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The map label for this gene is murA1

Identifier: 28377398

GI number: 28377398

Start: 455853

End: 457133

Strand: Direct

Name: murA1

Synonym: lp_0510

Alternate gene names: 28377398

Gene position: 455853-457133 (Clockwise)

Preceding gene: 28377397

Following gene: 28377399

Centisome position: 13.78

GC content: 46.68

Gene sequence:

>1281_bases
ATGAAAAAAATGATAATCCATGGCGGAAAACGACTTTCTGGGGAATTAACGATCGGTGGCGCAAAAAATAGTACCGTCGC
ACTGATTCCTGCTGCGATTCTTGCAGACACTCCGGTCCAATTCGATACGGTTCCGCACATCTTAGACGTTCACAACTTAC
GGCTCATCTTAGAGTCGATGAACGTCCATTCCACTTTTGAAAACGATGTTCTAACAATTGATCCAACAAATATTGAAGAA
TCTGAATTACCAAGTCATGCCATTAAAAGCTTGCGGGCTTCTTACTACTTTATGGGGGCCTTACTCGGTCGCTTTAACCG
TGCAACGGTGACTTTCCCTGGTGGTGATAATATTGGTCCACGACCAATTGATCAGCATATCAAGGGTTTTAAGGCGCTCG
GCGCTAACGTCGTTGAAGAGAATGACTCTGTCTTTATCTCAACGGGCACAGAGGGCCTTCACGGAGCGCGCATCTTTTTA
GACGTGGTTTCCGTTGGGGCGACGATCAACATTATTTTGGCTGCCGTCAAAGCTCATGGTACGACCACGATTGAAAATGC
GGCTAAAGAGCCTGAAATCATTGATTTAGCGACTTTTTTGAATAATATGGGCGCTAAAATTCGGGGTGCTGGTACCGACG
TGATTCGAATCGAAGGCGTTCCGGCACTGCATTCGCGGGCAACCCATACGATTATTCCTGATCGGATTGAGACGGGAACG
TATCTATCCCTGGCTGCTTCGATTGGGGACGGTATTTTGCTAAAGAATGTGATCCCTGAACATATGGAGTCATTCACGGC
AAAACTAGTCGAAATGGGTGTCGATTTACAGATTAATGAAGATAGTATTTACGTCCCACGGTCCAATGATTTGGACCCAA
TTCGGGTTAAAACAATGACTTACCCAGGCTTTGCCACTGATTTGCAACAACCAATCACCCCATTATTATTGCGTGCTAAC
GGTAGTAGCGTGGTGATTGATACGATTTATCCGCAACGCACGCAACACGTTGAACAGTTACGTAAGATGGGGGCGGACAT
TCGCGTTCAAGATAACTTGATTGTCGTGGGTCATTCTTCCCACTTACAAGGTGCACATGTCGAGGCCGGTGAGATTCGGT
CTGGGGCGGCACTAATGATTGCTGGTCTCGCGGCTAGTGGCGTTACGGAAATTAGTCGCGCTGACAATATTCTACGTGGC
TATGATCGGGTCATCGATAAATTGCATACACTTGGTGCGGATGTGGAAATTGCAGCCGACGAAGAAGTTCCCGAAAACTA
A

Upstream 100 bases:

>100_bases
CAGTTTCCTGATATTGGTTGTATTTTTGACGGACATTCTTTATTATGGTTAATGATTGTATGATACAGTGTGACACTTAT
TTAGCGAGGAAAGTTATGTT

Downstream 100 bases:

>100_bases
CGATGTACAGCTAAGAAAGAACAGTGGTTATGGAAAAAATTTTAACAATGCACGATCTCGAGCAGAAAACGTTAAAAGAA
ATTTATAACTATGCTCGTGA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 2; UDP-N-acetylglucosamine enolpyruvyl transferase 2; EPT 2

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKKMIIHGGKRLSGELTIGGAKNSTVALIPAAILADTPVQFDTVPHILDVHNLRLILESMNVHSTFENDVLTIDPTNIEE
SELPSHAIKSLRASYYFMGALLGRFNRATVTFPGGDNIGPRPIDQHIKGFKALGANVVEENDSVFISTGTEGLHGARIFL
DVVSVGATINIILAAVKAHGTTTIENAAKEPEIIDLATFLNNMGAKIRGAGTDVIRIEGVPALHSRATHTIIPDRIETGT
YLSLAASIGDGILLKNVIPEHMESFTAKLVEMGVDLQINEDSIYVPRSNDLDPIRVKTMTYPGFATDLQQPITPLLLRAN
GSSVVIDTIYPQRTQHVEQLRKMGADIRVQDNLIVVGHSSHLQGAHVEAGEIRSGAALMIAGLAASGVTEISRADNILRG
YDRVIDKLHTLGADVEIAADEEVPEN

Sequences:

>Translated_426_residues
MKKMIIHGGKRLSGELTIGGAKNSTVALIPAAILADTPVQFDTVPHILDVHNLRLILESMNVHSTFENDVLTIDPTNIEE
SELPSHAIKSLRASYYFMGALLGRFNRATVTFPGGDNIGPRPIDQHIKGFKALGANVVEENDSVFISTGTEGLHGARIFL
DVVSVGATINIILAAVKAHGTTTIENAAKEPEIIDLATFLNNMGAKIRGAGTDVIRIEGVPALHSRATHTIIPDRIETGT
YLSLAASIGDGILLKNVIPEHMESFTAKLVEMGVDLQINEDSIYVPRSNDLDPIRVKTMTYPGFATDLQQPITPLLLRAN
GSSVVIDTIYPQRTQHVEQLRKMGADIRVQDNLIVVGHSSHLQGAHVEAGEIRSGAALMIAGLAASGVTEISRADNILRG
YDRVIDKLHTLGADVEIAADEEVPEN
>Mature_426_residues
MKKMIIHGGKRLSGELTIGGAKNSTVALIPAAILADTPVQFDTVPHILDVHNLRLILESMNVHSTFENDVLTIDPTNIEE
SELPSHAIKSLRASYYFMGALLGRFNRATVTFPGGDNIGPRPIDQHIKGFKALGANVVEENDSVFISTGTEGLHGARIFL
DVVSVGATINIILAAVKAHGTTTIENAAKEPEIIDLATFLNNMGAKIRGAGTDVIRIEGVPALHSRATHTIIPDRIETGT
YLSLAASIGDGILLKNVIPEHMESFTAKLVEMGVDLQINEDSIYVPRSNDLDPIRVKTMTYPGFATDLQQPITPLLLRAN
GSSVVIDTIYPQRTQHVEQLRKMGADIRVQDNLIVVGHSSHLQGAHVEAGEIRSGAALMIAGLAASGVTEISRADNILRG
YDRVIDKLHTLGADVEIAADEEVPEN

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=419, Percent_Identity=40.0954653937947, Blast_Score=294, Evalue=7e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA2_LACPL (Q88Z54)

Other databases:

- EMBL:   AL935253
- RefSeq:   NP_784290.1
- ProteinModelPortal:   Q88Z54
- SMR:   Q88Z54
- GeneID:   1061497
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0510
- NMPDR:   fig|220668.1.peg.424
- HOGENOM:   HBG482701
- OMA:   MLAAVHA
- ProtClustDB:   PRK12830
- BioCyc:   LPLA220668:LP_0510-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45831; Mature: 45831

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKMIIHGGKRLSGELTIGGAKNSTVALIPAAILADTPVQFDTVPHILDVHNLRLILESM
CCCEEEECCCEECCEEEECCCCCCEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHC
NVHSTFENDVLTIDPTNIEESELPSHAIKSLRASYYFMGALLGRFNRATVTFPGGDNIGP
CCCCCCCCCEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
RPIDQHIKGFKALGANVVEENDSVFISTGTEGLHGARIFLDVVSVGATINIILAAVKAHG
CCHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCEEEHEEEHHHCC
TTTIENAAKEPEIIDLATFLNNMGAKIRGAGTDVIRIEGVPALHSRATHTIIPDRIETGT
CCHHHHHCCCCCEEHHHHHHHHCCCEEECCCCCEEEECCCCHHHCCCCEEECCCCCCCCC
YLSLAASIGDGILLKNVIPEHMESFTAKLVEMGVDLQINEDSIYVPRSNDLDPIRVKTMT
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEECCCCCCCCEEEEEEE
YPGFATDLQQPITPLLLRANGSSVVIDTIYPQRTQHVEQLRKMGADIRVQDNLIVVGHSS
CCCCHHHHHCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCEEEEECCC
HLQGAHVEAGEIRSGAALMIAGLAASGVTEISRADNILRGYDRVIDKLHTLGADVEIAAD
CCCCCCCCCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
EEVPEN
CCCCCC
>Mature Secondary Structure
MKKMIIHGGKRLSGELTIGGAKNSTVALIPAAILADTPVQFDTVPHILDVHNLRLILESM
CCCEEEECCCEECCEEEECCCCCCEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHC
NVHSTFENDVLTIDPTNIEESELPSHAIKSLRASYYFMGALLGRFNRATVTFPGGDNIGP
CCCCCCCCCEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
RPIDQHIKGFKALGANVVEENDSVFISTGTEGLHGARIFLDVVSVGATINIILAAVKAHG
CCHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCEEEHEEEHHHCC
TTTIENAAKEPEIIDLATFLNNMGAKIRGAGTDVIRIEGVPALHSRATHTIIPDRIETGT
CCHHHHHCCCCCEEHHHHHHHHCCCEEECCCCCEEEECCCCHHHCCCCEEECCCCCCCCC
YLSLAASIGDGILLKNVIPEHMESFTAKLVEMGVDLQINEDSIYVPRSNDLDPIRVKTMT
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEECCCCCCCCEEEEEEE
YPGFATDLQQPITPLLLRANGSSVVIDTIYPQRTQHVEQLRKMGADIRVQDNLIVVGHSS
CCCCHHHHHCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCEEEEECCC
HLQGAHVEAGEIRSGAALMIAGLAASGVTEISRADNILRGYDRVIDKLHTLGADVEIAAD
CCCCCCCCCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
EEVPEN
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566