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The map label for this gene is gmk2 [H]

Identifier: 28377706

GI number: 28377706

Start: 805432

End: 806013

Strand: Direct

Name: gmk2 [H]

Synonym: lp_0866

Alternate gene names: 28377706

Gene position: 805432-806013 (Clockwise)

Preceding gene: 28377704

Following gene: 28377707

Centisome position: 24.35

GC content: 49.66

Gene sequence:

>582_bases
TTGACAACGAAACGGATCTTTGTGATCACGGGACCAACGGGGAGTGGTAAGACCACTGTCAGTCATTACTTGCGGTCACA
ATACCAAATTCCTCAGGTGATTACTCATACGACCCGGGCTCCCCGGGAAGGTGAAGTCGGTGGGCGCGACTATTATTTTG
AAACTCCGGCGAGTTTTGTCACGAAACATTATTTAGAACACGTGACCTATAGTGGTAATCAATACGGTTCTTCACGAGAA
GGACTAGCGGCAGCCTGGGAACGGTCACCACTGATTAGTATCGTCTTAGATACGGCGGGGGCTATTACCTATGCGCGGGA
GTTGGGCGAACAAGCGGTGGTGATTTATCTCGAGGTTGCTGATCAAGAGGCGCTAATTCAGCGTTTGACCAAGCGAGGAG
ATCTTCCTAGCCGGATAAAAAAGCGAGTTGCTAGTGATGAGTATTTGCGGGACCAGGCTTTGCCAGTAGGATTAGTGGGG
CATGCACATGTTATCGTGAATGATGATTGGCAGGCGACGCGGCGCCAACTAGATGAGCTGGTCACTGAATATTGTCAGCA
TGATGTTGTGACGAAAGATTAG

Upstream 100 bases:

>100_bases
TCATCTATTTGAACCTTATAGGTACGTTACTATACTCGGTTTACCGAGCTAACGCAAATGAAAAGCTTTACATGAATTAA
AAAATGGAGGTTTATCAACT

Downstream 100 bases:

>100_bases
CGCTGACGTATAGACGGTCAACGTAATTCACTTTTACACTTGAGTATGCTAAACTAAATAGTAATGATTATGATTTAGTG
AAGTCCTGGTCAGTAGGAGG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTTKRIFVITGPTGSGKTTVSHYLRSQYQIPQVITHTTRAPREGEVGGRDYYFETPASFVTKHYLEHVTYSGNQYGSSRE
GLAAAWERSPLISIVLDTAGAITYARELGEQAVVIYLEVADQEALIQRLTKRGDLPSRIKKRVASDEYLRDQALPVGLVG
HAHVIVNDDWQATRRQLDELVTEYCQHDVVTKD

Sequences:

>Translated_193_residues
MTTKRIFVITGPTGSGKTTVSHYLRSQYQIPQVITHTTRAPREGEVGGRDYYFETPASFVTKHYLEHVTYSGNQYGSSRE
GLAAAWERSPLISIVLDTAGAITYARELGEQAVVIYLEVADQEALIQRLTKRGDLPSRIKKRVASDEYLRDQALPVGLVG
HAHVIVNDDWQATRRQLDELVTEYCQHDVVTKD
>Mature_192_residues
TTKRIFVITGPTGSGKTTVSHYLRSQYQIPQVITHTTRAPREGEVGGRDYYFETPASFVTKHYLEHVTYSGNQYGSSREG
LAAAWERSPLISIVLDTAGAITYARELGEQAVVIYLEVADQEALIQRLTKRGDLPSRIKKRVASDEYLRDQALPVGLVGH
AHVIVNDDWQATRRQLDELVTEYCQHDVVTKD

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=190, Percent_Identity=27.8947368421053, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI226874833, Length=190, Percent_Identity=27.8947368421053, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI4504221, Length=190, Percent_Identity=27.8947368421053, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1790080, Length=182, Percent_Identity=29.6703296703297, Blast_Score=64, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508835, Length=188, Percent_Identity=28.1914893617021, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193203132, Length=188, Percent_Identity=27.1276595744681, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=28.6486486486486, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356141, Length=173, Percent_Identity=28.3236994219653, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21693; Mature: 21561

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKRIFVITGPTGSGKTTVSHYLRSQYQIPQVITHTTRAPREGEVGGRDYYFETPASFV
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCEEEECCHHHH
TKHYLEHVTYSGNQYGSSREGLAAAWERSPLISIVLDTAGAITYARELGEQAVVIYLEVA
HHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEEEHHCCHHHHHHHCCCCEEEEEEEEC
DQEALIQRLTKRGDLPSRIKKRVASDEYLRDQALPVGLVGHAHVIVNDDWQATRRQLDEL
CHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHCCCEEEECCEEEEECCCHHHHHHHHHHH
VTEYCQHDVVTKD
HHHHHHCCCCCCC
>Mature Secondary Structure 
TTKRIFVITGPTGSGKTTVSHYLRSQYQIPQVITHTTRAPREGEVGGRDYYFETPASFV
CCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCEEEECCHHHH
TKHYLEHVTYSGNQYGSSREGLAAAWERSPLISIVLDTAGAITYARELGEQAVVIYLEVA
HHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEEEHHCCHHHHHHHCCCCEEEEEEEEC
DQEALIQRLTKRGDLPSRIKKRVASDEYLRDQALPVGLVGHAHVIVNDDWQATRRQLDEL
CHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHCCCEEEECCEEEEECCCHHHHHHHHHHH
VTEYCQHDVVTKD
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]