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The map label for this gene is dxr

Identifier: 28210954

GI number: 28210954

Start: 1357347

End: 1358501

Strand: Direct

Name: dxr

Synonym: CTC01268

Alternate gene names: 28210954

Gene position: 1357347-1358501 (Clockwise)

Preceding gene: 28210953

Following gene: 28210955

Centisome position: 48.49

GC content: 28.48

Gene sequence:

>1155_bases
TTGAAGAATATATGTATTTTAGGAGCAACAGGTTCAATAGGCACTCAAACATTAGAAGTTATAAGAGAGGAAAAGGAAAA
TCTTAAATTATATGCAGCTTCTGCTAATAAAAGCTCAGAAAAAATTATAAGTATAATAGAAGAGTTTGAACCTAAGTATG
TTTCTATGACAGATAAAGAGGCATTTTTAAAAGTAAAAGAGTTTTGTATGAAAAACAATAAGAATACAGAGGTTTTATAT
GGAATAGAAGGTATGAATACCATAGCAAGTTTAGATAAAGTAGATATTGTTTTAACCTCTGTAGTTGGAATGATAGGATT
AGAACCCACATTAAAAGCTATAAGAAATAAAAAGGATATAGCTCTTGCAAATAAAGAAACTCTCGTGGTAGCAGGAGAAA
TAATTAAAAAAGAGGCCCATGAAAATAAAGTAAATATACTTCCAGTAGATTCAGAACATGGGGCAATATTTCAATGCCTT
TTAGGGAATCTTAAAGGCGATATTAATAAAATACACCTAACAGCATCAGGAGGACCTTTTAGAGGAAAAAAAAGAGAAGA
ATTAGAAAATGTAACTGTAGAACAGGCACTAAAACATCCAAATTGGAATATGGGGAAAAAAATATCCATAGATTCTGCTA
CATTAATGAATAAAGGTCTAGAAGTAATAGAAGCTCATTTTTTATTTGATGTAGACTATGAAGATATAGAAGTTGTAGTA
CATCCAGAGAGTATAATTCATTCTATGGTAGAATATAAAGATGGAAGTGTAATTGCTCAATTGGCATCTCCAGATATGAA
ACTTCCAATACAATATGCTCTAAATTATCCTATAAGAAAGGATAGAGTTATTGAAAAACTTAATTTATTTGAAATTGAAA
AGTTAACCTTTTATAAACCAGATTTAAAAACTTTTAAGTGTCTGGATTTAGCATATAGAGCAGGAAAAATTGGAGGCATG
ATGCCTACTATTTTAAATAGTTCTAATGAATATGCTGTAGAATTGTTTTTAAATAAAAAAATAGGATTTTTAGAAATACC
AAAGATAATAGAAGAATGCATGAAAAAATTTTACACAAAAGAGGAGCAAAGTGTGGAAAAAATTATACATATGGATAAAA
TTATTGGTGAATATATAAGGGAAAAATATAATTGA

Upstream 100 bases:

>100_bases
GGTATAATAATAGCACCCTTATATGTATTAATATGCAAAAGTATATATTCAGAAGGGCTTATAGACTGTAGATAAATACA
GTACAAAGGAGAGATATGAC

Downstream 100 bases:

>100_bases
CATTGACAAGACAAATATTAAGGAGGAATAGCTTGTGAGTTTTATAAATATAATTGGAGCTTTACTAGCTTTTAGTTTAC
TAGTATTAGTTCACGAATTA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKNICILGATGSIGTQTLEVIREEKENLKLYAASANKSSEKIISIIEEFEPKYVSMTDKEAFLKVKEFCMKNNKNTEVLY
GIEGMNTIASLDKVDIVLTSVVGMIGLEPTLKAIRNKKDIALANKETLVVAGEIIKKEAHENKVNILPVDSEHGAIFQCL
LGNLKGDINKIHLTASGGPFRGKKREELENVTVEQALKHPNWNMGKKISIDSATLMNKGLEVIEAHFLFDVDYEDIEVVV
HPESIIHSMVEYKDGSVIAQLASPDMKLPIQYALNYPIRKDRVIEKLNLFEIEKLTFYKPDLKTFKCLDLAYRAGKIGGM
MPTILNSSNEYAVELFLNKKIGFLEIPKIIEECMKKFYTKEEQSVEKIIHMDKIIGEYIREKYN

Sequences:

>Translated_384_residues
MKNICILGATGSIGTQTLEVIREEKENLKLYAASANKSSEKIISIIEEFEPKYVSMTDKEAFLKVKEFCMKNNKNTEVLY
GIEGMNTIASLDKVDIVLTSVVGMIGLEPTLKAIRNKKDIALANKETLVVAGEIIKKEAHENKVNILPVDSEHGAIFQCL
LGNLKGDINKIHLTASGGPFRGKKREELENVTVEQALKHPNWNMGKKISIDSATLMNKGLEVIEAHFLFDVDYEDIEVVV
HPESIIHSMVEYKDGSVIAQLASPDMKLPIQYALNYPIRKDRVIEKLNLFEIEKLTFYKPDLKTFKCLDLAYRAGKIGGM
MPTILNSSNEYAVELFLNKKIGFLEIPKIIEECMKKFYTKEEQSVEKIIHMDKIIGEYIREKYN
>Mature_384_residues
MKNICILGATGSIGTQTLEVIREEKENLKLYAASANKSSEKIISIIEEFEPKYVSMTDKEAFLKVKEFCMKNNKNTEVLY
GIEGMNTIASLDKVDIVLTSVVGMIGLEPTLKAIRNKKDIALANKETLVVAGEIIKKEAHENKVNILPVDSEHGAIFQCL
LGNLKGDINKIHLTASGGPFRGKKREELENVTVEQALKHPNWNMGKKISIDSATLMNKGLEVIEAHFLFDVDYEDIEVVV
HPESIIHSMVEYKDGSVIAQLASPDMKLPIQYALNYPIRKDRVIEKLNLFEIEKLTFYKPDLKTFKCLDLAYRAGKIGGM
MPTILNSSNEYAVELFLNKKIGFLEIPKIIEECMKKFYTKEEQSVEKIIHMDKIIGEYIREKYN

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=392, Percent_Identity=40.8163265306122, Blast_Score=308, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_CLOTE (Q895K5)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781898.1
- ProteinModelPortal:   Q895K5
- SMR:   Q895K5
- GeneID:   1059139
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC01268
- NMPDR:   fig|212717.1.peg.1120
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q895K5
- ProtClustDB:   PRK05447
- BioCyc:   CTET212717:CTC_01268-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43452; Mature: 43452

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 176-176 BINDING 199-199 BINDING 221-221

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNICILGATGSIGTQTLEVIREEKENLKLYAASANKSSEKIISIIEEFEPKYVSMTDKE
CCCEEEEECCCCCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCHH
AFLKVKEFCMKNNKNTEVLYGIEGMNTIASLDKVDIVLTSVVGMIGLEPTLKAIRNKKDI
HHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCE
ALANKETLVVAGEIIKKEAHENKVNILPVDSEHGAIFQCLLGNLKGDINKIHLTASGGPF
EEECCCEEEEEHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCC
RGKKREELENVTVEQALKHPNWNMGKKISIDSATLMNKGLEVIEAHFLFDVDYEDIEVVV
CCCCHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHCHHHEEEEEEEECCCCCEEEEE
HPESIIHSMVEYKDGSVIAQLASPDMKLPIQYALNYPIRKDRVIEKLNLFEIEKLTFYKP
CCHHHHHHHHHCCCCCEEEEECCCCCCCCHHEEECCCCCHHHHHHHHCCEEEEEEEEECC
DLKTFKCLDLAYRAGKIGGMMPTILNSSNEYAVELFLNKKIGFLEIPKIIEECMKKFYTK
CCCHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCC
EEQSVEKIIHMDKIIGEYIREKYN
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNICILGATGSIGTQTLEVIREEKENLKLYAASANKSSEKIISIIEEFEPKYVSMTDKE
CCCEEEEECCCCCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCHH
AFLKVKEFCMKNNKNTEVLYGIEGMNTIASLDKVDIVLTSVVGMIGLEPTLKAIRNKKDI
HHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCE
ALANKETLVVAGEIIKKEAHENKVNILPVDSEHGAIFQCLLGNLKGDINKIHLTASGGPF
EEECCCEEEEEHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCC
RGKKREELENVTVEQALKHPNWNMGKKISIDSATLMNKGLEVIEAHFLFDVDYEDIEVVV
CCCCHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHCHHHEEEEEEEECCCCCEEEEE
HPESIIHSMVEYKDGSVIAQLASPDMKLPIQYALNYPIRKDRVIEKLNLFEIEKLTFYKP
CCHHHHHHHHHCCCCCEEEEECCCCCCCCHHEEECCCCCHHHHHHHHCCEEEEEEEEECC
DLKTFKCLDLAYRAGKIGGMMPTILNSSNEYAVELFLNKKIGFLEIPKIIEECMKKFYTK
CCCHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCC
EEQSVEKIIHMDKIIGEYIREKYN
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129