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The map label for this gene is macA [H]

Identifier: 28210232

GI number: 28210232

Start: 489447

End: 490760

Strand: Direct

Name: macA [H]

Synonym: CTC00484

Alternate gene names: 28210232

Gene position: 489447-490760 (Clockwise)

Preceding gene: 28210231

Following gene: 28210233

Centisome position: 17.48

GC content: 28.84

Gene sequence:

>1314_bases
ATGAAAAAAAAGTTTAAATTAAACAAAAAATATCTAATATTTGGAGTAATAGCTGTAGTTATAATATTAGTAGCATTTTC
AACAATTAAAGGGAAAAAGGATAATTTCACACAAGTAAGCACAAATACTGTTAGTAAAAAGAATTTAAATAAAGTTGCTA
CAGCAACAGGAAATGTGGAGGCAAACCATAGAAATGATATAGCTTTAAATCCATCTCTAAAAGTGATTAAAGTAAATGTT
AAAGAAGGACAAATGGTTAAAAAAGATGATGTATTAGTGGAACTAGATTCTAAAGATTTAAAAACTCAACTGGAGAAAGC
TGAATTAAACCTAAAGAATGCCAATGATACATTAGCACAATTTCAAGGAGCAGAGGTGGAAAATCAGAAAAAGACAGCAT
CAGGTTCTTTAGTACAAGCAAGACTTGCATTAGAAAATGCTAAAAGTACCCATGAGGATTTATCAAAGAAACTATCACAA
AACAAGAAATTATTTGAAGGAGGATATGTCTCTCAAAATGAATATGATGCTTCTGTAAAAGCGGCAAAAGAGGCTGAAAA
TGGAGTTAAAAATGCAGAAGCAGCATTAAAAAATGCAGAAAATAATTTATCAGGAATAGACATATCTACAAATAATAAAA
TAATATCTCAAAGAAATCAAATCGCAATGATTCAATCAGATATAAAATCCATAAAGGATAAAATAGAAGATTGCTATATA
AAAGCAAATGTTTCTGGAAAAATAGTTAGAATGGATGCAAAGGAAAATCAATATCCTAATTCAGGAGAAATGATAGTAAT
AGATGATGTTTCTAAGTATAGAGTTAATGCAGATATAAATCAATATGATGCAGTTAATATTAAAAAGGGACAAAAGGTAA
ATATAAAAATTAAAGGTATAGATAAAGAGTACAAAGGTAAGATAGAAGAAGTAGGAGAAATTGCAGAAAAGAAAATAGCT
AAAAGTGGTGCTGGAGCAGATGCAGAGCATAAATTAAATATAAAAGTAGCTTTAGACAAATCTGATAGTAAGGTAAAATC
AGGTTACGAAGCAGATTTAGAAATTATATTACAGGAAAGAAAATCATCTTTAGCTATAGGATTTGATGCTATAAGACAGG
ATAAAAAGGGAGGAAAAAAATACACATACGTATTAGATCAAGATAATGTTGTAAAGAAAAGAGAAATAAATACAGGATTA
GAAACGGAATATGATGTAGAAATTTTAGGCGGATTAAAAGAAGGAGAAAAATACATTATAAATCCTCCAGAAAATCTAAA
AGATGGAGAAAGAGTTAATCCTGCAGGTGAATAG

Upstream 100 bases:

>100_bases
TATCTAAAGCTACGGATGAGGATTTAAATACTTTAATAAATAGTACTAAGCTTTTTATTAAATTAATTGAGAAAGATAAT
AAGGAGGACGAGTATAAATT

Downstream 100 bases:

>100_bases
TAGGGGGTGGAGAAGTGATTATAAAACTTGAAGACATTGAAAAAATTTATGATACAGGAGCCATTAAACTAAAAGCCCTA
AATAAAATAAATTTATCTAT

Product: membrane-associated protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MKKKFKLNKKYLIFGVIAVVIILVAFSTIKGKKDNFTQVSTNTVSKKNLNKVATATGNVEANHRNDIALNPSLKVIKVNV
KEGQMVKKDDVLVELDSKDLKTQLEKAELNLKNANDTLAQFQGAEVENQKKTASGSLVQARLALENAKSTHEDLSKKLSQ
NKKLFEGGYVSQNEYDASVKAAKEAENGVKNAEAALKNAENNLSGIDISTNNKIISQRNQIAMIQSDIKSIKDKIEDCYI
KANVSGKIVRMDAKENQYPNSGEMIVIDDVSKYRVNADINQYDAVNIKKGQKVNIKIKGIDKEYKGKIEEVGEIAEKKIA
KSGAGADAEHKLNIKVALDKSDSKVKSGYEADLEIILQERKSSLAIGFDAIRQDKKGGKKYTYVLDQDNVVKKREINTGL
ETEYDVEILGGLKEGEKYIINPPENLKDGERVNPAGE

Sequences:

