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The map label for this gene is lytC [H]

Identifier: 28210257

GI number: 28210257

Start: 523777

End: 525531

Strand: Direct

Name: lytC [H]

Synonym: CTC00515

Alternate gene names: 28210257

Gene position: 523777-525531 (Clockwise)

Preceding gene: 28210256

Following gene: 28210260

Centisome position: 18.71

GC content: 31.05

Gene sequence:

>1755_bases
TTGAAAAGAAATTTTATAATTGCATTAATAGCATCTATGCTATTAACAAGTTTTACTTCATTAGGAAAAGTACAAGCATC
TGATATATCTCATGAAAGATATTGGGGAAAGGATAGGTATGAAACTTCTATAAAAATATCTCAAAAAGGTTGGGAAAACG
GAGCTAAATATGTGGTACTAGCATCAGGACAAGGTTATGCCGATGCATTATCTGCATCACCCTTTGCAAAGCTTATAGAT
GCACCCATACTACTTACCAAGGGGGATAAATTAGAGGAGAAAACCTTACAAGAAATAAAAAGATTAAATCCATCAAAAGT
TTATATAATAGGGGGCGAAGGTTCTATATCACAACATATTGAAGATGAAATAAAATCTAAGATAAGTAATGATGTGGAAA
GATTTAAAGGTGAAGATAGATATGAGACCTCTATGAAAATGGCGCAAAGATTTCCTAATAAAGAAAAGGTGATATTAGCC
TCTGGAGAAGGGTATGCTGATGCTTTATCTGCGGCACCTATAGCTGCTATAAACAGTATGCCTATTATATTAACTCCTAG
GGACAGGTTACCCAAATTAGCAGAAGATTATCTAAAAAAAGATGAAGTTAAAACTATTTATATAATAGGAGGAACTGCAT
CTATAAGTGACACAATTGAAAAAGAACTTCCATTATCTATTAGAATTTATGGAAAAGATAGATTTGAAACCAATGCTGAA
ATAATAAGAAATTTTATATTAGATTTTGATTATAAAAATGCATATATAGCCTTAGGAGCAGGAGAAACAGGCAATGAGTT
TGCAGATGCTTTAACTGGAGCAGTTGTTGCAGCTAAGGACAGAGCACCTGTTTTATTAACAGGAAAAAACTTAAATAGTA
GTACAAAAGCTATATCAAATGAAGTGTTATTTCCACATACTAAGTTTAAAGTATTAGGTGGAGCTAATAATGTATCAGAT
AAGCTGGTAGAGGATATAAAAGTTACAATAACGGATAATTTTTTAAATAAAGATAAGGAATATACTAGAAATACCGCTGG
AAATGCTATGATTTCAGAAGATGGTATAAGGTTGAAAAATAGTAAAATTAAAGGTAACTTATATGTAGAAAGCGATGATG
TGTCCCTAAAAAATGTAGAGGTTAGCGGAACTATATATCTTGACCCAGGAAGAAAAGGACAGACTAGATTAGAAAAGGTG
AAGGCTGATAAAATCATAGTTTTATCGGCAAGAAATGAAAATGATGGGATTTATTTAGAAGATGTAGATGCAAATTTACT
GGAAATTAAAAGTGGAACAAAGGCAAAGATAAGCATAAGAAGAGGGACGGATCTCAAAAAAATTAAAGTTTTAGCTAATA
CTTTAATTGAAAATTATCAAGGTGATTATAAAGAAATAATTATTCCTAAAACTCCAAACTATAAAGAACTTGAGTTAACA
GGAAGTTTTACTGAAAATATAATAGTAGAAGGTCAAACTGAGCTTAAAACCATAGGTGGAGCCTATGTTACAGATGTTTT
AATAAAGACAAATAAAGAAGATGTAGTTATATTAGATGGAAAGTTTGATGATGTAAAAGTTTATACAGCAGCAGATATAA
AAATTACAGAAAAAGCTTCTGCTAGAATATTTGGAGAAACTATTGAAGCACAAACAAAAGCCGAAATTTATGTTCCTAAA
GGGGCAGATGTTAATATAAGAAGAATTAGGCCGCATAATATAACTGGAGATGGAAAAGATAATGCATTAAATTAA

Upstream 100 bases:

>100_bases
GTATTAAGGAAATGGAGGGATTTAAATTATAATCTTAAAATATTGTTATAATGTAATAGATTAAGAGATTATGGACTAAA
TCATAAAGGAGTGGTTCCAA

Downstream 100 bases:

>100_bases
TAAAAAACCGATGGTTATTTAATTAAATTAAAATGTACCCTTTGTCAAGGACAGTTTAAAAAAAGACTAGGCGGTACTAA
GAAGATGATTTCTGTATTTT

Product: cwp66 homolog/N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MKRNFIIALIASMLLTSFTSLGKVQASDISHERYWGKDRYETSIKISQKGWENGAKYVVLASGQGYADALSASPFAKLID
APILLTKGDKLEEKTLQEIKRLNPSKVYIIGGEGSISQHIEDEIKSKISNDVERFKGEDRYETSMKMAQRFPNKEKVILA
SGEGYADALSAAPIAAINSMPIILTPRDRLPKLAEDYLKKDEVKTIYIIGGTASISDTIEKELPLSIRIYGKDRFETNAE
IIRNFILDFDYKNAYIALGAGETGNEFADALTGAVVAAKDRAPVLLTGKNLNSSTKAISNEVLFPHTKFKVLGGANNVSD
KLVEDIKVTITDNFLNKDKEYTRNTAGNAMISEDGIRLKNSKIKGNLYVESDDVSLKNVEVSGTIYLDPGRKGQTRLEKV
KADKIIVLSARNENDGIYLEDVDANLLEIKSGTKAKISIRRGTDLKKIKVLANTLIENYQGDYKEIIIPKTPNYKELELT
GSFTENIIVEGQTELKTIGGAYVTDVLIKTNKEDVVILDGKFDDVKVYTAADIKITEKASARIFGETIEAQTKAEIYVPK
GADVNIRRIRPHNITGDGKDNALN

Sequences:

>Translated_584_residues
MKRNFIIALIASMLLTSFTSLGKVQASDISHERYWGKDRYETSIKISQKGWENGAKYVVLASGQGYADALSASPFAKLID
APILLTKGDKLEEKTLQEIKRLNPSKVYIIGGEGSISQHIEDEIKSKISNDVERFKGEDRYETSMKMAQRFPNKEKVILA
SGEGYADALSAAPIAAINSMPIILTPRDRLPKLAEDYLKKDEVKTIYIIGGTASISDTIEKELPLSIRIYGKDRFETNAE
IIRNFILDFDYKNAYIALGAGETGNEFADALTGAVVAAKDRAPVLLTGKNLNSSTKAISNEVLFPHTKFKVLGGANNVSD
KLVEDIKVTITDNFLNKDKEYTRNTAGNAMISEDGIRLKNSKIKGNLYVESDDVSLKNVEVSGTIYLDPGRKGQTRLEKV
KADKIIVLSARNENDGIYLEDVDANLLEIKSGTKAKISIRRGTDLKKIKVLANTLIENYQGDYKEIIIPKTPNYKELELT
GSFTENIIVEGQTELKTIGGAYVTDVLIKTNKEDVVILDGKFDDVKVYTAADIKITEKASARIFGETIEAQTKAEIYVPK
GADVNIRRIRPHNITGDGKDNALN
>Mature_584_residues
MKRNFIIALIASMLLTSFTSLGKVQASDISHERYWGKDRYETSIKISQKGWENGAKYVVLASGQGYADALSASPFAKLID
APILLTKGDKLEEKTLQEIKRLNPSKVYIIGGEGSISQHIEDEIKSKISNDVERFKGEDRYETSMKMAQRFPNKEKVILA
SGEGYADALSAAPIAAINSMPIILTPRDRLPKLAEDYLKKDEVKTIYIIGGTASISDTIEKELPLSIRIYGKDRFETNAE
IIRNFILDFDYKNAYIALGAGETGNEFADALTGAVVAAKDRAPVLLTGKNLNSSTKAISNEVLFPHTKFKVLGGANNVSD
KLVEDIKVTITDNFLNKDKEYTRNTAGNAMISEDGIRLKNSKIKGNLYVESDDVSLKNVEVSGTIYLDPGRKGQTRLEKV
KADKIIVLSARNENDGIYLEDVDANLLEIKSGTKAKISIRRGTDLKKIKVLANTLIENYQGDYKEIIIPKTPNYKELELT
GSFTENIIVEGQTELKTIGGAYVTDVLIKTNKEDVVILDGKFDDVKVYTAADIKITEKASARIFGETIEAQTKAEIYVPK
GADVNIRRIRPHNITGDGKDNALN

