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The map label for this gene is tdk [H]

Identifier: 28210060

GI number: 28210060

Start: 283724

End: 284335

Strand: Direct

Name: tdk [H]

Synonym: CTC00298

Alternate gene names: 28210060

Gene position: 283724-284335 (Clockwise)

Preceding gene: 28210059

Following gene: 28210061

Centisome position: 10.14

GC content: 33.01

Gene sequence:

>612_bases
TTGTTTATTTATAAAATTAGGAGGTATTTTTTTATGTATGGACCTAAAAACCATGGTTGGATTGAAGTAATAACTGGACC
TATGTACAGCGGAAAATCAGAAGAACTTATAAGAAGAGTAAGGAGAGTAAAGATTGCTAAACAAAAGGTTCAAGTTTTTA
AACCAGAAATAGATAATAGATATAGCAATGAAGACGTAGTGTCTCATTGTGGAGATAAAGAAGGAGCAGTTCCTATTAAG
TCTTCAGAAGATATTTTAAAACTTATAAAAGAAGATACTGAAGTAGTAGCTATAGATGAAGCTCAATTTTTTGATAAAGG
TATACTAGAAGTTGTAAACAAAATAGCTAACGAAGGCAAAAGAGTTATATGTGCTGGATTAGATCAAGATTTTAAAGGAG
AGCCCTTTGGATATATGCCAGATATAATAGCAGTCGCAGAATTTGTACACAAAGTGCAAGCGGTTTGTATGATATGTGGT
AATCCAGCAACTAGAACACAAAGACTTATAAATGGAAAACCTGCTAAATATGATGACCCAGTAGTGCTTGTAGGAGCAAA
AGAATCCTATGAGGCAAGATGTAGAAAATGTCATATAGTACCTAAAGAGTGA

Upstream 100 bases:

>100_bases
CCATAGATTAAGTCAATAAATTTAATTGATAGGTAAATGATAAGTAGTTATTATTGAAAATTAGCCTTTAATATATTATA
TAGGTCTGATAAAATAATAC

Downstream 100 bases:

>100_bases
GGTGATACTATGAAAAAACAATGTAGTGTAGGCGGACAAGCTGTAATGGAAGGGGTCATGATGAGGGGAGTTAACGGAAT
TGCTACAGCAGTAAGAAAAA

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MFIYKIRRYFFMYGPKNHGWIEVITGPMYSGKSEELIRRVRRVKIAKQKVQVFKPEIDNRYSNEDVVSHCGDKEGAVPIK
SSEDILKLIKEDTEVVAIDEAQFFDKGILEVVNKIANEGKRVICAGLDQDFKGEPFGYMPDIIAVAEFVHKVQAVCMICG
NPATRTQRLINGKPAKYDDPVVLVGAKESYEARCRKCHIVPKE

Sequences:

>Translated_203_residues
MFIYKIRRYFFMYGPKNHGWIEVITGPMYSGKSEELIRRVRRVKIAKQKVQVFKPEIDNRYSNEDVVSHCGDKEGAVPIK
SSEDILKLIKEDTEVVAIDEAQFFDKGILEVVNKIANEGKRVICAGLDQDFKGEPFGYMPDIIAVAEFVHKVQAVCMICG
NPATRTQRLINGKPAKYDDPVVLVGAKESYEARCRKCHIVPKE
>Mature_203_residues
MFIYKIRRYFFMYGPKNHGWIEVITGPMYSGKSEELIRRVRRVKIAKQKVQVFKPEIDNRYSNEDVVSHCGDKEGAVPIK
SSEDILKLIKEDTEVVAIDEAQFFDKGILEVVNKIANEGKRVICAGLDQDFKGEPFGYMPDIIAVAEFVHKVQAVCMICG
NPATRTQRLINGKPAKYDDPVVLVGAKESYEARCRKCHIVPKE

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family [H]

Homologues:

Organism=Homo sapiens, GI164698438, Length=184, Percent_Identity=39.6739130434783, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17543396, Length=192, Percent_Identity=32.8125, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634 [H]

Pfam domain/function: PF00265 TK [H]

EC number: =2.7.1.21 [H]

Molecular weight: Translated: 23099; Mature: 23099

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIYKIRRYFFMYGPKNHGWIEVITGPMYSGKSEELIRRVRRVKIAKQKVQVFKPEIDNR
CHHHHEEEEHHEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YSNEDVVSHCGDKEGAVPIKSSEDILKLIKEDTEVVAIDEAQFFDKGILEVVNKIANEGK
CCCHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCC
RVICAGLDQDFKGEPFGYMPDIIAVAEFVHKVQAVCMICGNPATRTQRLINGKPAKYDDP
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
VVLVGAKESYEARCRKCHIVPKE
EEEEECCCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MFIYKIRRYFFMYGPKNHGWIEVITGPMYSGKSEELIRRVRRVKIAKQKVQVFKPEIDNR
CHHHHEEEEHHEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YSNEDVVSHCGDKEGAVPIKSSEDILKLIKEDTEVVAIDEAQFFDKGILEVVNKIANEGK
CCCHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCC
RVICAGLDQDFKGEPFGYMPDIIAVAEFVHKVQAVCMICGNPATRTQRLINGKPAKYDDP
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
VVLVGAKESYEARCRKCHIVPKE
EEEEECCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]