Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 28199266

GI number: 28199266

Start: 1605017

End: 1605574

Strand: Reverse

Name: hpt [H]

Synonym: PD1382

Alternate gene names: 28199266

Gene position: 1605574-1605017 (Counterclockwise)

Preceding gene: 28199267

Following gene: 28199265

Centisome position: 63.72

GC content: 51.25

Gene sequence:

>558_bases
TTGATGTCTAACTTCACTATTTCTCAGATACTTGCTCGGGCTGATTTATTGGTAGACCGTCCCAGTATTGATGTGGCTAT
TGCGCATATCGCCGATGACATCGCCAGGGACTATCAGGGGGATGTGCCGTTGTTTGTCACCATCATGCATGGTGGGTTGC
CGTTTGCGGGTCAATTAGCATTGGAGCTGGGCCAGCGTGGTCAGGACATAGAGTTGGATTCCTTACATGCGACGCGTTAC
CGTGGTGAGCAGACTGGCGGTGCATTGGTGTGGAGGCATTATCCGGTCAGTGCCATGTCTGGTCGTCGTGTGATTCTGGT
TGACGATATTCTCGACGAGGGTCATACCTTGTCTGAGATACGTCAGTGGTGCCTAAAGCGGGGGGCTACCGATGTGTCGC
TAGTGGTGCTGATGATTAAATGTCATGATCGTTGTATACCCAATATGAGGGCAGATTATTATGGCGTGGAGGTTCCGGAT
CGCTATGTGTTTGGTTTTGGAATGGACATAGCGGGGCAGCTGCGCGGTATCCCGGCAATTTATGCGATGAGGCAATAG

Upstream 100 bases:

>100_bases
GTTTGATCGGTCGCGGTGTGCTTGGTTGGGATGGGCTACTGGCCGATGTTCGTTATGGTTCCATTCAATCCCATTTATTT
GAACGATTCGGAACATCCAC

Downstream 100 bases:

>100_bases
TATGCAAACGATTGCTCTGGCGGTGATTGGTGGTACTGGTGTTTATACGTTGTCTCAGTTCGACGATGTACAGGTGTATG
AGGTTGAGACGTTGTATGGC

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MMSNFTISQILARADLLVDRPSIDVAIAHIADDIARDYQGDVPLFVTIMHGGLPFAGQLALELGQRGQDIELDSLHATRY
RGEQTGGALVWRHYPVSAMSGRRVILVDDILDEGHTLSEIRQWCLKRGATDVSLVVLMIKCHDRCIPNMRADYYGVEVPD
RYVFGFGMDIAGQLRGIPAIYAMRQ

Sequences:

>Translated_185_residues
MMSNFTISQILARADLLVDRPSIDVAIAHIADDIARDYQGDVPLFVTIMHGGLPFAGQLALELGQRGQDIELDSLHATRY
RGEQTGGALVWRHYPVSAMSGRRVILVDDILDEGHTLSEIRQWCLKRGATDVSLVVLMIKCHDRCIPNMRADYYGVEVPD
RYVFGFGMDIAGQLRGIPAIYAMRQ
>Mature_185_residues
MMSNFTISQILARADLLVDRPSIDVAIAHIADDIARDYQGDVPLFVTIMHGGLPFAGQLALELGQRGQDIELDSLHATRY
RGEQTGGALVWRHYPVSAMSGRRVILVDDILDEGHTLSEIRQWCLKRGATDVSLVVLMIKCHDRCIPNMRADYYGVEVPD
RYVFGFGMDIAGQLRGIPAIYAMRQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20644; Mature: 20644

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSNFTISQILARADLLVDRPSIDVAIAHIADDIARDYQGDVPLFVTIMHGGLPFAGQLA
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHH
LELGQRGQDIELDSLHATRYRGEQTGGALVWRHYPVSAMSGRRVILVDDILDEGHTLSEI
HHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHH
RQWCLKRGATDVSLVVLMIKCHDRCIPNMRADYYGVEVPDRYVFGFGMDIAGQLRGIPAI
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEECCCHHHHHCCCCCE
YAMRQ
EEECC
>Mature Secondary Structure
MMSNFTISQILARADLLVDRPSIDVAIAHIADDIARDYQGDVPLFVTIMHGGLPFAGQLA
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHH
LELGQRGQDIELDSLHATRYRGEQTGGALVWRHYPVSAMSGRRVILVDDILDEGHTLSEI
HHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHH
RQWCLKRGATDVSLVVLMIKCHDRCIPNMRADYYGVEVPDRYVFGFGMDIAGQLRGIPAI
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEECCCHHHHHCCCCCE
YAMRQ
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]