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The map label for this gene is ffh [H]

Identifier: 28210935

GI number: 28210935

Start: 1338662

End: 1340017

Strand: Direct

Name: ffh [H]

Synonym: CTC01249

Alternate gene names: 28210935

Gene position: 1338662-1340017 (Clockwise)

Preceding gene: 28210934

Following gene: 28210936

Centisome position: 47.82

GC content: 32.45

Gene sequence:

>1356_bases
ATGGCATTTGATGGGTTAGCCTCTAAATTGCAGGAAACCTTTAAGAAACTTAGAGGTAAGGGAAAGCTTTCCGAAAAAGA
TATAAAAGAGGCTATGAGAGAAGTTAGATTGGCTCTTTTAGAAGCAGATGTTAACTATAAAATAGTTAAAGACTTTGTTA
AAAGTGTAAGTGAAAAGTGTAATGGTAAAGAGGTTTTAGAAAGTCTTACTCCAGGGCAACAAGTAGTTAAAATCGTAAAC
GACGAATTAATAGAACTTATGGGGAGTAAGGAAAGTGAAATAAACTTTGAAGCCAATAAACCTACAGTAATAATGTTAGT
TGGTCTTCAAGGGGCAGGTAAAACTACCATGGCAGGTAAACTTGCTTTGCAACTTAGAAAAAAGAACAAGAAACCTTTAT
TAGTAGCTTGCGACATATATAGACCTGCGGCAATAAAGCAATTACAGGTTGTAGGAAGTCAAATTGATGTTCCAGTATTT
ACACTGGGAGATAAAACAAATCCTGTAGATATATCTAAAGCTGCAATAAAACATGCAAAGGAAAACAATTTAAATACTAT
AATTATAGATACAGCAGGACGACTTCATATTGATGAAAATCTAATGGATGAATTAAAATCTATTAAAGAAAACATAGAGC
CTAATGAAGTTTTGCTAGTAGTGGATTCTATGACAGGACAGGATGCTATAAATGTAGCTGAAAGCTTTAATGAAAAGTTA
AATATAAGTGGAGTTATCCTAACAAAACTTGATGGTGATACCAGAGGTGGTGCTGCATTATCAATTAAAGCAATGACAGG
AAAGCCTATAAAGTTTATAGGTATTGGAGAAAAAATGAATGACCTAGAAGTGTTCTATCCTGAAAGGATGGCATCAAGAA
TTCTAGGCATGGGAGATGTACTAAGCCTTATTGAAAAAGCTGAACAAGAAATTGATAAAGATGAAGCTGAAAAAATAGGT
AGTAGAATAATGAACCAAGAGTTCAACTTAGAAGATTTCCTTTCTGCAATGCAGCAAATGAAAAAATTAGGACCACTAAA
TAAATTAGTGGAAATGCTACCAGGTGCCAATAGTAAAGAACTTAAAGGTATTGACTTTGATAAAGGTGAAAAAGATCTTA
AAAGAATAGAATCAATTATAAGTTCTATGACAATAAAAGAAAGAAAAAACCCTTCATTAGTAAGTGGTTCTCCTACTAGA
AAAAAAAGAATTGCTAATGGTTCTGGTACCACAGTTCAGCAGGTAAACAAAATTTTAAAAGACTTTGAAAACATGAGAAA
AATGATGAAGCAAATGAATGGAATACAAAAAGGATTTAAGAAAAAGAAAGGTCTTTTTGGAAAGTTTCCATTTTAA

Upstream 100 bases:

>100_bases
ATAAACTAGACTATTTAAAAGAAAACTGTAAGGAAGAAGAACTACAGAAGTTAATAGAAGAATTAAAAAATGAATTAAAT
AATAGTTTAGGAGGTTAGAT

Downstream 100 bases:

>100_bases
TATAATAATTAATTCTATTTAAAGGAGGTGAAAAGTAAAATGGCAGTAAAGATAAGATTAAGAAGAATGGGTGCTAAAAA
AGCTCCTTTCTACAGAGTAA

Product: signal recognition particle, subunit ffh/srp54

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MAFDGLASKLQETFKKLRGKGKLSEKDIKEAMREVRLALLEADVNYKIVKDFVKSVSEKCNGKEVLESLTPGQQVVKIVN
DELIELMGSKESEINFEANKPTVIMLVGLQGAGKTTMAGKLALQLRKKNKKPLLVACDIYRPAAIKQLQVVGSQIDVPVF
TLGDKTNPVDISKAAIKHAKENNLNTIIIDTAGRLHIDENLMDELKSIKENIEPNEVLLVVDSMTGQDAINVAESFNEKL
NISGVILTKLDGDTRGGAALSIKAMTGKPIKFIGIGEKMNDLEVFYPERMASRILGMGDVLSLIEKAEQEIDKDEAEKIG
SRIMNQEFNLEDFLSAMQQMKKLGPLNKLVEMLPGANSKELKGIDFDKGEKDLKRIESIISSMTIKERKNPSLVSGSPTR
KKRIANGSGTTVQQVNKILKDFENMRKMMKQMNGIQKGFKKKKGLFGKFPF

Sequences:

>Translated_451_residues
MAFDGLASKLQETFKKLRGKGKLSEKDIKEAMREVRLALLEADVNYKIVKDFVKSVSEKCNGKEVLESLTPGQQVVKIVN
DELIELMGSKESEINFEANKPTVIMLVGLQGAGKTTMAGKLALQLRKKNKKPLLVACDIYRPAAIKQLQVVGSQIDVPVF
TLGDKTNPVDISKAAIKHAKENNLNTIIIDTAGRLHIDENLMDELKSIKENIEPNEVLLVVDSMTGQDAINVAESFNEKL
NISGVILTKLDGDTRGGAALSIKAMTGKPIKFIGIGEKMNDLEVFYPERMASRILGMGDVLSLIEKAEQEIDKDEAEKIG
SRIMNQEFNLEDFLSAMQQMKKLGPLNKLVEMLPGANSKELKGIDFDKGEKDLKRIESIISSMTIKERKNPSLVSGSPTR
KKRIANGSGTTVQQVNKILKDFENMRKMMKQMNGIQKGFKKKKGLFGKFPF
>Mature_450_residues
AFDGLASKLQETFKKLRGKGKLSEKDIKEAMREVRLALLEADVNYKIVKDFVKSVSEKCNGKEVLESLTPGQQVVKIVND
ELIELMGSKESEINFEANKPTVIMLVGLQGAGKTTMAGKLALQLRKKNKKPLLVACDIYRPAAIKQLQVVGSQIDVPVFT
LGDKTNPVDISKAAIKHAKENNLNTIIIDTAGRLHIDENLMDELKSIKENIEPNEVLLVVDSMTGQDAINVAESFNEKLN
ISGVILTKLDGDTRGGAALSIKAMTGKPIKFIGIGEKMNDLEVFYPERMASRILGMGDVLSLIEKAEQEIDKDEAEKIGS
RIMNQEFNLEDFLSAMQQMKKLGPLNKLVEMLPGANSKELKGIDFDKGEKDLKRIESIISSMTIKERKNPSLVSGSPTRK
KRIANGSGTTVQQVNKILKDFENMRKMMKQMNGIQKGFKKKKGLFGKFPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=443, Percent_Identity=31.8284424379233, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI226371618, Length=381, Percent_Identity=32.0209973753281, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI89061728, Length=151, Percent_Identity=39.0728476821192, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI295424842, Length=301, Percent_Identity=26.578073089701, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI23308697, Length=301, Percent_Identity=26.578073089701, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=50.5854800936768, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1789874, Length=250, Percent_Identity=36.4, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17539958, Length=447, Percent_Identity=29.5302013422819, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI193206261, Length=293, Percent_Identity=31.0580204778157, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325345, Length=415, Percent_Identity=33.9759036144578, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320498, Length=320, Percent_Identity=28.125, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17647949, Length=444, Percent_Identity=30.6306306306306, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24641198, Length=307, Percent_Identity=27.3615635179153, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49985; Mature: 49854

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDGLASKLQETFKKLRGKGKLSEKDIKEAMREVRLALLEADVNYKIVKDFVKSVSEKC
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
NGKEVLESLTPGQQVVKIVNDELIELMGSKESEINFEANKPTVIMLVGLQGAGKTTMAGK
CHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHH
LALQLRKKNKKPLLVACDIYRPAAIKQLQVVGSQIDVPVFTLGDKTNPVDISKAAIKHAK
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHH
ENNLNTIIIDTAGRLHIDENLMDELKSIKENIEPNEVLLVVDSMTGQDAINVAESFNEKL
CCCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCC
NISGVILTKLDGDTRGGAALSIKAMTGKPIKFIGIGEKMNDLEVFYPERMASRILGMGDV
CCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCEECHHHHHHHHCCHHHH
LSLIEKAEQEIDKDEAEKIGSRIMNQEFNLEDFLSAMQQMKKLGPLNKLVEMLPGANSKE
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
LKGIDFDKGEKDLKRIESIISSMTIKERKNPSLVSGSPTRKKRIANGSGTTVQQVNKILK
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHH
DFENMRKMMKQMNGIQKGFKKKKGLFGKFPF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AFDGLASKLQETFKKLRGKGKLSEKDIKEAMREVRLALLEADVNYKIVKDFVKSVSEKC
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
NGKEVLESLTPGQQVVKIVNDELIELMGSKESEINFEANKPTVIMLVGLQGAGKTTMAGK
CHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHH
LALQLRKKNKKPLLVACDIYRPAAIKQLQVVGSQIDVPVFTLGDKTNPVDISKAAIKHAK
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHH
ENNLNTIIIDTAGRLHIDENLMDELKSIKENIEPNEVLLVVDSMTGQDAINVAESFNEKL
CCCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCC
NISGVILTKLDGDTRGGAALSIKAMTGKPIKFIGIGEKMNDLEVFYPERMASRILGMGDV
CCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCEECHHHHHHHHCCHHHH
LSLIEKAEQEIDKDEAEKIGSRIMNQEFNLEDFLSAMQQMKKLGPLNKLVEMLPGANSKE
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
LKGIDFDKGEKDLKRIESIISSMTIKERKNPSLVSGSPTRKKRIANGSGTTVQQVNKILK
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHH
DFENMRKMMKQMNGIQKGFKKKKGLFGKFPF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]