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The map label for this gene is fba [H]

Identifier: 28377250

GI number: 28377250

Start: 301990

End: 302853

Strand: Direct

Name: fba [H]

Synonym: lp_0330

Alternate gene names: 28377250

Gene position: 301990-302853 (Clockwise)

Preceding gene: 28377248

Following gene: 28377254

Centisome position: 9.13

GC content: 43.87

Gene sequence:

>864_bases
ATGTCATTTGTAAATGCTGTTGATATGACACAAGACGCATACAAGAACCATTATGCTATTGGTGCGTTCAACACAAACAA
CCTTGAATGGACTCGTTGCATCTTGAAGGGTGCTCAAGACACTAACACCCCAGTTATTATCCAAGTTTCAATGGGTGCTG
CTAAGTACATGGGCGGCTACAAGCTCGTTATGGACTTAGTTGCTGATGAAATGGAAAGCATGAACATCACTGTTCCTGTT
GTTATGCACTTAGACCACGGTAACTACGAAGCTGCCAAGGAATGTATCGAAGTTGGTTACTCATCAGTTATGTTTGATGG
CCATGACCTACCATTTGCCGAAAACTTAGAAAAGACTAAGGAAATCGTCAAATTAGCTCATGCTAAGGGCATCTCTGTTG
AAGCCGAAGTTGGTTCAATTGGTGGTGAAGAAGACGGTATCATCGGTGAAGGTGAATTAGCTGATGTTGAAGAAGCTAAG
ACTTTAGCTGCTACTGGTATCGACATCTTAGCCGCTGGGATTGGTAACATCCACGGCAAGTACCCAGAAAACTGGACTGG
CTTACACTTCGATCGTCTTCAAGAAATCTCAGAAGCCGTTAAGATGCCATTGGTACTTCACGGTGGTTCTGGTATTCCTA
AGGACCAAATCGTTAAGGCTGTTGAATTGGGTATTAGCAAGGTTAACGTTAACACCGAAAACCAAGTTGCTTTTGCCAAT
GCAACTCGTGCTTACATCGAATCTGGCGCAGACCAAATCGGTAAGGGCTACGACCCTCGTAAGTTATTGGCACCTGGTAA
GAAGGCCATCGTTGATGTTGTTACATCACGGATTGGCTGGTTCAAGACTCCAGCTGTTAAATAA

Upstream 100 bases:

>100_bases
TAATAAATATGACAAATCGGTTATCACTCCTATGTAAAATGTGCTAAAATGAATGTGATTCAAAAATCGTATCTCTTAAT
TAACCTAGGAGGGTTATTTT

Downstream 100 bases:

>100_bases
TTGGATTTTTGATTCAGAAAAAGTCGACTCTTCGGGGTCGGCTTTTTTCCTGCGCTTTTTTGGGGAACTTGGTACTGACT
TACCACCTGGGAGTGCCAGT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSFVNAVDMTQDAYKNHYAIGAFNTNNLEWTRCILKGAQDTNTPVIIQVSMGAAKYMGGYKLVMDLVADEMESMNITVPV
VMHLDHGNYEAAKECIEVGYSSVMFDGHDLPFAENLEKTKEIVKLAHAKGISVEAEVGSIGGEEDGIIGEGELADVEEAK
TLAATGIDILAAGIGNIHGKYPENWTGLHFDRLQEISEAVKMPLVLHGGSGIPKDQIVKAVELGISKVNVNTENQVAFAN
ATRAYIESGADQIGKGYDPRKLLAPGKKAIVDVVTSRIGWFKTPAVK

Sequences:

>Translated_287_residues
MSFVNAVDMTQDAYKNHYAIGAFNTNNLEWTRCILKGAQDTNTPVIIQVSMGAAKYMGGYKLVMDLVADEMESMNITVPV
VMHLDHGNYEAAKECIEVGYSSVMFDGHDLPFAENLEKTKEIVKLAHAKGISVEAEVGSIGGEEDGIIGEGELADVEEAK
TLAATGIDILAAGIGNIHGKYPENWTGLHFDRLQEISEAVKMPLVLHGGSGIPKDQIVKAVELGISKVNVNTENQVAFAN
ATRAYIESGADQIGKGYDPRKLLAPGKKAIVDVVTSRIGWFKTPAVK
>Mature_286_residues
SFVNAVDMTQDAYKNHYAIGAFNTNNLEWTRCILKGAQDTNTPVIIQVSMGAAKYMGGYKLVMDLVADEMESMNITVPVV
MHLDHGNYEAAKECIEVGYSSVMFDGHDLPFAENLEKTKEIVKLAHAKGISVEAEVGSIGGEEDGIIGEGELADVEEAKT
LAATGIDILAAGIGNIHGKYPENWTGLHFDRLQEISEAVKMPLVLHGGSGIPKDQIVKAVELGISKVNVNTENQVAFANA
TRAYIESGADQIGKGYDPRKLLAPGKKAIVDVVTSRIGWFKTPAVK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=283, Percent_Identity=36.7491166077738, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87082041, Length=284, Percent_Identity=35.9154929577465, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1788072, Length=228, Percent_Identity=37.719298245614, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1789293, Length=321, Percent_Identity=27.1028037383178, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322790, Length=338, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30922; Mature: 30790

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFVNAVDMTQDAYKNHYAIGAFNTNNLEWTRCILKGAQDTNTPVIIQVSMGAAKYMGGY
CCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCHHHHHCHH
KLVMDLVADEMESMNITVPVVMHLDHGNYEAAKECIEVGYSSVMFDGHDLPFAENLEKTK
HHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHCCCHHEEECCCCCCHHHHHHHHH
EIVKLAHAKGISVEAEVGSIGGEEDGIIGEGELADVEEAKTLAATGIDILAAGIGNIHGK
HHHHHHHHCCCEEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YPENWTGLHFDRLQEISEAVKMPLVLHGGSGIPKDQIVKAVELGISKVNVNTENQVAFAN
CCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCEEEHH
ATRAYIESGADQIGKGYDPRKLLAPGKKAIVDVVTSRIGWFKTPAVK
HHHHHHHHCHHHHCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SFVNAVDMTQDAYKNHYAIGAFNTNNLEWTRCILKGAQDTNTPVIIQVSMGAAKYMGGY
CCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCHHHHHCHH
KLVMDLVADEMESMNITVPVVMHLDHGNYEAAKECIEVGYSSVMFDGHDLPFAENLEKTK
HHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHCCCHHEEECCCCCCHHHHHHHHH
EIVKLAHAKGISVEAEVGSIGGEEDGIIGEGELADVEEAKTLAATGIDILAAGIGNIHGK
HHHHHHHHCCCEEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YPENWTGLHFDRLQEISEAVKMPLVLHGGSGIPKDQIVKAVELGISKVNVNTENQVAFAN
CCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCEEEHH
ATRAYIESGADQIGKGYDPRKLLAPGKKAIVDVVTSRIGWFKTPAVK
HHHHHHHHCHHHHCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]