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The map label for this gene is fur [H]

Identifier: 28199258

GI number: 28199258

Start: 1598476

End: 1598886

Strand: Reverse

Name: fur [H]

Synonym: PD1374

Alternate gene names: 28199258

Gene position: 1598886-1598476 (Counterclockwise)

Preceding gene: 28199260

Following gene: 28199256

Centisome position: 63.45

GC content: 48.42

Gene sequence:

>411_bases
ATGGAATTAAATGATTTACGTAAAGTTGGTTTGAAGGTGACACATCCGCGGATCCGTATCCTCGAACTGCTCGAACAGTC
CAGTAGTGAACATCACCTTAGTGCTGAAGACATTTACCGGCAGTTGCTTGAGCAGGGTAACGAAATTGGCTTGGCAACAG
TGTATCGGGTGCTGACTCAGTTTGAGGCGGCAGGATTAGTGCTTAAGCATAATTTCGAGAGCGGGCAGGCGGTCTACGAG
ATCGACCGTGGCGGACATCACGATCATATGGTGGATGTCGATACCGGTAAGATCATTGAGTTTCACAACGAGGAGATTGA
GTTGTTGCAGCGCAGCATTGCTGCTGAACGCGGTTATGAGTTGGAAGAACACTCGTTGGTCTTGTACGTACGTAAAAAAC
GCGGTCGTTGA

Upstream 100 bases:

>100_bases
GTCAACAGGTAAATATTTGCACGATGATACACTCCTATGCGGTTGCCGTAACCGATTCACGAGGTCGCGGATGCTAAATG
GTCCATCAATTGAGAAGTCA

Downstream 100 bases:

>100_bases
TGGTGAGTGCGTTTCCGTGCGTGTAACGGGAGAACAGAGTGGTGTGAGGGTAGGGGGAGCGGAGTTATTTTCTTGAATGT
ACAGTGCTTCATGGATGCCT

Product: ferric uptake regulator

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MELNDLRKVGLKVTHPRIRILELLEQSSSEHHLSAEDIYRQLLEQGNEIGLATVYRVLTQFEAAGLVLKHNFESGQAVYE
IDRGGHHDHMVDVDTGKIIEFHNEEIELLQRSIAAERGYELEEHSLVLYVRKKRGR

Sequences:

>Translated_136_residues
MELNDLRKVGLKVTHPRIRILELLEQSSSEHHLSAEDIYRQLLEQGNEIGLATVYRVLTQFEAAGLVLKHNFESGQAVYE
IDRGGHHDHMVDVDTGKIIEFHNEEIELLQRSIAAERGYELEEHSLVLYVRKKRGR
>Mature_136_residues
MELNDLRKVGLKVTHPRIRILELLEQSSSEHHLSAEDIYRQLLEQGNEIGLATVYRVLTQFEAAGLVLKHNFESGQAVYE
IDRGGHHDHMVDVDTGKIIEFHNEEIELLQRSIAAERGYELEEHSLVLYVRKKRGR

Specific function: Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon. Involved in exotoxin A regulation, siderophore regulation and manganese susceptibility [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=124, Percent_Identity=56.4516129032258, Blast_Score=146, Evalue=5e-37,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 15725; Mature: 15725

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNDLRKVGLKVTHPRIRILELLEQSSSEHHLSAEDIYRQLLEQGNEIGLATVYRVLTQ
CCHHHHHHCCEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
FEAAGLVLKHNFESGQAVYEIDRGGHHDHMVDVDTGKIIEFHNEEIELLQRSIAAERGYE
HHHCCEEEEECCCCCCEEEEECCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHCCCC
LEEHSLVLYVRKKRGR
CCCCCEEEEEECCCCC
>Mature Secondary Structure
MELNDLRKVGLKVTHPRIRILELLEQSSSEHHLSAEDIYRQLLEQGNEIGLATVYRVLTQ
CCHHHHHHCCEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
FEAAGLVLKHNFESGQAVYEIDRGGHHDHMVDVDTGKIIEFHNEEIELLQRSIAAERGYE
HHHCCEEEEECCCCCCEEEEECCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHCCCC
LEEHSLVLYVRKKRGR
CCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8478325; 9852033; 10984043 [H]