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 64509; Mature: 64509

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNFIIALIASMLLTSFTSLGKVQASDISHERYWGKDRYETSIKISQKGWENGAKYVVL
CCCCCHHHHHHHHHHHHHHHHCCEECCCCCHHHCCCCCCCEEEEEEECCCCCCCCCEEEE
ASGQGYADALSASPFAKLIDAPILLTKGDKLEEKTLQEIKRLNPSKVYIIGGEGSISQHI
ECCCCCHHHCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHH
EDEIKSKISNDVERFKGEDRYETSMKMAQRFPNKEKVILASGEGYADALSAAPIAAINSM
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCCCHHHCCC
PIILTPRDRLPKLAEDYLKKDEVKTIYIIGGTASISDTIEKELPLSIRIYGKDRFETNAE
CEEECCHHHCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCCCHH
IIRNFILDFDYKNAYIALGAGETGNEFADALTGAVVAAKDRAPVLLTGKNLNSSTKAISN
HHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCEEEECCCCCEEEECCCCCCHHHHHCC
EVLFPHTKFKVLGGANNVSDKLVEDIKVTITDNFLNKDKEYTRNTAGNAMISEDGIRLKN
CEECCCCEEEEEECCCCHHHHHHCCEEEEEEECHHCCCHHHHHCCCCCEEEECCCEEEEC
SKIKGNLYVESDDVSLKNVEVSGTIYLDPGRKGQTRLEKVKADKIIVLSARNENDGIYLE
CEEEEEEEEECCCCEEEEEEEEEEEEECCCCCCCHHHHHHCCCEEEEEEECCCCCCEEEE
DVDANLLEIKSGTKAKISIRRGTDLKKIKVLANTLIENYQGDYKEIIIPKTPNYKELELT
ECCCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEE
GSFTENIIVEGQTELKTIGGAYVTDVLIKTNKEDVVILDGKFDDVKVYTAADIKITEKAS
CCCCCCEEEECCHHHHHCCCCEEEEEEEEECCCCEEEECCCCCCEEEEEEECEEEECCCC
ARIFGETIEAQTKAEIYVPKGADVNIRRIRPHNITGDGKDNALN
CEEEHHHHCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRNFIIALIASMLLTSFTSLGKVQASDISHERYWGKDRYETSIKISQKGWENGAKYVVL
CCCCCHHHHHHHHHHHHHHHHCCEECCCCCHHHCCCCCCCEEEEEEECCCCCCCCCEEEE
ASGQGYADALSASPFAKLIDAPILLTKGDKLEEKTLQEIKRLNPSKVYIIGGEGSISQHI
ECCCCCHHHCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHH
EDEIKSKISNDVERFKGEDRYETSMKMAQRFPNKEKVILASGEGYADALSAAPIAAINSM
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCCCHHHCCC
PIILTPRDRLPKLAEDYLKKDEVKTIYIIGGTASISDTIEKELPLSIRIYGKDRFETNAE
CEEECCHHHCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCCCHH
IIRNFILDFDYKNAYIALGAGETGNEFADALTGAVVAAKDRAPVLLTGKNLNSSTKAISN
HHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCEEEECCCCCEEEECCCCCCHHHHHCC
EVLFPHTKFKVLGGANNVSDKLVEDIKVTITDNFLNKDKEYTRNTAGNAMISEDGIRLKN
CEECCCCEEEEEECCCCHHHHHHCCEEEEEEECHHCCCHHHHHCCCCCEEEECCCEEEEC
SKIKGNLYVESDDVSLKNVEVSGTIYLDPGRKGQTRLEKVKADKIIVLSARNENDGIYLE
CEEEEEEEEECCCCEEEEEEEEEEEEECCCCCCCHHHHHHCCCEEEEEEECCCCCCEEEE
DVDANLLEIKSGTKAKISIRRGTDLKKIKVLANTLIENYQGDYKEIIIPKTPNYKELELT
ECCCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEE
GSFTENIIVEGQTELKTIGGAYVTDVLIKTNKEDVVILDGKFDDVKVYTAADIKITEKAS
CCCCCCEEEECCHHHHHCCCCEEEEEEEEECCCCEEEECCCCCCEEEEEEECEEEECCCC
ARIFGETIEAQTKAEIYVPKGADVNIRRIRPHNITGDGKDNALN
CEEEHHHHCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]