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The map label for this gene is lepA [H]

Identifier: 28210762

GI number: 28210762

Start: 1130388

End: 1132214

Strand: Direct

Name: lepA [H]

Synonym: CTC01060

Alternate gene names: 28210762

Gene position: 1130388-1132214 (Clockwise)

Preceding gene: 28210761

Following gene: 28210763

Centisome position: 40.38

GC content: 31.96

Gene sequence:

>1827_bases
ATGGAATTATTTACAAGAAATGACATTAGGAATATAGCAATAATTGCTCACGTTGATCATGGTAAAACTACTTTAGTAGA
TGCTATGCTTAAAGAAAGTCACGTTTTCAGAGAAAACGAAAAAGTTGAAGAAAGAGTAATGGATTCTAATGATCTAGAAA
GAGAAAGAGGAATTACTATACTTTCAAAAAATACATCTGTAATGTATGATGGAGTTAAAATAAATATAATAGATACTCCA
GGTCACGCGGACTTTGGAGGAGAAGTTGAACGTGTTCTTAAGATGGTAGATAGTGTACTTTTAGTTGTAGATTCTTATGA
AGGACCTATGCCACAAACAAAATTTGTTTTAAAAAAGGCATTAGAGCTTGATTTAAAACCAATAGTTGTAATAAATAAAA
TAGATAGACCAGATGCTAGAGCAGAAGATGTTTTAGATGAAATTTTCGATTTGTTTGTAGAATTAGGAGCTTCTGATGAC
CAATTGGATTTTCCTGTAGTATATTGTTCTGCTAGAAGTGGAATAGCAAAAAAACAATTGGAAGATGAAGCAGAAAATAT
GATACCATTATTCGACACAATAATAAAAAATGTAAAAGCACCAGAAGGATATATAGATAAACCATTCCAAATTCTTATAA
CAACAATAGATTCTAATGAATATGTAGGTAGAATTGGAGTAGGTAAAGTTGAAAGAGGTGTTGTTAAGCGTAATCAACAG
GCAGCACTTATGAGAAAAGATGGCAAAATAGATAATGTTAAGATAAGTAAACTATATACTTATAGCGGATTACAAAGAGA
AGAAACAGAAGAAGCTAAAATTGGAGATATTGTTGCAGTTGCAGGAATAGATGATATAAACATAGGAGAAACCCTAGCAG
ATATACAAAATCCTGAAGCTCTTCCTTTTGTAGAGATAGATGAACCGACTCTTACAATGAATTTCATGGTAAATGACTCA
CCTTTTGCAGGAAAAGAAGGAGATTATTTAACTTCAAGACATTTAAGAGATAGACTATTGAAAGAGTTGGAGACTAATGT
AAGTTTAAAAGTAGAAGAAACTGATTCAGCAGATTGCTTTAAGGTTAGCGGTAGAGGGGAGTTACATCTTTCTGTACTTA
TTGAAACTATGAGAAGACAAGGATATGAATTTCAAGTTTCAAAACCAAGCGTAATATTTAAAGAAGAAGATGGTAAAAAG
TTAGAACCAATAGAATACTTAACTATAGATGTTCCAGAAGAGTATATGGGAACAGTAATGGAAAAACTAGGACCTAGAAA
AGGAGATATGGTGAACATGACTTCTGCATTGAATGGATATTCAAGACTAGAATTTAGAATACCTGCAAGAGGATTAATAG
GTTTTAGAAGTGAATTTATGACAGATACTAGAGGAAACGGTATAATGAATCATATTTTTGATGGATATGAACCTTATAAA
GGAGAAATGCCAAGTAAACCAAGAGGATCTCTAGTAGTATTTGAAACTGGTACAGCAATAACTTATGGACTGTATAATGC
TCAAGAAAGAGGAGAATTATTCATAGGACCAGGAACTGAAGTTTACCAAGGTATGATAGCAGGAGAATATTCAAGAGCTG
GGGATATAGAAGTAAATGTATGTAAGAAGAAACATTTAAGTAATACAAGATCATCAGGAGCAGATGATGCATTAAAATTA
ACACCAATTACTCCTATGTCTTTAGAAGAATGTTTGGAATTTATAGCTGCAGATGAATTAGTTGAAGTCACACCTATTAG
TATAAGGATGAGAAAGAAAATATTAGATCCTGATAAAAGAAAAAGGGCACAAATGAGAAAAAAATAA

