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The map label for this gene is glk [H]

Identifier: 28378278

GI number: 28378278

Start: 1438505

End: 1439467

Strand: Direct

Name: glk [H]

Synonym: lp_1573

Alternate gene names: 28378278

Gene position: 1438505-1439467 (Clockwise)

Preceding gene: 28378277

Following gene: 28378279

Centisome position: 43.48

GC content: 44.76

Gene sequence:

>963_bases
ATGGAGCGTAAGTTAATCGGAGTCGACCTTGGTGGGACGACAACTAAGTTTGCCATTTTAACAGAAAATGGTGATATTCA
ACAAAAGTGGAGTATTGAAACCACGATTTTAGATGAAGGGGCCCACATTGTGCCTAACATCATCGATTCCATCAACCACC
ACATTGAGTTATATAAGATGGACCGTTCTCAATTTATCGGAATTGGAATGGGGACTCCCGGGACCGTTGATTTGGATAAT
GGTACGGTTATCGGTGCCTACAACTTAAACTGGAAGACCTTACAACCAGTTAAGGCTCAAATCGAAAAAGGGACTGGCAT
CAAATTTACGCTGGATAACGACGCTAACGTTGCTGCACTTGGCGAACGTTGGAAGGGCGCTGGCGAAAACGGTAGTGACG
TTGTCTTTGTAACGCTTGGAACTGGTGTTGGTGGTGGGATCATCGCCGATGGCCGTTTACTCCATGGTATTGCCGGTGGT
GCCGGTGAAATTGGTCACGTAACGGTTGAACCAAACGGCTACATGTGTACTTGTGGTAAGAAAGGTTGTTTGGAACAATA
CGCTTCTGCAACTGGTGTCGTTCACGTTGCTCGCGATATGGCAGAAGAATTCTCTGGTGCTTCTAAGTTGAAACAATTAT
TAGACAACGGTGAAGAAATTAGTTCAAAGATCACTTTCGATTTAGCTAAAGAAGGCGATGTCTTGGCTAAACGCGTTGTT
GATCGGGTTTCTTATTACTTAGGCTTGGCATTAGCTAATGTCGGGAACACGATGAACCCATCTTCAATCATTATCGGTGG
TGGGGTTTCAGCTGCTGGTGATTTCTTATTAGATCAAGTCATCAGTTACTTTAACCAATTCACATTCCCAACGATTCGCG
ACACGACTGCTTTGAAGTTAGCGGTCTTAGGTAACGACGCTGGTGTTATCGGAGCAGGTTCATTGGCCCAACGGTTTATT
TAA

Upstream 100 bases:

>100_bases
TGTATGCCCGCGTCAAGCTCGTATTGAGCCATGAGCACCGGATAGAAGCAGAACGCGCCCGTGAAGACGCGGCGCATGAC
TAATGGAGGGATTTAGCAAC

Downstream 100 bases:

>100_bases
GTTAAAATCAATCGTCAAGAAGCTTGGAAGTAATGTCCGAGCTTCTTTTTTATACTAAGCTCCAAAAACTGTGCTGATTA
GGTTGTGGTTAAAAACTGAG

Product: glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MERKLIGVDLGGTTTKFAILTENGDIQQKWSIETTILDEGAHIVPNIIDSINHHIELYKMDRSQFIGIGMGTPGTVDLDN
GTVIGAYNLNWKTLQPVKAQIEKGTGIKFTLDNDANVAALGERWKGAGENGSDVVFVTLGTGVGGGIIADGRLLHGIAGG
AGEIGHVTVEPNGYMCTCGKKGCLEQYASATGVVHVARDMAEEFSGASKLKQLLDNGEEISSKITFDLAKEGDVLAKRVV
DRVSYYLGLALANVGNTMNPSSIIIGGGVSAAGDFLLDQVISYFNQFTFPTIRDTTALKLAVLGNDAGVIGAGSLAQRFI

Sequences:

>Translated_320_residues
MERKLIGVDLGGTTTKFAILTENGDIQQKWSIETTILDEGAHIVPNIIDSINHHIELYKMDRSQFIGIGMGTPGTVDLDN
GTVIGAYNLNWKTLQPVKAQIEKGTGIKFTLDNDANVAALGERWKGAGENGSDVVFVTLGTGVGGGIIADGRLLHGIAGG
AGEIGHVTVEPNGYMCTCGKKGCLEQYASATGVVHVARDMAEEFSGASKLKQLLDNGEEISSKITFDLAKEGDVLAKRVV
DRVSYYLGLALANVGNTMNPSSIIIGGGVSAAGDFLLDQVISYFNQFTFPTIRDTTALKLAVLGNDAGVIGAGSLAQRFI
>Mature_320_residues
MERKLIGVDLGGTTTKFAILTENGDIQQKWSIETTILDEGAHIVPNIIDSINHHIELYKMDRSQFIGIGMGTPGTVDLDN
GTVIGAYNLNWKTLQPVKAQIEKGTGIKFTLDNDANVAALGERWKGAGENGSDVVFVTLGTGVGGGIIADGRLLHGIAGG
AGEIGHVTVEPNGYMCTCGKKGCLEQYASATGVVHVARDMAEEFSGASKLKQLLDNGEEISSKITFDLAKEGDVLAKRVV
DRVSYYLGLALANVGNTMNPSSIIIGGGVSAAGDFLLDQVISYFNQFTFPTIRDTTALKLAVLGNDAGVIGAGSLAQRFI

Specific function: May Be A Regulator In Specific Sugar Metabolism. May Influence The Rate Of Glucose Uptake Or Glycolysis In Cells In The Rich Medium. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566325, Length=283, Percent_Identity=29.6819787985866, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI298566315, Length=283, Percent_Identity=29.6819787985866, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4885285, Length=283, Percent_Identity=29.6819787985866, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI190014632, Length=283, Percent_Identity=29.6819787985866, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1787878, Length=273, Percent_Identity=28.9377289377289, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1786891, Length=299, Percent_Identity=27.0903010033445, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87081733, Length=322, Percent_Identity=30.1242236024845, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082127, Length=262, Percent_Identity=27.0992366412214, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787363, Length=322, Percent_Identity=25.776397515528, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082230, Length=282, Percent_Identity=26.5957446808511, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33734; Mature: 33734

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERKLIGVDLGGTTTKFAILTENGDIQQKWSIETTILDEGAHIVPNIIDSINHHIELYKM
CCCEEEEEECCCCCEEEEEEECCCCCCEEEEEEEEEECCCCCHHHHHHHHHCCEEEEEEE
DRSQFIGIGMGTPGTVDLDNGTVIGAYNLNWKTLQPVKAQIEKGTGIKFTLDNDANVAAL
CCCEEEEEECCCCCEEECCCCEEEEEEECCCCCCCHHHHHHCCCCCEEEEECCCCCEEEH
GERWKGAGENGSDVVFVTLGTGVGGGIIADGRLLHGIAGGAGEIGHVTVEPNGYMCTCGK
HHHCCCCCCCCCCEEEEEECCCCCCCEEECCEEEEEECCCCCCCCEEEECCCCEEEECCC
KGCLEQYASATGVVHVARDMAEEFSGASKLKQLLDNGEEISSKITFDLAKEGDVLAKRVV
HHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHEEEEEECCCCHHHHHHHH
DRVSYYLGLALANVGNTMNPSSIIIGGGVSAAGDFLLDQVISYFNQFTFPTIRDTTALKL
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
AVLGNDAGVIGAGSLAQRFI
EEECCCCCEEECCHHHHHCC
>Mature Secondary Structure
MERKLIGVDLGGTTTKFAILTENGDIQQKWSIETTILDEGAHIVPNIIDSINHHIELYKM
CCCEEEEEECCCCCEEEEEEECCCCCCEEEEEEEEEECCCCCHHHHHHHHHCCEEEEEEE
DRSQFIGIGMGTPGTVDLDNGTVIGAYNLNWKTLQPVKAQIEKGTGIKFTLDNDANVAAL
CCCEEEEEECCCCCEEECCCCEEEEEEECCCCCCCHHHHHHCCCCCEEEEECCCCCEEEH
GERWKGAGENGSDVVFVTLGTGVGGGIIADGRLLHGIAGGAGEIGHVTVEPNGYMCTCGK
HHHCCCCCCCCCCEEEEEECCCCCCCEEECCEEEEEECCCCCCCCEEEECCCCEEEECCC
KGCLEQYASATGVVHVARDMAEEFSGASKLKQLLDNGEEISSKITFDLAKEGDVLAKRVV
HHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHEEEEEECCCCHHHHHHHH
DRVSYYLGLALANVGNTMNPSSIIIGGGVSAAGDFLLDQVISYFNQFTFPTIRDTTALKL
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
AVLGNDAGVIGAGSLAQRFI
EEECCCCCEEECCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]