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The map label for this gene is cobC [H]

Identifier: 28210438

GI number: 28210438

Start: 743335

End: 743928

Strand: Direct

Name: cobC [H]

Synonym: CTC00717

Alternate gene names: 28210438

Gene position: 743335-743928 (Clockwise)

Preceding gene: 28210436

Following gene: 28210439

Centisome position: 26.55

GC content: 29.12

Gene sequence:

>594_bases
ATGAATATATATTTAGTAAGACATGGTGAAACAGAAAAAAATACACTAAAAAAGTATTATGGAAACTTAGATGTTGGCCT
TAACGAAAAAGGAAAGATGCAATGTGAGTATTTAAGAGAAAAACTAAGAAATATAGAGTTAGATAAAGTTTATACAAGTG
AAATGAAACGAGCCATAGAAACTGCTAATATAATACTTCAGGATAGGGAGTATAAAATAACAAAAGATAATAGGTTAAAC
GAAATGAATATGGGGGATTTTGAAGGGAAAGACCATAAAGAGTTAGAAAAATTATATCCGAAAGAATGGAACGCTTGGTG
TGAGGATTGGAAGGAATGTTCACCGCCTAAGGGGGAAAGTTATAAAACATTTTATTATAGAGTAAAAGAATTTATAGAAG
ATGTTTTGAAAGAAGAGGTCGAGAATATATTAATTGTAGCCCACGGAGGAGTGATAAAAAGTATATATACTTATATACTA
GGAGAGGATTTTGATATTTTTTGGAAAGTATCAAGTAGAAATGGAGAACTATCTTTGATAAAATATGAATATGGGAATTT
ATATTTAGAATTTAAAATTCCAGCAGGATTTTAA

Upstream 100 bases:

>100_bases
TTATAAAAAATGGAAGGAATTTTTGTATATGTACATAAAAGGCTTTATTATATATAAAATTTTGTGTTATCATAAATAAT
TAGATAGAAGGAGGATTGAA

Downstream 100 bases:

>100_bases
ATGTAAAAAATAGTATTTAGGAGGAGTATAAGAAAATGAATTCAGGTAAAGTCGTATTAGTAACTGGAGGCTCTAGAAGT
GGTAAAAGTTCTTTTGCTGA

Product: alpha-ribazole-5-phosphate phosphatase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MNIYLVRHGETEKNTLKKYYGNLDVGLNEKGKMQCEYLREKLRNIELDKVYTSEMKRAIETANIILQDREYKITKDNRLN
EMNMGDFEGKDHKELEKLYPKEWNAWCEDWKECSPPKGESYKTFYYRVKEFIEDVLKEEVENILIVAHGGVIKSIYTYIL
GEDFDIFWKVSSRNGELSLIKYEYGNLYLEFKIPAGF

Sequences:

>Translated_197_residues
MNIYLVRHGETEKNTLKKYYGNLDVGLNEKGKMQCEYLREKLRNIELDKVYTSEMKRAIETANIILQDREYKITKDNRLN
EMNMGDFEGKDHKELEKLYPKEWNAWCEDWKECSPPKGESYKTFYYRVKEFIEDVLKEEVENILIVAHGGVIKSIYTYIL
GEDFDIFWKVSSRNGELSLIKYEYGNLYLEFKIPAGF
>Mature_197_residues
MNIYLVRHGETEKNTLKKYYGNLDVGLNEKGKMQCEYLREKLRNIELDKVYTSEMKRAIETANIILQDREYKITKDNRLN
EMNMGDFEGKDHKELEKLYPKEWNAWCEDWKECSPPKGESYKTFYYRVKEFIEDVLKEEVENILIVAHGGVIKSIYTYIL
GEDFDIFWKVSSRNGELSLIKYEYGNLYLEFKIPAGF

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Homo sapiens, GI64762445, Length=167, Percent_Identity=34.7305389221557, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI64762406, Length=167, Percent_Identity=34.7305389221557, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4758902, Length=162, Percent_Identity=34.5679012345679, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI118582286, Length=166, Percent_Identity=33.1325301204819, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI4758900, Length=162, Percent_Identity=31.4814814814815, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI224282149, Length=162, Percent_Identity=31.4814814814815, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1786857, Length=181, Percent_Identity=33.1491712707182, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1790856, Length=192, Percent_Identity=27.6041666666667, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17510917, Length=166, Percent_Identity=31.3253012048193, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71993390, Length=166, Percent_Identity=31.3253012048193, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25145314, Length=159, Percent_Identity=28.9308176100629, Blast_Score=63, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322697, Length=200, Percent_Identity=30.5, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322306, Length=162, Percent_Identity=34.5679012345679, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324857, Length=193, Percent_Identity=27.979274611399, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643252, Length=165, Percent_Identity=30.3030303030303, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17137706, Length=165, Percent_Identity=30.3030303030303, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24643264, Length=166, Percent_Identity=30.1204819277108, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24643254, Length=166, Percent_Identity=30.1204819277108, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24643260, Length=166, Percent_Identity=30.1204819277108, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24643258, Length=166, Percent_Identity=30.1204819277108, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24643256, Length=166, Percent_Identity=30.1204819277108, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24643262, Length=166, Percent_Identity=30.1204819277108, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 23492; Mature: 23492

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIYLVRHGETEKNTLKKYYGNLDVGLNEKGKMQCEYLREKLRNIELDKVYTSEMKRAIE
CEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
TANIILQDREYKITKDNRLNEMNMGDFEGKDHKELEKLYPKEWNAWCEDWKECSPPKGES
HHHEEEECCCEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCC
YKTFYYRVKEFIEDVLKEEVENILIVAHGGVIKSIYTYILGEDFDIFWKVSSRNGELSLI
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEE
KYEYGNLYLEFKIPAGF
EEEECCEEEEEEECCCC
>Mature Secondary Structure
MNIYLVRHGETEKNTLKKYYGNLDVGLNEKGKMQCEYLREKLRNIELDKVYTSEMKRAIE
CEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
TANIILQDREYKITKDNRLNEMNMGDFEGKDHKELEKLYPKEWNAWCEDWKECSPPKGES
HHHEEEECCCEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCC
YKTFYYRVKEFIEDVLKEEVENILIVAHGGVIKSIYTYILGEDFDIFWKVSSRNGELSLI
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEE
KYEYGNLYLEFKIPAGF
EEEECCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]