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The map label for this gene is hecB [H]

Identifier: 28199800

GI number: 28199800

Start: 2268193

End: 2269902

Strand: Reverse

Name: hecB [H]

Synonym: PD1933

Alternate gene names: 28199800

Gene position: 2269902-2268193 (Counterclockwise)

Preceding gene: 77747719

Following gene: 28199796

Centisome position: 90.08

GC content: 54.97

Gene sequence:

>1710_bases
ATGGCAATACGATTCAAACCATATATTCGATGGTGCCTGCTCCCATTGATCGCAGCGCTGCTCCAACAACAGAGCGCATA
CGCCCAAGTCGCACCACCCGATCAAGAATTGCTCCGCCAACAAGAACGTGAACGCGCACTCCGTGAACAACTGGAGCGCG
GCACCGATACCCGTTTACAAGAAGTACCGGGAAAAATCCCCTCCTTATTGCCACATGACGAAACCCCCTGCTTCCCTATC
CAGAAAATTTTTCTCGAAGGTGACAAAGCCGCCCGCTTTCAATGGGCCTTGACCGCTGCCAACCCACCCCATGATCCAGC
TATCGGGCGTTGCCTCGGCACCGCAGGCATCAACATTGTTATCTCCCGCGTACAAAACGCCATCATTTCCCGTGGCTACG
TCACCACACGCGTCCTTGCTACCCCACAAGACCTCAAAAGCGGAGAACTTCACCTCACCCTCATTCCCGGCATACTCGCC
CACATTCGTTTTGCTCCCGGCACCAAACCCGATGCCACTTTTTGGAACGCCATCCCCGCCCACCCTGGCGACCTACTCAA
CCTGCGCGATATAGAACAAGGTCTAGAGAACTTCAAACGCGTTCCCACAGTCGAAGCGGATATCCAAATCGTTCCCACCG
AAGGAGACAACTCTCAGCCCGGTCAAAGCGATTTACTTATTTCCTGGACCCAAGGCCGCCCTGTCCGTTTCAATGCCAGT
TTTGACGACTCAGGCAGCAAAAGTACCGGCAAAACCCAGGCTGGAGTCACTCTCTCTCTGGACCATGCCCTGACTCAAAA
TGACCTCTTCTACATCAGCCTCAACCGTTCTGCCTTCAACGGCAGCAAACGCGGGACCCGAGGCATCACCCTCCATTACT
CCATGCCCTTAGGTAACTGGTTAATCGCCGCCACCCACAGCGGCTACAACTACCACCAAAGCATTGCAGGCAGCCAACAA
ACCTATATTTACAGCGGTGAAAGCCATAACAGCGAACTCAAACTATCCCGGCGCCTCATCCGTACCGCCAGCAGCAAAAG
CGGTATCTACCTACGTGGTTGGACCCGTGACTCGAAAAATTTCATCGACGATACAGAAGTCCTCGTACAACGCCGTCGCA
TGGCAGGTTGGGAAATGGGCCTCACCTATCGCCGCTACATCAATACCGCAACACTGGATACTACTCTGGGTTTCCGGCGC
GGTACCGGTGCCTTTGGTGCATTACCCGCCCCAGAAGAACTCTTTGATGAAGGCACCTCCCGTCCCAAAATCTACTTTGC
TGACTTACAGTTCAACCTTCCCTTTCAACTGGGTCACCAATCCTTGCGCTATACCGGTAGTTGGCGTGCCCAATGGAACC
GTACCCCTCTGATTACCCAAGACCGTTTTTCCATCGGCGGGCGCTACACCGTCCGTGGCTTCGATGGCGAAACTACCTTG
ATCGGCGAGCGCGGCTGGCTGTTGCGTAACGATCTTGGGCTATCCCTTGGAGGCGGCCAAGAAGCGTACCTCGCCCTTGA
CTATGCACACATCGGAGGGGCGTCGGCCTACTTACAACAAGGCAACCACCTTGCCGGTACCGCCTTGGGATTGCGTGGAG
GCCACCGCAGCCTATTTTGGGATGTCTTCGTAGGCGCCCCAATCAACCGCCCACGCACCTTCTCAAACGCCTATACCGTG
ACCGGATTCAGCTTGAACTGGTCCTTCTAA

Upstream 100 bases:

>100_bases
GAATGAATAGGGTGCATGGCACTTGGAGCGCTCCCTTTCACAGCAACACAAGCAAGGTAAAGGGATGATCCAGAATACAA
AAACGTCTTCTTTGAACACC

Downstream 100 bases:

