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The map label for this gene is lytC [H]

Identifier: 28210238

GI number: 28210238

Start: 496243

End: 497769

Strand: Direct

Name: lytC [H]

Synonym: CTC00491

Alternate gene names: 28210238

Gene position: 496243-497769 (Clockwise)

Preceding gene: 28210237

Following gene: 28210239

Centisome position: 17.73

GC content: 33.27

Gene sequence:

>1527_bases
ATGTTTGCTAAGAAAAGTAAAAAAGCAATTATATCTACGTTAATAACTAGCTTTATATTTGCACCATCAGTAGGAGGAAT
TTCAAAGGTAGGAGCAAAGGCAGAAGTTGTGAGGATGCCGGGACTTAATAGATTTATTACAGCTCAAAATGTAGCTAAGC
AAAGCTTTGGACAGGCTGAAAATGTAATATTAGTTAATGGTCTTGGATATGCAGATGCAGTAAGTGCGGCCCCTCTTGCT
AAAATATTAAAAGCACCTATCTTACTTACAGATGCTTCAAAAAAACCTTCTGTGGATTTGCTAGAAACTCTAAGTAAACT
AGGAACTAAGAAGGTTTACATAATAGGAGGAGAAGGTGTTGTAACTAAAACTCTAGAAACAGAATTAGCTAAAAGCTATG
CAGTGGAAAGAATAGCGGGAGCCCCTAAAGATGGTAGATATGGAACTAATGCAGCAGTTGCTAAAAGAGTTATAGAAAAA
ACAAGTGCTAAAGGTGGAATATTAGTAAGTGCTGAGGGTTATGCAGATGCACTATCAGTAGCATCAATAGCTGCAAGTAA
AGGATATCCTGTATTGTTTGCTAATAGAGAAGAAATGCCTAAAATAGTAAAGGATATTGCTTCAAATCTTGATGTAAAAG
CTGTTGGAGGGGAAGGAGTTCTTCCTAATAAAGTTTTAGAAAGTGTAAATGCCAAGAGAATAGCTGAGGGAAAAGATAGA
TTTGAAAGCAATTTAAAAGTTTTAGATTATTATAAAGATGATTTAAATTTTAAGAATATATATATAGCAGCAGGTGGAGA
TGACAGCAGATATAAATTTGCTGATGCATTGGTTGCTTCTGCCGTAGCAGGAAAAGATGGAGCACCATTAGTATTAAATG
GTCTTGGAACAAATGCTGAAAGTAGAAATTTTGCCAATGAATATATAAAGGATAATATGACAAAGGATGTAAAAGTTACA
ATAGTTGGCGGCGGAGCTTCTATAGATGGATTTATTGAAAGTGAGCTTTTAGCTAAGGCACAAAAAATAAATGAAGACTT
AGGAGAGGCTGAATCCGAAGACATTGTTGAAGGAGACAAGCAAGAGCATGAAGACCAAGTAGATACAAAAGATCCAACAA
AAGATGAATCAGAAAAGGAACCAGAGAAAGAAAAACCAACTACAGAAGAACCAGAAAAAAAACCAGAAGAAGAAAAACCA
TCTAAAGAAGAATCAGTAAAGCAAGGATTTATAGGTATTTCAAAAATAGAAGCCACAAGCACAAAAGAAATAAAGGTAGT
ATTTGACGAAAAAGTAGTAAAACATAATGCAGAAATATCAATCTACTATGAAATGGATGGAAAAGATCTAACTTATGATA
AATGTGATATAAAGTTATTAGACGATGAAAAAACTGTAGTAATAACCTTTAAAGAAGAACTTAAAAAGGGTACTAAAAAG
AAATTTAAAGTAAAAGAAGGATATATAGAAGCAAAAAATACTGGATACCCAGCACAAGAAAAAGAGGTAGAATTAATATT
TAATTAA

Upstream 100 bases:

>100_bases
AAAAAAGTTAGGAGTATTTTTAAATACACTGTAATTAATTACATAAGTAATATATAATATATATGTTGGAATTATTTATT
TACATAAAGGAGGACTATTT

Downstream 100 bases:

>100_bases
AATTATGGAAGGAGTCGTAGATAAATTTCTCTACAGACTCCTTATCTTTAAATTTGCATAAAATCAATGAAATGATGAAT
AAGTTCTTTCAATATTAACA

Product: putative S-layer protein/N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MFAKKSKKAIISTLITSFIFAPSVGGISKVGAKAEVVRMPGLNRFITAQNVAKQSFGQAENVILVNGLGYADAVSAAPLA
KILKAPILLTDASKKPSVDLLETLSKLGTKKVYIIGGEGVVTKTLETELAKSYAVERIAGAPKDGRYGTNAAVAKRVIEK
TSAKGGILVSAEGYADALSVASIAASKGYPVLFANREEMPKIVKDIASNLDVKAVGGEGVLPNKVLESVNAKRIAEGKDR
FESNLKVLDYYKDDLNFKNIYIAAGGDDSRYKFADALVASAVAGKDGAPLVLNGLGTNAESRNFANEYIKDNMTKDVKVT
IVGGGASIDGFIESELLAKAQKINEDLGEAESEDIVEGDKQEHEDQVDTKDPTKDESEKEPEKEKPTTEEPEKKPEEEKP
SKEESVKQGFIGISKIEATSTKEIKVVFDEKVVKHNAEISIYYEMDGKDLTYDKCDIKLLDDEKTVVITFKEELKKGTKK
KFKVKEGYIEAKNTGYPAQEKEVELIFN

Sequences:

>Translated_508_residues
MFAKKSKKAIISTLITSFIFAPSVGGISKVGAKAEVVRMPGLNRFITAQNVAKQSFGQAENVILVNGLGYADAVSAAPLA
KILKAPILLTDASKKPSVDLLETLSKLGTKKVYIIGGEGVVTKTLETELAKSYAVERIAGAPKDGRYGTNAAVAKRVIEK
TSAKGGILVSAEGYADALSVASIAASKGYPVLFANREEMPKIVKDIASNLDVKAVGGEGVLPNKVLESVNAKRIAEGKDR
FESNLKVLDYYKDDLNFKNIYIAAGGDDSRYKFADALVASAVAGKDGAPLVLNGLGTNAESRNFANEYIKDNMTKDVKVT
IVGGGASIDGFIESELLAKAQKINEDLGEAESEDIVEGDKQEHEDQVDTKDPTKDESEKEPEKEKPTTEEPEKKPEEEKP
SKEESVKQGFIGISKIEATSTKEIKVVFDEKVVKHNAEISIYYEMDGKDLTYDKCDIKLLDDEKTVVITFKEELKKGTKK
KFKVKEGYIEAKNTGYPAQEKEVELIFN
>Mature_508_residues
MFAKKSKKAIISTLITSFIFAPSVGGISKVGAKAEVVRMPGLNRFITAQNVAKQSFGQAENVILVNGLGYADAVSAAPLA
KILKAPILLTDASKKPSVDLLETLSKLGTKKVYIIGGEGVVTKTLETELAKSYAVERIAGAPKDGRYGTNAAVAKRVIEK
TSAKGGILVSAEGYADALSVASIAASKGYPVLFANREEMPKIVKDIASNLDVKAVGGEGVLPNKVLESVNAKRIAEGKDR
FESNLKVLDYYKDDLNFKNIYIAAGGDDSRYKFADALVASAVAGKDGAPLVLNGLGTNAESRNFANEYIKDNMTKDVKVT
IVGGGASIDGFIESELLAKAQKINEDLGEAESEDIVEGDKQEHEDQVDTKDPTKDESEKEPEKEKPTTEEPEKKPEEEKP
SKEESVKQGFIGISKIEATSTKEIKVVFDEKVVKHNAEISIYYEMDGKDLTYDKCDIKLLDDEKTVVITFKEELKKGTKK
KFKVKEGYIEAKNTGYPAQEKEVELIFN

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 55039; Mature: 55039

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAKKSKKAIISTLITSFIFAPSVGGISKVGAKAEVVRMPGLNRFITAQNVAKQSFGQAE
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
NVILVNGLGYADAVSAAPLAKILKAPILLTDASKKPSVDLLETLSKLGTKKVYIIGGEGV
CEEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCE
VTKTLETELAKSYAVERIAGAPKDGRYGTNAAVAKRVIEKTSAKGGILVSAEGYADALSV
EEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
ASIAASKGYPVLFANREEMPKIVKDIASNLDVKAVGGEGVLPNKVLESVNAKRIAEGKDR
HHHHHCCCCEEEEECHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHH
FESNLKVLDYYKDDLNFKNIYIAAGGDDSRYKFADALVASAVAGKDGAPLVLNGLGTNAE
HHCCCEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
SRNFANEYIKDNMTKDVKVTIVGGGASIDGFIESELLAKAQKINEDLGEAESEDIVEGDK
CHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCH
QEHEDQVDTKDPTKDESEKEPEKEKPTTEEPEKKPEEEKPSKEESVKQGFIGISKIEATS
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCC
TKEIKVVFDEKVVKHNAEISIYYEMDGKDLTYDKCDIKLLDDEKTVVITFKEELKKGTKK
CCEEEEEECHHHHHCCCEEEEEEEECCCCCEECCCEEEEECCCCEEEEEEHHHHCCCCHH
KFKVKEGYIEAKNTGYPAQEKEVELIFN
EEEEECCEEEECCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MFAKKSKKAIISTLITSFIFAPSVGGISKVGAKAEVVRMPGLNRFITAQNVAKQSFGQAE
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
NVILVNGLGYADAVSAAPLAKILKAPILLTDASKKPSVDLLETLSKLGTKKVYIIGGEGV
CEEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCE
VTKTLETELAKSYAVERIAGAPKDGRYGTNAAVAKRVIEKTSAKGGILVSAEGYADALSV
EEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
ASIAASKGYPVLFANREEMPKIVKDIASNLDVKAVGGEGVLPNKVLESVNAKRIAEGKDR
HHHHHCCCCEEEEECHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHH
FESNLKVLDYYKDDLNFKNIYIAAGGDDSRYKFADALVASAVAGKDGAPLVLNGLGTNAE
HHCCCEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
SRNFANEYIKDNMTKDVKVTIVGGGASIDGFIESELLAKAQKINEDLGEAESEDIVEGDK
CHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCH
QEHEDQVDTKDPTKDESEKEPEKEKPTTEEPEKKPEEEKPSKEESVKQGFIGISKIEATS
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCC
TKEIKVVFDEKVVKHNAEISIYYEMDGKDLTYDKCDIKLLDDEKTVVITFKEELKKGTKK
CCEEEEEECHHHHHCCCEEEEEEEECCCCCEECCCEEEEECCCCEEEEEEHHHHCCCCHH
KFKVKEGYIEAKNTGYPAQEKEVELIFN
EEEEECCEEEECCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]