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The map label for this gene is hgdC [H]

Identifier: 28210201

GI number: 28210201

Start: 445553

End: 446518

Strand: Direct

Name: hgdC [H]

Synonym: CTC00448

Alternate gene names: 28210201

Gene position: 445553-446518 (Clockwise)

Preceding gene: 28210200

Following gene: 28210205

Centisome position: 15.92

GC content: 32.09

Gene sequence:

>966_bases
ATGTATCATATGGGAGTTGACGTAGGTTCTGTTAGTACAGATATAGTCATTTTAGATGAAAATAATAACTTAGTAGAAGG
TCTTTATTTAAAAACCATGGGAAATCCTATACAAATATTAGGAGAAGGTTTTAAGAAATTAGGAGAAAAATATAGAGATG
AAGAAATATCATCCATTGGTATTACAGGAAGTGGTAGAAAATTTGCTTCCTTTTTTATAGGAGGAGATGCTGTTAAAAAT
GAAATAACAGCTCATGCAGTAGCTTCTTTAGAATTGGATCCAAAAGTTAGAACTATAATAGAAATAGGAGGACAGGATTC
TAAAATAATAACCTTACAAAATGGAATTATAAATGACTTTGCTATGAATACAGTATGTGCAGCAGGTACAGGTTCATTTT
TGGATAGGCAAGCAGAAAGAATGGGGATTTCCATAGAAGATCTGGGAAGTTTAGCCTTAAAGGGAAAAGGTGATGTAAGA
ATTGCTGGTAGATGTGCTGTATTTGCCGAATCTGATATGATACATAAACAGCAAATAGGATGTAGTAGAGAAGATATTTT
AAGGGGACTTTGTAAGGCTTTAGTTAGAAACTATTTAAGTAATGTAGCAAAGGGAAAAGAAATAAAAGAAAAAATATTTT
TCCAAGGTGGAGTTGCTTCCAATAAAGGCATAAAAAGAGCCTTTGAAGAAACATTAGGTTGTGAAATATATGTACCTGAA
AATCATAAATTGATGGGAGCTATAGGAGCATCTCATTTAGGAAAAAGTGAAGCTTTAAAAAATAGAAATACAGAATTTAA
AGGCTTTAACTTTTGGAAAAGTAATTTTAAAACAGAAACACACAACTGTGATGGCTGTGGAAACTGCTGTGAAGTAATAA
AAATATTGAGTTCCGGAAAAGTTGTAGGCTTTTTTGGAGATAGATGTAGCAAGTGGAGTAATCAAATTATGACAAAGGCA
ATCTAA

Upstream 100 bases:

>100_bases
CCTATAATGTCTTTAGTAGTAGATGAATTAACGGGAGAATCAGGTTTTGACACAAGATTGGAAGCTTTTGTAGATTTATT
AGAAAGGAGAAAATTTAAAA

Downstream 100 bases:

>100_bases
AAAATCTAGGCTATTGAAGAATACTAAAATGTACCCTTTGTCAAGGACAGTTTAAAAAAAGACTAGGCGGTACTAAGAAG
ATGATTTCTGTATTTTACAG

Product: putative activator of (R)-2-hydroxyglutaryl-CoA dehydratase

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MYHMGVDVGSVSTDIVILDENNNLVEGLYLKTMGNPIQILGEGFKKLGEKYRDEEISSIGITGSGRKFASFFIGGDAVKN
EITAHAVASLELDPKVRTIIEIGGQDSKIITLQNGIINDFAMNTVCAAGTGSFLDRQAERMGISIEDLGSLALKGKGDVR
IAGRCAVFAESDMIHKQQIGCSREDILRGLCKALVRNYLSNVAKGKEIKEKIFFQGGVASNKGIKRAFEETLGCEIYVPE
NHKLMGAIGASHLGKSEALKNRNTEFKGFNFWKSNFKTETHNCDGCGNCCEVIKILSSGKVVGFFGDRCSKWSNQIMTKA
I

Sequences:

>Translated_321_residues
MYHMGVDVGSVSTDIVILDENNNLVEGLYLKTMGNPIQILGEGFKKLGEKYRDEEISSIGITGSGRKFASFFIGGDAVKN
EITAHAVASLELDPKVRTIIEIGGQDSKIITLQNGIINDFAMNTVCAAGTGSFLDRQAERMGISIEDLGSLALKGKGDVR
IAGRCAVFAESDMIHKQQIGCSREDILRGLCKALVRNYLSNVAKGKEIKEKIFFQGGVASNKGIKRAFEETLGCEIYVPE
NHKLMGAIGASHLGKSEALKNRNTEFKGFNFWKSNFKTETHNCDGCGNCCEVIKILSSGKVVGFFGDRCSKWSNQIMTKA
I
>Mature_321_residues
MYHMGVDVGSVSTDIVILDENNNLVEGLYLKTMGNPIQILGEGFKKLGEKYRDEEISSIGITGSGRKFASFFIGGDAVKN
EITAHAVASLELDPKVRTIIEIGGQDSKIITLQNGIINDFAMNTVCAAGTGSFLDRQAERMGISIEDLGSLALKGKGDVR
IAGRCAVFAESDMIHKQQIGCSREDILRGLCKALVRNYLSNVAKGKEIKEKIFFQGGVASNKGIKRAFEETLGCEIYVPE
NHKLMGAIGASHLGKSEALKNRNTEFKGFNFWKSNFKTETHNCDGCGNCCEVIKILSSGKVVGFFGDRCSKWSNQIMTKA
I

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=255, Percent_Identity=32.5490196078431, Blast_Score=121, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 34938; Mature: 34938

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYHMGVDVGSVSTDIVILDENNNLVEGLYLKTMGNPIQILGEGFKKLGEKYRDEEISSIG
CEEECCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHEEC
ITGSGRKFASFFIGGDAVKNEITAHAVASLELDPKVRTIIEIGGQDSKIITLQNGIINDF
CCCCCCEEEEEEECCHHHHHHHHHHHEEEEECCCCEEEEEEECCCCCEEEEEECCCCHHH
AMNTVCAAGTGSFLDRQAERMGISIEDLGSLALKGKGDVRIAGRCAVFAESDMIHKQQIG
HHHHHHCCCCCHHHHHHHHHHCCCHHHHCCEEECCCCCEEEEEEEEEEECCCCHHHHHCC
CSREDILRGLCKALVRNYLSNVAKGKEIKEKIFFQGGVASNKGIKRAFEETLGCEIYVPE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEECC
NHKLMGAIGASHLGKSEALKNRNTEFKGFNFWKSNFKTETHNCDGCGNCCEVIKILSSGK
CCEEEEECCHHHCCHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCC
VVGFFGDRCSKWSNQIMTKAI
EEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYHMGVDVGSVSTDIVILDENNNLVEGLYLKTMGNPIQILGEGFKKLGEKYRDEEISSIG
CEEECCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHEEC
ITGSGRKFASFFIGGDAVKNEITAHAVASLELDPKVRTIIEIGGQDSKIITLQNGIINDF
CCCCCCEEEEEEECCHHHHHHHHHHHEEEEECCCCEEEEEEECCCCCEEEEEECCCCHHH
AMNTVCAAGTGSFLDRQAERMGISIEDLGSLALKGKGDVRIAGRCAVFAESDMIHKQQIG
HHHHHHCCCCCHHHHHHHHHHCCCHHHHCCEEECCCCCEEEEEEEEEEECCCCHHHHHCC
CSREDILRGLCKALVRNYLSNVAKGKEIKEKIFFQGGVASNKGIKRAFEETLGCEIYVPE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEECC
NHKLMGAIGASHLGKSEALKNRNTEFKGFNFWKSNFKTETHNCDGCGNCCEVIKILSSGK
CCEEEEECCHHHCCHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCC
VVGFFGDRCSKWSNQIMTKAI
EEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]