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The map label for this gene is pepA

Identifier: 28211503

GI number: 28211503

Start: 1982704

End: 1984149

Strand: Direct

Name: pepA

Synonym: CTC01866

Alternate gene names: 28211503

Gene position: 1982704-1984149 (Clockwise)

Preceding gene: 28211496

Following gene: 28211514

Centisome position: 70.83

GC content: 30.91

Gene sequence:

>1446_bases
ATGAAGTTTCATATTGGAAAAGACGGAGAAGTTAAAATAATACTTGTTTACAAAAATGCAGAAAAAGTAGAAGAAGCTAA
TGATTTATATAGCTATCTAAAAGAAAAAGAATTGTTTAAAGGGGATTTAGGTGAAGTATATTCCCACATTTCGCATTCTG
AAGATAAATTTATACTATTAGGAATTGGGGAAAAAGAAAAAACAACTGCTAATTCCCTTAGAAAAGCTTTCTTTAATGCT
GGTAAAGAATTAATGAAATTTAAAGTTACAAGTATAAAAATTTCTATACCTATGTTTAAAAACCTTAAATATGAAAGTAT
AGTTCAATCTATCACTGAAGGTTTGCTACAATCAGAATACAGTTTTGAAAAATATTTAACTAAAAAGAAAATTAGTCCTA
GTATAAAAAATGTTTATCTTGATATATTAGAAGAAAAAAAAGAAGAAACTATTAATACTATAAATGAAAGTAAAAACCTT
ATAGAAGGTATTTTTTTAGCAAGAAATCTTGTAAATGAACCTGCTATATACATGACACCTACTGTCCTTGCAAATAATGC
TAAAAACCAATTAGAGTCCCTTGGAGTTGAAGTAAAAATTTATGGAAAAGAAAAAATAAAAGAGCTTGGTATGGAAGCAT
TTTTAGCTGTTTCTAAAGGATCCTTTGAAGAATCTCAACTTATAGTTATGAATTACAAGGGTAATTCTAATTCAGATAAA
AAATTAGCCCTTGTTGGAAAAGGATTAACCTATGACTCTGGTGGTTATTCTATTAAACCTACTAGTAGCATGATTAATAT
GCATTCAGATATGGCAGGTTCAGCCTCTGTTATAGGTGCAATGAAAGCCATTGCCATGTCAAAACTTGAGGTTAATGTGG
TGGCAATAGTTGCAGCTTGCGAAAATATGATTTCAGGTGGAGCTTATAAACCTGGAGATATTATTAGCTCTATGTCAGGT
AAAACTATAGAAATTCTAAACACTGATGCTGAAGGTAGATTAACCCTAGCTGATGCACTATGGTATGCTGTTGATGTTGT
GAAAGCTGATAAAATAATAGATATTGCAACTCTTACTGGTGCATGTGTAACAGCTTTAGGAAGTATAAATACAGGAGCTA
TTACAAATAATAGCTACCTTATGGATAATGTTAAAAAGGCTTCTGAATGTGCGGGAGAACCTGTTTGGGAGTTTCCAAAT
AATGATGAATACAAAGAACTTATAAAAGGAACTTTTGGTGATTTAAAAAATAGTTCTGGTAGAGAAGCTGGAGCTATTAC
CGCTGGTATGTTCCTTCAAGAATTTGTAGGTAATACTCCATGGGTTCATCTTGATGTTGCAGGTACTGCATATCTTTCTT
CTAAAAATGGTTATCTTCAAAAAGGTGCCACTGGAGTACCAGTAAAAACTTTATACTATTTGGCAAAAGGTTTTAAAAAT
AAATAA

Upstream 100 bases:

>100_bases
TTTTAATTTAGAAAACTATTTGTTTTAAATATAACCTTATATTTGAGATTATATTCATAATTTGGTAAAATTATAATAAA
TACTAGAAAGGAGTGATTTT

Downstream 100 bases:

