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The map label for this gene is norM [H]

Identifier: 28199905

GI number: 28199905

Start: 2407639

End: 2408985

Strand: Reverse

Name: norM [H]

Synonym: PD2044

Alternate gene names: 28199905

Gene position: 2408985-2407639 (Counterclockwise)

Preceding gene: 28199906

Following gene: 28199904

Centisome position: 95.6

GC content: 51.08

Gene sequence:

>1347_bases
GTGATATCCCGCTTTGGTTCCGAAGTTCGTCCTACTCTTTTGCTTGCGCTGCCGCTCGTTTTGGGTCACGTTTCCACTGG
TCTGATCGGCTTTGTACTTAACGTTATTGCTGGTCATCACTCTACCGTCACTCTAGCGGCATCGACTATCGGCACTGCAT
TGCTTTGGTTGCCGATGTTGGTACCCATGGGTACGTTGATTTCGTTAACGGTGTTGGTATCGCAATTGCATGGTGCTGAG
CGTGAACGGGACATTGGGCCTTTGTTCCGCCAAGCGTTGTGGCTGGCCATGCTGTTGGGGTTGGTGATGTTCACTTTCCT
CAGTGTGGTGCCAGCCTTGTTGCCGCTCTTTGGTATCGTCCCGGATATCGTTCCGGGTGCTGCTAAGTTTTTGCATGTAG
TGCGTTGGGGGAGTTTGGCATTCCCTCTTTACTTCTGTATGCGTTATTTCTGTGAGGGAATGCACTGTACTTTTCCAACG
ATGCTTCTGGGTTTTGGTGGGTTGCTAGTGCTGGTGCCATTGAGTTATGCGTTGACATACGGTCGTTTTGGTTTTGCCGA
GTATGGTGTTGAGGGCTTGGGGATCGCAACAGTGACGGTCATGTGGCTACAGGCGGTTGTATTTGCGTTGTACTTGTGGA
GATCACGTCGCTTCGCCCATCTGCAGCTATTTGCGCATCTGGAATTGCCGTGCTGGGCACGTATCCGTGATCTGTTGAAT
ATAGGATTACCCATCGGCATTAGTATTTTGATGGAGGGCGGATTATTTATTGTCACCACGTTGCTGATTGGTCGGTTTGG
TACTGATGAAATTGCCGCGCATCAAATTGCCCTAAGTGTTGCTCAATTGTGCTTCATGATCCCGATGGGTGTAGCTGAGG
CAACCACGGTGCGAATCGGCCATGCTGTGGGTCGTTGCGATCTTTTGGTGATGCGCCGTGTCGCTTGGGCTGGTTATGCA
ATCGTGATCGGGACGCAGACACTCTCAGCAAGTGTGCTTTTGCTCGGATATGACGTGATTGTAGCCGCTTATACGGATGA
TTTGGTGGTGGCGTCTCTGGCTTCTAAATTACTGTTGTTTGCGGCTATATTCCAGTTCCCGGATGGTCTCCAGATGCTTT
CGTCCGGTGTATTACGTGGGATGAAGGACACCCGGGTGCCGATGCTGCTGGCGATGATCTCGTATTGGGGTTTAGGTATG
CCGCTTGGTCTTGGCCTTGGTTTTGCCTTGGAATGGAATTCTCGCGGTATGTGGATCGGCTTAATCATTGGCTTGACTGC
AGCTGCATTGTTGCTTGGTTGGCGATTTCGTGTGGTTAGCGAGCGCATGTTTGCCGGTATTCCCTAA

Upstream 100 bases:

>100_bases
CCATAAATTGCGCCTTTACGCGCATCCTAAATGCCTAGTGTTTTTACCTAGGCCCGATTTCAGGATCGCTCTTTCTATTT
GCTTTATGGCAGTCTCGTTT

Downstream 100 bases:

>100_bases
TTGTCAGTCACAGCGCGGTTATGCTGACACCCGCTGCGCTGATTCGCGTTCAAAATGATGTCAGTTTTTCAAGGAGCGTT
TCATGAACCAGTCTGTGCCT

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALLWLPMLVPMGTLISLTVLVSQLHGAE
RERDIGPLFRQALWLAMLLGLVMFTFLSVVPALLPLFGIVPDIVPGAAKFLHVVRWGSLAFPLYFCMRYFCEGMHCTFPT
MLLGFGGLLVLVPLSYALTYGRFGFAEYGVEGLGIATVTVMWLQAVVFALYLWRSRRFAHLQLFAHLELPCWARIRDLLN
IGLPIGISILMEGGLFIVTTLLIGRFGTDEIAAHQIALSVAQLCFMIPMGVAEATTVRIGHAVGRCDLLVMRRVAWAGYA
IVIGTQTLSASVLLLGYDVIVAAYTDDLVVASLASKLLLFAAIFQFPDGLQMLSSGVLRGMKDTRVPMLLAMISYWGLGM
PLGLGLGFALEWNSRGMWIGLIIGLTAAALLLGWRFRVVSERMFAGIP

Sequences:

>Translated_448_residues
MISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALLWLPMLVPMGTLISLTVLVSQLHGAE
RERDIGPLFRQALWLAMLLGLVMFTFLSVVPALLPLFGIVPDIVPGAAKFLHVVRWGSLAFPLYFCMRYFCEGMHCTFPT
MLLGFGGLLVLVPLSYALTYGRFGFAEYGVEGLGIATVTVMWLQAVVFALYLWRSRRFAHLQLFAHLELPCWARIRDLLN
IGLPIGISILMEGGLFIVTTLLIGRFGTDEIAAHQIALSVAQLCFMIPMGVAEATTVRIGHAVGRCDLLVMRRVAWAGYA
IVIGTQTLSASVLLLGYDVIVAAYTDDLVVASLASKLLLFAAIFQFPDGLQMLSSGVLRGMKDTRVPMLLAMISYWGLGM
PLGLGLGFALEWNSRGMWIGLIIGLTAAALLLGWRFRVVSERMFAGIP
>Mature_448_residues
MISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALLWLPMLVPMGTLISLTVLVSQLHGAE
RERDIGPLFRQALWLAMLLGLVMFTFLSVVPALLPLFGIVPDIVPGAAKFLHVVRWGSLAFPLYFCMRYFCEGMHCTFPT
MLLGFGGLLVLVPLSYALTYGRFGFAEYGVEGLGIATVTVMWLQAVVFALYLWRSRRFAHLQLFAHLELPCWARIRDLLN
IGLPIGISILMEGGLFIVTTLLIGRFGTDEIAAHQIALSVAQLCFMIPMGVAEATTVRIGHAVGRCDLLVMRRVAWAGYA
IVIGTQTLSASVLLLGYDVIVAAYTDDLVVASLASKLLLFAAIFQFPDGLQMLSSGVLRGMKDTRVPMLLAMISYWGLGM
PLGLGLGFALEWNSRGMWIGLIIGLTAAALLLGWRFRVVSERMFAGIP

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=451, Percent_Identity=25.0554323725055, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI22907060, Length=423, Percent_Identity=24.113475177305, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI38261960, Length=487, Percent_Identity=24.435318275154, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI48994890, Length=442, Percent_Identity=34.841628959276, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI226510954, Length=296, Percent_Identity=25, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320545, Length=439, Percent_Identity=21.6400911161731, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48693; Mature: 48693

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALLWLPML
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHH
VPMGTLISLTVLVSQLHGAERERDIGPLFRQALWLAMLLGLVMFTFLSVVPALLPLFGIV
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDIVPGAAKFLHVVRWGSLAFPLYFCMRYFCEGMHCTFPTMLLGFGGLLVLVPLSYALTY
HHHCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GRFGFAEYGVEGLGIATVTVMWLQAVVFALYLWRSRRFAHLQLFAHLELPCWARIRDLLN
CCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHH
IGLPIGISILMEGGLFIVTTLLIGRFGTDEIAAHQIALSVAQLCFMIPMGVAEATTVRIG
CCCCHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HAVGRCDLLVMRRVAWAGYAIVIGTQTLSASVLLLGYDVIVAAYTDDLVVASLASKLLLF
HHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAIFQFPDGLQMLSSGVLRGMKDTRVPMLLAMISYWGLGMPLGLGLGFALEWNSRGMWIG
HHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCCHHH
LIIGLTAAALLLGWRFRVVSERMFAGIP
HHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]