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The map label for this gene is accB3 [H]

Identifier: 28377277

GI number: 28377277

Start: 328642

End: 329214

Strand: Direct

Name: accB3 [H]

Synonym: lp_0362

Alternate gene names: 28377277

Gene position: 328642-329214 (Clockwise)

Preceding gene: 28377276

Following gene: 28377279

Centisome position: 9.93

GC content: 50.79

Gene sequence:

>573_bases
ATGGAATTAGATAAGATTTATCAGTTAATGGACAAGTTTGAACAAAGCAGTTTAACTAGTTTTGAGTATCGGGACCAAGA
TTTTGAAATTCAAATGGGTAAGAAGGGACACGGCAAGACGACGGTGACTCCGCAGCCGGCGCCACTTCCCAATCAGCCGG
TGATTGACCCAACGCCGGTCACACCGACACCGGTCTCAACGGTTAGTACCCCAGTTGTTGCGGAGGCGGAACCAACCCCA
GTGGCGACCAGTACGGCTAGCAATCCGACGAGCGTTGTAACACCTGATCCTGAACCAGAACCGGCGCCAATCGATCCTAA
GGAATGCGTGACGGCACCGGTCGTCGGAATCTATTACCCAGCGCATTCTTCAGAAGAAGCGCCATACGTTAAGTTAGGCG
ACCACGTTAGCGTTGGTCAACAAGTCGGTCTCATTCAAGCGATGCAGATGATGCGGCCCGTGGTTGCTAAGCAAGCGGGG
ACGGTCAAGGCCTTCCTAGTGAAGAATGGTGAAGAAGTCAACTTCGGTCAACCATTGATTCAATTAATCCCAGATACACC
GGATGACATTTAA

Upstream 100 bases:

>100_bases
AAATATTGACGAATTCTTAAAGAAGCGTTCATACTTCCACCACACTCCTGCGCTAAACTATGCGGTATAATCAAAGCGTA
AATTAATTGGAGGGTGTTGT

Downstream 100 bases:

>100_bases
TCAGGTACAATCAGTGGTTGCTGAGCGTATTAAGCACTTTGAGTAGCACTATGTCTTGATAAAAGCGTGACACAAATTAA
AAATGAACCACTTCAAGCGC

Product: acetyl-CoA carboxylase, biotin carboxyl carrier protein

Products: ADP; phosphate; malonyl-CoA

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MELDKIYQLMDKFEQSSLTSFEYRDQDFEIQMGKKGHGKTTVTPQPAPLPNQPVIDPTPVTPTPVSTVSTPVVAEAEPTP
VATSTASNPTSVVTPDPEPEPAPIDPKECVTAPVVGIYYPAHSSEEAPYVKLGDHVSVGQQVGLIQAMQMMRPVVAKQAG
TVKAFLVKNGEEVNFGQPLIQLIPDTPDDI

Sequences:

>Translated_190_residues
MELDKIYQLMDKFEQSSLTSFEYRDQDFEIQMGKKGHGKTTVTPQPAPLPNQPVIDPTPVTPTPVSTVSTPVVAEAEPTP
VATSTASNPTSVVTPDPEPEPAPIDPKECVTAPVVGIYYPAHSSEEAPYVKLGDHVSVGQQVGLIQAMQMMRPVVAKQAG
TVKAFLVKNGEEVNFGQPLIQLIPDTPDDI
>Mature_190_residues
MELDKIYQLMDKFEQSSLTSFEYRDQDFEIQMGKKGHGKTTVTPQPAPLPNQPVIDPTPVTPTPVSTVSTPVVAEAEPTP
VATSTASNPTSVVTPDPEPEPAPIDPKECVTAPVVGIYYPAHSSEEAPYVKLGDHVSVGQQVGLIQAMQMMRPVVAKQAG
TVKAFLVKNGEEVNFGQPLIQLIPDTPDDI

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=180, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: 6.4.1.2

Molecular weight: Translated: 20446; Mature: 20446

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELDKIYQLMDKFEQSSLTSFEYRDQDFEIQMGKKGHGKTTVTPQPAPLPNQPVIDPTPV
CCHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
TPTPVSTVSTPVVAEAEPTPVATSTASNPTSVVTPDPEPEPAPIDPKECVTAPVVGIYYP
CCCCCCCCCCCEEECCCCCCCEECCCCCCCEEECCCCCCCCCCCCHHHHHHCCEEEEEEC
AHSSEEAPYVKLGDHVSVGQQVGLIQAMQMMRPVVAKQAGTVKAFLVKNGEEVNFGQPLI
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHH
QLIPDTPDDI
HCCCCCCCCC
>Mature Secondary Structure
MELDKIYQLMDKFEQSSLTSFEYRDQDFEIQMGKKGHGKTTVTPQPAPLPNQPVIDPTPV
CCHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
TPTPVSTVSTPVVAEAEPTPVATSTASNPTSVVTPDPEPEPAPIDPKECVTAPVVGIYYP
CCCCCCCCCCCEEECCCCCCCEECCCCCCCEEECCCCCCCCCCCCHHHHHHCCEEEEEEC
AHSSEEAPYVKLGDHVSVGQQVGLIQAMQMMRPVVAKQAGTVKAFLVKNGEEVNFGQPLI
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHH
QLIPDTPDDI
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetyl-CoA; HCO3-

Specific reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]