>100_bases
ATTTATAAAAATCCACCAAATAAACTGGTGGATTTTTCATTTATATAAACTGAAAAAAACTTCTCAATTTTTCACTGATA
AGATATAATGTCCCTATTTG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKFHIGKDGEVKIILVYKNAEKVEEANDLYSYLKEKELFKGDLGEVYSHISHSEDKFILLGIGEKEKTTANSLRKAFFNA
GKELMKFKVTSIKISIPMFKNLKYESIVQSITEGLLQSEYSFEKYLTKKKISPSIKNVYLDILEEKKEETINTINESKNL
IEGIFLARNLVNEPAIYMTPTVLANNAKNQLESLGVEVKIYGKEKIKELGMEAFLAVSKGSFEESQLIVMNYKGNSNSDK
KLALVGKGLTYDSGGYSIKPTSSMINMHSDMAGSASVIGAMKAIAMSKLEVNVVAIVAACENMISGGAYKPGDIISSMSG
KTIEILNTDAEGRLTLADALWYAVDVVKADKIIDIATLTGACVTALGSINTGAITNNSYLMDNVKKASECAGEPVWEFPN
NDEYKELIKGTFGDLKNSSGREAGAITAGMFLQEFVGNTPWVHLDVAGTAYLSSKNGYLQKGATGVPVKTLYYLAKGFKN
K

Sequences:

>Translated_481_residues
MKFHIGKDGEVKIILVYKNAEKVEEANDLYSYLKEKELFKGDLGEVYSHISHSEDKFILLGIGEKEKTTANSLRKAFFNA
GKELMKFKVTSIKISIPMFKNLKYESIVQSITEGLLQSEYSFEKYLTKKKISPSIKNVYLDILEEKKEETINTINESKNL
IEGIFLARNLVNEPAIYMTPTVLANNAKNQLESLGVEVKIYGKEKIKELGMEAFLAVSKGSFEESQLIVMNYKGNSNSDK
KLALVGKGLTYDSGGYSIKPTSSMINMHSDMAGSASVIGAMKAIAMSKLEVNVVAIVAACENMISGGAYKPGDIISSMSG
KTIEILNTDAEGRLTLADALWYAVDVVKADKIIDIATLTGACVTALGSINTGAITNNSYLMDNVKKASECAGEPVWEFPN
NDEYKELIKGTFGDLKNSSGREAGAITAGMFLQEFVGNTPWVHLDVAGTAYLSSKNGYLQKGATGVPVKTLYYLAKGFKN
K
>Mature_481_residues
MKFHIGKDGEVKIILVYKNAEKVEEANDLYSYLKEKELFKGDLGEVYSHISHSEDKFILLGIGEKEKTTANSLRKAFFNA
GKELMKFKVTSIKISIPMFKNLKYESIVQSITEGLLQSEYSFEKYLTKKKISPSIKNVYLDILEEKKEETINTINESKNL
IEGIFLARNLVNEPAIYMTPTVLANNAKNQLESLGVEVKIYGKEKIKELGMEAFLAVSKGSFEESQLIVMNYKGNSNSDK
KLALVGKGLTYDSGGYSIKPTSSMINMHSDMAGSASVIGAMKAIAMSKLEVNVVAIVAACENMISGGAYKPGDIISSMSG
KTIEILNTDAEGRLTLADALWYAVDVVKADKIIDIATLTGACVTALGSINTGAITNNSYLMDNVKKASECAGEPVWEFPN
NDEYKELIKGTFGDLKNSSGREAGAITAGMFLQEFVGNTPWVHLDVAGTAYLSSKNGYLQKGATGVPVKTLYYLAKGFKN
K

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=426, Percent_Identity=37.3239436619718, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI47155554, Length=331, Percent_Identity=32.6283987915408, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1790710, Length=306, Percent_Identity=47.0588235294118, Blast_Score=281, Evalue=8e-77,
Organism=Escherichia coli, GI87082123, Length=350, Percent_Identity=35.7142857142857, Blast_Score=181, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=334, Percent_Identity=33.5329341317365, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=150, Percent_Identity=39.3333333333333, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355725, Length=312, Percent_Identity=36.2179487179487, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24661038, Length=309, Percent_Identity=35.9223300970874, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24662227, Length=349, Percent_Identity=32.6647564469914, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI20129969, Length=393, Percent_Identity=31.2977099236641, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI161077148, Length=321, Percent_Identity=33.9563862928349, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI20130057, Length=321, Percent_Identity=33.9563862928349, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI21355645, Length=310, Percent_Identity=32.5806451612903, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24662223, Length=310, Percent_Identity=32.5806451612903, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI19922386, Length=320, Percent_Identity=33.75, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129963, Length=319, Percent_Identity=33.5423197492163, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI21357381, Length=347, Percent_Identity=29.971181556196, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI221379063, Length=347, Percent_Identity=29.971181556196, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI221379062, Length=347, Percent_Identity=29.971181556196, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24646701, Length=277, Percent_Identity=30.6859205776173, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24646703, Length=277, Percent_Identity=30.6859205776173, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21358201, Length=277, Percent_Identity=30.6859205776173, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_CLOTE (Q893F8)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_782447.1
- ProteinModelPortal:   Q893F8
- SMR:   Q893F8
- MEROPS:   M17.010
- GeneID:   1060963
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC01866
- NMPDR:   fig|212717.1.peg.1669
- HOGENOM:   HBG742580
- OMA:   KEETINT
- PhylomeDB:   Q893F8
- ProtClustDB:   PRK00913
- BioCyc:   CTET212717:CTC_01866-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52612; Mature: 52612