>100_bases
ACACATACCGCTCTCAAAACATTTCACTTAATGGGGATACCATGAACAAGGATCTCTAGCGTCTCATCTACAACTGTGCT
CTGCGTTTGTGGCAAGTCAC

Product: hemolysin activation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MAIRFKPYIRWCLLPLIAALLQQQSAYAQVAPPDQELLRQQERERALREQLERGTDTRLQEVPGKIPSLLPHDETPCFPI
QKIFLEGDKAARFQWALTAANPPHDPAIGRCLGTAGINIVISRVQNAIISRGYVTTRVLATPQDLKSGELHLTLIPGILA
HIRFAPGTKPDATFWNAIPAHPGDLLNLRDIEQGLENFKRVPTVEADIQIVPTEGDNSQPGQSDLLISWTQGRPVRFNAS
FDDSGSKSTGKTQAGVTLSLDHALTQNDLFYISLNRSAFNGSKRGTRGITLHYSMPLGNWLIAATHSGYNYHQSIAGSQQ
TYIYSGESHNSELKLSRRLIRTASSKSGIYLRGWTRDSKNFIDDTEVLVQRRRMAGWEMGLTYRRYINTATLDTTLGFRR
GTGAFGALPAPEELFDEGTSRPKIYFADLQFNLPFQLGHQSLRYTGSWRAQWNRTPLITQDRFSIGGRYTVRGFDGETTL
IGERGWLLRNDLGLSLGGGQEAYLALDYAHIGGASAYLQQGNHLAGTALGLRGGHRSLFWDVFVGAPINRPRTFSNAYTV
TGFSLNWSF

Sequences:

>Translated_569_residues
MAIRFKPYIRWCLLPLIAALLQQQSAYAQVAPPDQELLRQQERERALREQLERGTDTRLQEVPGKIPSLLPHDETPCFPI
QKIFLEGDKAARFQWALTAANPPHDPAIGRCLGTAGINIVISRVQNAIISRGYVTTRVLATPQDLKSGELHLTLIPGILA
HIRFAPGTKPDATFWNAIPAHPGDLLNLRDIEQGLENFKRVPTVEADIQIVPTEGDNSQPGQSDLLISWTQGRPVRFNAS
FDDSGSKSTGKTQAGVTLSLDHALTQNDLFYISLNRSAFNGSKRGTRGITLHYSMPLGNWLIAATHSGYNYHQSIAGSQQ
TYIYSGESHNSELKLSRRLIRTASSKSGIYLRGWTRDSKNFIDDTEVLVQRRRMAGWEMGLTYRRYINTATLDTTLGFRR
GTGAFGALPAPEELFDEGTSRPKIYFADLQFNLPFQLGHQSLRYTGSWRAQWNRTPLITQDRFSIGGRYTVRGFDGETTL
IGERGWLLRNDLGLSLGGGQEAYLALDYAHIGGASAYLQQGNHLAGTALGLRGGHRSLFWDVFVGAPINRPRTFSNAYTV
TGFSLNWSF
>Mature_568_residues
AIRFKPYIRWCLLPLIAALLQQQSAYAQVAPPDQELLRQQERERALREQLERGTDTRLQEVPGKIPSLLPHDETPCFPIQ
KIFLEGDKAARFQWALTAANPPHDPAIGRCLGTAGINIVISRVQNAIISRGYVTTRVLATPQDLKSGELHLTLIPGILAH
IRFAPGTKPDATFWNAIPAHPGDLLNLRDIEQGLENFKRVPTVEADIQIVPTEGDNSQPGQSDLLISWTQGRPVRFNASF
DDSGSKSTGKTQAGVTLSLDHALTQNDLFYISLNRSAFNGSKRGTRGITLHYSMPLGNWLIAATHSGYNYHQSIAGSQQT
YIYSGESHNSELKLSRRLIRTASSKSGIYLRGWTRDSKNFIDDTEVLVQRRRMAGWEMGLTYRRYINTATLDTTLGFRRG
TGAFGALPAPEELFDEGTSRPKIYFADLQFNLPFQLGHQSLRYTGSWRAQWNRTPLITQDRFSIGGRYTVRGFDGETTLI
GERGWLLRNDLGLSLGGGQEAYLALDYAHIGGASAYLQQGNHLAGTALGLRGGHRSLFWDVFVGAPINRPRTFSNAYTVT
GFSLNWSF

Specific function: Probable member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 63332; Mature: 63201

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRFKPYIRWCLLPLIAALLQQQSAYAQVAPPDQELLRQQERERALREQLERGTDTRLQ
CCEEEHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
EVPGKIPSLLPHDETPCFPIQKIFLEGDKAARFQWALTAANPPHDPAIGRCLGTAGINIV
HCCCCCCCCCCCCCCCCCCHHHEEECCCCCEEEEEEEECCCCCCCCHHHHHHHHCCHHHH
ISRVQNAIISRGYVTTRVLATPQDLKSGELHLTLIPGILAHIRFAPGTKPDATFWNAIPA
HHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEECCHHHHHEEECCCCCCCCCCCCCCCC
HPGDLLNLRDIEQGLENFKRVPTVEADIQIVPTEGDNSQPGQSDLLISWTQGRPVRFNAS
CCCCCCCHHHHHHHHHHHHHCCCEECCEEEEECCCCCCCCCCCCEEEEECCCCCEEEECC
FDDSGSKSTGKTQAGVTLSLDHALTQNDLFYISLNRSAFNGSKRGTRGITLHYSMPLGNW
CCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCE
LIAATHSGYNYHQSIAGSQQTYIYSGESHNSELKLSRRLIRTASSKSGIYLRGWTRDSKN
EEEEECCCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCC
FIDDTEVLVQRRRMAGWEMGLTYRRYINTATLDTTLGFRRGTGAFGALPAPEELFDEGTS
CCCHHHHHHHHHHHCCHHHCCCHHHHHCCCEEEHCCCCCCCCCCCCCCCCCHHHHHCCCC
RPKIYFADLQFNLPFQLGHQSLRYTGSWRAQWNRTPLITQDRFSIGGRYTVRGFDGETTL
CCEEEEEEEEECCCHHHCCCEEEECCCEEEECCCCCCEECCCCCCCCEEEEEECCCCEEE
IGERGWLLRNDLGLSLGGGQEAYLALDYAHIGGASAYLQQGNHLAGTALGLRGGHRSLFW
EECCCCEEECCCCEEECCCCEEEEEEEEHHCCCHHHHHHCCCCEEEEEEECCCCCCCEEE
DVFVGAPINRPRTFSNAYTVTGFSLNWSF
EEEECCCCCCCCCCCCEEEEEEEEEEECC
>Mature Secondary Structure 
AIRFKPYIRWCLLPLIAALLQQQSAYAQVAPPDQELLRQQERERALREQLERGTDTRLQ
CEEEHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
EVPGKIPSLLPHDETPCFPIQKIFLEGDKAARFQWALTAANPPHDPAIGRCLGTAGINIV
HCCCCCCCCCCCCCCCCCCHHHEEECCCCCEEEEEEEECCCCCCCCHHHHHHHHCCHHHH
ISRVQNAIISRGYVTTRVLATPQDLKSGELHLTLIPGILAHIRFAPGTKPDATFWNAIPA
HHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEECCHHHHHEEECCCCCCCCCCCCCCCC
HPGDLLNLRDIEQGLENFKRVPTVEADIQIVPTEGDNSQPGQSDLLISWTQGRPVRFNAS
CCCCCCCHHHHHHHHHHHHHCCCEECCEEEEECCCCCCCCCCCCEEEEECCCCCEEEECC
FDDSGSKSTGKTQAGVTLSLDHALTQNDLFYISLNRSAFNGSKRGTRGITLHYSMPLGNW
CCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCE
LIAATHSGYNYHQSIAGSQQTYIYSGESHNSELKLSRRLIRTASSKSGIYLRGWTRDSKN
EEEEECCCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCC
FIDDTEVLVQRRRMAGWEMGLTYRRYINTATLDTTLGFRRGTGAFGALPAPEELFDEGTS
CCCHHHHHHHHHHHCCHHHCCCHHHHHCCCEEEHCCCCCCCCCCCCCCCCCHHHHHCCCC
RPKIYFADLQFNLPFQLGHQSLRYTGSWRAQWNRTPLITQDRFSIGGRYTVRGFDGETTL
CCEEEEEEEEECCCHHHCCCEEEECCCEEEECCCCCCEECCCCCCCCEEEEEECCCCEEE
IGERGWLLRNDLGLSLGGGQEAYLALDYAHIGGASAYLQQGNHLAGTALGLRGGHRSLFW
EECCCCEEECCCCEEECCCCEEEEEEEEHHCCCHHHHHHCCCCEEEEEEECCCCCCCEEE
DVFVGAPINRPRTFSNAYTVTGFSLNWSF
EEEECCCCCCCCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2407716 [H]