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The map label for this gene is lepB2 [H]

Identifier: 28210939

GI number: 28210939

Start: 1342341

End: 1342865

Strand: Direct

Name: lepB2 [H]

Synonym: CTC01253

Alternate gene names: 28210939

Gene position: 1342341-1342865 (Clockwise)

Preceding gene: 28210938

Following gene: 28210940

Centisome position: 47.95

GC content: 27.62

Gene sequence:

>525_bases
ATGGTAAAGGAATTAATTGAATTAGGAAAATCTATTTTAATAGCAATTATTGCTGCTTTTTTTATAATTACATTTATATT
TGAAACAGTAAGTGTAGATGGTCATTCTATGTATCCCACTTTAAATAACAGGGATAGACTAATAGTTGAGAAGGTAACTT
ATTATTTTAGAGAACCCAAGAAGGGAGATATAGTAGTTATAAAATATCCTAAAAATCCAAAAGAAAAATTTATAAAAAGA
GTTATAGCTACAGGTGGAGATAGAGTTAGAGTAGAGGACAATAAAGTTTATGTAAATGATGAACCTAAAGATGAAAATTA
TATTTTTGAACAAAATATGGAAGATTTTCATGAAGTGAAAATACCAGAAGGAACTATCTTTGTAATGGGTGATAACAGAA
ATAATAGTTTAGACAGTAGAGATGAAAGAGTGGGCTTTGTAAAGCTAAATATGGTAGTAGGAAAAGCTACATTAAGAATA
TATCCTTTTAAAAAGTGGGGTATGTTATCTGCTATAACAAATTAA

Upstream 100 bases:

>100_bases
AGATAGAGTAGGTAAAGCTGCAAAAGTAAAAGAACGTAGATATTAAGAAAATGGGGCTTTGAAGAGTCCCTTTTTTTGCA
TATTAGGATGGTGATATATA

Downstream 100 bases:

>100_bases
CTTCGGAAAGGAAGATTAACATGGATATAAACTGGTTTCCTGGTCATATGGCTAAAACTAGAAGAGAGTTAAAAGAAAAT
TTAAAAATGGTAGACGCAAT

Product: putative signal peptidase I

Products: NA

Alternate protein names: SPase I-2; Leader peptidase I-2 [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MVKELIELGKSILIAIIAAFFIITFIFETVSVDGHSMYPTLNNRDRLIVEKVTYYFREPKKGDIVVIKYPKNPKEKFIKR
VIATGGDRVRVEDNKVYVNDEPKDENYIFEQNMEDFHEVKIPEGTIFVMGDNRNNSLDSRDERVGFVKLNMVVGKATLRI
YPFKKWGMLSAITN

Sequences:

>Translated_174_residues
MVKELIELGKSILIAIIAAFFIITFIFETVSVDGHSMYPTLNNRDRLIVEKVTYYFREPKKGDIVVIKYPKNPKEKFIKR
VIATGGDRVRVEDNKVYVNDEPKDENYIFEQNMEDFHEVKIPEGTIFVMGDNRNNSLDSRDERVGFVKLNMVVGKATLRI
YPFKKWGMLSAITN
>Mature_174_residues
MVKELIELGKSILIAIIAAFFIITFIFETVSVDGHSMYPTLNNRDRLIVEKVTYYFREPKKGDIVVIKYPKNPKEKFIKR
VIATGGDRVRVEDNKVYVNDEPKDENYIFEQNMEDFHEVKIPEGTIFVMGDNRNNSLDSRDERVGFVKLNMVVGKATLRI
YPFKKWGMLSAITN

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Homo sapiens, GI21450679, Length=167, Percent_Identity=29.3413173652695, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI14211845, Length=168, Percent_Identity=30.952380952381, Blast_Score=71, Evalue=4e-13,
Organism=Escherichia coli, GI1788921, Length=96, Percent_Identity=35.4166666666667, Blast_Score=63, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24656387, Length=167, Percent_Identity=28.7425149700599, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20187; Mature: 20187

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKELIELGKSILIAIIAAFFIITFIFETVSVDGHSMYPTLNNRDRLIVEKVTYYFREPK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCEEHHHHHHHHHCCCC
KGDIVVIKYPKNPKEKFIKRVIATGGDRVRVEDNKVYVNDEPKDENYIFEQNMEDFHEVK
CCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCEEECCCCCHHHHEE
IPEGTIFVMGDNRNNSLDSRDERVGFVKLNMVVGKATLRIYPFKKWGMLSAITN
CCCCEEEEEECCCCCCCCCHHHEEEEEEEEEEEEEEEEEEEECHHCCCHHHCCC
>Mature Secondary Structure
MVKELIELGKSILIAIIAAFFIITFIFETVSVDGHSMYPTLNNRDRLIVEKVTYYFREPK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCEEHHHHHHHHHCCCC
KGDIVVIKYPKNPKEKFIKRVIATGGDRVRVEDNKVYVNDEPKDENYIFEQNMEDFHEVK
CCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCEEECCCCCHHHHEE
IPEGTIFVMGDNRNNSLDSRDERVGFVKLNMVVGKATLRIYPFKKWGMLSAITN
CCCCEEEEEECCCCCCCCCHHHEEEEEEEEEEEEEEEEEEEECHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]