Click here to switch to the map view.

The map label for this gene is ribA [H]

Identifier: 28378159

GI number: 28378159

Start: 1316447

End: 1317661

Strand: Direct

Name: ribA [H]

Synonym: lp_1437

Alternate gene names: 28378159

Gene position: 1316447-1317661 (Clockwise)

Preceding gene: 28378157

Following gene: 28378160

Centisome position: 39.79

GC content: 50.7

Gene sequence:

>1215_bases
ATGGATACAATGAAAAAGGTAGCAGCGGCCTTGGCCGCATTAAAACGGGGCGAATTGATTATTGTTGCGGATGATGAGAC
GCGTGAAGCGGAAGGAGACATGGTTGGCCTAGCCGCTAAAGCAACCACTGCGACAGTGAATCGGATGATTACATCAGCGC
GGGGACTACTCTGTGTTCCGATGGCGCCAAGTATCGCCACGCGACTACATTTGACACCGATGACTAGTGAACACGATGCG
TTTGGAACGGCATTTACAGTCTCAACGGATCACCATACGACGTCCACGGGAATCTCGGCAGCTGATCGGGCGACCACGAT
TCAAGCGTTAGCCAATCCCAATAGTCAGGCCGCTGATTTCTATCATCCCGGGCACGTTTTTCCATTGATTGCGCGGACTG
GTGGATTGTTAGCGCGGCGTGGTCATACTGAAGCGGCCGTCACGTTAGCACAATTAGCAGGTGTGACCCCCGCGGCCTAT
ATTTGTGAAGTTATCAAGAAAAATGGCTTAATGGCGCGGCGCCGTGATCTCAAAGCTTTGGCAGAGGGCTTACAATTACC
GCTAATCACCATTGAAGATATTACCACCTACGTGATTCAAACGGGTGCCGCCCAGCTAACAACGACCCCGAGTGTCAACT
TACCGACCAAGGATGGTCAGTTCACGATGACTGGTTTCGAAGTCCCCGGTCATACGGCGTTGCCAGTGGCACTGCAAGCT
GGTGATATCAGTGGCGATGAACCAGTGTTAGTGCGGTTACACTCTGAATGTTTTACGGGCGATGTTTTAGGATCGCGGCG
GTGTGACTGTGGTGATCAATTACACGCTGCACTCCAAAAAATCAGTCAAGCTCAGCGCGGTGTTTTCGTCTATTTACGGC
AAGAGGGTCGCGGTATTGGCTTGGCTAACAAACTAGCAGCTTACGCACTCCAAGAACACGGGGTTGATACGTATGATGCG
AACGTGCAGTTGGGCTTTCAACCGGATGAGCGCCGGTATGATATTGCGGCATTAGTGCTACGCCAAATGGGGATTACACG
GGTTCGTTTGCTGACTAATAATCCTGACAAGGTTGAGCAGTTACGTGCAGCGGGGATTGATGTTGTTGAACGGGTCCCCT
TAGAAATACCAGCCAATCAGTACGATCAAGCTTACTTAAAAACAAAACGTGATCGATTTCATCATCAACTCACACTAACG
GAGGGACACGAATGA

Upstream 100 bases:

>100_bases
ACCTTGTCTAAGTTACAAGTTGGAACGCTGGTGAATGTAGAAACGGATATTCTGGGCAAGTACTTGGCCCGGCAATTAGC
ATTAGAGGGGAGTCATTAAG

Downstream 100 bases:

>100_bases
CAACTTTTAACGGCAAAATTAATGGCAACGGGCTTAAGATTGGGATTGCCGTGGCGCGTTTCAATGCGTTTGTAACGCAG
CAACTTTTAACTGGGGCACA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MDTMKKVAAALAALKRGELIIVADDETREAEGDMVGLAAKATTATVNRMITSARGLLCVPMAPSIATRLHLTPMTSEHDA
FGTAFTVSTDHHTTSTGISAADRATTIQALANPNSQAADFYHPGHVFPLIARTGGLLARRGHTEAAVTLAQLAGVTPAAY
ICEVIKKNGLMARRRDLKALAEGLQLPLITIEDITTYVIQTGAAQLTTTPSVNLPTKDGQFTMTGFEVPGHTALPVALQA
GDISGDEPVLVRLHSECFTGDVLGSRRCDCGDQLHAALQKISQAQRGVFVYLRQEGRGIGLANKLAAYALQEHGVDTYDA
NVQLGFQPDERRYDIAALVLRQMGITRVRLLTNNPDKVEQLRAAGIDVVERVPLEIPANQYDQAYLKTKRDRFHHQLTLT
EGHE

