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The map label for this gene is coaA

Identifier: 28377743

GI number: 28377743

Start: 843592

End: 844521

Strand: Direct

Name: coaA

Synonym: lp_0913

Alternate gene names: 28377743

Gene position: 843592-844521 (Clockwise)

Preceding gene: 28377742

Following gene: 28377744

Centisome position: 25.5

GC content: 44.19

Gene sequence:

>930_bases
ATGGAAGATCAGATGAACTATTATCGCTTCTCACGTGAACAGTGGAAGCAATTTTATCGTAACAATCAGCATCAAGTACC
ATTGACCGCAGCCAATTTGCACGAAATTGAGGCGTTTAATGACCGGATTAGTCTCGACGATGTCCGTGATATTTATATGC
CGTTTGCGCATTTGTTGCAGGCCAAGTATGAACACTACTTGTCATGGCGGGAAACGGAGTCCGTTTTTTTACACCGTCAG
AACCGCCAATCACCCTTTATTATTGGAGTGTCTGGAAGTGTGGCAGTTGGCAAGACCACCACAGCAAGGTTATTAGAGAT
TCTATTTAAATATTTATATCCAGACCGGCGGACGCAATTGATTACGACGGATGGTTTCTTATACCCGAATGCCGAGCTCA
AAAAGATGCAATTGATGGAACGCAAAGGGTTTCCGGAAAGCTATGATATGACGCGGCTGATCCAATTCTTGAACGATGTG
AAGAGCGGAAAGCCGTTAGCGAAGGCCCCGGTGTACTCTCATCAGACTTATGATATTGTGCCAAACCGTTTTGACGTGAT
CACGCATCCTGATATTTTGATTATTGAAGGAATCAACGTGTTGCAATTGCCAAGCAATCAGGCGATCTACATTAGTGATT
TTACGGACTTCTCAGTGTATGTCGATGCGGATGCCGATTTAATTGAAGATTGGTACTTAGAACGCTTCAAGGCCCTGATG
AAAACGGCTTTCCAGGATCCGACGAATTATTTCTATCCTTGGGCGATCGGTGATCCGAAGGACGCGATGGCGATGGCCGA
GCGTGTTTGGGAAGAGGTTAACTTGAAAAACTTGAATGATTATATCTTGCCAACCCGTAATCGTGCGGATTTAATTTTGC
ACAAAGTTGCGCATCATGTGATTGATGCCGTGTATTTCCGCAAATATTAG

Upstream 100 bases:

>100_bases
CCAATTAGGAATCCGGTTAATTTGAATTTTAATCAGCGTTTGATAAGGGTTTCATGTTATAATCAACCCATTAATTTAGT
AATGGTGGCAGACAGAAATC

Downstream 100 bases:

>100_bases
CACCTAAGAAATTTCTCATACTGGTTGACCGAACGTTTAGAAATCAGTATGATAGACCTATTGAGCATTAATTAATCCAA
AGGAGTGAACAACTTGGCAA

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MEDQMNYYRFSREQWKQFYRNNQHQVPLTAANLHEIEAFNDRISLDDVRDIYMPFAHLLQAKYEHYLSWRETESVFLHRQ
NRQSPFIIGVSGSVAVGKTTTARLLEILFKYLYPDRRTQLITTDGFLYPNAELKKMQLMERKGFPESYDMTRLIQFLNDV
KSGKPLAKAPVYSHQTYDIVPNRFDVITHPDILIIEGINVLQLPSNQAIYISDFTDFSVYVDADADLIEDWYLERFKALM
KTAFQDPTNYFYPWAIGDPKDAMAMAERVWEEVNLKNLNDYILPTRNRADLILHKVAHHVIDAVYFRKY

Sequences:

>Translated_309_residues
MEDQMNYYRFSREQWKQFYRNNQHQVPLTAANLHEIEAFNDRISLDDVRDIYMPFAHLLQAKYEHYLSWRETESVFLHRQ
NRQSPFIIGVSGSVAVGKTTTARLLEILFKYLYPDRRTQLITTDGFLYPNAELKKMQLMERKGFPESYDMTRLIQFLNDV
KSGKPLAKAPVYSHQTYDIVPNRFDVITHPDILIIEGINVLQLPSNQAIYISDFTDFSVYVDADADLIEDWYLERFKALM
KTAFQDPTNYFYPWAIGDPKDAMAMAERVWEEVNLKNLNDYILPTRNRADLILHKVAHHVIDAVYFRKY
>Mature_309_residues
MEDQMNYYRFSREQWKQFYRNNQHQVPLTAANLHEIEAFNDRISLDDVRDIYMPFAHLLQAKYEHYLSWRETESVFLHRQ
NRQSPFIIGVSGSVAVGKTTTARLLEILFKYLYPDRRTQLITTDGFLYPNAELKKMQLMERKGFPESYDMTRLIQFLNDV
KSGKPLAKAPVYSHQTYDIVPNRFDVITHPDILIIEGINVLQLPSNQAIYISDFTDFSVYVDADADLIEDWYLERFKALM
KTAFQDPTNYFYPWAIGDPKDAMAMAERVWEEVNLKNLNDYILPTRNRADLILHKVAHHVIDAVYFRKY

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family

Homologues:

Organism=Escherichia coli, GI1790409, Length=309, Percent_Identity=43.6893203883495, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI1789296, Length=190, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAA_LACPL (Q88Y75)

Other databases:

- EMBL:   AL935254
- RefSeq:   NP_784635.1
- ProteinModelPortal:   Q88Y75
- SMR:   Q88Y75
- GeneID:   1062106
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0913
- NMPDR:   fig|220668.1.peg.769
- HOGENOM:   HBG732538
- OMA:   GLNVLQP
- ProtClustDB:   PRK05439
- BioCyc:   LPLA220668:LP_0913-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_00215
- InterPro:   IPR004566
- InterPro:   IPR006083
- PANTHER:   PTHR10285:SF7
- PIRSF:   PIRSF000545
- TIGRFAMs:   TIGR00554

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.33

Molecular weight: Translated: 36558; Mature: 36558

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDQMNYYRFSREQWKQFYRNNQHQVPLTAANLHEIEAFNDRISLDDVRDIYMPFAHLLQ
CCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AKYEHYLSWRETESVFLHRQNRQSPFIIGVSGSVAVGKTTTARLLEILFKYLYPDRRTQL
HHHHHHHHHHCHHHHEEECCCCCCCEEEEECCCEEECCCHHHHHHHHHHHHHCCCCCCEE
ITTDGFLYPNAELKKMQLMERKGFPESYDMTRLIQFLNDVKSGKPLAKAPVYSHQTYDIV
EEECCEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECC
PNRFDVITHPDILIIEGINVLQLPSNQAIYISDFTDFSVYVDADADLIEDWYLERFKALM
CCCEEEECCCCEEEEECCCEEECCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHH
KTAFQDPTNYFYPWAIGDPKDAMAMAERVWEEVNLKNLNDYILPTRNRADLILHKVAHHV
HHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IDAVYFRKY
HHHHHHHCC
>Mature Secondary Structure
MEDQMNYYRFSREQWKQFYRNNQHQVPLTAANLHEIEAFNDRISLDDVRDIYMPFAHLLQ
CCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AKYEHYLSWRETESVFLHRQNRQSPFIIGVSGSVAVGKTTTARLLEILFKYLYPDRRTQL
HHHHHHHHHHCHHHHEEECCCCCCCEEEEECCCEEECCCHHHHHHHHHHHHHCCCCCCEE
ITTDGFLYPNAELKKMQLMERKGFPESYDMTRLIQFLNDVKSGKPLAKAPVYSHQTYDIV
EEECCEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECC
PNRFDVITHPDILIIEGINVLQLPSNQAIYISDFTDFSVYVDADADLIEDWYLERFKALM
CCCEEEECCCCEEEEECCCEEECCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHH
KTAFQDPTNYFYPWAIGDPKDAMAMAERVWEEVNLKNLNDYILPTRNRADLILHKVAHHV
HHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IDAVYFRKY
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566