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The map label for this gene is gltT [H]

Identifier: 28210539

GI number: 28210539

Start: 870751

End: 871995

Strand: Direct

Name: gltT [H]

Synonym: CTC00822

Alternate gene names: 28210539

Gene position: 870751-871995 (Clockwise)

Preceding gene: 28210538

Following gene: 28210540

Centisome position: 31.11

GC content: 33.33

Gene sequence:

>1245_bases
ATGGGTAAAAAGAAAATGAATCTTGTAACTAAAATTATGCTAGGATTAATACTGGGTGTTTTTGTAGGTTTATTTTTTAC
TTCGTCACCTGCCTTTGCAATAAACTATATAAAACCTTTTGGAACTTTATTTTTAAATCTTATAAAAATGACCATAGTTC
CATTGGTTTTTGCATCTTTAGTAGTAGGGGCAGCTAGTATAGGAGATGTAAAAAAACTAGGTAGAATTGGTGGAAAGACT
ATGATCTACTTTTTTGTAACTACAGCTATTGCTATAGTTATAGGATTGGTGCTTGCTAATGTATGTAAACCAGGTGTTGG
AGTGCCACTGGCAGTAGATGCACAAGTAAAAGCAACAGAAGCACCCTCCTTAGTAAAAACTTTATTAGACATAATTCCGA
CAAATCCAATAGACGCTTTAGCTAAGGGGAATATGCTACAAATAATATTCTTTGCAATATTTACAGGAGTTGGGGCAACT
TATATAGGTGAAAAGGGGAATGCATATTTAAAATTTTTTGATAGTTTAGCAGAAATAATGTATAAAATAACTGAAGTTAT
AATGGGATTAGCTCCATACGGAGTCTTTGCACTTATGGTTCCAGTAGTTGCAGAAAATGGTCCAAAGGTTTTACTACCTT
TATTAAAATTAATAGCTGTTTGTTATTTAGGATTTATATTACATGGTATACTAGCCTATTCCTTATCCGTTGCAGTATTT
TCTAAAATATCACCTTTAGAATTTTTTAAAGGAACATCAACATCTACCATGATAGCTTTTAGCACCAGTAGTAGTGCAGG
CACATTGCCAGTAACTATAAAAACTGTTAGAGAAAAATTTGGAGTGTCTGAAGGAATTGCAAGTTTTATTTTGCCATTAG
GAACTACTATTAATATGGATGGGACTGCTATATATCAAGGAGTATGTGCTGTATTTATAGCCCAAGCCTATGGAATGAAT
TTAACTCTAAGTCAACAATTAACTATACTTTTAACAGCATTACTTGCATCTATAGGTACAGCAGGTGTACCAGGAGCAGG
ATTTATGATGCTTATGATGGTATTAAGTTCAGTTGGACTTCCATTAGAAGGAGCAGCTTTAATTGCCGGTATAGATAGAG
TTTTAGATATGGGAAGAACTGCTATAAATGTTACAGGAAATGTAGCCGCCTCAATTGTAGTAGGAGCTAGTGAAAATGAA
ATAAACTATGAAAATGCAAGCATAAAGAAAACAATGAGTAGTTAA

Upstream 100 bases:

>100_bases
ATTTTTTACTAATATGGGTTATAATGATGATGTAGGAATTTTTAATAAATAGCAAGATTTATTTCAAAAAAATGATATAA
TAATTTAAAGGGGGCATTTC

Downstream 100 bases:

>100_bases
AAAGGCAATGTCTTATGAGTAAAATAGTAGGGATAATTGGGGGAATGGGGCCTAAAGCTACGGTAGACCTTTACAATAAA
ATTGTAGACTACACAGATGC

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MGKKKMNLVTKIMLGLILGVFVGLFFTSSPAFAINYIKPFGTLFLNLIKMTIVPLVFASLVVGAASIGDVKKLGRIGGKT
MIYFFVTTAIAIVIGLVLANVCKPGVGVPLAVDAQVKATEAPSLVKTLLDIIPTNPIDALAKGNMLQIIFFAIFTGVGAT
YIGEKGNAYLKFFDSLAEIMYKITEVIMGLAPYGVFALMVPVVAENGPKVLLPLLKLIAVCYLGFILHGILAYSLSVAVF
SKISPLEFFKGTSTSTMIAFSTSSSAGTLPVTIKTVREKFGVSEGIASFILPLGTTINMDGTAIYQGVCAVFIAQAYGMN
LTLSQQLTILLTALLASIGTAGVPGAGFMMLMMVLSSVGLPLEGAALIAGIDRVLDMGRTAINVTGNVAASIVVGASENE
INYENASIKKTMSS

Sequences:

>Translated_414_residues
MGKKKMNLVTKIMLGLILGVFVGLFFTSSPAFAINYIKPFGTLFLNLIKMTIVPLVFASLVVGAASIGDVKKLGRIGGKT
MIYFFVTTAIAIVIGLVLANVCKPGVGVPLAVDAQVKATEAPSLVKTLLDIIPTNPIDALAKGNMLQIIFFAIFTGVGAT
YIGEKGNAYLKFFDSLAEIMYKITEVIMGLAPYGVFALMVPVVAENGPKVLLPLLKLIAVCYLGFILHGILAYSLSVAVF
SKISPLEFFKGTSTSTMIAFSTSSSAGTLPVTIKTVREKFGVSEGIASFILPLGTTINMDGTAIYQGVCAVFIAQAYGMN
LTLSQQLTILLTALLASIGTAGVPGAGFMMLMMVLSSVGLPLEGAALIAGIDRVLDMGRTAINVTGNVAASIVVGASENE
INYENASIKKTMSS
>Mature_413_residues
GKKKMNLVTKIMLGLILGVFVGLFFTSSPAFAINYIKPFGTLFLNLIKMTIVPLVFASLVVGAASIGDVKKLGRIGGKTM
IYFFVTTAIAIVIGLVLANVCKPGVGVPLAVDAQVKATEAPSLVKTLLDIIPTNPIDALAKGNMLQIIFFAIFTGVGATY
IGEKGNAYLKFFDSLAEIMYKITEVIMGLAPYGVFALMVPVVAENGPKVLLPLLKLIAVCYLGFILHGILAYSLSVAVFS
KISPLEFFKGTSTSTMIAFSTSSSAGTLPVTIKTVREKFGVSEGIASFILPLGTTINMDGTAIYQGVCAVFIAQAYGMNL
TLSQQLTILLTALLASIGTAGVPGAGFMMLMMVLSSVGLPLEGAALIAGIDRVLDMGRTAINVTGNVAASIVVGASENEI
NYENASIKKTMSS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI194239697, Length=462, Percent_Identity=31.3852813852814, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI21314632, Length=397, Percent_Identity=33.5012594458438, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI66773030, Length=457, Percent_Identity=31.5098468271335, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI169790839, Length=463, Percent_Identity=30.6695464362851, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI5032093, Length=371, Percent_Identity=35.8490566037736, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI223468564, Length=246, Percent_Identity=39.0243902439024, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI223468566, Length=255, Percent_Identity=38.4313725490196, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI40254478, Length=334, Percent_Identity=32.6347305389222, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4827012, Length=319, Percent_Identity=32.9153605015674, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI262359914, Length=383, Percent_Identity=28.4595300261097, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI301601644, Length=142, Percent_Identity=41.5492957746479, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1790514, Length=427, Percent_Identity=38.8758782201405, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI1789947, Length=408, Percent_Identity=34.8039215686275, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1788024, Length=387, Percent_Identity=30.4909560723514, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789473, Length=283, Percent_Identity=25.4416961130742, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71983106, Length=462, Percent_Identity=31.8181818181818, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71983099, Length=462, Percent_Identity=31.8181818181818, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71996953, Length=459, Percent_Identity=31.1546840958606, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17537407, Length=440, Percent_Identity=29.5454545454545, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI193206505, Length=459, Percent_Identity=31.1546840958606, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI193206654, Length=413, Percent_Identity=28.5714285714286, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17541374, Length=393, Percent_Identity=29.7709923664122, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24583025, Length=438, Percent_Identity=29.9086757990868, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI17137668, Length=438, Percent_Identity=29.9086757990868, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24583023, Length=438, Percent_Identity=29.9086757990868, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI281360483, Length=460, Percent_Identity=28.4782608695652, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI17137666, Length=460, Percent_Identity=28.4782608695652, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI281360481, Length=460, Percent_Identity=28.4782608695652, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43386; Mature: 43254

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKKMNLVTKIMLGLILGVFVGLFFTSSPAFAINYIKPFGTLFLNLIKMTIVPLVFASL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
VVGAASIGDVKKLGRIGGKTMIYFFVTTAIAIVIGLVLANVCKPGVGVPLAVDAQVKATE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCC
APSLVKTLLDIIPTNPIDALAKGNMLQIIFFAIFTGVGATYIGEKGNAYLKFFDSLAEIM
CHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHH
YKITEVIMGLAPYGVFALMVPVVAENGPKVLLPLLKLIAVCYLGFILHGILAYSLSVAVF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKISPLEFFKGTSTSTMIAFSTSSSAGTLPVTIKTVREKFGVSEGIASFILPLGTTINMD
HCCCHHHHHCCCCCCEEEEEECCCCCCCCEEHHHHHHHHHCHHHHHHHHHHHCCCEECCC
GTAIYQGVCAVFIAQAYGMNLTLSQQLTILLTALLASIGTAGVPGAGFMMLMMVLSSVGL
CHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
PLEGAALIAGIDRVLDMGRTAINVTGNVAASIVVGASENEINYENASIKKTMSS
CCCCHHHHHHHHHHHHCCCCEEEECCCEEEEEEEECCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
GKKKMNLVTKIMLGLILGVFVGLFFTSSPAFAINYIKPFGTLFLNLIKMTIVPLVFASL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
VVGAASIGDVKKLGRIGGKTMIYFFVTTAIAIVIGLVLANVCKPGVGVPLAVDAQVKATE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCC
APSLVKTLLDIIPTNPIDALAKGNMLQIIFFAIFTGVGATYIGEKGNAYLKFFDSLAEIM
CHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHH
YKITEVIMGLAPYGVFALMVPVVAENGPKVLLPLLKLIAVCYLGFILHGILAYSLSVAVF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKISPLEFFKGTSTSTMIAFSTSSSAGTLPVTIKTVREKFGVSEGIASFILPLGTTINMD
HCCCHHHHHCCCCCCEEEEEECCCCCCCCEEHHHHHHHHHCHHHHHHHHHHHCCCEECCC
GTAIYQGVCAVFIAQAYGMNLTLSQQLTILLTALLASIGTAGVPGAGFMMLMMVLSSVGL
CHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
PLEGAALIAGIDRVLDMGRTAINVTGNVAASIVVGASENEINYENASIKKTMSS
CCCCHHHHHHHHHHHHCCCCEEEECCCEEEEEEEECCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]