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The map label for this gene is xpt

Identifier: 28377919

GI number: 28377919

Start: 1035676

End: 1036263

Strand: Direct

Name: xpt

Synonym: lp_1139

Alternate gene names: 28377919

Gene position: 1035676-1036263 (Clockwise)

Preceding gene: 28377918

Following gene: 28377920

Centisome position: 31.31

GC content: 46.09

Gene sequence:

>588_bases
ATGCGAGAACTTGAAGAACGCATTTTGAAAGATGGCCGGGTACTTCCCGGTGAAGTATTGAAAGTGGACGGCTTTTTGAA
TCACCAAGTTGATCCCGACCTGATGTTTGCCATGGGAACGGAATTTGCCCACTTGTTTCAAGATGCGGGTGTAACGAAAA
TCTTGACGGTTGAATCATCAGGAATTGCGCCGGCAGTCATGGCGGGGTTAGCAATGCACGTGCCCGTTGTGTTCGCACGT
AAGCACAAATCTGTCACGTTAATTGATGATTTATATACAGCCGAAGTTTATTCTTACACGAAGAAGACGTCTAACCACAT
CTCGATTGCCAAGAAGTTCTTACAGGCGGATGACCAAGTCTTGTTAATTGACGACTTTTTGGCCAATGGTCAGGCGGTTC
AAGGGATGTTTGAAATCTGTGATAAAGCGCACGTAAAAATTGCGGGTGTCGGTATTGTGATTGAAAAAGTCTTCCAAACG
GGTCATCAACTGATTGCTGATCGGGGTGTCCGTTTAGAATCACTAGCACAGATTACGTCATTTGATGGTGACCGGGTGCA
CTTTGCATCGGAGGACACCCAGGCTTAA

Upstream 100 bases:

>100_bases
TAATTAATATTATTCAAAAATATGACTTACAACGGTATGATAGAAAGTAATGAAATTAATAGCAGTATTTCAATGTCGCT
TATAATTCTAGGAGGGTACT

Downstream 100 bases:

>100_bases
GTTAAGAAAGCGGGGGATTGTGATGCACATTGACATGGGGATGCTAGTCCTTATTTTCATCATCAACTTTGCTTACATTA
CGTTAAACACCGTACGTTTT

Product: xanthine phosphoribosyltransferase

Products: NA

Alternate protein names: XPRTase

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRELEERILKDGRVLPGEVLKVDGFLNHQVDPDLMFAMGTEFAHLFQDAGVTKILTVESSGIAPAVMAGLAMHVPVVFAR
KHKSVTLIDDLYTAEVYSYTKKTSNHISIAKKFLQADDQVLLIDDFLANGQAVQGMFEICDKAHVKIAGVGIVIEKVFQT
GHQLIADRGVRLESLAQITSFDGDRVHFASEDTQA

Sequences:

>Translated_195_residues
MRELEERILKDGRVLPGEVLKVDGFLNHQVDPDLMFAMGTEFAHLFQDAGVTKILTVESSGIAPAVMAGLAMHVPVVFAR
KHKSVTLIDDLYTAEVYSYTKKTSNHISIAKKFLQADDQVLLIDDFLANGQAVQGMFEICDKAHVKIAGVGIVIEKVFQT
GHQLIADRGVRLESLAQITSFDGDRVHFASEDTQA
>Mature_195_residues
MRELEERILKDGRVLPGEVLKVDGFLNHQVDPDLMFAMGTEFAHLFQDAGVTKILTVESSGIAPAVMAGLAMHVPVVFAR
KHKSVTLIDDLYTAEVYSYTKKTSNHISIAKKFLQADDQVLLIDDFLANGQAVQGMFEICDKAHVKIAGVGIVIEKVFQT
GHQLIADRGVRLESLAQITSFDGDRVHFASEDTQA

Specific function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XPT subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XPT_LACPL (Q88XQ4)

Other databases:

- EMBL:   AL935255
- RefSeq:   NP_784811.1
- HSSP:   P42085
- ProteinModelPortal:   Q88XQ4
- SMR:   Q88XQ4
- GeneID:   1063247
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1139
- NMPDR:   fig|220668.1.peg.945
- HOGENOM:   HBG288993
- OMA:   ATVYSFT
- ProtClustDB:   PRK09219
- BioCyc:   LPLA220668:LP_1139-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01184
- InterPro:   IPR000836
- InterPro:   IPR010079
- TIGRFAMs:   TIGR01744

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 21454; Mature: 21454

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00228 TUBULIN_B_AUTOREG

Important sites: BINDING 20-20 BINDING 27-27 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELEERILKDGRVLPGEVLKVDGFLNHQVDPDLMFAMGTEFAHLFQDAGVTKILTVESS
CCHHHHHHHHCCCCCCCHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECC
GIAPAVMAGLAMHVPVVFARKHKSVTLIDDLYTAEVYSYTKKTSNHISIAKKFLQADDQV
CCCHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCE
LLIDDFLANGQAVQGMFEICDKAHVKIAGVGIVIEKVFQTGHQLIADRGVRLESLAQITS
EEEEHHHCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
FDGDRVHFASEDTQA
CCCCEEEECCCCCCC
>Mature Secondary Structure
MRELEERILKDGRVLPGEVLKVDGFLNHQVDPDLMFAMGTEFAHLFQDAGVTKILTVESS
CCHHHHHHHHCCCCCCCHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECC
GIAPAVMAGLAMHVPVVFARKHKSVTLIDDLYTAEVYSYTKKTSNHISIAKKFLQADDQV
CCCHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCE
LLIDDFLANGQAVQGMFEICDKAHVKIAGVGIVIEKVFQTGHQLIADRGVRLESLAQITS
EEEEHHHCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
FDGDRVHFASEDTQA
CCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566