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The map label for this gene is htpX

Identifier: 28377404

GI number: 28377404

Start: 461680

End: 462579

Strand: Direct

Name: htpX

Synonym: lp_0516

Alternate gene names: 28377404

Gene position: 461680-462579 (Clockwise)

Preceding gene: 28377403

Following gene: 28377405

Centisome position: 13.96

GC content: 48.0

Gene sequence:

>900_bases
ATGTTATTTGAGCAAATTGCCCGCAACAAGCGGCACACGTTATACGTGATGGCCGCTTTTGTCATATTACTTGCAGTGAT
TGGTTTAGCAGTTGGCTACGTGTTTTTTAATAGTGCGATTGCAGGGTTACTAGTAGCCTTGATTGCAGCGGTATTTTATA
TGGTATTAATGATTAGTCAGTCGACCGACATTGTCATGAGCATGAATCATGGACGTGAGCTGCATCAAGCTGACGATGAT
CCCGAGCTCTGGCACATTGTGGAAGACATGGCGTTGGTTGCTAAAGTACCGATGCCACGCGTCTTTATTATTGATGATGA
GAGCCCCAATGCGTTTGCGACAGGAAATGACCCTGAGCATGCGGCAGTTGCAGTGACAACTGGTATTCAGGCACGATTAA
CGCGTGAAGAGATGGAAGGCGTCATTGGTCACGAGATGAGTCATGTGCGTAACTATGATATTCGGTTACAGACCATTGCC
TTGGCTCTGACAGCGGCCATCAGTTTGTTAGTCAATTGGGGTATGAACGCCTTTTGGTGGGGCGGTGGCCGGCGCAGTCG
GGATAATGATCGTGACGGCAACGGTGCCCAGGTCTTACTAATGATCCTAGCGATTGTTGTCATTATTTTAGCGCCACTAG
CAGCTAGTTTAGTGCAGATGGCGCTATCCCGTAATCGCGAATACTTAGCGGATGCTGGCAGTGTGGAACTGACTCGTAAT
CCGTTGGGCTTAATCAGTGCACTTGAAAAAATCGATGACAGCCAACCCATGCAAGCGGCGGATCCTAGTAGCGCGGCCCT
CTATATTTCTGATCCGTTTAAGGCGAAGAAATCATGGACGCACTTATTCGATACCCACCCACCGATGGCTGATCGCATCA
CTCGTTTAAAAAACATGTAA

Upstream 100 bases:

>100_bases
TTGCTGGCATTCATCACTTCAAGAACGTTGAATTCTTAACTGTTCCTGAAGCAGAAAAAGCAGCACCCACGGTTTCATTT
GAAGATTAGAGGTTATGCCC

Downstream 100 bases:

>100_bases
TAAAAAAATGCGTTTAGGTTAATAACGGATTATAATGAAAACAAATAGAAAGTTGAAAGAGTGAGACGGTTGCAACGCAA
ATATATTTACGCCAATTTGG

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLFEQIARNKRHTLYVMAAFVILLAVIGLAVGYVFFNSAIAGLLVALIAAVFYMVLMISQSTDIVMSMNHGRELHQADDD
PELWHIVEDMALVAKVPMPRVFIIDDESPNAFATGNDPEHAAVAVTTGIQARLTREEMEGVIGHEMSHVRNYDIRLQTIA
LALTAAISLLVNWGMNAFWWGGGRRSRDNDRDGNGAQVLLMILAIVVIILAPLAASLVQMALSRNREYLADAGSVELTRN
PLGLISALEKIDDSQPMQAADPSSAALYISDPFKAKKSWTHLFDTHPPMADRITRLKNM

Sequences:

>Translated_299_residues
MLFEQIARNKRHTLYVMAAFVILLAVIGLAVGYVFFNSAIAGLLVALIAAVFYMVLMISQSTDIVMSMNHGRELHQADDD
PELWHIVEDMALVAKVPMPRVFIIDDESPNAFATGNDPEHAAVAVTTGIQARLTREEMEGVIGHEMSHVRNYDIRLQTIA
LALTAAISLLVNWGMNAFWWGGGRRSRDNDRDGNGAQVLLMILAIVVIILAPLAASLVQMALSRNREYLADAGSVELTRN
PLGLISALEKIDDSQPMQAADPSSAALYISDPFKAKKSWTHLFDTHPPMADRITRLKNM
>Mature_299_residues
MLFEQIARNKRHTLYVMAAFVILLAVIGLAVGYVFFNSAIAGLLVALIAAVFYMVLMISQSTDIVMSMNHGRELHQADDD
PELWHIVEDMALVAKVPMPRVFIIDDESPNAFATGNDPEHAAVAVTTGIQARLTREEMEGVIGHEMSHVRNYDIRLQTIA
LALTAAISLLVNWGMNAFWWGGGRRSRDNDRDGNGAQVLLMILAIVVIILAPLAASLVQMALSRNREYLADAGSVELTRN
PLGLISALEKIDDSQPMQAADPSSAALYISDPFKAKKSWTHLFDTHPPMADRITRLKNM

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=288, Percent_Identity=29.8611111111111, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_LACPL (Q88Z48)

Other databases:

- EMBL:   AL935253
- RefSeq:   NP_784296.1
- ProteinModelPortal:   Q88Z48
- MEROPS:   M48.004
- GeneID:   1064137
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0516
- NMPDR:   fig|220668.1.peg.430
- HOGENOM:   HBG739460
- OMA:   RTHPETH
- ProtClustDB:   PRK04897
- BioCyc:   LPLA220668:LP_0516-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 32949; Mature: 32949

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 145-145

Signals:

None

Transmembrane regions:

HASH(0xb1b913c)-; HASH(0xc890a50)-; HASH(0xc7ba834)-; HASH(0xc86901c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFEQIARNKRHTLYVMAAFVILLAVIGLAVGYVFFNSAIAGLLVALIAAVFYMVLMISQ
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
STDIVMSMNHGRELHQADDDPELWHIVEDMALVAKVPMPRVFIIDDESPNAFATGNDPEH
CCCEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCC
AAVAVTTGIQARLTREEMEGVIGHEMSHVRNYDIRLQTIALALTAAISLLVNWGMNAFWW
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
GGGRRSRDNDRDGNGAQVLLMILAIVVIILAPLAASLVQMALSRNREYLADAGSVELTRN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEECC
PLGLISALEKIDDSQPMQAADPSSAALYISDPFKAKKSWTHLFDTHPPMADRITRLKNM
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCH
>Mature Secondary Structure
MLFEQIARNKRHTLYVMAAFVILLAVIGLAVGYVFFNSAIAGLLVALIAAVFYMVLMISQ
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
STDIVMSMNHGRELHQADDDPELWHIVEDMALVAKVPMPRVFIIDDESPNAFATGNDPEH
CCCEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCC
AAVAVTTGIQARLTREEMEGVIGHEMSHVRNYDIRLQTIALALTAAISLLVNWGMNAFWW
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
GGGRRSRDNDRDGNGAQVLLMILAIVVIILAPLAASLVQMALSRNREYLADAGSVELTRN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEECC
PLGLISALEKIDDSQPMQAADPSSAALYISDPFKAKKSWTHLFDTHPPMADRITRLKNM
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12566566