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The map label for this gene is manC [H]

Identifier: 28210028

GI number: 28210028

Start: 240171

End: 241238

Strand: Direct

Name: manC [H]

Synonym: CTC00265

Alternate gene names: 28210028

Gene position: 240171-241238 (Clockwise)

Preceding gene: 28210027

Following gene: 28210029

Centisome position: 8.58

GC content: 28.56

Gene sequence:

>1068_bases
TTGTTATATGCACTAATTTTAGCAGGAGGAAAAGGAACAAGATTATATCCTCTTTCAAGGGAAGATAAACCTAAACAATT
TTTAAAAATAATTAATAATAAAAGCTTCTTAAAAAGTACAGTAGATAGAATAAAGACTTTAGTAAATATGGAGAATATAT
ATATAGTTACAAATGAAGTTTATCTAGAAAAAATATATGAAGAATTACCTGAATTAAATAAAGAGAATATATTCTTAGAA
CCAGAGAATAAGGAAACAGCAACTTGCATAGGTCTTTCTGCAGTTAAATTACTTAAAAAAGATAAAGATGCTGTGATGAT
GGTTCTTCCTTCAGATCATCATATTCAAGATGAAAAAGTCTTTATAGATACTATGAAACAAGCAGTAGAAACAGTAGAAA
AAAAAAGGGGGTTAGTAACAGTTGGAGTTAAGCCCATAAGACCAGAAACTGGATATGGATATATTGAAGCAGGAGAGAGA
GTACAGGGAAGTATTGCTACCTATAAAGTAGAAAGATTTGTAGAAAAACCAAATGTAGAAGTTGCAAAGGATTTAATAAT
GAAAGGTAATTACCTTTGGAATAGTGGAATGTTTGTTTGGAGAGCCGATATATATTTGAGAGAAATGGAAAAATATTTAC
CAAAGATGTATAAGAGTATGATGAATATATATTCTAGTCTAGGTACAGAAGAAGAAGAGGAGGTTATAAGACAAGAATAT
AATCTAATAGATGGAATTTCTGTAGATTTTGGAATTATGCAAAAAACTAGAAAAGCTTATGTTATAAAATGTGAGTTTAC
ATGGGATGATATAGGTAGTTTTATGTCGCTATCCAGATTCTTAAAAAATTTCCGGGGAAATAATGTAGAAGGAAATACTT
TCTTGGAACAAAGTAATAACTGTATAGTTTTTAGTAAAGAGAAGTTAATTATAGGATTTGGAATAAATGATTTGATAATA
GTAGATTCAGGAGATGTAATGCTTATAATGGATAAAAATAAAGACCAGGAGATAAAGCATTTAGTTGATGAGTTAAAATG
TTCCAAGGAATTTAATAAATTTACTTAG

Upstream 100 bases:

>100_bases
AATAAAGGACTTAAAGCAGTTTAAATTTAAAAAAGTAATCACCACTCCGGTTATTACTTCATAATATATTTTATGACTAA
TAATTCGGAGTGATGTTTTT

Downstream 100 bases:

>100_bases
TATATAAAGAAAGTCCTTAGATACTCCTAATATATTAAGGTCTTTCTTTTTTATAATAATATATATATATATATATATAG
TAAATAAAAACCATTCCTAG

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MLYALILAGGKGTRLYPLSREDKPKQFLKIINNKSFLKSTVDRIKTLVNMENIYIVTNEVYLEKIYEELPELNKENIFLE
PENKETATCIGLSAVKLLKKDKDAVMMVLPSDHHIQDEKVFIDTMKQAVETVEKKRGLVTVGVKPIRPETGYGYIEAGER
VQGSIATYKVERFVEKPNVEVAKDLIMKGNYLWNSGMFVWRADIYLREMEKYLPKMYKSMMNIYSSLGTEEEEEVIRQEY
NLIDGISVDFGIMQKTRKAYVIKCEFTWDDIGSFMSLSRFLKNFRGNNVEGNTFLEQSNNCIVFSKEKLIIGFGINDLII
VDSGDVMLIMDKNKDQEIKHLVDELKCSKEFNKFT

Sequences:

>Translated_355_residues
MLYALILAGGKGTRLYPLSREDKPKQFLKIINNKSFLKSTVDRIKTLVNMENIYIVTNEVYLEKIYEELPELNKENIFLE
PENKETATCIGLSAVKLLKKDKDAVMMVLPSDHHIQDEKVFIDTMKQAVETVEKKRGLVTVGVKPIRPETGYGYIEAGER
VQGSIATYKVERFVEKPNVEVAKDLIMKGNYLWNSGMFVWRADIYLREMEKYLPKMYKSMMNIYSSLGTEEEEEVIRQEY
NLIDGISVDFGIMQKTRKAYVIKCEFTWDDIGSFMSLSRFLKNFRGNNVEGNTFLEQSNNCIVFSKEKLIIGFGINDLII
VDSGDVMLIMDKNKDQEIKHLVDELKCSKEFNKFT
>Mature_355_residues
MLYALILAGGKGTRLYPLSREDKPKQFLKIINNKSFLKSTVDRIKTLVNMENIYIVTNEVYLEKIYEELPELNKENIFLE
PENKETATCIGLSAVKLLKKDKDAVMMVLPSDHHIQDEKVFIDTMKQAVETVEKKRGLVTVGVKPIRPETGYGYIEAGER
VQGSIATYKVERFVEKPNVEVAKDLIMKGNYLWNSGMFVWRADIYLREMEKYLPKMYKSMMNIYSSLGTEEEEEVIRQEY
NLIDGISVDFGIMQKTRKAYVIKCEFTWDDIGSFMSLSRFLKNFRGNNVEGNTFLEQSNNCIVFSKEKLIIGFGINDLII
VDSGDVMLIMDKNKDQEIKHLVDELKCSKEFNKFT

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=356, Percent_Identity=36.2359550561798, Blast_Score=216, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 41045; Mature: 41045

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYALILAGGKGTRLYPLSREDKPKQFLKIINNKSFLKSTVDRIKTLVNMENIYIVTNEV
CEEEEEEECCCCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEHHH
YLEKIYEELPELNKENIFLEPENKETATCIGLSAVKLLKKDKDAVMMVLPSDHHIQDEKV
HHHHHHHHHHCCCCCCEEECCCCCCCCEEHHHHHHHHHHCCCCEEEEEECCCCCCCCHHH
FIDTMKQAVETVEKKRGLVTVGVKPIRPETGYGYIEAGERVQGSIATYKVERFVEKPNVE
HHHHHHHHHHHHHHHCCEEEECCEECCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCHH
VAKDLIMKGNYLWNSGMFVWRADIYLREMEKYLPKMYKSMMNIYSSLGTEEEEEVIRQEY
HHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
NLIDGISVDFGIMQKTRKAYVIKCEFTWDDIGSFMSLSRFLKNFRGNNVEGNTFLEQSNN
CHHCCCCCCHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCC
CIVFSKEKLIIGFGINDLIIVDSGDVMLIMDKNKDQEIKHLVDELKCSKEFNKFT
EEEEECCEEEEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLYALILAGGKGTRLYPLSREDKPKQFLKIINNKSFLKSTVDRIKTLVNMENIYIVTNEV
CEEEEEEECCCCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEHHH
YLEKIYEELPELNKENIFLEPENKETATCIGLSAVKLLKKDKDAVMMVLPSDHHIQDEKV
HHHHHHHHHHCCCCCCEEECCCCCCCCEEHHHHHHHHHHCCCCEEEEEECCCCCCCCHHH
FIDTMKQAVETVEKKRGLVTVGVKPIRPETGYGYIEAGERVQGSIATYKVERFVEKPNVE
HHHHHHHHHHHHHHHCCEEEECCEECCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCHH
VAKDLIMKGNYLWNSGMFVWRADIYLREMEKYLPKMYKSMMNIYSSLGTEEEEEVIRQEY
HHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
NLIDGISVDFGIMQKTRKAYVIKCEFTWDDIGSFMSLSRFLKNFRGNNVEGNTFLEQSNN
CHHCCCCCCHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCC
CIVFSKEKLIIGFGINDLIIVDSGDVMLIMDKNKDQEIKHLVDELKCSKEFNKFT
EEEEECCEEEEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042; 9004408 [H]