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The map label for this gene is ispA [C]

Identifier: 28378303

GI number: 28378303

Start: 1456997

End: 1457887

Strand: Direct

Name: ispA [C]

Synonym: lp_1602

Alternate gene names: 28378303

Gene position: 1456997-1457887 (Clockwise)

Preceding gene: 28378302

Following gene: 28378304

Centisome position: 44.04

GC content: 47.7

Gene sequence:

>891_bases
ATGAATAAGCAATTATTAACTGAATTTGAATCCAAGTGGCGTCCTCAGATTAATCAGTATTTAGATGAGCAGCTTCAAGC
GTGTTCTGACCAATCAACCCTGACTGACGCCATGCGTTATTCGGTACTAGCAGGTGGCAAACGGTTACGGCCGTTATTGA
CGTTAGCCATTTTAGATACTTTTGATATCACAACGACGGCTGCAAACTTGCGGGCAAGTGTGGCCGTTGAGTTGATGCAT
ACTTATTCGCTAATTCACGATGATTTACCGGCGATGGATAATGATCAGCTACGACGTGGCGAACCGACTAACCATGTTAA
GTTTGGGGAAGACGTTGCCATTCTTGCAGGGGATGCTTTACAACCGTTGACTTTCGAATGGATTGCGGATAGTGGGTTAC
CGGCATCGATCGTCGCTAATCAAACCTTAGCATTAGCGCAGGCCACCGGACCTCGCGGGATGGTGGCTGGTCAAGTTGCT
GATGTCCTTGGAGCGGGACAACATCTGGCTTTGCCAGCCTTACAACAGCTGCATCGCGAGAAGACGGGGGCGTTAATTCA
CTACGCTGTCCAGGCAGGGTTGATTCAAGCTCAAGTGCAACCAACCGTGCAGGAATTGCTATTACAATATGCTGATGCCT
ATGGATTGGCGTTTCAAATTTACGATGATATTTTAGACGTGACGAGTACGCCTGCTCAGTTAGGAAAAGCTACGCATAAG
GATGCCGATGAGCATAAGAATACGTATCCAGGTTTGCTGGGGCTTGCAGGCGCACGAACAGCGTTAGAACAAGCGGTAAC
AGCTGCTCAAACGGCGTTAGTAAAAGCTAGTGCTGCTAGTCAACGAGGCATGGGCTTGCTTGCAGCTTTTCTAACGTATT
TTACAGATTAA

Upstream 100 bases:

>100_bases
AGCAAGCAGTTGCAAGCAACCCTTGAAGGTGCTGAAAAGACGCTCACTAAGATGATGAATGAAAATGGCGACGAAGTTCC
ATTTGAGCAAGCTGACGCCA

Downstream 100 bases:

>100_bases
GGACTTAAATTTAGATGGAAAAAGAACGAGTTGACGTATTATTAGTACAACAAGGATTATTTGATACCCGCGAAAAGGCT
AAGCGTGCCGTAATGGCCGG

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNKQLLTEFESKWRPQINQYLDEQLQACSDQSTLTDAMRYSVLAGGKRLRPLLTLAILDTFDITTTAANLRASVAVELMH
TYSLIHDDLPAMDNDQLRRGEPTNHVKFGEDVAILAGDALQPLTFEWIADSGLPASIVANQTLALAQATGPRGMVAGQVA
DVLGAGQHLALPALQQLHREKTGALIHYAVQAGLIQAQVQPTVQELLLQYADAYGLAFQIYDDILDVTSTPAQLGKATHK
DADEHKNTYPGLLGLAGARTALEQAVTAAQTALVKASAASQRGMGLLAAFLTYFTD

Sequences:

>Translated_296_residues
MNKQLLTEFESKWRPQINQYLDEQLQACSDQSTLTDAMRYSVLAGGKRLRPLLTLAILDTFDITTTAANLRASVAVELMH
TYSLIHDDLPAMDNDQLRRGEPTNHVKFGEDVAILAGDALQPLTFEWIADSGLPASIVANQTLALAQATGPRGMVAGQVA
DVLGAGQHLALPALQQLHREKTGALIHYAVQAGLIQAQVQPTVQELLLQYADAYGLAFQIYDDILDVTSTPAQLGKATHK
DADEHKNTYPGLLGLAGARTALEQAVTAAQTALVKASAASQRGMGLLAAFLTYFTD
>Mature_296_residues
MNKQLLTEFESKWRPQINQYLDEQLQACSDQSTLTDAMRYSVLAGGKRLRPLLTLAILDTFDITTTAANLRASVAVELMH
TYSLIHDDLPAMDNDQLRRGEPTNHVKFGEDVAILAGDALQPLTFEWIADSGLPASIVANQTLALAQATGPRGMVAGQVA
DVLGAGQHLALPALQQLHREKTGALIHYAVQAGLIQAQVQPTVQELLLQYADAYGLAFQIYDDILDVTSTPAQLGKATHK
DADEHKNTYPGLLGLAGARTALEQAVTAAQTALVKASAASQRGMGLLAAFLTYFTD

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=241, Percent_Identity=27.8008298755187, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1786623, Length=267, Percent_Identity=45.3183520599251, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789578, Length=284, Percent_Identity=27.4647887323944, Blast_Score=84, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24651612, Length=229, Percent_Identity=28.82096069869, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31863; Mature: 31863

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQLLTEFESKWRPQINQYLDEQLQACSDQSTLTDAMRYSVLAGGKRLRPLLTLAILDT
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FDITTTAANLRASVAVELMHTYSLIHDDLPAMDNDQLRRGEPTNHVKFGEDVAILAGDAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCC
QPLTFEWIADSGLPASIVANQTLALAQATGPRGMVAGQVADVLGAGQHLALPALQQLHRE
CCCCCEEHHCCCCCHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
KTGALIHYAVQAGLIQAQVQPTVQELLLQYADAYGLAFQIYDDILDVTSTPAQLGKATHK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
DADEHKNTYPGLLGLAGARTALEQAVTAAQTALVKASAASQRGMGLLAAFLTYFTD
CCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNKQLLTEFESKWRPQINQYLDEQLQACSDQSTLTDAMRYSVLAGGKRLRPLLTLAILDT
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FDITTTAANLRASVAVELMHTYSLIHDDLPAMDNDQLRRGEPTNHVKFGEDVAILAGDAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCC
QPLTFEWIADSGLPASIVANQTLALAQATGPRGMVAGQVADVLGAGQHLALPALQQLHRE
CCCCCEEHHCCCCCHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
KTGALIHYAVQAGLIQAQVQPTVQELLLQYADAYGLAFQIYDDILDVTSTPAQLGKATHK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
DADEHKNTYPGLLGLAGARTALEQAVTAAQTALVKASAASQRGMGLLAAFLTYFTD
CCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]