>Translated_437_residues
MKKKFKLNKKYLIFGVIAVVIILVAFSTIKGKKDNFTQVSTNTVSKKNLNKVATATGNVEANHRNDIALNPSLKVIKVNV
KEGQMVKKDDVLVELDSKDLKTQLEKAELNLKNANDTLAQFQGAEVENQKKTASGSLVQARLALENAKSTHEDLSKKLSQ
NKKLFEGGYVSQNEYDASVKAAKEAENGVKNAEAALKNAENNLSGIDISTNNKIISQRNQIAMIQSDIKSIKDKIEDCYI
KANVSGKIVRMDAKENQYPNSGEMIVIDDVSKYRVNADINQYDAVNIKKGQKVNIKIKGIDKEYKGKIEEVGEIAEKKIA
KSGAGADAEHKLNIKVALDKSDSKVKSGYEADLEIILQERKSSLAIGFDAIRQDKKGGKKYTYVLDQDNVVKKREINTGL
ETEYDVEILGGLKEGEKYIINPPENLKDGERVNPAGE
>Mature_437_residues
MKKKFKLNKKYLIFGVIAVVIILVAFSTIKGKKDNFTQVSTNTVSKKNLNKVATATGNVEANHRNDIALNPSLKVIKVNV
KEGQMVKKDDVLVELDSKDLKTQLEKAELNLKNANDTLAQFQGAEVENQKKTASGSLVQARLALENAKSTHEDLSKKLSQ
NKKLFEGGYVSQNEYDASVKAAKEAENGVKNAEAALKNAENNLSGIDISTNNKIISQRNQIAMIQSDIKSIKDKIEDCYI
KANVSGKIVRMDAKENQYPNSGEMIVIDDVSKYRVNADINQYDAVNIKKGQKVNIKIKGIDKEYKGKIEEVGEIAEKKIA
KSGAGADAEHKLNIKVALDKSDSKVKSGYEADLEIILQERKSSLAIGFDAIRQDKKGGKKYTYVLDQDNVVKKREINTGL
ETEYDVEILGGLKEGEKYIINPPENLKDGERVNPAGE

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=428, Percent_Identity=23.8317757009346, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790519, Length=293, Percent_Identity=22.1843003412969, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 48292; Mature: 48292

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKFKLNKKYLIFGVIAVVIILVAFSTIKGKKDNFTQVSTNTVSKKNLNKVATATGNVE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHCCCHHEEECCCEE
ANHRNDIALNPSLKVIKVNVKEGQMVKKDDVLVELDSKDLKTQLEKAELNLKNANDTLAQ
CCCCCCEEECCCEEEEEEECCCCCEEECCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHH
FQGAEVENQKKTASGSLVQARLALENAKSTHEDLSKKLSQNKKLFEGGYVSQNEYDASVK
HCCCCCCCCHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
AAKEAENGVKNAEAALKNAENNLSGIDISTNNKIISQRNQIAMIQSDIKSIKDKIEDCYI
HHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHEEE
KANVSGKIVRMDAKENQYPNSGEMIVIDDVSKYRVNADINQYDAVNIKKGQKVNIKIKGI
EECCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCCCEEEECCCCEEEEEEEEC
DKEYKGKIEEVGEIAEKKIAKSGAGADAEHKLNIKVALDKSDSKVKSGYEADLEIILQER
CHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCHHHCCCHHHHHHHHHHH
KSSLAIGFDAIRQDKKGGKKYTYVLDQDNVVKKREINTGLETEYDVEILGGLKEGEKYII
HCCEEECHHHHHHHHCCCCEEEEEECCCCCEEHHHCCCCCCCCCCCCEECCCCCCCEEEE
NPPENLKDGERVNPAGE
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKKFKLNKKYLIFGVIAVVIILVAFSTIKGKKDNFTQVSTNTVSKKNLNKVATATGNVE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHCCCHHEEECCCEE
ANHRNDIALNPSLKVIKVNVKEGQMVKKDDVLVELDSKDLKTQLEKAELNLKNANDTLAQ
CCCCCCEEECCCEEEEEEECCCCCEEECCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHH
FQGAEVENQKKTASGSLVQARLALENAKSTHEDLSKKLSQNKKLFEGGYVSQNEYDASVK
HCCCCCCCCHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
AAKEAENGVKNAEAALKNAENNLSGIDISTNNKIISQRNQIAMIQSDIKSIKDKIEDCYI
HHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHEEE
KANVSGKIVRMDAKENQYPNSGEMIVIDDVSKYRVNADINQYDAVNIKKGQKVNIKIKGI
EECCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCCCEEEECCCCEEEEEEEEC
DKEYKGKIEEVGEIAEKKIAKSGAGADAEHKLNIKVALDKSDSKVKSGYEADLEIILQER
CHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCHHHCCCHHHHHHHHHHH
KSSLAIGFDAIRQDKKGGKKYTYVLDQDNVVKKREINTGLETEYDVEILGGLKEGEKYII
HCCEEECHHHHHHHHCCCCEEEEEECCCCCEEHHHCCCCCCCCCCCCEECCCCCCCEEEE
NPPENLKDGERVNPAGE
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]