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The map label for this gene is rnc

Identifier: 28378329

GI number: 28378329

Start: 1484500

End: 1485195

Strand: Direct

Name: rnc

Synonym: lp_1631

Alternate gene names: 28378329

Gene position: 1484500-1485195 (Clockwise)

Preceding gene: 28378328

Following gene: 28378330

Centisome position: 44.87

GC content: 44.54

Gene sequence:

>696_bases
ATGATTACAGAATTAGCTGCAATGTTGAAGGAACGGTTTGGCATTGTGTTTAACGATCCCGATTTATTGGCGGAGGCGTT
TACACAAGCCTCGTATGTCAATGAACATCAGGACCAACAGTTGAAGTATTACGAACGGGTCGAATTTTTGGGGGATGCCG
TCTTGGAGTTAGTGGTGTCCGAATATTTATACAAACGTTATAAAGACATGCCCCAAGGTAAGTTGACTCGTTTACGGGCC
GCCATGGTTTGTGAAGAAAGTTTTGCAAGCTTTGCCCGTGAATGTGACTTTCCTCAGTACATCCGGTTAGGCAAGGGCGA
ACAAAAAGCGCATGCTTGGGAACGAGATTCACTTTTATGTGATATTTTTGAATCATTTGTCGGGGCACTGTACCTGGATC
AAGGACGGGAACCTGTTTTGAAGTTCGTTCATCAAGTAATTTTTCCTAAGCTGGATGAGGGTCGTTTTGATGGTGTTTTT
GATTATAAGACGACCTTGCAAGAATACTTGCAACGGGATGGCGATGTCGCAATCGACTATCAATTAATTGAACAAGATGG
TCCAGCCAATGAGCGGTCTTATGAGATTGCCGTACTTGCCGATGGTCAAAAAATCGGTGAGGGCTGGGGGCATTCCAAGA
AGGAAGCCGAACAGAGCGCTGCTCGGCAAGCTTATTCACAATTACAGCAAAAGTAA

Upstream 100 bases:

>100_bases
TAATGATTCATGCTAAGTTAGGCACCACCAGTAACAGATTGTGATAACTGGCTGATCCAATGGGGTTAGTCGATAGAATG
ATAACGAAAGGAAGTTTCAA

Downstream 100 bases:

>100_bases
CCATTAATAATTACAGGAAGTTTGTGTCGAATGCAACTTAAATCATTAGAAATCAGCGGATTTAAATCATTTGCTGATAA
AACCAAAATTGATTTTCAAG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MITELAAMLKERFGIVFNDPDLLAEAFTQASYVNEHQDQQLKYYERVEFLGDAVLELVVSEYLYKRYKDMPQGKLTRLRA
AMVCEESFASFARECDFPQYIRLGKGEQKAHAWERDSLLCDIFESFVGALYLDQGREPVLKFVHQVIFPKLDEGRFDGVF
DYKTTLQEYLQRDGDVAIDYQLIEQDGPANERSYEIAVLADGQKIGEGWGHSKKEAEQSAARQAYSQLQQK

Sequences:

>Translated_231_residues
MITELAAMLKERFGIVFNDPDLLAEAFTQASYVNEHQDQQLKYYERVEFLGDAVLELVVSEYLYKRYKDMPQGKLTRLRA
AMVCEESFASFARECDFPQYIRLGKGEQKAHAWERDSLLCDIFESFVGALYLDQGREPVLKFVHQVIFPKLDEGRFDGVF
DYKTTLQEYLQRDGDVAIDYQLIEQDGPANERSYEIAVLADGQKIGEGWGHSKKEAEQSAARQAYSQLQQK
>Mature_231_residues
MITELAAMLKERFGIVFNDPDLLAEAFTQASYVNEHQDQQLKYYERVEFLGDAVLELVVSEYLYKRYKDMPQGKLTRLRA
AMVCEESFASFARECDFPQYIRLGKGEQKAHAWERDSLLCDIFESFVGALYLDQGREPVLKFVHQVIFPKLDEGRFDGVF
DYKTTLQEYLQRDGDVAIDYQLIEQDGPANERSYEIAVLADGQKIGEGWGHSKKEAEQSAARQAYSQLQQK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=226, Percent_Identity=33.6283185840708, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI155030236, Length=226, Percent_Identity=33.6283185840708, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1788920, Length=195, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17506883, Length=228, Percent_Identity=30.2631578947368, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI193202651, Length=228, Percent_Identity=30.2631578947368, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17552834, Length=178, Percent_Identity=33.1460674157303, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137682, Length=224, Percent_Identity=32.5892857142857, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_LACPL (Q88WK0)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785221.1
- ProteinModelPortal:   Q88WK0
- SMR:   Q88WK0
- GeneID:   1063816
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1631
- NMPDR:   fig|220668.1.peg.1355
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   LPLA220668:LP_1631-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26652; Mature: 26652

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITELAAMLKERFGIVFNDPDLLAEAFTQASYVNEHQDQQLKYYERVEFLGDAVLELVVS
CHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYLYKRYKDMPQGKLTRLRAAMVCEESFASFARECDFPQYIRLGKGEQKAHAWERDSLLC
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHH
DIFESFVGALYLDQGREPVLKFVHQVIFPKLDEGRFDGVFDYKTTLQEYLQRDGDVAIDY
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEH
QLIEQDGPANERSYEIAVLADGQKIGEGWGHSKKEAEQSAARQAYSQLQQK
EEECCCCCCCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITELAAMLKERFGIVFNDPDLLAEAFTQASYVNEHQDQQLKYYERVEFLGDAVLELVVS
CHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYLYKRYKDMPQGKLTRLRAAMVCEESFASFARECDFPQYIRLGKGEQKAHAWERDSLLC
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHH
DIFESFVGALYLDQGREPVLKFVHQVIFPKLDEGRFDGVFDYKTTLQEYLQRDGDVAIDY
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEH
QLIEQDGPANERSYEIAVLADGQKIGEGWGHSKKEAEQSAARQAYSQLQQK
EEECCCCCCCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566