Upstream 100 bases:

>100_bases
TTTAGGAGTAGAATATTAGAATTAGTATGGTAGAAATATAGGTTGGATACTACGAAGTATCCAATTTTTTTGAGACAAAT
TTAAAATTGGAGGAACATAT

Downstream 100 bases:

>100_bases
GATTAAGAGGATGAGTTATGGGAAAAAGGAAAAAAATGGGGATAATAATACCTGTGGTCTTTTGTATAATAGCTTTATCT
ATTATAGGAACCGTTACTTA

Product: GTP-binding protein lepA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MELFTRNDIRNIAIIAHVDHGKTTLVDAMLKESHVFRENEKVEERVMDSNDLERERGITILSKNTSVMYDGVKINIIDTP
GHADFGGEVERVLKMVDSVLLVVDSYEGPMPQTKFVLKKALELDLKPIVVINKIDRPDARAEDVLDEIFDLFVELGASDD
QLDFPVVYCSARSGIAKKQLEDEAENMIPLFDTIIKNVKAPEGYIDKPFQILITTIDSNEYVGRIGVGKVERGVVKRNQQ
AALMRKDGKIDNVKISKLYTYSGLQREETEEAKIGDIVAVAGIDDINIGETLADIQNPEALPFVEIDEPTLTMNFMVNDS
PFAGKEGDYLTSRHLRDRLLKELETNVSLKVEETDSADCFKVSGRGELHLSVLIETMRRQGYEFQVSKPSVIFKEEDGKK
LEPIEYLTIDVPEEYMGTVMEKLGPRKGDMVNMTSALNGYSRLEFRIPARGLIGFRSEFMTDTRGNGIMNHIFDGYEPYK
GEMPSKPRGSLVVFETGTAITYGLYNAQERGELFIGPGTEVYQGMIAGEYSRAGDIEVNVCKKKHLSNTRSSGADDALKL
TPITPMSLEECLEFIAADELVEVTPISIRMRKKILDPDKRKRAQMRKK

Sequences:

>Translated_608_residues
MELFTRNDIRNIAIIAHVDHGKTTLVDAMLKESHVFRENEKVEERVMDSNDLERERGITILSKNTSVMYDGVKINIIDTP
GHADFGGEVERVLKMVDSVLLVVDSYEGPMPQTKFVLKKALELDLKPIVVINKIDRPDARAEDVLDEIFDLFVELGASDD
QLDFPVVYCSARSGIAKKQLEDEAENMIPLFDTIIKNVKAPEGYIDKPFQILITTIDSNEYVGRIGVGKVERGVVKRNQQ
AALMRKDGKIDNVKISKLYTYSGLQREETEEAKIGDIVAVAGIDDINIGETLADIQNPEALPFVEIDEPTLTMNFMVNDS
PFAGKEGDYLTSRHLRDRLLKELETNVSLKVEETDSADCFKVSGRGELHLSVLIETMRRQGYEFQVSKPSVIFKEEDGKK
LEPIEYLTIDVPEEYMGTVMEKLGPRKGDMVNMTSALNGYSRLEFRIPARGLIGFRSEFMTDTRGNGIMNHIFDGYEPYK
GEMPSKPRGSLVVFETGTAITYGLYNAQERGELFIGPGTEVYQGMIAGEYSRAGDIEVNVCKKKHLSNTRSSGADDALKL
TPITPMSLEECLEFIAADELVEVTPISIRMRKKILDPDKRKRAQMRKK
>Mature_608_residues
MELFTRNDIRNIAIIAHVDHGKTTLVDAMLKESHVFRENEKVEERVMDSNDLERERGITILSKNTSVMYDGVKINIIDTP
GHADFGGEVERVLKMVDSVLLVVDSYEGPMPQTKFVLKKALELDLKPIVVINKIDRPDARAEDVLDEIFDLFVELGASDD
QLDFPVVYCSARSGIAKKQLEDEAENMIPLFDTIIKNVKAPEGYIDKPFQILITTIDSNEYVGRIGVGKVERGVVKRNQQ
AALMRKDGKIDNVKISKLYTYSGLQREETEEAKIGDIVAVAGIDDINIGETLADIQNPEALPFVEIDEPTLTMNFMVNDS
PFAGKEGDYLTSRHLRDRLLKELETNVSLKVEETDSADCFKVSGRGELHLSVLIETMRRQGYEFQVSKPSVIFKEEDGKK
LEPIEYLTIDVPEEYMGTVMEKLGPRKGDMVNMTSALNGYSRLEFRIPARGLIGFRSEFMTDTRGNGIMNHIFDGYEPYK
GEMPSKPRGSLVVFETGTAITYGLYNAQERGELFIGPGTEVYQGMIAGEYSRAGDIEVNVCKKKHLSNTRSSGADDALKL
TPITPMSLEECLEFIAADELVEVTPISIRMRKKILDPDKRKRAQMRKK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=481, Percent_Identity=28.2744282744283, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=43.609022556391, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=38.0952380952381, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI18390331, Length=145, Percent_Identity=41.3793103448276, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI34147630, Length=267, Percent_Identity=29.5880149812734, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI25306283, Length=142, Percent_Identity=38.0281690140845, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI19923640, Length=160, Percent_Identity=36.25, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI25306287, Length=160, Percent_Identity=36.25, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=39.6396396396396, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=39.6396396396396, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=39.6396396396396, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=37.5, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=37.5, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI53729339, Length=145, Percent_Identity=32.4137931034483, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI53729337, Length=145, Percent_Identity=32.4137931034483, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI48994988, Length=601, Percent_Identity=56.0732113144759, Blast_Score=686, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=504, Percent_Identity=28.968253968254, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1789738, Length=151, Percent_Identity=38.4105960264901, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1790412, Length=301, Percent_Identity=31.8936877076412, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789737, Length=301, Percent_Identity=31.8936877076412, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=31.0344827586207, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17557151, Length=521, Percent_Identity=27.831094049904, Blast_Score=142, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI71988811, Length=128, Percent_Identity=41.40625, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=41.40625, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=39.4366197183099, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17506493, Length=175, Percent_Identity=33.7142857142857, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17533571, Length=144, Percent_Identity=43.0555555555556, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17556456, Length=277, Percent_Identity=29.6028880866426, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=35.0746268656716, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI25141371, Length=276, Percent_Identity=26.8115942028986, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994658, Length=232, Percent_Identity=29.3103448275862, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532067, Length=269, Percent_Identity=27.8810408921933, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532065, Length=269, Percent_Identity=27.8810408921933, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=517, Percent_Identity=27.4661508704062, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324707, Length=146, Percent_Identity=41.7808219178082, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=146, Percent_Identity=41.7808219178082, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324761, Length=275, Percent_Identity=29.8181818181818, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323098, Length=179, Percent_Identity=37.4301675977654, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=38.9261744966443, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=38.0281690140845, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324550, Length=168, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78706572, Length=516, Percent_Identity=24.6124031007752, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI28574573, Length=156, Percent_Identity=39.7435897435897, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281363316, Length=316, Percent_Identity=28.7974683544304, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17864358, Length=316, Percent_Identity=28.7974683544304, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585711, Length=167, Percent_Identity=34.7305389221557, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585713, Length=167, Percent_Identity=34.7305389221557, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585709, Length=167, Percent_Identity=34.7305389221557, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24582462, Length=146, Percent_Identity=41.7808219178082, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21357743, Length=171, Percent_Identity=35.672514619883, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI221458488, Length=160, Percent_Identity=40, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19921738, Length=252, Percent_Identity=28.968253968254, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28572034, Length=279, Percent_Identity=24.0143369175627, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550900, Length=325, Percent_Identity=25.8461538461538, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 68347; Mature: 68347