Sequences:

>Translated_404_residues
MDTMKKVAAALAALKRGELIIVADDETREAEGDMVGLAAKATTATVNRMITSARGLLCVPMAPSIATRLHLTPMTSEHDA
FGTAFTVSTDHHTTSTGISAADRATTIQALANPNSQAADFYHPGHVFPLIARTGGLLARRGHTEAAVTLAQLAGVTPAAY
ICEVIKKNGLMARRRDLKALAEGLQLPLITIEDITTYVIQTGAAQLTTTPSVNLPTKDGQFTMTGFEVPGHTALPVALQA
GDISGDEPVLVRLHSECFTGDVLGSRRCDCGDQLHAALQKISQAQRGVFVYLRQEGRGIGLANKLAAYALQEHGVDTYDA
NVQLGFQPDERRYDIAALVLRQMGITRVRLLTNNPDKVEQLRAAGIDVVERVPLEIPANQYDQAYLKTKRDRFHHQLTLT
EGHE
>Mature_404_residues
MDTMKKVAAALAALKRGELIIVADDETREAEGDMVGLAAKATTATVNRMITSARGLLCVPMAPSIATRLHLTPMTSEHDA
FGTAFTVSTDHHTTSTGISAADRATTIQALANPNSQAADFYHPGHVFPLIARTGGLLARRGHTEAAVTLAQLAGVTPAAY
ICEVIKKNGLMARRRDLKALAEGLQLPLITIEDITTYVIQTGAAQLTTTPSVNLPTKDGQFTMTGFEVPGHTALPVALQA
GDISGDEPVLVRLHSECFTGDVLGSRRCDCGDQLHAALQKISQAQRGVFVYLRQEGRGIGLANKLAAYALQEHGVDTYDA
NVQLGFQPDERRYDIAALVLRQMGITRVRLLTNNPDKVEQLRAAGIDVVERVPLEIPANQYDQAYLKTKRDRFHHQLTLT
EGHE

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=53.5714285714286, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1789420, Length=197, Percent_Identity=40.6091370558376, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320695, Length=202, Percent_Identity=37.6237623762376, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=43.2748538011696, Blast_Score=126, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 43615; Mature: 43615

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTMKKVAAALAALKRGELIIVADDETREAEGDMVGLAAKATTATVNRMITSARGLLCVP
CCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEE
MAPSIATRLHLTPMTSEHDAFGTAFTVSTDHHTTSTGISAADRATTIQALANPNSQAADF
CCCCHHHEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
YHPGHVFPLIARTGGLLARRGHTEAAVTLAQLAGVTPAAYICEVIKKNGLMARRRDLKAL
CCCCCCEEHHHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHH
AEGLQLPLITIEDITTYVIQTGAAQLTTTPSVNLPTKDGQFTMTGFEVPGHTALPVALQA
HCCCCCCEEEHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEE
GDISGDEPVLVRLHSECFTGDVLGSRRCDCGDQLHAALQKISQAQRGVFVYLRQEGRGIG
CCCCCCCCEEEEEECHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
LANKLAAYALQEHGVDTYDANVQLGFQPDERRYDIAALVLRQMGITRVRLLTNNPDKVEQ
HHHHHHHHHHHHCCCCEECCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHH
LRAAGIDVVERVPLEIPANQYDQAYLKTKRDRFHHQLTLTEGHE
HHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCC
>Mature Secondary Structure
MDTMKKVAAALAALKRGELIIVADDETREAEGDMVGLAAKATTATVNRMITSARGLLCVP
CCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEE
MAPSIATRLHLTPMTSEHDAFGTAFTVSTDHHTTSTGISAADRATTIQALANPNSQAADF
CCCCHHHEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
YHPGHVFPLIARTGGLLARRGHTEAAVTLAQLAGVTPAAYICEVIKKNGLMARRRDLKAL
CCCCCCEEHHHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHH
AEGLQLPLITIEDITTYVIQTGAAQLTTTPSVNLPTKDGQFTMTGFEVPGHTALPVALQA
HCCCCCCEEEHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEE
GDISGDEPVLVRLHSECFTGDVLGSRRCDCGDQLHAALQKISQAQRGVFVYLRQEGRGIG
CCCCCCCCEEEEEECHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
LANKLAAYALQEHGVDTYDANVQLGFQPDERRYDIAALVLRQMGITRVRLLTNNPDKVEQ
HHHHHHHHHHHHCCCCEECCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHH
LRAAGIDVVERVPLEIPANQYDQAYLKTKRDRFHHQLTLTEGHE
HHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA