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The map label for this gene is lctP [H]

Identifier: 28210680

GI number: 28210680

Start: 1038823

End: 1040343

Strand: Direct

Name: lctP [H]

Synonym: CTC00972

Alternate gene names: 28210680

Gene position: 1038823-1040343 (Clockwise)

Preceding gene: 28210679

Following gene: 28210681

Centisome position: 37.11

GC content: 33.33

Gene sequence:

>1521_bases
ATGAATAGTTATTTGTTATTTTTTATTGCCATGATACCTATTGTCTGTTTGATGGTTGCCTTAGGAGTTTTTAAAATCTC
TGCCCATAAAGCTTGTCCTGCGGTTTTGGTTATAACTTTTGTTTTGGCAATGCTATTTTGGAAAATGAGATTTATAGATG
CTTTTACTGCAATTTTAGAAGGGGGAGCTTTAGGATTATGGCCCATAATGTTGGTCATAATATCTGCAGTATTTATTTAC
AACGTATCCATAAAGACAGGGAGTATGGAAACCATAAAAAACATGATAACTGGTATTACTAATGATAAGCGCATATTAGT
ACTTATATTAGCTTGGGGTTTTGGGGGATTTCTAGAAGCAATTGCAGGCTTTGGAACAGCAGTTGCAATACCTGCAAGCA
TTATGGCAGCTTTGGGTTTTGATCCAGTTTTCGCGGCTATTATTTGTCTAATTGCCAATACTACACCTACAGCTTTTGGA
GCTATAGGAATACCTATTACAACTTTAGCAAAAATAACAGGACTAGATGTTAATATCTTAAGCTATGCTGTTGGTCTACA
ATTATCAGGACTAATAGTAATAGTACCTATACTTTTAGTTATGCTTGCTGGAAGAAGTGTAAAAGCTATAAAAGGAGTTT
TTGGAATATCCATTATGTCTGGACTAGCCTTTGCAATACCAGAAGTACTACTAGCTAAATACATGGGTGCAGAATTACCT
GCAATTGTAGGTAGTCTCTGTAGCATGATCGTTACAATTCTTATTGCAAAAACATTCTATAAAGACACAGCGATAAAAGA
AAATAAGATTCCTATGGAAGATATTCTACTATCATGGCTGTCCTTTATATTGGTTTTTGTATTCATATTATTTTCAAGTT
CATTATTCCCTACAATTAATAAACTACTCTCATCTGTAAGTACATCTTTAAATATATATACAGGACAAGATGCGGAACCA
TATACTTTTCTTTGGATAGCAACACCAGGAACACTTATTATAATTGCAACATTTATTGGAGGAGTGATTCAAGGAGCTAA
AGTTAAAGAGATATTTGATATTTTAGTAGGTACCTTTAAACAAATGAAAAATTCCTTTATAACTATTTTATCCATAGTGG
CATTAGCCAAAGTTATGGGATACAGTGGAATGATAAAATCAATAGCTGTAGTTTTAGTATTAATTACAGGAGACTTTTAT
CCATTATTTGCACCATTGATTGGAGCTTTAGGCACCTTTGTAACAGGAAGTGATACTTCAGCCAATGTATTATTTGGAGG
ATTACAAGTAGAAGTTGCAAATAGTCTTAACTTGAATCCTTATTGGCTAGCAGCGGCAAATACAGGAGGTGCAACAGCTG
GTAAAATGATATCGCCTCAAAGTATTGCAGTGGCAACAGCAGCAACTGGATTAGAAGGTACTGAAGGATATATTTTAAAA
GCTACACTAAAATTTTGTATATTTTACGTAGTAATTTTAGGACTAATATCTTATTTAGGAGGATCATTATTTAATATTTA
A

Upstream 100 bases:

>100_bases
TTTTTATTTTAAAATATATAGCAATGTTCTAAAAATTGTGATAATATATATTTAACTGGTACTATGGTATGACCAGTAAC
ATTAAATAAGGAGAGGTAAT

Downstream 100 bases:

>100_bases
ATGTAATAAAGAATATTAATTTAAATCTAAAAAATAGGGGGTATTAATATGAGAATATTGGTATGTATTAAACAAGTACC
TGGAACTTCTAAAGTGGAAG

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MNSYLLFFIAMIPIVCLMVALGVFKISAHKACPAVLVITFVLAMLFWKMRFIDAFTAILEGGALGLWPIMLVIISAVFIY
NVSIKTGSMETIKNMITGITNDKRILVLILAWGFGGFLEAIAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFG
AIGIPITTLAKITGLDVNILSYAVGLQLSGLIVIVPILLVMLAGRSVKAIKGVFGISIMSGLAFAIPEVLLAKYMGAELP
AIVGSLCSMIVTILIAKTFYKDTAIKENKIPMEDILLSWLSFILVFVFILFSSSLFPTINKLLSSVSTSLNIYTGQDAEP
YTFLWIATPGTLIIIATFIGGVIQGAKVKEIFDILVGTFKQMKNSFITILSIVALAKVMGYSGMIKSIAVVLVLITGDFY
PLFAPLIGALGTFVTGSDTSANVLFGGLQVEVANSLNLNPYWLAAANTGGATAGKMISPQSIAVATAATGLEGTEGYILK
ATLKFCIFYVVILGLISYLGGSLFNI

Sequences:

>Translated_506_residues
MNSYLLFFIAMIPIVCLMVALGVFKISAHKACPAVLVITFVLAMLFWKMRFIDAFTAILEGGALGLWPIMLVIISAVFIY
NVSIKTGSMETIKNMITGITNDKRILVLILAWGFGGFLEAIAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFG
AIGIPITTLAKITGLDVNILSYAVGLQLSGLIVIVPILLVMLAGRSVKAIKGVFGISIMSGLAFAIPEVLLAKYMGAELP
AIVGSLCSMIVTILIAKTFYKDTAIKENKIPMEDILLSWLSFILVFVFILFSSSLFPTINKLLSSVSTSLNIYTGQDAEP
YTFLWIATPGTLIIIATFIGGVIQGAKVKEIFDILVGTFKQMKNSFITILSIVALAKVMGYSGMIKSIAVVLVLITGDFY
PLFAPLIGALGTFVTGSDTSANVLFGGLQVEVANSLNLNPYWLAAANTGGATAGKMISPQSIAVATAATGLEGTEGYILK
ATLKFCIFYVVILGLISYLGGSLFNI
>Mature_506_residues
MNSYLLFFIAMIPIVCLMVALGVFKISAHKACPAVLVITFVLAMLFWKMRFIDAFTAILEGGALGLWPIMLVIISAVFIY
NVSIKTGSMETIKNMITGITNDKRILVLILAWGFGGFLEAIAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFG
AIGIPITTLAKITGLDVNILSYAVGLQLSGLIVIVPILLVMLAGRSVKAIKGVFGISIMSGLAFAIPEVLLAKYMGAELP
AIVGSLCSMIVTILIAKTFYKDTAIKENKIPMEDILLSWLSFILVFVFILFSSSLFPTINKLLSSVSTSLNIYTGQDAEP
YTFLWIATPGTLIIIATFIGGVIQGAKVKEIFDILVGTFKQMKNSFITILSIVALAKVMGYSGMIKSIAVVLVLITGDFY
PLFAPLIGALGTFVTGSDTSANVLFGGLQVEVANSLNLNPYWLAAANTGGATAGKMISPQSIAVATAATGLEGTEGYILK
ATLKFCIFYVVILGLISYLGGSLFNI

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=540, Percent_Identity=34.6296296296296, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1790031, Length=532, Percent_Identity=34.0225563909774, Blast_Score=254, Evalue=8e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 53598; Mature: 53598

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSYLLFFIAMIPIVCLMVALGVFKISAHKACPAVLVITFVLAMLFWKMRFIDAFTAILE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGALGLWPIMLVIISAVFIYNVSIKTGSMETIKNMITGITNDKRILVLILAWGFGGFLEA
CCCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCEEEEEEEHHCHHHHHHH
IAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFGAIGIPITTLAKITGLDVNIL
HHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHCCCCHHHH
SYAVGLQLSGLIVIVPILLVMLAGRSVKAIKGVFGISIMSGLAFAIPEVLLAKYMGAELP
HHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AIVGSLCSMIVTILIAKTFYKDTAIKENKIPMEDILLSWLSFILVFVFILFSSSLFPTIN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
KLLSSVSTSLNIYTGQDAEPYTFLWIATPGTLIIIATFIGGVIQGAKVKEIFDILVGTFK
HHHHHHHHCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
QMKNSFITILSIVALAKVMGYSGMIKSIAVVLVLITGDFYPLFAPLIGALGTFVTGSDTS
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
ANVLFGGLQVEVANSLNLNPYWLAAANTGGATAGKMISPQSIAVATAATGLEGTEGYILK
CCEEEECEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHH
ATLKFCIFYVVILGLISYLGGSLFNI
HHHHHHHHHHHHHHHHHHHCCHHCCC
>Mature Secondary Structure
MNSYLLFFIAMIPIVCLMVALGVFKISAHKACPAVLVITFVLAMLFWKMRFIDAFTAILE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGALGLWPIMLVIISAVFIYNVSIKTGSMETIKNMITGITNDKRILVLILAWGFGGFLEA
CCCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCEEEEEEEHHCHHHHHHH
IAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFGAIGIPITTLAKITGLDVNIL
HHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHCCCCHHHH
SYAVGLQLSGLIVIVPILLVMLAGRSVKAIKGVFGISIMSGLAFAIPEVLLAKYMGAELP
HHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AIVGSLCSMIVTILIAKTFYKDTAIKENKIPMEDILLSWLSFILVFVFILFSSSLFPTIN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
KLLSSVSTSLNIYTGQDAEPYTFLWIATPGTLIIIATFIGGVIQGAKVKEIFDILVGTFK
HHHHHHHHCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
QMKNSFITILSIVALAKVMGYSGMIKSIAVVLVLITGDFYPLFAPLIGALGTFVTGSDTS
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
ANVLFGGLQVEVANSLNLNPYWLAAANTGGATAGKMISPQSIAVATAATGLEGTEGYILK
CCEEEECEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHH
ATLKFCIFYVVILGLISYLGGSLFNI
HHHHHHHHHHHHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]