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The map label for this gene is srrA [H]

Identifier: 28210587

GI number: 28210587

Start: 926067

End: 926753

Strand: Direct

Name: srrA [H]

Synonym: CTC00872

Alternate gene names: 28210587

Gene position: 926067-926753 (Clockwise)

Preceding gene: 28210585

Following gene: 28210588

Centisome position: 33.08

GC content: 27.51

Gene sequence:

>687_bases
GTGAAAGAAAGTATTTTGATAATTGAAGATGAAGAAAAAGTATCTTCTGTATTAAAAGCTTATTTAGGGAAAGAAGGATA
TAAAGTTATTTCTACAACTAGTGGAATAGAAGGAATAGAAATATTTAAAAAAGGAAACTTTAAACTTATAATATTAGATT
TAATGCTTCCAGATATAGAAGGAGAAGAGGTATGTAAAATAATAAGAGGAATATCAGATGTATATATATTTATGTTGACA
GCTAAGGGAGATTTATCTAATAGAATAGAAGGTTTAAATATAGGAGGGGATGAGTATTTAGTAAAACCATTTAGTCCCAG
GGAATTAACTGCTAGAGTAAATGCACTTTTTAGAAGAATAGGTGGGGAAGATGAAGAAATTTTGAGTTTCAATAATGGGG
AATTAAAAATAAATAAAATAAAAAGAATAGTAGAAATAGAAAAAAGAGATGTAAAGCTAACTCCTAATGAATTTCAAATT
TTATATGCATTAGCTTCGAATAAAGGAAAGGTGTTTACTAGAGAAATGTTGATAAATTCAGCTCTAGGATTAGACTTTCA
AGGATTTGATAGAACTGTAGACGTACATGTAAAAAATATAAGAAAGAAAATAGAAAAGGATAGTAGAAATCCTAAGTACG
TATTAACAGTTACTAGAGTTGGATATAAATTTGGTGGTGAAAGTTAA

Upstream 100 bases:

>100_bases
TTCTTATGAAGATACTATGAAGAAAAATAAAGTATCTTCATAGTATCTTTATTTAACTATGGTATTATTTAAATATAAAA
TTAAATAGGAGGGTATACTT

Downstream 100 bases:

>100_bases
TGCATAGCATAAGAAAAAAAATACTTATATCAATCTTAATATGTTCTATATTTGGACTTATTATATCCTTTGCACTTATA
AATTTAAATGTAAATAAGAG

Product: two-component response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKESILIIEDEEKVSSVLKAYLGKEGYKVISTTSGIEGIEIFKKGNFKLIILDLMLPDIEGEEVCKIIRGISDVYIFMLT
AKGDLSNRIEGLNIGGDEYLVKPFSPRELTARVNALFRRIGGEDEEILSFNNGELKINKIKRIVEIEKRDVKLTPNEFQI
LYALASNKGKVFTREMLINSALGLDFQGFDRTVDVHVKNIRKKIEKDSRNPKYVLTVTRVGYKFGGES

Sequences:

>Translated_228_residues
MKESILIIEDEEKVSSVLKAYLGKEGYKVISTTSGIEGIEIFKKGNFKLIILDLMLPDIEGEEVCKIIRGISDVYIFMLT
AKGDLSNRIEGLNIGGDEYLVKPFSPRELTARVNALFRRIGGEDEEILSFNNGELKINKIKRIVEIEKRDVKLTPNEFQI
LYALASNKGKVFTREMLINSALGLDFQGFDRTVDVHVKNIRKKIEKDSRNPKYVLTVTRVGYKFGGES
>Mature_228_residues
MKESILIIEDEEKVSSVLKAYLGKEGYKVISTTSGIEGIEIFKKGNFKLIILDLMLPDIEGEEVCKIIRGISDVYIFMLT
AKGDLSNRIEGLNIGGDEYLVKPFSPRELTARVNALFRRIGGEDEEILSFNNGELKINKIKRIVEIEKRDVKLTPNEFQI
LYALASNKGKVFTREMLINSALGLDFQGFDRTVDVHVKNIRKKIEKDSRNPKYVLTVTRVGYKFGGES

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=35.5263157894737, Blast_Score=156, Evalue=9e-40,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=36.8888888888889, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=34.4827586206897, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=35.1598173515982, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=31.8777292576419, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=31.3636363636364, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=30.9734513274336, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=31.2217194570136, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=32.7354260089686, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=33.3333333333333, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790552, Length=205, Percent_Identity=35.609756097561, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787229, Length=213, Percent_Identity=32.8638497652582, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=28.936170212766, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=29.5964125560538, Blast_Score=87, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25811; Mature: 25811

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKESILIIEDEEKVSSVLKAYLGKEGYKVISTTSGIEGIEIFKKGNFKLIILDLMLPDIE
CCCCEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCEEEEEEEEECCCCC
GEEVCKIIRGISDVYIFMLTAKGDLSNRIEGLNIGGDEYLVKPFSPRELTARVNALFRRI
HHHHHHHHHCCCEEEEEEEEECCCCCCCCCEEECCCCCEEECCCCCHHHHHHHHHHHHHH
GGEDEEILSFNNGELKINKIKRIVEIEKRDVKLTPNEFQILYALASNKGKVFTREMLINS
CCCCCCEEEECCCCEEHHHHHHHHHHHCCCEEECCCCEEEEEEEECCCCCEEHHHHHHHH
ALGLDFQGFDRTVDVHVKNIRKKIEKDSRNPKYVLTVTRVGYKFGGES
HCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEEEECEECCCCC
>Mature Secondary Structure
MKESILIIEDEEKVSSVLKAYLGKEGYKVISTTSGIEGIEIFKKGNFKLIILDLMLPDIE
CCCCEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCEEEEEEEEECCCCC
GEEVCKIIRGISDVYIFMLTAKGDLSNRIEGLNIGGDEYLVKPFSPRELTARVNALFRRI
HHHHHHHHHCCCEEEEEEEEECCCCCCCCCEEECCCCCEEECCCCCHHHHHHHHHHHHHH
GGEDEEILSFNNGELKINKIKRIVEIEKRDVKLTPNEFQILYALASNKGKVFTREMLINS
CCCCCCEEEECCCCEEHHHHHHHHHHHCCCEEECCCCEEEEEEEECCCCCEEHHHHHHHH
ALGLDFQGFDRTVDVHVKNIRKKIEKDSRNPKYVLTVTRVGYKFGGES
HCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEEEECEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA