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The map label for this gene is adh1 [H]

Identifier: 28378356

GI number: 28378356

Start: 1518459

End: 1519502

Strand: Direct

Name: adh1 [H]

Synonym: lp_1665

Alternate gene names: 28378356

Gene position: 1518459-1519502 (Clockwise)

Preceding gene: 28378355

Following gene: 28378357

Centisome position: 45.9

GC content: 48.66

Gene sequence:

>1044_bases
ATGAAATCAACAATTTTCGAAAAAGCTGGACTAGTATCTGTTCAGGAAGTTGACAAACCAACATTACAATCTGATGATGA
TGTCATTGTGCGCATCGTGCGGACTTGTGTTTGTGGTTCCGATTTGTGGTCATATGCGCATGGTGATGACAAGGCTGCCC
ATTCGATCAACGAAGGACATGAAGCTATCGGAATCGTTGAGGCAATTGGCTCGGCCATTACGACGGTCAAGCCAGGCGAC
TTTGTCATCACCCCATTTACCCATGGCTGTGGTGAGTGCGCGGCTTGTTTGGCTGGTTTCGATGGTACTTGTGATCGGCA
TCCGGGTCACACAAATTGGTCTAATGGCTTTCAAGCAGAATACATTCGCTTCACTTATGGTAATTGGGCGTTAGTTAAGA
TTCCTGGTCAACCTAGTGACTATACGGAAGGGATGCTCAAGTCATTGTTGACGCTGGCAGACGTGATGCCGACTGGTTAT
CATGCGGCACGGTGTGCAAACGTTCAAAAGGGCGATAAAGTCGTGGTTATTGGTGACGGTGCCGTTGGGCAATGTGCTGT
GATTGCAGCTAAGTTGCGGGGTGCCGCGCAAATCGTCTTGATGAGTCGCCACGAAGATCGGCAGCAAATGGCACTTGCTT
CTGGCGCGACCGCGGTTGTTGCTGAACGTGGTGACGAAGGCATTGCGAAGGTACGTGAAATCCTTGGTGGCGGCGCGGAT
GCGGCGTTGGAATGTGTCGGCACTGAAGCGGCCATTGACCAAGCTTTAGGTGTTTTGCATAATGGGGGTCGCGTAGGCTA
TGTGGGTGTACCACATTATAATAACCGGCCACTTGGGTCAACCTTTGCTCAAAATATTGCGGTTGCTGGTGGTTCCGCCT
CCGTTACGACTTATGACAAACAGTTCTTACTCAAAGCAGTTTTGGACGGTAATATTAATCCGGGCCGGGTATTTACGCAA
ACGTATCCATTAGCCGACATTAATCAGGCTTATCAAGACATGCAAAATCGAAAGACAATTAAGGCTATGATTACCATTGA
TTAA

Upstream 100 bases:

>100_bases
TTGTTATAATATATGTGTATTAGTTTTAATATTATTATTTTAATGATGAAGGGAACGACCGCTGATTGAATTTTGGTTGA
GGCGGCCAAAGGTGATTAGG

Downstream 100 bases:

>100_bases
TCTCGACTAGGTAACTAGTCGCTTAAAAGCAATCGATTAAAAGTCGTTTCAGTACTGATTCATCGTGCTGAAACGACTTT
TTCGATGGCGATAATTTAAT

Product: alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKSTIFEKAGLVSVQEVDKPTLQSDDDVIVRIVRTCVCGSDLWSYAHGDDKAAHSINEGHEAIGIVEAIGSAITTVKPGD
FVITPFTHGCGECAACLAGFDGTCDRHPGHTNWSNGFQAEYIRFTYGNWALVKIPGQPSDYTEGMLKSLLTLADVMPTGY
HAARCANVQKGDKVVVIGDGAVGQCAVIAAKLRGAAQIVLMSRHEDRQQMALASGATAVVAERGDEGIAKVREILGGGAD
AALECVGTEAAIDQALGVLHNGGRVGYVGVPHYNNRPLGSTFAQNIAVAGGSASVTTYDKQFLLKAVLDGNINPGRVFTQ
TYPLADINQAYQDMQNRKTIKAMITID

Sequences:

>Translated_347_residues
MKSTIFEKAGLVSVQEVDKPTLQSDDDVIVRIVRTCVCGSDLWSYAHGDDKAAHSINEGHEAIGIVEAIGSAITTVKPGD
FVITPFTHGCGECAACLAGFDGTCDRHPGHTNWSNGFQAEYIRFTYGNWALVKIPGQPSDYTEGMLKSLLTLADVMPTGY
HAARCANVQKGDKVVVIGDGAVGQCAVIAAKLRGAAQIVLMSRHEDRQQMALASGATAVVAERGDEGIAKVREILGGGAD
AALECVGTEAAIDQALGVLHNGGRVGYVGVPHYNNRPLGSTFAQNIAVAGGSASVTTYDKQFLLKAVLDGNINPGRVFTQ
TYPLADINQAYQDMQNRKTIKAMITID
>Mature_347_residues
MKSTIFEKAGLVSVQEVDKPTLQSDDDVIVRIVRTCVCGSDLWSYAHGDDKAAHSINEGHEAIGIVEAIGSAITTVKPGD
FVITPFTHGCGECAACLAGFDGTCDRHPGHTNWSNGFQAEYIRFTYGNWALVKIPGQPSDYTEGMLKSLLTLADVMPTGY
HAARCANVQKGDKVVVIGDGAVGQCAVIAAKLRGAAQIVLMSRHEDRQQMALASGATAVVAERGDEGIAKVREILGGGAD
AALECVGTEAAIDQALGVLHNGGRVGYVGVPHYNNRPLGSTFAQNIAVAGGSASVTTYDKQFLLKAVLDGNINPGRVFTQ
TYPLADINQAYQDMQNRKTIKAMITID

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=25.2032520325203, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71743840, Length=376, Percent_Identity=26.063829787234, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI156627571, Length=336, Percent_Identity=27.9761904761905, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI262073058, Length=376, Percent_Identity=26.063829787234, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI71565152, Length=348, Percent_Identity=26.7241379310345, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786825, Length=385, Percent_Identity=26.7532467532467, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1788073, Length=357, Percent_Identity=26.3305322128852, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87082125, Length=346, Percent_Identity=26.878612716763, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1786552, Length=345, Percent_Identity=28.1159420289855, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1790045, Length=342, Percent_Identity=24.8538011695906, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI226510992, Length=326, Percent_Identity=22.6993865030675, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788075, Length=340, Percent_Identity=26.1764705882353, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788407, Length=290, Percent_Identity=26.551724137931, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081918, Length=314, Percent_Identity=28.6624203821656, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787863, Length=218, Percent_Identity=27.0642201834862, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=352, Percent_Identity=26.9886363636364, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=359, Percent_Identity=26.4623955431755, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=333, Percent_Identity=25.8258258258258, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=347, Percent_Identity=26.2247838616715, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=326, Percent_Identity=24.8466257668712, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=28.7634408602151, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319258, Length=382, Percent_Identity=22.7748691099476, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=350, Percent_Identity=26, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=350, Percent_Identity=26, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=381, Percent_Identity=24.1469816272966, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=26.2872628726287, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17737897, Length=336, Percent_Identity=27.3809523809524, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17137530, Length=339, Percent_Identity=27.4336283185841, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 36710; Mature: 36710

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00059 ADH_ZINC ; PS00222 IGF_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTIFEKAGLVSVQEVDKPTLQSDDDVIVRIVRTCVCGSDLWSYAHGDDKAAHSINEGH
CCCCHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHCCCH
EAIGIVEAIGSAITTVKPGDFVITPFTHGCGECAACLAGFDGTCDRHPGHTNWSNGFQAE
HHHHHHHHHHHHHEECCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
YIRFTYGNWALVKIPGQPSDYTEGMLKSLLTLADVMPTGYHAARCANVQKGDKVVVIGDG
EEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEECC
AVGQCAVIAAKLRGAAQIVLMSRHEDRQQMALASGATAVVAERGDEGIAKVREILGGGAD
CCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCC
AALECVGTEAAIDQALGVLHNGGRVGYVGVPHYNNRPLGSTFAQNIAVAGGSASVTTYDK
HHHEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHEEEECCCCEEEHHHH
QFLLKAVLDGNINPGRVFTQTYPLADINQAYQDMQNRKTIKAMITID
HHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEEEC
>Mature Secondary Structure
MKSTIFEKAGLVSVQEVDKPTLQSDDDVIVRIVRTCVCGSDLWSYAHGDDKAAHSINEGH
CCCCHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHCCCH
EAIGIVEAIGSAITTVKPGDFVITPFTHGCGECAACLAGFDGTCDRHPGHTNWSNGFQAE
HHHHHHHHHHHHHEECCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
YIRFTYGNWALVKIPGQPSDYTEGMLKSLLTLADVMPTGYHAARCANVQKGDKVVVIGDG
EEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEECC
AVGQCAVIAAKLRGAAQIVLMSRHEDRQQMALASGATAVVAERGDEGIAKVREILGGGAD
CCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCC
AALECVGTEAAIDQALGVLHNGGRVGYVGVPHYNNRPLGSTFAQNIAVAGGSASVTTYDK
HHHEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHEEEECCCCEEEHHHH
QFLLKAVLDGNINPGRVFTQTYPLADINQAYQDMQNRKTIKAMITID
HHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]