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The map label for this gene is menA [H]

Identifier: 28377916

GI number: 28377916

Start: 1032399

End: 1033349

Strand: Direct

Name: menA [H]

Synonym: lp_1135

Alternate gene names: 28377916

Gene position: 1032399-1033349 (Clockwise)

Preceding gene: 28377913

Following gene: 28377918

Centisome position: 31.21

GC content: 40.59

Gene sequence:

>951_bases
TTGTTTCGTTGTCAAACAAAAGGATGGTGTAAATCATTGAAACCAAAAGTGTTTCTTGAATTTGTTGAAATTAAATCATT
AATTGCGAGCGTGTTACCGTTCGTTTTGGGGAGTATGTACGCCTATTATAATTATCATCAGTTACATCTTGGTTATTTAT
TGCTATTTTTCATTGCATCTTCACTTTTTCACATGGCGACTAATGCGAATGATAATTACCAAGACTTCCTACACGCGCCA
CGTAATGACGACAATCAAGAATTTTTGCAAGAGACTAATGTGGTCGGTGTTAACCAGATTTCCATTGGTCAGGCCCGGAC
GATTACGTTTGGTTTAGCCGGAATCTCATTGATTATCGGACTATGGTTAGTAACACAAACGGGGTTGCCGTTGTTGTGGA
TGGGGCTATATTCATATGCGGTCGGTTACTTTTACGCTGGCGGACCGAAGCCAATTTCACAAGGCCCGTTTGGCGAATTT
TTCTCGGGCTTTACGATGGGCTTTATGATCTTCTGGATTGCCGTCTTTATTAATACGTATGACACGGCAGCCATTACTTG
GCAGTCAACGCTGGCTGTTTTAATTGCGTCAGGTCTGGCCATTTTTGCAATTTCTAACATTATGTTAGCTAATAATATTT
GTGATATGGACGAGGACATTGCGTTAGGCCGACACACGATTTTGTATTACCTTGGCAAACCGGTGATGCTTCAGGTATTT
GCATGGAGTTACGTTGCTGGTTATGCTTGTCTGGTGATTGCGGTCTTGATGGGTGTGCTACCAAAGTTTAGTTTACTAAC
GTTGCTCAGTATTATTCCAGTTTGGAAAAATACGCGGGTCTTCTTGCACAAACAGGTCAAACGAGAAACTTTCACGATTT
CAATTAAAAACGCAACGTTGATTTGTCTTTCATTTATCGTTTTCATGGGCTTAGGACTGATTTTTAACTAG

Upstream 100 bases:

>100_bases
TACCCCGCTTTATTTGAGAGATGGCTCCGGGACGTTTTGACGCCAACACTTGCAGCCAGTCACATTCTAAAATACAATCT
ATACTAAAGGTACAAATAAC

Downstream 100 bases:

>100_bases
TCCTTCAATAAACGAGTATGGCTTTGAGAAAGCGCCAACTAACCAAGTTGATACTAAGCAGTATTTTTCCCAGCGAGTCC
AAGCTGGCTTTCTGATTTTA

Product: prenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MFRCQTKGWCKSLKPKVFLEFVEIKSLIASVLPFVLGSMYAYYNYHQLHLGYLLLFFIASSLFHMATNANDNYQDFLHAP
RNDDNQEFLQETNVVGVNQISIGQARTITFGLAGISLIIGLWLVTQTGLPLLWMGLYSYAVGYFYAGGPKPISQGPFGEF
FSGFTMGFMIFWIAVFINTYDTAAITWQSTLAVLIASGLAIFAISNIMLANNICDMDEDIALGRHTILYYLGKPVMLQVF
AWSYVAGYACLVIAVLMGVLPKFSLLTLLSIIPVWKNTRVFLHKQVKRETFTISIKNATLICLSFIVFMGLGLIFN

Sequences:

>Translated_316_residues
MFRCQTKGWCKSLKPKVFLEFVEIKSLIASVLPFVLGSMYAYYNYHQLHLGYLLLFFIASSLFHMATNANDNYQDFLHAP
RNDDNQEFLQETNVVGVNQISIGQARTITFGLAGISLIIGLWLVTQTGLPLLWMGLYSYAVGYFYAGGPKPISQGPFGEF
FSGFTMGFMIFWIAVFINTYDTAAITWQSTLAVLIASGLAIFAISNIMLANNICDMDEDIALGRHTILYYLGKPVMLQVF
AWSYVAGYACLVIAVLMGVLPKFSLLTLLSIIPVWKNTRVFLHKQVKRETFTISIKNATLICLSFIVFMGLGLIFN
>Mature_316_residues
MFRCQTKGWCKSLKPKVFLEFVEIKSLIASVLPFVLGSMYAYYNYHQLHLGYLLLFFIASSLFHMATNANDNYQDFLHAP
RNDDNQEFLQETNVVGVNQISIGQARTITFGLAGISLIIGLWLVTQTGLPLLWMGLYSYAVGYFYAGGPKPISQGPFGEF
FSGFTMGFMIFWIAVFINTYDTAAITWQSTLAVLIASGLAIFAISNIMLANNICDMDEDIALGRHTILYYLGKPVMLQVF
AWSYVAGYACLVIAVLMGVLPKFSLLTLLSIIPVWKNTRVFLHKQVKRETFTISIKNATLICLSFIVFMGLGLIFN

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 35450; Mature: 35450

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRCQTKGWCKSLKPKVFLEFVEIKSLIASVLPFVLGSMYAYYNYHQLHLGYLLLFFIAS
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLFHMATNANDNYQDFLHAPRNDDNQEFLQETNVVGVNQISIGQARTITFGLAGISLIIG
HHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHH
LWLVTQTGLPLLWMGLYSYAVGYFYAGGPKPISQGPFGEFFSGFTMGFMIFWIAVFINTY
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
DTAAITWQSTLAVLIASGLAIFAISNIMLANNICDMDEDIALGRHTILYYLGKPVMLQVF
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
AWSYVAGYACLVIAVLMGVLPKFSLLTLLSIIPVWKNTRVFLHKQVKRETFTISIKNATL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECCHHH
ICLSFIVFMGLGLIFN
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFRCQTKGWCKSLKPKVFLEFVEIKSLIASVLPFVLGSMYAYYNYHQLHLGYLLLFFIAS
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLFHMATNANDNYQDFLHAPRNDDNQEFLQETNVVGVNQISIGQARTITFGLAGISLIIG
HHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHH
LWLVTQTGLPLLWMGLYSYAVGYFYAGGPKPISQGPFGEFFSGFTMGFMIFWIAVFINTY
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
DTAAITWQSTLAVLIASGLAIFAISNIMLANNICDMDEDIALGRHTILYYLGKPVMLQVF
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
AWSYVAGYACLVIAVLMGVLPKFSLLTLLSIIPVWKNTRVFLHKQVKRETFTISIKNATL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECCHHH
ICLSFIVFMGLGLIFN
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]