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELFTRNDIRNIAIIAHVDHGKTTLVDAMLKESHVFRENEKVEERVMDSNDLERERGITI
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHCCCEE
LSKNTSVMYDGVKINIIDTPGHADFGGEVERVLKMVDSVLLVVDSYEGPMPQTKFVLKKA
EECCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHH
LELDLKPIVVINKIDRPDARAEDVLDEIFDLFVELGASDDQLDFPVVYCSARSGIAKKQL
HHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHH
EDEAENMIPLFDTIIKNVKAPEGYIDKPFQILITTIDSNEYVGRIGVGKVERGVVKRNQQ
HHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEECCCCHHHHHHHHCCCH
AALMRKDGKIDNVKISKLYTYSGLQREETEEAKIGDIVAVAGIDDINIGETLADIQNPEA
HHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCCCC
LPFVEIDEPTLTMNFMVNDSPFAGKEGDYLTSRHLRDRLLKELETNVSLKVEETDSADCF
CCEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEE
KVSGRGELHLSVLIETMRRQGYEFQVSKPSVIFKEEDGKKLEPIEYLTIDVPEEYMGTVM
EECCCCCEEHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCEEEEEEECCHHHHHHHH
EKLGPRKGDMVNMTSALNGYSRLEFRIPARGLIGFRSEFMTDTRGNGIMNHIFDGYEPYK
HHHCCCCCCEEEHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCC
GEMPSKPRGSLVVFETGTAITYGLYNAQERGELFIGPGTEVYQGMIAGEYSRAGDIEVNV
CCCCCCCCCCEEEEECCCEEEEEECCCCCCCCEEECCCHHHHHHHHHCCCCCCCCEEEEE
CKKKHLSNTRSSGADDALKLTPITPMSLEECLEFIAADELVEVTPISIRMRKKILDPDKR
EHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEECCHHHHHHHHHCCCCHH
KRAQMRKK
HHHHHCCC
>Mature Secondary Structure
MELFTRNDIRNIAIIAHVDHGKTTLVDAMLKESHVFRENEKVEERVMDSNDLERERGITI
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHCCCEE
LSKNTSVMYDGVKINIIDTPGHADFGGEVERVLKMVDSVLLVVDSYEGPMPQTKFVLKKA
EECCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHH
LELDLKPIVVINKIDRPDARAEDVLDEIFDLFVELGASDDQLDFPVVYCSARSGIAKKQL
HHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHH
EDEAENMIPLFDTIIKNVKAPEGYIDKPFQILITTIDSNEYVGRIGVGKVERGVVKRNQQ
HHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEECCCCHHHHHHHHCCCH
AALMRKDGKIDNVKISKLYTYSGLQREETEEAKIGDIVAVAGIDDINIGETLADIQNPEA
HHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCCCC
LPFVEIDEPTLTMNFMVNDSPFAGKEGDYLTSRHLRDRLLKELETNVSLKVEETDSADCF
CCEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEE
KVSGRGELHLSVLIETMRRQGYEFQVSKPSVIFKEEDGKKLEPIEYLTIDVPEEYMGTVM
EECCCCCEEHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCEEEEEEECCHHHHHHHH
EKLGPRKGDMVNMTSALNGYSRLEFRIPARGLIGFRSEFMTDTRGNGIMNHIFDGYEPYK
HHHCCCCCCEEEHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCC
GEMPSKPRGSLVVFETGTAITYGLYNAQERGELFIGPGTEVYQGMIAGEYSRAGDIEVNV
CCCCCCCCCCEEEEECCCEEEEEECCCCCCCCEEECCCHHHHHHHHHCCCCCCCCEEEEE
CKKKHLSNTRSSGADDALKLTPITPMSLEECLEFIAADELVEVTPISIRMRKKILDPDKR
EHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEECCHHHHHHHHHCCCCHH
KRAQMRKK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]