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 259-259 ACT_SITE 333-333

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFHIGKDGEVKIILVYKNAEKVEEANDLYSYLKEKELFKGDLGEVYSHISHSEDKFILL
CEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEE
GIGEKEKTTANSLRKAFFNAGKELMKFKVTSIKISIPMFKNLKYESIVQSITEGLLQSEY
ECCCCCHHHHHHHHHHHHHCCHHHHEEEEEEEEEECCHHHCCCHHHHHHHHHHHHHHCCH
SFEKYLTKKKISPSIKNVYLDILEEKKEETINTINESKNLIEGIFLARNLVNEPAIYMTP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
TVLANNAKNQLESLGVEVKIYGKEKIKELGMEAFLAVSKGSFEESQLIVMNYKGNSNSDK
HHHHCCHHHHHHHCCCEEEEECHHHHHHHCHHHEEEECCCCCCCCEEEEEEECCCCCCCC
KLALVGKGLTYDSGGYSIKPTSSMINMHSDMAGSASVIGAMKAIAMSKLEVNVVAIVAAC
EEEEEECCCEECCCCCEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ENMISGGAYKPGDIISSMSGKTIEILNTDAEGRLTLADALWYAVDVVKADKIIDIATLTG
HHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHCCEEEHHHHHH
ACVTALGSINTGAITNNSYLMDNVKKASECAGEPVWEFPNNDEYKELIKGTFGDLKNSSG
HHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
REAGAITAGMFLQEFVGNTPWVHLDVAGTAYLSSKNGYLQKGATGVPVKTLYYLAKGFKN
CCCCHHHHHHHHHHHHCCCCEEEEEECCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCC
K
C
>Mature Secondary Structure
MKFHIGKDGEVKIILVYKNAEKVEEANDLYSYLKEKELFKGDLGEVYSHISHSEDKFILL
CEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEE
GIGEKEKTTANSLRKAFFNAGKELMKFKVTSIKISIPMFKNLKYESIVQSITEGLLQSEY
ECCCCCHHHHHHHHHHHHHCCHHHHEEEEEEEEEECCHHHCCCHHHHHHHHHHHHHHCCH
SFEKYLTKKKISPSIKNVYLDILEEKKEETINTINESKNLIEGIFLARNLVNEPAIYMTP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
TVLANNAKNQLESLGVEVKIYGKEKIKELGMEAFLAVSKGSFEESQLIVMNYKGNSNSDK
HHHHCCHHHHHHHCCCEEEEECHHHHHHHCHHHEEEECCCCCCCCEEEEEEECCCCCCCC
KLALVGKGLTYDSGGYSIKPTSSMINMHSDMAGSASVIGAMKAIAMSKLEVNVVAIVAAC
EEEEEECCCEECCCCCEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ENMISGGAYKPGDIISSMSGKTIEILNTDAEGRLTLADALWYAVDVVKADKIIDIATLTG
HHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHCCEEEHHHHHH
ACVTALGSINTGAITNNSYLMDNVKKASECAGEPVWEFPNNDEYKELIKGTFGDLKNSSG
HHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
REAGAITAGMFLQEFVGNTPWVHLDVAGTAYLSSKNGYLQKGATGVPVKTLYYLAKGFKN
CCCCHHHHHHHHHHHHCCCCEEEEEECCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129