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The map label for this gene is aroB

Identifier: 28377879

GI number: 28377879

Start: 988561

End: 989646

Strand: Direct

Name: aroB

Synonym: lp_1086

Alternate gene names: 28377879

Gene position: 988561-989646 (Clockwise)

Preceding gene: 28377878

Following gene: 28377885

Centisome position: 29.88

GC content: 51.38

Gene sequence:

>1086_bases
GTGCCTATGACAAACATTGAAGTCAAGACGCGAGTTAAACAGTATCAGATCAAGATCATGATTAACAGTTTACATCACCT
AGGAACATTGGTAACTAAAGTATGGTGTGCCCGTCAAGTAGCGGTGGTAACGGATACCAATGTGGGCCCGTACTATGCGA
AGCTGGTAACTGATGAACTGACGGCGGCTGGATTCAAGGTGCGCGTGATGACGGTTCCAGCCGGTGAGGAGAGCAAAAGT
TGGTCACAAGTCCAGTCGTTAATCGATCAGCTGAGTGCCGCCCATTTTAGCCGCAGTGACGGTGTCCTCGCTCTTGGTGG
CGGGGTGGTTGGTGACTTAGCAGGGTTTGTCGCTTCGATTTATATGCGCGGTATTGCCTTGATTCAAGTACCGACATCAT
TATTAGCGCAAGTCGATAGTTCGGTGGGCGGTAAGACCGCGATTGACTTACCAACTGGCAAAAACTTAGTGGGCAGTTTT
TACCAACCAGATTTAGTCGTCATTGATCCGGCAATTCTGGTGACGTTACCGCCGCGGATGCTCGCAGAAGGTTATGGCGA
AATCGTTAAGTGCGCAGCATTAGTTGGCGGTGATTTTTGGCAATCCTTGCACCAAATTACCAGTGTGGCAGCGATTTTAC
CAGCAGCACCAGATTTAATTGCAGCTAGTGTGGCGTTCAAAGCGCGCGTCGTTATGGCGGATGAGCATGAACAGGGTCAG
CGGCAATTATTGAATTTTGGTCATACGATTGGTCACGCAGTCGAACTATTGGCTGACGGTCAACTAATGCATGGGGAAGC
GGTAGCGATTGGTCTAGTACAGGTTTGTCGGTTGTTTGCAGCACATGGGTTAGCGCCGACTAGTTTAACGTCGACGCTCA
AGGCACGCTTAATGGCGGTAGGGTTGCCCACGGAATTACCGCCGATAGCGCCGCAAGCCGTGGCCGCAGTGATGCAACAC
GACAAAAAAGTGCACGGTACAGCGCTGACCTGGGTCTACTTATCGGCGGTTGGGCAACCCCACCTGTATCCCATAGCGGT
CACGGACTTGGCGACTTGGATGGGTGACTTGTGGTCGGTGTCGTGA

Upstream 100 bases:

>100_bases
TTTATCCGATGGGCCGCAAGCGTTAAAACCCGCGACGTACTTAAAAATGGCGCAACAGGCTTTCCAGTTACATGATCTGA
TGCAAACGTGGGCGTAGGAT

Downstream 100 bases:

>100_bases
TTAGACGTAAGTTTACAATATGCTTCAGTTCGACACATGACGGTTAGCCGGGTGGGATCTGAAAATTTGAGGGAGCATCA
GAACTTTTGACGTCCAGGTT

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MPMTNIEVKTRVKQYQIKIMINSLHHLGTLVTKVWCARQVAVVTDTNVGPYYAKLVTDELTAAGFKVRVMTVPAGEESKS
WSQVQSLIDQLSAAHFSRSDGVLALGGGVVGDLAGFVASIYMRGIALIQVPTSLLAQVDSSVGGKTAIDLPTGKNLVGSF
YQPDLVVIDPAILVTLPPRMLAEGYGEIVKCAALVGGDFWQSLHQITSVAAILPAAPDLIAASVAFKARVVMADEHEQGQ
RQLLNFGHTIGHAVELLADGQLMHGEAVAIGLVQVCRLFAAHGLAPTSLTSTLKARLMAVGLPTELPPIAPQAVAAVMQH
DKKVHGTALTWVYLSAVGQPHLYPIAVTDLATWMGDLWSVS

Sequences:

>Translated_361_residues
MPMTNIEVKTRVKQYQIKIMINSLHHLGTLVTKVWCARQVAVVTDTNVGPYYAKLVTDELTAAGFKVRVMTVPAGEESKS
WSQVQSLIDQLSAAHFSRSDGVLALGGGVVGDLAGFVASIYMRGIALIQVPTSLLAQVDSSVGGKTAIDLPTGKNLVGSF
YQPDLVVIDPAILVTLPPRMLAEGYGEIVKCAALVGGDFWQSLHQITSVAAILPAAPDLIAASVAFKARVVMADEHEQGQ
RQLLNFGHTIGHAVELLADGQLMHGEAVAIGLVQVCRLFAAHGLAPTSLTSTLKARLMAVGLPTELPPIAPQAVAAVMQH
DKKVHGTALTWVYLSAVGQPHLYPIAVTDLATWMGDLWSVS
>Mature_360_residues
PMTNIEVKTRVKQYQIKIMINSLHHLGTLVTKVWCARQVAVVTDTNVGPYYAKLVTDELTAAGFKVRVMTVPAGEESKSW
SQVQSLIDQLSAAHFSRSDGVLALGGGVVGDLAGFVASIYMRGIALIQVPTSLLAQVDSSVGGKTAIDLPTGKNLVGSFY
QPDLVVIDPAILVTLPPRMLAEGYGEIVKCAALVGGDFWQSLHQITSVAAILPAAPDLIAASVAFKARVVMADEHEQGQR
QLLNFGHTIGHAVELLADGQLMHGEAVAIGLVQVCRLFAAHGLAPTSLTSTLKARLMAVGLPTELPPIAPQAVAAVMQHD
KKVHGTALTWVYLSAVGQPHLYPIAVTDLATWMGDLWSVS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=309, Percent_Identity=41.747572815534, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320332, Length=368, Percent_Identity=35.5978260869565, Blast_Score=194, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_LACPL (Q88XU0)

Other databases:

- EMBL:   AL935255
- RefSeq:   NP_784771.1
- ProteinModelPortal:   Q88XU0
- SMR:   Q88XU0
- GeneID:   1063379
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1086
- NMPDR:   fig|220668.1.peg.905
- HOGENOM:   HBG632303
- OMA:   PRREWIN
- ProtClustDB:   PRK00002
- BioCyc:   LPLA220668:LP_1086-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 38334; Mature: 38203

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMTNIEVKTRVKQYQIKIMINSLHHLGTLVTKVWCARQVAVVTDTNVGPYYAKLVTDEL
CCCCCCHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHH
TAAGFKVRVMTVPAGEESKSWSQVQSLIDQLSAAHFSRSDGVLALGGGVVGDLAGFVASI
HHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHH
YMRGIALIQVPTSLLAQVDSSVGGKTAIDLPTGKNLVGSFYQPDLVVIDPAILVTLPPRM
HHHCCCEEEHHHHHHHHHHHCCCCCEEEECCCCCHHHCCCCCCCEEEECCEEEEECCHHH
LAEGYGEIVKCAALVGGDFWQSLHQITSVAAILPAAPDLIAASVAFKARVVMADEHEQGQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCCHHHH
RQLLNFGHTIGHAVELLADGQLMHGEAVAIGLVQVCRLFAAHGLAPTSLTSTLKARLMAV
HHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GLPTELPPIAPQAVAAVMQHDKKVHGTALTWVYLSAVGQPHLYPIAVTDLATWMGDLWSV
CCCCCCCCCCHHHHHHHHHHCCHHCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCC
S
C
>Mature Secondary Structure 
PMTNIEVKTRVKQYQIKIMINSLHHLGTLVTKVWCARQVAVVTDTNVGPYYAKLVTDEL
CCCCCHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHH
TAAGFKVRVMTVPAGEESKSWSQVQSLIDQLSAAHFSRSDGVLALGGGVVGDLAGFVASI
HHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHH
YMRGIALIQVPTSLLAQVDSSVGGKTAIDLPTGKNLVGSFYQPDLVVIDPAILVTLPPRM
HHHCCCEEEHHHHHHHHHHHCCCCCEEEECCCCCHHHCCCCCCCEEEECCEEEEECCHHH
LAEGYGEIVKCAALVGGDFWQSLHQITSVAAILPAAPDLIAASVAFKARVVMADEHEQGQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCCHHHH
RQLLNFGHTIGHAVELLADGQLMHGEAVAIGLVQVCRLFAAHGLAPTSLTSTLKARLMAV
HHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GLPTELPPIAPQAVAAVMQHDKKVHGTALTWVYLSAVGQPHLYPIAVTDLATWMGDLWSV
CCCCCCCCCCHHHHHHHHHHCCHHCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566