTTGCGTGAAAACCGCACTTCAGTCCGCCGCGAGTTGATTGGTGGTCTGACGACCTT
TTTAGCCATGTCATATATTTTAGCCGTAAATCCCGAACTATTGGGAAGTACTGGTATGAGTAAGACCGCCGTCTTCACCG
CAACGATTTTAGCGGCCATTGTTGGTTGTCTCTTGATGGGGCTAGTTGCCAACTTTCCCGTAGCATTAGCACCGGGGATG
GGGCTGAATGCCTTCTTTACTTACACAGTTGTCCAGGAATGGCACATTCCTTGGCAAACCGCTTTGGCGGGAGTCTTTGT
TGCCGGAATTCTTTTCATCCTACTAACGCTCTCCAAGTTACGCGATAAACTGATCAACTTGATTCCAAGTGCGCTAAAAT
ACGCCGTATCTGCCGGAATTGGCTTGTTCATTGCTTTTTCAGGACTACAAACCTCTGGGATTATCGTTGCGAATAAGTCC
AACGCGGTCGCCCTGGGTAACTTGCACAGTCCCACCGTTTTGTTGGCGATTTTCGGGATTATCGTCGGCATCATGCTAGT
CACCGCTAATGTAACTGGTGGTATTTTCTGGGGCATGTTCATCACCGCCGCAGTCGGAATGATCTTCGGGATTATTCCCC
TACCAACTGGGATTATCAGTGGGGTTCCGAGCGTTCAACCGATTTTTGGTCAAGCTGTGACACACCTTGGTAATATTAAT
TCGTTTCAAATGATCATTGTCATCCTGACGTTCTTCATCATTGGCCTTTTCGATACGTCGGGAACCTTGGTTGGGGTGGC
AACCGAAGCCGGCATGGTGGACAAAGAATCCGGCGAAGTCAAAGGCGTTGGTAAAGCGCTCTTTAGTGGTGCACTCGCCA
CAACTTTAGGAGCAGTCTTTGGCACGTCACCGACGACGGCTTATGTTGAATCGACTTCCGGCGTTGCCGTGGGGGCCCGT
ACTGGGTTATCTTCCGTCTTCGTTGCCCTCTTGTTTGCCATCGCCGCCTTTTTCTCTCCAATTTTGACGGTGATTACGTC
CGCGGTGACCGCTTCAGCCCTGATTATCGTTGGTATTTTAATGTTATCAAACGTTCAATATATTGATTGGACCAAGTTTG
AAATCGCCGTCCCAGCCTTTTTCACCATGATTATGATGCTACTAACTTACAGTATCTCAGAAGGTTTGGCCGTTGGCTTT
ATCTTCTACCCAATCACCATGACGGTCAAAGGCCGTTGGCGTGAAGTAAACGCCCTCATGTGGACGATGATGGTCGTCTT
CATTCTCTACTTTGCATTTGTCGCTTAG

Upstream 100 bases:

>100_bases
GAGGCAATAAACTGATTAATCCCCTGTTACCCTAAAAATCAGTATGTTATACTAGACAATTGTTGAATTGTTAGTTTTTT
ATTAATTTTAGGAGTGGGTC

Downstream 100 bases:

>100_bases
AACTGATGGTTCGCTAAGCAATGATGGCAGTCTAAAACACCCCTGAGTCTTTAACTCAGGGGTGTTTTTTAGTAGGCACG
GCTGCATCTAACGCCTACTA

Product: transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MILEQLFHLRENRTSVRRELIGGLTTFLAMSYILAVNPELLGSTGMSKTAVFTATILAAIVGCLLMGLVANFPVALAPGM
GLNAFFTYTVVQEWHIPWQTALAGVFVAGILFILLTLSKLRDKLINLIPSALKYAVSAGIGLFIAFSGLQTSGIIVANKS
NAVALGNLHSPTVLLAIFGIIVGIMLVTANVTGGIFWGMFITAAVGMIFGIIPLPTGIISGVPSVQPIFGQAVTHLGNIN
SFQMIIVILTFFIIGLFDTSGTLVGVATEAGMVDKESGEVKGVGKALFSGALATTLGAVFGTSPTTAYVESTSGVAVGAR
TGLSSVFVALLFAIAAFFSPILTVITSAVTASALIIVGILMLSNVQYIDWTKFEIAVPAFFTMIMMLLTYSISEGLAVGF
IFYPITMTVKGRWREVNALMWTMMVVFILYFAFVA

Sequences:

>Translated_435_residues
MILEQLFHLRENRTSVRRELIGGLTTFLAMSYILAVNPELLGSTGMSKTAVFTATILAAIVGCLLMGLVANFPVALAPGM
GLNAFFTYTVVQEWHIPWQTALAGVFVAGILFILLTLSKLRDKLINLIPSALKYAVSAGIGLFIAFSGLQTSGIIVANKS
NAVALGNLHSPTVLLAIFGIIVGIMLVTANVTGGIFWGMFITAAVGMIFGIIPLPTGIISGVPSVQPIFGQAVTHLGNIN
SFQMIIVILTFFIIGLFDTSGTLVGVATEAGMVDKESGEVKGVGKALFSGALATTLGAVFGTSPTTAYVESTSGVAVGAR
TGLSSVFVALLFAIAAFFSPILTVITSAVTASALIIVGILMLSNVQYIDWTKFEIAVPAFFTMIMMLLTYSISEGLAVGF
IFYPITMTVKGRWREVNALMWTMMVVFILYFAFVA
>Mature_435_residues
MILEQLFHLRENRTSVRRELIGGLTTFLAMSYILAVNPELLGSTGMSKTAVFTATILAAIVGCLLMGLVANFPVALAPGM
GLNAFFTYTVVQEWHIPWQTALAGVFVAGILFILLTLSKLRDKLINLIPSALKYAVSAGIGLFIAFSGLQTSGIIVANKS
NAVALGNLHSPTVLLAIFGIIVGIMLVTANVTGGIFWGMFITAAVGMIFGIIPLPTGIISGVPSVQPIFGQAVTHLGNIN
SFQMIIVILTFFIIGLFDTSGTLVGVATEAGMVDKESGEVKGVGKALFSGALATTLGAVFGTSPTTAYVESTSGVAVGAR
TGLSSVFVALLFAIAAFFSPILTVITSAVTASALIIVGILMLSNVQYIDWTKFEIAVPAFFTMIMMLLTYSISEGLAVGF
IFYPITMTVKGRWREVNALMWTMMVVFILYFAFVA

Specific function: Involved in the uptake of the purine bases hypoxanthine and guanine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082309, Length=415, Percent_Identity=42.8915662650602, Blast_Score=327, Evalue=8e-91,
Organism=Escherichia coli, GI1790150, Length=435, Percent_Identity=41.8390804597701, Blast_Score=314, Evalue=9e-87,
Organism=Escherichia coli, GI1790499, Length=438, Percent_Identity=32.8767123287671, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI48994909, Length=420, Percent_Identity=32.1428571428571, Blast_Score=190, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46020; Mature: 46020

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILEQLFHLRENRTSVRRELIGGLTTFLAMSYILAVNPELLGSTGMSKTAVFTATILAAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHH
VGCLLMGLVANFPVALAPGMGLNAFFTYTVVQEWHIPWQTALAGVFVAGILFILLTLSKL
HHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RDKLINLIPSALKYAVSAGIGLFIAFSGLQTSGIIVANKSNAVALGNLHSPTVLLAIFGI
HHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHH
IVGIMLVTANVTGGIFWGMFITAAVGMIFGIIPLPTGIISGVPSVQPIFGQAVTHLGNIN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCC
SFQMIIVILTFFIIGLFDTSGTLVGVATEAGMVDKESGEVKGVGKALFSGALATTLGAVF
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GTSPTTAYVESTSGVAVGARTGLSSVFVALLFAIAAFFSPILTVITSAVTASALIIVGIL
CCCCCCEEEECCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLSNVQYIDWTKFEIAVPAFFTMIMMLLTYSISEGLAVGFIFYPITMTVKGRWREVNALM
HHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEHEEEEECCHHHHHHHH
WTMMVVFILYFAFVA
HHHHHHHHHHHHHHC
>Mature Secondary Structure
MILEQLFHLRENRTSVRRELIGGLTTFLAMSYILAVNPELLGSTGMSKTAVFTATILAAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHH
VGCLLMGLVANFPVALAPGMGLNAFFTYTVVQEWHIPWQTALAGVFVAGILFILLTLSKL
HHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RDKLINLIPSALKYAVSAGIGLFIAFSGLQTSGIIVANKSNAVALGNLHSPTVLLAIFGI
HHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHH
IVGIMLVTANVTGGIFWGMFITAAVGMIFGIIPLPTGIISGVPSVQPIFGQAVTHLGNIN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCC
SFQMIIVILTFFIIGLFDTSGTLVGVATEAGMVDKESGEVKGVGKALFSGALATTLGAVF
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GTSPTTAYVESTSGVAVGARTGLSSVFVALLFAIAAFFSPILTVITSAVTASALIIVGIL
CCCCCCEEEECCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLSNVQYIDWTKFEIAVPAFFTMIMMLLTYSISEGLAVGFIFYPITMTVKGRWREVNALM
HHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEHEEEEECCHHHHHHHH
WTMMVVFILYFAFVA
HHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377; 11591660 [H]