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The map label for this gene is patB [H]

Identifier: 28210542

GI number: 28210542

Start: 874260

End: 875438

Strand: Direct

Name: patB [H]

Synonym: CTC00825

Alternate gene names: 28210542

Gene position: 874260-875438 (Clockwise)

Preceding gene: 28210541

Following gene: 28210543

Centisome position: 31.23

GC content: 27.99

Gene sequence:

>1179_bases
ATGTATAATTTTGATGAAATAGTTGATAGAAGAAATACATCAGCCGTTAAATGGGATAAGCCTAAAATACTATACAACAG
AGATGATATAATTCCCATGGGTATAGCTGATATGGATTTTAAAACTGCTCCAGAAATAATTTCTGCAATAAAAAATAGGG
TGGAACATGGAGTGTTTGGGTACTCTTATTTAGACGAAGATTACTATAATGTTTTAATAAATTGGTTGGATAATATACAC
AATTTTCAAATAAAAAAAGACTGGATATGTACAGCACCTACAATAGTTGCAGCTATAAGTTGGATGATTCAAAGCTATAC
AGAAAAAGGCGATAAAATAATAATACAATCTCCTGTATATCATCAATTTAAAAGATGTATTGAAAGTGATGGACGTATTG
TAGTAAATAATCCATTAAAATATGAAAACAATAAATACTTTACGGACTTTGAAGATTTAGAAAGTAAGATAGATTCAAAG
GTAAAAATGATGATTCTATGTAATCCTCATAATCCAGGAGGAAGGGTTTGGAAAGCAGATGAATTGAAAAAGTTAGGAGA
TATATGTTTAAAGCATAATATTTTAATAATATCTGATGAAATACATTGTGATTTAGTATTTAAAGGTCATAAACATATAC
CTTTAATCAATGTAGATGAAAAATTAAAAGATATATCCTTAATATGTGTTTCTCCAACAAAAACTTTTAATTTAGCGGCA
CTTCATGTTTCAAATGTTATTATTCCAAATAAAGATTTAAGAGATAAATATTTAAATACAGCATATAAAAATGCAGTAGA
GGGCATAAATGTATTTGGAATAGAGGCTATGAAGGCTGCCTATAAGTATGGAGAAAAGTGGTATAGGGATATGTTACAGT
ATGTAGAAGATAACTACAATTTTCTATGTAATTATATAGAAAAAAATATACCTAAACTAAAAGTATCTAAATCAGAAGGA
ACATATTTAGCATGGATAGATTTTAGGGCTTTATCTATGGATTGTGAAGAGTTAAGAGATTTTATGATAAAAGAAGCAAG
AGTTCTTTTTGATGAGGGGCATGTATTTGGTAAAGAGGGACAAGGTTTTCAAAGAATAAACTTAGCTTGCTCTAGAATAC
TTTTAAAAGAAGCTTTAGATAGAATATATAAAGCTGTAGAAAATATTAACAAACTGTAA

Upstream 100 bases:

>100_bases
AAAAAAGTAAAAAGGTTATAAAAAGTCTGCAAAAATGCAGACTTTTTATTTACTAGATGGTAAAATTTAATTAGGATGAA
TATAAGAAGGAGGAAGAATC

Downstream 100 bases:

>100_bases
ACAATGTGGAAAATTTAAAAAAAGTAGTTGCAAAAGGATAATAATTATTATATAATAACAATTGTAAATAAGAGATATAT
GACAGGAGGAATTTAAAATG

Product: putative aspartate aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MYNFDEIVDRRNTSAVKWDKPKILYNRDDIIPMGIADMDFKTAPEIISAIKNRVEHGVFGYSYLDEDYYNVLINWLDNIH
NFQIKKDWICTAPTIVAAISWMIQSYTEKGDKIIIQSPVYHQFKRCIESDGRIVVNNPLKYENNKYFTDFEDLESKIDSK
VKMMILCNPHNPGGRVWKADELKKLGDICLKHNILIISDEIHCDLVFKGHKHIPLINVDEKLKDISLICVSPTKTFNLAA
LHVSNVIIPNKDLRDKYLNTAYKNAVEGINVFGIEAMKAAYKYGEKWYRDMLQYVEDNYNFLCNYIEKNIPKLKVSKSEG
TYLAWIDFRALSMDCEELRDFMIKEARVLFDEGHVFGKEGQGFQRINLACSRILLKEALDRIYKAVENINKL

Sequences:

>Translated_392_residues
MYNFDEIVDRRNTSAVKWDKPKILYNRDDIIPMGIADMDFKTAPEIISAIKNRVEHGVFGYSYLDEDYYNVLINWLDNIH
NFQIKKDWICTAPTIVAAISWMIQSYTEKGDKIIIQSPVYHQFKRCIESDGRIVVNNPLKYENNKYFTDFEDLESKIDSK
VKMMILCNPHNPGGRVWKADELKKLGDICLKHNILIISDEIHCDLVFKGHKHIPLINVDEKLKDISLICVSPTKTFNLAA
LHVSNVIIPNKDLRDKYLNTAYKNAVEGINVFGIEAMKAAYKYGEKWYRDMLQYVEDNYNFLCNYIEKNIPKLKVSKSEG
TYLAWIDFRALSMDCEELRDFMIKEARVLFDEGHVFGKEGQGFQRINLACSRILLKEALDRIYKAVENINKL
>Mature_392_residues
MYNFDEIVDRRNTSAVKWDKPKILYNRDDIIPMGIADMDFKTAPEIISAIKNRVEHGVFGYSYLDEDYYNVLINWLDNIH
NFQIKKDWICTAPTIVAAISWMIQSYTEKGDKIIIQSPVYHQFKRCIESDGRIVVNNPLKYENNKYFTDFEDLESKIDSK
VKMMILCNPHNPGGRVWKADELKKLGDICLKHNILIISDEIHCDLVFKGHKHIPLINVDEKLKDISLICVSPTKTFNLAA
LHVSNVIIPNKDLRDKYLNTAYKNAVEGINVFGIEAMKAAYKYGEKWYRDMLQYVEDNYNFLCNYIEKNIPKLKVSKSEG
TYLAWIDFRALSMDCEELRDFMIKEARVLFDEGHVFGKEGQGFQRINLACSRILLKEALDRIYKAVENINKL

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=187, Percent_Identity=29.9465240641711, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI56713254, Length=187, Percent_Identity=29.9465240641711, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI95147551, Length=179, Percent_Identity=26.2569832402235, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI169881279, Length=179, Percent_Identity=26.2569832402235, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI169881281, Length=118, Percent_Identity=30.5084745762712, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787909, Length=392, Percent_Identity=33.1632653061224, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1786816, Length=254, Percent_Identity=21.6535433070866, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788627, Length=276, Percent_Identity=22.1014492753623, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994472, Length=110, Percent_Identity=34.5454545454545, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994476, Length=103, Percent_Identity=36.8932038834951, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=110, Percent_Identity=25.4545454545455, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=273, Percent_Identity=26.7399267399267, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573069, Length=281, Percent_Identity=23.8434163701068, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24646114, Length=281, Percent_Identity=23.8434163701068, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28573067, Length=281, Percent_Identity=23.8434163701068, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28573065, Length=281, Percent_Identity=23.8434163701068, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45668; Mature: 45668

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNFDEIVDRRNTSAVKWDKPKILYNRDDIIPMGIADMDFKTAPEIISAIKNRVEHGVFG
CCCHHHHHHCCCCCCEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
YSYLDEDYYNVLINWLDNIHNFQIKKDWICTAPTIVAAISWMIQSYTEKGDKIIIQSPVY
HHHHCHHHHHHHHHHHHHHCCCEEECCEEECCHHHHHHHHHHHHHHHCCCCEEEEECHHH
HQFKRCIESDGRIVVNNPLKYENNKYFTDFEDLESKIDSKVKMMILCNPHNPGGRVWKAD
HHHHHHHCCCCEEEECCCEEECCCCEECCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHH
ELKKLGDICLKHNILIISDEIHCDLVFKGHKHIPLINVDEKLKDISLICVSPTKTFNLAA
HHHHHHHHHHHCCEEEEECCCEEEEEEECCCCCCEEECCHHHCCEEEEEECCCCCCEEEE
LHVSNVIIPNKDLRDKYLNTAYKNAVEGINVFGIEAMKAAYKYGEKWYRDMLQYVEDNYN
EEECCEEECCCCHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCHH
FLCNYIEKNIPKLKVSKSEGTYLAWIDFRALSMDCEELRDFMIKEARVLFDEGHVFGKEG
HHHHHHHCCCCCEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHEEECCCEECCCC
QGFQRINLACSRILLKEALDRIYKAVENINKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYNFDEIVDRRNTSAVKWDKPKILYNRDDIIPMGIADMDFKTAPEIISAIKNRVEHGVFG
CCCHHHHHHCCCCCCEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
YSYLDEDYYNVLINWLDNIHNFQIKKDWICTAPTIVAAISWMIQSYTEKGDKIIIQSPVY
HHHHCHHHHHHHHHHHHHHCCCEEECCEEECCHHHHHHHHHHHHHHHCCCCEEEEECHHH
HQFKRCIESDGRIVVNNPLKYENNKYFTDFEDLESKIDSKVKMMILCNPHNPGGRVWKAD
HHHHHHHCCCCEEEECCCEEECCCCEECCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHH
ELKKLGDICLKHNILIISDEIHCDLVFKGHKHIPLINVDEKLKDISLICVSPTKTFNLAA
HHHHHHHHHHHCCEEEEECCCEEEEEEECCCCCCEEECCHHHCCEEEEEECCCCCCEEEE
LHVSNVIIPNKDLRDKYLNTAYKNAVEGINVFGIEAMKAAYKYGEKWYRDMLQYVEDNYN
EEECCEEECCCCHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCHH
FLCNYIEKNIPKLKVSKSEGTYLAWIDFRALSMDCEELRDFMIKEARVLFDEGHVFGKEG
HHHHHHHCCCCCEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHEEECCCEECCCC
QGFQRINLACSRILLKEALDRIYKAVENINKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]