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The map label for this gene is infC

Identifier: 28378229

GI number: 28378229

Start: 1388025

End: 1388546

Strand: Direct

Name: infC

Synonym: lp_1515

Alternate gene names: 28378229

Gene position: 1388025-1388546 (Clockwise)

Preceding gene: 28378228

Following gene: 28378230

Centisome position: 41.96

GC content: 45.4

Gene sequence:

>522_bases
ATTACCATAGCTAAAGATTCAATGGTTAATGACGGCATCCGTGCTCGCGAAGTACGTTTGATCGCCAGCGATGGTGAACA
ATTAGGTGTCAAGTCACGACAAGAAGCAATGCAGATTGCTGAAGACGCTAGTTTAGATCTAGTATTGGTTGCGCCGAAAG
CGAAACCACCCGTGGCCAGAATTATGGATTATGGGAAGTACCGTTTCGAGCAACAAAAGAAGGATCGGGAAGCCCGTAAG
AAGCAAAAAGTGGTCAGCATCAAAGAGGTCCGCTTGAGCCCAGCTATCGACACCAATGACTTTAACACGAAGCTGAAACA
TGCTGAAAAGTTCTTGTCAAAAGGTGACAAGGTTCGCGTCTCCATCCGGTTTAAGGGCCGCGCTATTACCCATAAGGACA
TTGGTCGCCAAGTCTTAAATCGAATGATTGAAGCTACTAAGGAATTTTCTACGGTCGAAGCCTATCCTAAGATGGATGGT
CGGAGTATGTTCCTAGTACTAGCACCAAAAACAGATAAGTAA

Upstream 100 bases:

>100_bases
CGGGCAGATGAACGATGAATTGATTCCCATTAACGGGGTTGAGCGGGCGTACTATGCGCCCGCTCTTTTTGTGAATTTCT
CTAAAATATTTCGGAGGTGA

Downstream 100 bases:

>100_bases
TTTCTAGGAGGATTATTGATTATGCCAAAACAAAAGACAAACCGCGCTGCTGCAAAGCGTTTCAAGGTAACTGCTAAGGG
TAAGATTAAGAGCGCCAACG

Product: translation initiation factor IF-3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MTIAKDSMVNDGIRAREVRLIASDGEQLGVKSRQEAMQIAEDASLDLVLVAPKAKPPVARIMDYGKYRFEQQKKDREARK
KQKVVSIKEVRLSPAIDTNDFNTKLKHAEKFLSKGDKVRVSIRFKGRAITHKDIGRQVLNRMIEATKEFSTVEAYPKMDG
RSMFLVLAPKTDK

Sequences:

>Translated_173_residues
MTIAKDSMVNDGIRAREVRLIASDGEQLGVKSRQEAMQIAEDASLDLVLVAPKAKPPVARIMDYGKYRFEQQKKDREARK
KQKVVSIKEVRLSPAIDTNDFNTKLKHAEKFLSKGDKVRVSIRFKGRAITHKDIGRQVLNRMIEATKEFSTVEAYPKMDG
RSMFLVLAPKTDK
>Mature_172_residues
TIAKDSMVNDGIRAREVRLIASDGEQLGVKSRQEAMQIAEDASLDLVLVAPKAKPPVARIMDYGKYRFEQQKKDREARKK
QKVVSIKEVRLSPAIDTNDFNTKLKHAEKFLSKGDKVRVSIRFKGRAITHKDIGRQVLNRMIEATKEFSTVEAYPKMDGR
SMFLVLAPKTDK

Specific function: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins

COG id: COG0290

COG function: function code J; Translation initiation factor 3 (IF-3)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IF-3 family

Homologues:

Organism=Escherichia coli, GI1788012, Length=168, Percent_Identity=47.0238095238095, Blast_Score=158, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF3_LACPL (Q88WU8)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785121.1
- ProteinModelPortal:   Q88WU8
- GeneID:   1061201
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1515
- HOGENOM:   HBG744268
- OMA:   APKAPIN
- ProtClustDB:   PRK00028
- BioCyc:   LPLA220668:LP_1515-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00080
- InterPro:   IPR019813
- InterPro:   IPR001288
- InterPro:   IPR019815
- InterPro:   IPR019814
- Gene3D:   G3DSA:3.10.20.80
- Gene3D:   G3DSA:3.30.110.10
- PANTHER:   PTHR10938
- TIGRFAMs:   TIGR00168

Pfam domain/function: PF00707 IF3_C; PF05198 IF3_N; SSF54364 IF3; SSF55200 IF3

EC number: NA

Molecular weight: Translated: 19648; Mature: 19517

Theoretical pI: Translated: 10.67; Mature: 10.67

Prosite motif: PS00938 IF3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAKDSMVNDGIRAREVRLIASDGEQLGVKSRQEAMQIAEDASLDLVLVAPKAKPPVAR
CCCCCCCHHCCCCCEEEEEEEECCCHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHH
IMDYGKYRFEQQKKDREARKKQKVVSIKEVRLSPAIDTNDFNTKLKHAEKFLSKGDKVRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCCCEEEE
SIRFKGRAITHKDIGRQVLNRMIEATKEFSTVEAYPKMDGRSMFLVLAPKTDK
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
TIAKDSMVNDGIRAREVRLIASDGEQLGVKSRQEAMQIAEDASLDLVLVAPKAKPPVAR
CCCCCCHHCCCCCEEEEEEEECCCHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHH
IMDYGKYRFEQQKKDREARKKQKVVSIKEVRLSPAIDTNDFNTKLKHAEKFLSKGDKVRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCCCEEEE
SIRFKGRAITHKDIGRQVLNRMIEATKEFSTVEAYPKMDGRSMFLVLAPKTDK
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566