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The map label for this gene is clcR [H]

Identifier: 28378024

GI number: 28378024

Start: 1143595

End: 1144476

Strand: Direct

Name: clcR [H]

Synonym: lp_1258

Alternate gene names: 28378024

Gene position: 1143595-1144476 (Clockwise)

Preceding gene: 28378022

Following gene: 28378025

Centisome position: 34.57

GC content: 51.93

Gene sequence:

>882_bases
ATGAATCTAAAACAATTACAATATTTTTTGGCCGTGGCAGAGGAAGGTCAGATGACAGCGGCCGCCAAACGCTTGCACGT
GGCGCAGCCACCACTGAGCTATCAGATTAAGCAATTAGAACTTGAACTAGGCGTCACCCTCTTCAATCGCTTGCCTCAGG
GTGTGACTGTTACTGAAGCTGGCAAGCTACTGGTGGGGTATGCCCAACAGCTCACGCAGTTGTCGGCGACTGCGGAGAAC
AAGGTCCTGGCCCTGGCACACGGCGTGACGGGGACCATTAATCTGGGGACAGTTTCATCCTCGGCAGGGGTCATGCCGAA
TACGGCATTACTAAAGTGGTTAGGGCAACATCCCGATGTTCAGCTTGCGATTACGGAAGGCAATACGTATGAGTTGTTAG
ACGATCTGCATAAACGGTTGCTAGACGTGGCGGTGTTACGAACACCGTTCAACGCGCAACATCTAGTCTGTCGTTACTTT
CCCGCAGAACGGATGGCAGCAGTCATTCCGAAGCGATATTCACGGTTTGAAAAGCGGCGCCAGTTACAACTAAGTGACCT
CGCTACGTTACCATTGATCAAGTACCGTCGTTTTAATGAATTATTCCACGTTGCCTTTCTGGAAGCGTCGGTTACACCGA
CTTACATCATGACTTGTGATGATGCCCGCACGGCGATGCACTGGGCTAATCACCAATTGGGAGTGGCCCTGGTGCCACGG
TCATTGGCTGAAACCTATGACGGTGGTGACGTGCTGATTCGATCATTGGCGGATCATCGTTTTCAGACTCAACTGGCCCT
AGCAACGACCCCGGAAGCCTTAGCGACCCCATTAGTTGCCGGTTTGATGGCACAATTCCAGCAAGCGCAGTCGCTAGACT
AG

Upstream 100 bases:

>100_bases
TAACGCATTCACAAGGGTTCTGGCACGTCTTAAATAAATTGTAAAATTCCCGCTTTGTCAGTCGTGTATACTAATATTTA
ATAACAGGGGGCGTTAACGG

Downstream 100 bases:

>100_bases
TTTAATCAGTTTGATATCTAAAAATTTAATCGCGGTTAAGGGTGAATTGCTGATTTACTCGGGTTGTTACCGATTACACT
AGCTAGAAATTGCAGTGGTG

Product: transcription regulator

Products: NA

Alternate protein names: ClcABD operon transcriptional activator [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNLKQLQYFLAVAEEGQMTAAAKRLHVAQPPLSYQIKQLELELGVTLFNRLPQGVTVTEAGKLLVGYAQQLTQLSATAEN
KVLALAHGVTGTINLGTVSSSAGVMPNTALLKWLGQHPDVQLAITEGNTYELLDDLHKRLLDVAVLRTPFNAQHLVCRYF
PAERMAAVIPKRYSRFEKRRQLQLSDLATLPLIKYRRFNELFHVAFLEASVTPTYIMTCDDARTAMHWANHQLGVALVPR
SLAETYDGGDVLIRSLADHRFQTQLALATTPEALATPLVAGLMAQFQQAQSLD

Sequences:

>Translated_293_residues
MNLKQLQYFLAVAEEGQMTAAAKRLHVAQPPLSYQIKQLELELGVTLFNRLPQGVTVTEAGKLLVGYAQQLTQLSATAEN
KVLALAHGVTGTINLGTVSSSAGVMPNTALLKWLGQHPDVQLAITEGNTYELLDDLHKRLLDVAVLRTPFNAQHLVCRYF
PAERMAAVIPKRYSRFEKRRQLQLSDLATLPLIKYRRFNELFHVAFLEASVTPTYIMTCDDARTAMHWANHQLGVALVPR
SLAETYDGGDVLIRSLADHRFQTQLALATTPEALATPLVAGLMAQFQQAQSLD
>Mature_293_residues
MNLKQLQYFLAVAEEGQMTAAAKRLHVAQPPLSYQIKQLELELGVTLFNRLPQGVTVTEAGKLLVGYAQQLTQLSATAEN
KVLALAHGVTGTINLGTVSSSAGVMPNTALLKWLGQHPDVQLAITEGNTYELLDDLHKRLLDVAVLRTPFNAQHLVCRYF
PAERMAAVIPKRYSRFEKRRQLQLSDLATLPLIKYRRFNELFHVAFLEASVTPTYIMTCDDARTAMHWANHQLGVALVPR
SLAETYDGGDVLIRSLADHRFQTQLALATTPEALATPLVAGLMAQFQQAQSLD

Specific function: Involved in regulation of chlorinated catechol metabolism. Transcriptional activator of the clcABD chlorocatechol oxidative operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787806, Length=252, Percent_Identity=29.3650793650794, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787879, Length=252, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI2367136, Length=146, Percent_Identity=34.9315068493151, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI157672245, Length=170, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788297, Length=147, Percent_Identity=31.9727891156463, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=30.1369863013699, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790399, Length=150, Percent_Identity=34.6666666666667, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788887, Length=266, Percent_Identity=24.812030075188, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787530, Length=250, Percent_Identity=25.6, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790208, Length=291, Percent_Identity=25.085910652921, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787589, Length=175, Percent_Identity=29.7142857142857, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32430; Mature: 32430

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKQLQYFLAVAEEGQMTAAAKRLHVAQPPLSYQIKQLELELGVTLFNRLPQGVTVTEA
CCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECC
GKLLVGYAQQLTQLSATAENKVLALAHGVTGTINLGTVSSSAGVMPNTALLKWLGQHPDV
CHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECEECCCCCCCCHHHHHHHHCCCCCE
QLAITEGNTYELLDDLHKRLLDVAVLRTPFNAQHLVCRYFPAERMAAVIPKRYSRFEKRR
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEECCHHHHHHHHHHHHHHHHHHH
QLQLSDLATLPLIKYRRFNELFHVAFLEASVTPTYIMTCDDARTAMHWANHQLGVALVPR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHCCCCCCCEECCH
SLAETYDGGDVLIRSLADHRFQTQLALATTPEALATPLVAGLMAQFQQAQSLD
HHHHHCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLKQLQYFLAVAEEGQMTAAAKRLHVAQPPLSYQIKQLELELGVTLFNRLPQGVTVTEA
CCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECC
GKLLVGYAQQLTQLSATAENKVLALAHGVTGTINLGTVSSSAGVMPNTALLKWLGQHPDV
CHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECEECCCCCCCCHHHHHHHHCCCCCE
QLAITEGNTYELLDDLHKRLLDVAVLRTPFNAQHLVCRYFPAERMAAVIPKRYSRFEKRR
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEECCHHHHHHHHHHHHHHHHHHH
QLQLSDLATLPLIKYRRFNELFHVAFLEASVTPTYIMTCDDARTAMHWANHQLGVALVPR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHCCCCCCCEECCH
SLAETYDGGDVLIRSLADHRFQTQLALATTPEALATPLVAGLMAQFQQAQSLD
HHHHHCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419291 [H]