Click here to switch to the map view.

The map label for this gene is rnc

Identifier: 28210930

GI number: 28210930

Start: 1331154

End: 1331861

Strand: Direct

Name: rnc

Synonym: CTC01243

Alternate gene names: 28210930

Gene position: 1331154-1331861 (Clockwise)

Preceding gene: 28210929

Following gene: 28210931

Centisome position: 47.55

GC content: 26.69

Gene sequence:

>708_bases
ATGAATAAATACATGGATTTGAAAGATCTTCAAAATAAAATAGAAATAAAATTTGAAAATATAAAGTTATTACATATAGC
TCTAACTCATAGTTCATATGCAAATGAAAAAAAGAGAATACAATACAATGAAAGACTAGAATTTTTGGGTGATTCTGTAC
TACAATTAGTTATAACGGAATATTTATTTATGAACTATAAGGATAAATCAGAAGGAGAGCTTTCAAAAAAAAGGGCTTTA
ATCGTATGTGAGAATTCCTTATTTAGTATAGCTAAAAATTTGGAATTAGGAGAATATATAAAGATGAGCAAAGGAGAAGA
ACTAACAGGTGGTAGAGAAAGAATCTCTATTTTAGCAGATGCTGTAGAGGCATTAATCGCTTCTATATATTTAGACAAAG
GTATTGATGTAGTTCGAGAGTTTATATTAAAAAATTTTTATAATATAGTTGAAAAGGCCATGAAGGATGAGATAATACTT
GATTATAAAACTAAACTACAGGAAATAATTCAAAAAGATGGAGACATACAAATAAATTATATTCTCATAAAACATGAAGG
ACCACCCCATAGAAGAAAATTTTATACAGAAGTAAAAATAAAAGATAATGTATTAGGTTATGGTATAGGATACAGCAAAA
AAGAATCAGAACAAAATGCTGCTAAAAAAGCCATAGAAAATATGGAGGTTAATAAAGAATATGAGTAA

Upstream 100 bases:

>100_bases
GCTTTAAATTTATTTTAAGAAAATCTAAGTTTATTGTTGAATTTGTTAATCCTAGCAAATTGAATAATAAACTTCTTTAT
TTAAAAGGAGTTTTAGAATT

Downstream 100 bases:

>100_bases
AAAACATTATATAATTCCTATTTTCGTTCCTCATGAAGGATGCGTTCATAACTGTGTGTTTTGTAATCAGAACTCAATAA
CGGGAATAAGTGAAGTAATA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MNKYMDLKDLQNKIEIKFENIKLLHIALTHSSYANEKKRIQYNERLEFLGDSVLQLVITEYLFMNYKDKSEGELSKKRAL
IVCENSLFSIAKNLELGEYIKMSKGEELTGGRERISILADAVEALIASIYLDKGIDVVREFILKNFYNIVEKAMKDEIIL
DYKTKLQEIIQKDGDIQINYILIKHEGPPHRRKFYTEVKIKDNVLGYGIGYSKKESEQNAAKKAIENMEVNKEYE

Sequences:

>Translated_235_residues
MNKYMDLKDLQNKIEIKFENIKLLHIALTHSSYANEKKRIQYNERLEFLGDSVLQLVITEYLFMNYKDKSEGELSKKRAL
IVCENSLFSIAKNLELGEYIKMSKGEELTGGRERISILADAVEALIASIYLDKGIDVVREFILKNFYNIVEKAMKDEIIL
DYKTKLQEIIQKDGDIQINYILIKHEGPPHRRKFYTEVKIKDNVLGYGIGYSKKESEQNAAKKAIENMEVNKEYE
>Mature_235_residues
MNKYMDLKDLQNKIEIKFENIKLLHIALTHSSYANEKKRIQYNERLEFLGDSVLQLVITEYLFMNYKDKSEGELSKKRAL
IVCENSLFSIAKNLELGEYIKMSKGEELTGGRERISILADAVEALIASIYLDKGIDVVREFILKNFYNIVEKAMKDEIIL
DYKTKLQEIIQKDGDIQINYILIKHEGPPHRRKFYTEVKIKDNVLGYGIGYSKKESEQNAAKKAIENMEVNKEYE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=227, Percent_Identity=31.2775330396476, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI155030236, Length=227, Percent_Identity=31.2775330396476, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1788920, Length=202, Percent_Identity=36.1386138613861, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17506883, Length=228, Percent_Identity=29.3859649122807, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193202651, Length=228, Percent_Identity=29.3859649122807, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137682, Length=236, Percent_Identity=29.6610169491525, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_CLOTE (Q895M9)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781874.1
- ProteinModelPortal:   Q895M9
- SMR:   Q895M9
- GeneID:   1059341
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC01243
- NMPDR:   fig|212717.1.peg.1096
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q895M9
- ProtClustDB:   PRK00102
- BioCyc:   CTET212717:CTC_01243-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27387; Mature: 27387

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKYMDLKDLQNKIEIKFENIKLLHIALTHSSYANEKKRIQYNERLEFLGDSVLQLVITE
CCCCCCHHHHHHHEEEEECCEEEEEEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YLFMNYKDKSEGELSKKRALIVCENSLFSIAKNLELGEYIKMSKGEELTGGRERISILAD
HHHHCCCCCCCCCHHHCEEEEEECCHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHH
AVEALIASIYLDKGIDVVREFILKNFYNIVEKAMKDEIILDYKTKLQEIIQKDGDIQINY
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHCCCCEEEEE
ILIKHEGPPHRRKFYTEVKIKDNVLGYGIGYSKKESEQNAAKKAIENMEVNKEYE
EEEECCCCCHHHHEEEEEEEECCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNKYMDLKDLQNKIEIKFENIKLLHIALTHSSYANEKKRIQYNERLEFLGDSVLQLVITE
CCCCCCHHHHHHHEEEEECCEEEEEEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YLFMNYKDKSEGELSKKRALIVCENSLFSIAKNLELGEYIKMSKGEELTGGRERISILAD
HHHHCCCCCCCCCHHHCEEEEEECCHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHH
AVEALIASIYLDKGIDVVREFILKNFYNIVEKAMKDEIILDYKTKLQEIIQKDGDIQINY
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHCCCCEEEEE
ILIKHEGPPHRRKFYTEVKIKDNVLGYGIGYSKKESEQNAAKKAIENMEVNKEYE
EEEECCCCCHHHHEEEEEEEECCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129