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The map label for this gene is pyrD [H]

Identifier: 28210641

GI number: 28210641

Start: 989533

End: 990438

Strand: Direct

Name: pyrD [H]

Synonym: CTC00930

Alternate gene names: 28210641

Gene position: 989533-990438 (Clockwise)

Preceding gene: 28210640

Following gene: 28210642

Centisome position: 35.35

GC content: 32.67

Gene sequence:

>906_bases
GTGAGTAGATTAGAAGTTGACTTTGCAGGAGTAAAATTTAAAAATCCTGTGGTATTAGCATCTGGAACTTGTGGTTTTGG
AAGAGAATATAGTGAAATATTTGATATAGAAAAGTTAGGTGGGCTGTCTTCTAAAGGACTTACACTAAATCCAAGAGCAG
GAAATGATGGAATAAGGGTATGGGAAACAGACAGTGGAATGATGAATAGTGTTGGACTTGAAAATCCAGGGGTAAAAGCC
TTTATAGAAAAGGATTTACATTGGATAAATAGTTTGAATATTGTGAATATAGTTAATCTAGGCGGACATTCTATGGATGA
TTATTTACAGGCAGTGGAGCTATTAAATAAAGAAAAAATAGACTTATTAGAATTAAATATATCTTGTCCAAACGTAAAAC
AGGGTGGAATGAATTTTGGTGTTAAGACAGATTTTGCAAGGGAAGTTGTAAGAAAAATAAGAGAAGTTTGTAAACATAAA
TTAGTTGTAAAACTTTCTCCAAATGCTGAAGATATAGTGGGAATAGCTAAAGTTTGTGAAGAAGAAGGGGCAAATGGAAT
ATCCCTTGTAAATACTTTTTTAGGACTTGCTATAGACATAAACAAAAGAAAATCTGTATTTAATAATGGCTATGCTGGAC
TTTCAGGTCCTGCCATAAAACCTATAGCTTTAAGAATGGTAAATCAAGTAGCTAAAGAATTAACTATACCTGTTATGGGA
CTTGGAGGAATCTCTACATGGCAGGATGCTATAGAATTTATAATGGCTGGTGCTACTACTGTTCAAGTTGGTACGGCATC
CTTTATGAAACCTGATATTTCAATAGACATAATACAAGGTATGGAAAAATACATGATAGATAACAATATTCAAAGTTTAG
ATGAAATAAGAGGGATTATAAAATAG

Upstream 100 bases:

>100_bases
TGGAGTTGGAGTTTGCCTAGTATGTACTTGTAAGACTAAAAAAGGGAATAAAAGAGCTTGTAAAGAAGGACCAGTATTTT
TAGGAGAGGATGTGTTTTAA

Downstream 100 bases:

>100_bases
CGCAATAAATCGTATTAACATATGAAGTACTTAGCTAAGTAAAAATTTAATGAAAGGAAGAATTTTAAAATATGCGGCAG
CCTGCAGTGAATGAGACTCC

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSRLEVDFAGVKFKNPVVLASGTCGFGREYSEIFDIEKLGGLSSKGLTLNPRAGNDGIRVWETDSGMMNSVGLENPGVKA
FIEKDLHWINSLNIVNIVNLGGHSMDDYLQAVELLNKEKIDLLELNISCPNVKQGGMNFGVKTDFAREVVRKIREVCKHK
LVVKLSPNAEDIVGIAKVCEEEGANGISLVNTFLGLAIDINKRKSVFNNGYAGLSGPAIKPIALRMVNQVAKELTIPVMG
LGGISTWQDAIEFIMAGATTVQVGTASFMKPDISIDIIQGMEKYMIDNNIQSLDEIRGIIK

Sequences:

>Translated_301_residues
MSRLEVDFAGVKFKNPVVLASGTCGFGREYSEIFDIEKLGGLSSKGLTLNPRAGNDGIRVWETDSGMMNSVGLENPGVKA
FIEKDLHWINSLNIVNIVNLGGHSMDDYLQAVELLNKEKIDLLELNISCPNVKQGGMNFGVKTDFAREVVRKIREVCKHK
LVVKLSPNAEDIVGIAKVCEEEGANGISLVNTFLGLAIDINKRKSVFNNGYAGLSGPAIKPIALRMVNQVAKELTIPVMG
LGGISTWQDAIEFIMAGATTVQVGTASFMKPDISIDIIQGMEKYMIDNNIQSLDEIRGIIK
>Mature_300_residues
SRLEVDFAGVKFKNPVVLASGTCGFGREYSEIFDIEKLGGLSSKGLTLNPRAGNDGIRVWETDSGMMNSVGLENPGVKAF
IEKDLHWINSLNIVNIVNLGGHSMDDYLQAVELLNKEKIDLLELNISCPNVKQGGMNFGVKTDFAREVVRKIREVCKHKL
VVKLSPNAEDIVGIAKVCEEEGANGISLVNTFLGLAIDINKRKSVFNNGYAGLSGPAIKPIALRMVNQVAKELTIPVMGL
GGISTWQDAIEFIMAGATTVQVGTASFMKPDISIDIIQGMEKYMIDNNIQSLDEIRGIIK

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=341, Percent_Identity=28.1524926686217, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI45006951, Length=295, Percent_Identity=26.7796610169492, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI87082059, Length=319, Percent_Identity=27.8996865203762, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787177, Length=287, Percent_Identity=26.8292682926829, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71984108, Length=291, Percent_Identity=28.8659793814433, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6322633, Length=316, Percent_Identity=29.1139240506329, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24640763, Length=297, Percent_Identity=27.6094276094276, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18858217, Length=297, Percent_Identity=27.6094276094276, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281361352, Length=290, Percent_Identity=30.3448275862069, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137316, Length=290, Percent_Identity=30.3448275862069, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32743; Mature: 32612

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLEVDFAGVKFKNPVVLASGTCGFGREYSEIFDIEKLGGLSSKGLTLNPRAGNDGIRV
CCCEEEEECCEEECCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEE
WETDSGMMNSVGLENPGVKAFIEKDLHWINSLNIVNIVNLGGHSMDDYLQAVELLNKEKI
EECCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCC
DLLELNISCPNVKQGGMNFGVKTDFAREVVRKIREVCKHKLVVKLSPNAEDIVGIAKVCE
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
EEGANGISLVNTFLGLAIDINKRKSVFNNGYAGLSGPAIKPIALRMVNQVAKELTIPVMG
HHCCCCHHHHHHHHHHEEECCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
LGGISTWQDAIEFIMAGATTVQVGTASFMKPDISIDIIQGMEKYMIDNNIQSLDEIRGII
CCCCHHHHHHHHHHHCCCCEEEECCHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHC
K
C
>Mature Secondary Structure 
SRLEVDFAGVKFKNPVVLASGTCGFGREYSEIFDIEKLGGLSSKGLTLNPRAGNDGIRV
CCEEEEECCEEECCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEE
WETDSGMMNSVGLENPGVKAFIEKDLHWINSLNIVNIVNLGGHSMDDYLQAVELLNKEKI
EECCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCC
DLLELNISCPNVKQGGMNFGVKTDFAREVVRKIREVCKHKLVVKLSPNAEDIVGIAKVCE
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
EEGANGISLVNTFLGLAIDINKRKSVFNNGYAGLSGPAIKPIALRMVNQVAKELTIPVMG
HHCCCCHHHHHHHHHHEEECCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
LGGISTWQDAIEFIMAGATTVQVGTASFMKPDISIDIIQGMEKYMIDNNIQSLDEIRGII
CCCCHHHHHHHHHHHCCCCEEEECCHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA