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The map label for this gene is pepI [H]

Identifier: 28377046

GI number: 28377046

Start: 82631

End: 83515

Strand: Direct

Name: pepI [H]

Synonym: lp_0088

Alternate gene names: 28377046

Gene position: 82631-83515 (Clockwise)

Preceding gene: 28377044

Following gene: 28377048

Centisome position: 2.5

GC content: 47.91

Gene sequence:

>885_bases
TTGGACGTGCAAGAAGGATACATGCCATTTAATGGTTATCAGACGTATTATCGAATCGTAGGGGATCGGCAATCAAATAA
GACACCGTTAGTTTTGCTACATGGTGGTCCAGGATCAACGCATAATTACTTTGAAGGATTTGATGACCTGGCCGCTCAAA
CGGGACGACCAATCGTTATGTATGATCAATTAGGCTGTGGGCGTTCATCGATACCTGATGACGATCAATTATGGCAAGCC
GCAATGTGGGTGGCAGAGTTGCGGGCGTTACGTACGTATTTAGACTTACCCGAGATTCACTTACTAGGGCAGTCCTGGGG
TGGTATGCTAGCCATTATTTATGGTTGTGACTATCGGCCGCAGGGGATTAAAAGTTTGATTTTAGCCAGTACCTTATCTT
CAGCCCGACTGTGGGCTCAGGAACAGCATCGGATGATTCGGTTAATGTCCCCAGTGGATCAGTCGGCTATTGCGACAGCA
GAACGGTTACAGGATTTCACAGGTGCTGCCTACCTGACTGCTAATCAACATTTTATGACGCAACATGCGTCGGGCCCGAT
TACTGCTGATGATCCTGAATTCCTACGGCGATCAAAACGGGTGGGGACCACGGCTTATAATGTAGCGTGGGGTCCCAATG
AATATAATCCGACTGGTACGTTAGCGGATTATGAGTATACCGACCGATTACAGTATTTGCAGATGCCAACTTTAGTCACC
AGTGGAACGGATGATTTGTGTACGCCATTAGTCGCTAAGACCATGGTCGACCAGTTACCTCATGCGACTTGGACGTTATT
TCCCCGTAGCCGTCACATGGCGTTTATCGATGAAAACACGGCCTATATGACGCGATTGCGTCACTGGCTAGCAGCCCATG
ATTAG

Upstream 100 bases:

>100_bases
TCTGTTTGGCACGTTTTAATCAAGGCTAATGCTAAATAGCGGCTAGCATAACGCATAACGCGTAACAAGTAAAAAATTAG
TAACGAAAGTGAGTGATATT

Downstream 100 bases:

>100_bases
AGAAATGAGCGTAATCATTTCCCGGGAAATAATTTGCTGAATAGCTAGATTGAGAAGTTTATCGGTGTGATCTGATTTTG
TTTGGCTGTCACTATAATGG

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MDVQEGYMPFNGYQTYYRIVGDRQSNKTPLVLLHGGPGSTHNYFEGFDDLAAQTGRPIVMYDQLGCGRSSIPDDDQLWQA
AMWVAELRALRTYLDLPEIHLLGQSWGGMLAIIYGCDYRPQGIKSLILASTLSSARLWAQEQHRMIRLMSPVDQSAIATA
ERLQDFTGAAYLTANQHFMTQHASGPITADDPEFLRRSKRVGTTAYNVAWGPNEYNPTGTLADYEYTDRLQYLQMPTLVT
SGTDDLCTPLVAKTMVDQLPHATWTLFPRSRHMAFIDENTAYMTRLRHWLAAHD

Sequences:

>Translated_294_residues
MDVQEGYMPFNGYQTYYRIVGDRQSNKTPLVLLHGGPGSTHNYFEGFDDLAAQTGRPIVMYDQLGCGRSSIPDDDQLWQA
AMWVAELRALRTYLDLPEIHLLGQSWGGMLAIIYGCDYRPQGIKSLILASTLSSARLWAQEQHRMIRLMSPVDQSAIATA
ERLQDFTGAAYLTANQHFMTQHASGPITADDPEFLRRSKRVGTTAYNVAWGPNEYNPTGTLADYEYTDRLQYLQMPTLVT
SGTDDLCTPLVAKTMVDQLPHATWTLFPRSRHMAFIDENTAYMTRLRHWLAAHD
>Mature_294_residues
MDVQEGYMPFNGYQTYYRIVGDRQSNKTPLVLLHGGPGSTHNYFEGFDDLAAQTGRPIVMYDQLGCGRSSIPDDDQLWQA
AMWVAELRALRTYLDLPEIHLLGQSWGGMLAIIYGCDYRPQGIKSLILASTLSSARLWAQEQHRMIRLMSPVDQSAIATA
ERLQDFTGAAYLTANQHFMTQHASGPITADDPEFLRRSKRVGTTAYNVAWGPNEYNPTGTLADYEYTDRLQYLQMPTLVT
SGTDDLCTPLVAKTMVDQLPHATWTLFPRSRHMAFIDENTAYMTRLRHWLAAHD

Specific function: Characterized by a high specificity towards di- or tripeptides with proline at the NH(2)-terminal position, but is not able to hydrolyze longer peptides, or peptides with hydroxyproline at the NH(2)-end [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell envelope [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 33234; Mature: 33234

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVQEGYMPFNGYQTYYRIVGDRQSNKTPLVLLHGGPGSTHNYFEGFDDLAAQTGRPIVM
CCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCHHHHCHHHHHHHCCCCEEE
YDQLGCGRSSIPDDDQLWQAAMWVAELRALRTYLDLPEIHLLGQSWGGMLAIIYGCDYRP
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCC
QGIKSLILASTLSSARLWAQEQHRMIRLMSPVDQSAIATAERLQDFTGAAYLTANQHFMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCHHHH
QHASGPITADDPEFLRRSKRVGTTAYNVAWGPNEYNPTGTLADYEYTDRLQYLQMPTLVT
HCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCEE
SGTDDLCTPLVAKTMVDQLPHATWTLFPRSRHMAFIDENTAYMTRLRHWLAAHD
CCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDVQEGYMPFNGYQTYYRIVGDRQSNKTPLVLLHGGPGSTHNYFEGFDDLAAQTGRPIVM
CCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCHHHHCHHHHHHHCCCCEEE
YDQLGCGRSSIPDDDQLWQAAMWVAELRALRTYLDLPEIHLLGQSWGGMLAIIYGCDYRP
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCC
QGIKSLILASTLSSARLWAQEQHRMIRLMSPVDQSAIATAERLQDFTGAAYLTANQHFMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCHHHH
QHASGPITADDPEFLRRSKRVGTTAYNVAWGPNEYNPTGTLADYEYTDRLQYLQMPTLVT
HCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCEE
SGTDDLCTPLVAKTMVDQLPHATWTLFPRSRHMAFIDENTAYMTRLRHWLAAHD
CCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8012575; 8012576 [H]